LOCUS       NM_001432               4615 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens epiregulin (EREG), mRNA.
ACCESSION   NM_001432
VERSION     NM_001432.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4615)
  AUTHORS   Xu,S., Wang,H., Zhu,Y., Han,Y., Liu,L., Zhang,X., Hu,J., Zhang,W.,
            Duan,S., Deng,J., Zhang,Z. and Liu,S.
  TITLE     Stabilization of EREG via STT3B-mediated N-glycosylation is
            critical for PDL1 upregulation and immune evasion in head and neck
            squamous cell carcinoma
  JOURNAL   Int J Oral Sci 16 (1), 47 (2024)
   PUBMED   38945975
  REMARK    GeneRIF: Stabilization of EREG via STT3B-mediated N-glycosylation
            is critical for PDL1 upregulation and immune evasion in head and
            neck squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4615)
  AUTHORS   Cubillos,P., Ditzer,N., Kolodziejczyk,A., Schwenk,G., Hoffmann,J.,
            Schutze,T.M., Derihaci,R.P., Birdir,C., Kollner,J.E., Petzold,A.,
            Sarov,M., Martin,U., Long,K.R., Wimberger,P. and Albert,M.
  TITLE     The growth factor EPIREGULIN promotes basal progenitor cell
            proliferation in the developing neocortex
  JOURNAL   EMBO J 43 (8), 1388-1419 (2024)
   PUBMED   38514807
  REMARK    GeneRIF: The growth factor EPIREGULIN promotes basal progenitor
            cell proliferation in the developing neocortex.
REFERENCE   3  (bases 1 to 4615)
  AUTHORS   Lin,C.W., Yang,W.E., Su,C.W., Lu,H.J., Su,S.C. and Yang,S.F.
  TITLE     IGF2BP2 promotes cell invasion and epithelial-mesenchymal
            transition through Src-mediated upregulation of EREG in oral cancer
  JOURNAL   Int J Biol Sci 20 (3), 818-830 (2024)
   PUBMED   38250159
  REMARK    GeneRIF: IGF2BP2 promotes cell invasion and epithelial-mesenchymal
            transition through Src-mediated upregulation of EREG in oral
            cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4615)
  AUTHORS   Liu,X., Qin,L., Li,W. and Fei,F.
  TITLE     MicroRNA-1179 targets Epiregulin (EREG) regulates the proliferation
            and metastasis of human multiple myeloma cells
  JOURNAL   Acta Biochim Pol 70 (2), 389-393 (2023)
   PUBMED   37329522
  REMARK    GeneRIF: MicroRNA-1179 targets Epiregulin (EREG) regulates the
            proliferation and metastasis of human multiple myeloma cells.
REFERENCE   5  (bases 1 to 4615)
  AUTHORS   Zheng,L., Wang,X.I., Chen,S., Moosvi,A.M., Wan,D.Q. and Zhang,S.
  TITLE     Two Cases of Biphasic Synovial Sarcoma With Expression of PAX8 and
            ER: A Diagnostic Pitfall
  JOURNAL   Int J Gynecol Pathol 42 (3), 234-240 (2023)
   PUBMED   36730878
  REMARK    GeneRIF: Two Cases of Biphasic Synovial Sarcoma With Expression of
            PAX8 and ER: A Diagnostic Pitfall.
REFERENCE   6  (bases 1 to 4615)
  AUTHORS   Riese,D.J. 2nd and Cullum,R.L.
  TITLE     Epiregulin: roles in normal physiology and cancer
  JOURNAL   Semin Cell Dev Biol 28, 49-56 (2014)
   PUBMED   24631357
  REMARK    Review article
REFERENCE   7  (bases 1 to 4615)
  AUTHORS   Riese,D.J. 2nd, Komurasaki,T., Plowman,G.D. and Stern,D.F.
  TITLE     Activation of ErbB4 by the bifunctional epidermal growth factor
            family hormone epiregulin is regulated by ErbB2
  JOURNAL   J Biol Chem 273 (18), 11288-11294 (1998)
   PUBMED   9556621
REFERENCE   8  (bases 1 to 4615)
  AUTHORS   Shelly,M., Pinkas-Kramarski,R., Guarino,B.C., Waterman,H.,
            Wang,L.M., Lyass,L., Alimandi,M., Kuo,A., Bacus,S.S., Pierce,J.H.,
            Andrews,G.C. and Yarden,Y.
  TITLE     Epiregulin is a potent pan-ErbB ligand that preferentially
            activates heterodimeric receptor complexes
  JOURNAL   J Biol Chem 273 (17), 10496-10505 (1998)
   PUBMED   9553109
REFERENCE   9  (bases 1 to 4615)
  AUTHORS   Komurasaki,T., Toyoda,H., Uchida,D. and Morimoto,S.
  TITLE     Epiregulin binds to epidermal growth factor receptor and ErbB-4 and
            induces tyrosine phosphorylation of epidermal growth factor
            receptor, ErbB-2, ErbB-3 and ErbB-4
  JOURNAL   Oncogene 15 (23), 2841-2848 (1997)
   PUBMED   9419975
REFERENCE   10 (bases 1 to 4615)
  AUTHORS   Toyoda,H., Komurasaki,T., Uchida,D. and Morimoto,S.
  TITLE     Distribution of mRNA for human epiregulin, a differentially
            expressed member of the epidermal growth factor family
  JOURNAL   Biochem J 326 (Pt 1) (Pt 1), 69-75 (1997)
   PUBMED   9337852
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D30783.1 and AC021180.6.
            
            On Nov 22, 2018 this sequence version replaced NM_001432.2.
            
            Summary: This gene encodes a secreted peptide hormone and member of
            the epidermal growth factor (EGF) family of proteins. The encoded
            protein is a ligand of the epidermal growth factor receptor (EGFR)
            and the structurally related erb-b2 receptor tyrosine kinase 4
            (ERBB4). The encoded protein may be involved in a wide range of
            biological processes including inflammation, wound healing, oocyte
            maturation, and cell proliferation. Additionally, the encoded
            protein may promote the progression of cancers of various human
            tissues. [provided by RefSeq, Jul 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D30783.1, BC136404.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244869.3/ ENSP00000244869.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-514               D30783.1           3-516
            515-592             AC021180.6         53495-53572
            593-4615            AC021180.6         55505-59527
FEATURES             Location/Qualifiers
     source          1..4615
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..4615
                     /gene="EREG"
                     /gene_synonym="Ep; EPR; ER"
                     /note="epiregulin"
                     /db_xref="GeneID:2069"
                     /db_xref="HGNC:HGNC:3443"
                     /db_xref="MIM:602061"
     exon            1..231
                     /gene="EREG"
                     /gene_synonym="Ep; EPR; ER"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..674
                     /gene="EREG"
                     /gene_synonym="Ep; EPR; ER"
                     /note="proepiregulin"
                     /codon_start=1
                     /product="proepiregulin preproprotein"
                     /protein_id="NP_001423.1"
                     /db_xref="CCDS:CCDS3564.1"
                     /db_xref="GeneID:2069"
                     /db_xref="HGNC:HGNC:3443"
                     /db_xref="MIM:602061"
                     /translation="MTAGRRMEMLCAGRVPALLLCLGFHLLQAVLSTTVIPSCIPGES
                     SDNCTALVQTEDNPRVAQVSITKCSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVR
                     CEHFFLTVHQPLSKEYVALTVILIILFLITVVGSTYYFCRWYRNRKSKEPKKEYERVT
                     SGDPELPQV"
     exon            232..318
                     /gene="EREG"
                     /gene_synonym="Ep; EPR; ER"
                     /inference="alignment:Splign:2.1.0"
     exon            319..442
                     /gene="EREG"
                     /gene_synonym="Ep; EPR; ER"
                     /inference="alignment:Splign:2.1.0"
     exon            443..592
                     /gene="EREG"
                     /gene_synonym="Ep; EPR; ER"
                     /inference="alignment:Splign:2.1.0"
     exon            593..4615
                     /gene="EREG"
                     /gene_synonym="Ep; EPR; ER"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4583..4588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EREG"
                     /gene_synonym="Ep; EPR; ER"
                     /note="hexamer: AATAAA"
     polyA_site      4615
                     /gene="EREG"
                     /gene_synonym="Ep; EPR; ER"
                     /note="major polyA site"
ORIGIN      
        1 acttgcctga tatttccagt gtcagaggga cacagccaac gtggggtccc ttctaggctg
       61 acagccgctc tccagccact gccgcgagcc cgtctgctcc cgccctgccc gtgcactctc
      121 cgcagccgcc ctccgccaag ccccagcgcc cgctcccatc gccgatgacc gcggggagga
      181 ggatggagat gctctgtgcc ggcagggtcc ctgcgctgct gctctgcctg ggtttccatc
      241 ttctacaggc agtcctcagt acaactgtga ttccatcatg tatcccagga gagtccagtg
      301 ataactgcac agctttagtt cagacagaag acaatccacg tgtggctcaa gtgtcaataa
      361 caaagtgtag ctctgacatg aatggctatt gtttgcatgg acagtgcatc tatctggtgg
      421 acatgagtca aaactactgc aggtgtgaag tgggttatac tggtgtccga tgtgaacact
      481 tctttttaac cgtccaccaa cctttaagca aagaatatgt ggctttgacc gtgattctta
      541 ttattttgtt tcttatcaca gtcgtcggtt ccacatatta tttctgcaga tggtacagaa
      601 atcgaaaaag taaagaacca aagaaggaat atgagagagt tacctcaggg gatccagagt
      661 tgccgcaagt ctgaatggcg ccatcaaact tatgggcagg gataacagtg tgcctggtta
      721 atattaatat tcccatttta ttaataatat ttatgttggg tcaagtgtta ggtcaataac
      781 actgtatttt aatgtacttg aaaaatgttt ttatttttgt tttatttttg acagactatt
      841 tgctaatgta taatgtgcag aaaatattta atatcaaaag aaaattgata tttttataca
      901 agtaatttcc tgagctaaat gcttcattga aagcttcaaa gtttatatgc ctggtgcaca
      961 gtgcttagaa gtaagcaatt cccaggtcat agctcaagaa ttgttagcaa atgacagatt
     1021 tctgtaagcc tatatatata gtcaaatcga tttagtaagt atgtttttta tgttcctcaa
     1081 atcagtgata attggtttga ctgtaccatg gtttgatatg tagttggcac catggtatca
     1141 tatattaaaa caataatgca attagaattt gggagaagca aatataggtc ctgtgttaaa
     1201 cactacacat ttgaaacaag ctaaccctgg ggagtctatg gtctcttcac tcaggtctca
     1261 gctataattc tgttatatga ggggcagtgg acagttccct atgccaactc acgactccta
     1321 caggtactag tcactcatct accagattct gcctatgtaa aatgaattga aaaacaattt
     1381 tctgtaatct tttatttaag tagtgggcat ttcatagctt cacaatgttc cttttttgta
     1441 tattacaaca tttatgtgag gtaattattg ctcaacagac aattagaaaa aagtccacac
     1501 ttgaagccta aatttgtgct ttttaagaat atttttagac tatttctttt tataggggct
     1561 ttgctgaatt ctaacattaa atcacagccc aaaatttgat ggactaatta ttattttaaa
     1621 atatatgaag acaataattc tacatgttgt cttaagatgg aaatacagtt atttcatctt
     1681 ttattcaagg aagttttaac tttaatacag ctcagtaaat ggcttcttct agaatgtaaa
     1741 gttatgtatt taaagttgta tcttgacaca ggaaatggga aaaaacttaa aaattaatat
     1801 ggtgtatttt tccaaatgaa aaatctcaat tgaaagcttt taaaatgtag aaacttaaac
     1861 acaccttcct gtggaggctg agatgaaaac tagggctcat tttcctgaca tttgtttatt
     1921 ttttggaaga gacaaagatt tcttctgcac tctgagccca taggtctcag agagttaata
     1981 ggagtatttt tgggctattg cataaggagc cactgctgcc accacttttg gattttatgg
     2041 gaggctcctt catcgaatgc taaacctttg agtagagtct ccctggatca cataccaggt
     2101 cagggaggat ctgttcttcc tctacgttta tcctggcatg tgctagggta aacgaaggca
     2161 taataagcca tggctgacct ctggagcacc aggtgccagg acttgtctcc atgtgtatcc
     2221 atgcattata taccctggtg caatcacacg actgtcatct aaagtcctgg ccctggccct
     2281 tactattagg aaaataaaca gacaaaaaca agtaaatata tatggtcata tacatattgt
     2341 atatatattc atatacaaac atgtatgtat acatgacctt aatggatcat agaattgcag
     2401 tcatttggtg ctctgctaac catttatata aaacttaaaa acaagagaaa agaaaaatca
     2461 attagatcta aacagttatt tctgtttcct atttaataca gctgaagtca aaatatgtaa
     2521 gaacacattt taaatactct acttacagtt ggccctctgt ggttagttcc acatctgtgg
     2581 attcaaccaa ccaaggacgg aaaatgctta aaaaataata caacaacaac aaaaaataca
     2641 ttataacaac tatttacttt tttttttttc tttttgagat ggagtctcgc tctgttgccc
     2701 aggttggagt gcagtggcac gatctcggct cactgcaacc tcacctcccg ggttcaagag
     2761 atcctcctgc ctcagcctcc tgagcagctg ggactacagg cgcatgccac catgcccagc
     2821 taatttttgt atttttagta gaggcggggt ttcaccatgt tggccaggat ggtctcaatc
     2881 tcctaacctt gagatccacc ctccacagcc tcccaaactg ctgggattac aggtgtgagc
     2941 caccgcacgt agcatttaca ttaggtatta caagtaatgt aaagatgatt taagtataca
     3001 ggaggatgtg aataggttat atgcaagcac tatgcccttt tatataagtg acttgaacat
     3061 ctgtgcccga ttttagtatg tgcagggggg cgatctggga atcagtcccc tgtggatacc
     3121 aaggtacaac tgtatttatt aacgcttact agatgtgagg agagtctgaa tattttcagt
     3181 gatcttggct gtttcaaaaa aatctattga cttttcaata aatcagctgc aatccattta
     3241 tttcatttac aaaagattta ttgtaagcat ctcaatcttg gtttgtcagt ttatcttaag
     3301 catgtcaatt cataaaaaca agtcattttt gtatttttca tctttaagaa tgcttaaaaa
     3361 agctaatccc taaaatagtt agatctttgt aaatgcatat taaataataa agtatgaccc
     3421 acattacttt ttatgggtga aaataagaca aaaataatag ttttagtgag gatggtgctg
     3481 agtaaacata aaaactgatt tgctctcagc tgatgtgtcc tgtacacagt gggaagattt
     3541 tagttcacac ttagtctaac tcccccattt tacagatttc tcactatata tatttctaga
     3601 aggggctatg catattcaat gtattgagaa ccaaagcaac cacaaatgca taaatgcata
     3661 atttatggtc ttcaaccaag gccacataat aacccagtta acttactctt taaccaggaa
     3721 tattaagttc tataactagt actcaaggtt taaccttaaa attaagattt ccttaacctt
     3781 aaccttaaaa ttgatattat attaaacata cataatacaa tgtaactcca ctgttctcct
     3841 gaatattttt tgctctaatc tctctgccga aagtcaaagt gatgggagaa ttggtatact
     3901 ggtatgacta cgtcttaagt cagattttta tttatgagtc tttgagacta aattcaatca
     3961 ccaccaggta tcaaatcaac ttttatgcag caaatatatg attctagtgt ctgacttttg
     4021 ttaaattcag taatgcagtt tttaaaaacc tgtatctgac ccactttgta atttttgctc
     4081 caatatccat tctgtagact tttgaaaaaa aagtttttaa tttgatgccc aatatattct
     4141 gaccgttaaa aaattcttgt tcatatggga gaagggggag taatgacttg tacaaacagt
     4201 atttctggtg tatattttaa tgtttttaaa aagagtaatt tcatttaaat atctgttatt
     4261 caaatttgat gatgttaaat gtaatataat gtattttctt tttattttgc actctgtaat
     4321 tgcacttttt aagtttgaag agccattttg gtaaacggtt tttattaaag atgctatgga
     4381 acataaagtt gtattgcatg caatttgaag taacttattt gactatgaat gttatcggat
     4441 tactgaattg tatcaatttg tttgtgttca atatcagctt tgataattgt gtaccttaag
     4501 atattgaagg agaaaataga taatttacaa gatattatta atttttattt atttttcttg
     4561 ggaattgaaa aaaattgaaa taaataaaaa tgcattgaac atcttgcatt caaaa
//
