LOCUS       NM_015576               6239 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens ELKS/RAB6-interacting/CAST family member 2 (ERC2),
            transcript variant 1, mRNA.
ACCESSION   NM_015576
VERSION     NM_015576.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6239)
  AUTHORS   Cheng,P., Chen,K., Zhang,S., Mu,K.T., Liang,S. and Zhang,Y.
  TITLE     IDH1 R132C and ERC2 L309I Mutations Contribute to the Development
            of Maffucci's Syndrome
  JOURNAL   Front Endocrinol (Lausanne) 12, 763349 (2021)
   PUBMED   34790172
  REMARK    GeneRIF: IDH1 R132C and ERC2 L309I Mutations Contribute to the
            Development of Maffucci's Syndrome.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6239)
  AUTHORS   Arancibia,D., Lira,M., Cruz,Y., Barrera,D.P.,
            Montenegro-Venegas,C., Godoy,J.A., Garner,C.C., Inestrosa,N.C.,
            Gundelfinger,E.D., Zamorano,P. and Torres,V.I.
  TITLE     Serine-Arginine Protein Kinase SRPK2 Modulates the Assembly of the
            Active Zone Scaffolding Protein CAST1/ERC2
  JOURNAL   Cells 8 (11), 1333 (2019)
   PUBMED   31671734
  REMARK    GeneRIF: Serine-Arginine Protein Kinase SRPK2 Modulates the
            Assembly of the Active Zone Scaffolding Protein CAST1/ERC2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6239)
  AUTHORS   Teumer,A., Holtfreter,B., Volker,U., Petersmann,A., Nauck,M.,
            Biffar,R., Volzke,H., Kroemer,H.K., Meisel,P., Homuth,G. and
            Kocher,T.
  TITLE     Genome-wide association study of chronic periodontitis in a general
            German population
  JOURNAL   J Clin Periodontol 40 (11), 977-985 (2013)
   PUBMED   24024966
REFERENCE   4  (bases 1 to 6239)
  AUTHORS   Ellinghaus,E., Stanulla,M., Richter,G., Ellinghaus,D., te
            Kronnie,G., Cario,G., Cazzaniga,G., Horstmann,M., Panzer
            Grumayer,R., Cave,H., Trka,J., Cinek,O., Teigler-Schlegel,A.,
            ElSharawy,A., Hasler,R., Nebel,A., Meissner,B., Bartram,T.,
            Lescai,F., Franceschi,C., Giordan,M., Nurnberg,P., Heinzow,B.,
            Zimmermann,M., Schreiber,S., Schrappe,M. and Franke,A.
  TITLE     Identification of germline susceptibility loci in
            ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia
  JOURNAL   Leukemia 26 (5), 902-909 (2012)
   PUBMED   22076464
REFERENCE   5  (bases 1 to 6239)
  AUTHORS   Curtis,D., Vine,A.E., McQuillin,A., Bass,N.J., Pereira,A.,
            Kandaswamy,R., Lawrence,J., Anjorin,A., Choudhury,K., Datta,S.R.,
            Puri,V., Krasucki,R., Pimm,J., Thirumalai,S., Quested,D. and
            Gurling,H.M.
  TITLE     Case-case genome-wide association analysis shows markers
            differentially associated with schizophrenia and bipolar disorder
            and implicates calcium channel genes
  JOURNAL   Psychiatr Genet 21 (1), 1-4 (2011)
   PUBMED   21057379
REFERENCE   6  (bases 1 to 6239)
  AUTHORS   Takao-Rikitsu,E., Mochida,S., Inoue,E., Deguchi-Tawarada,M.,
            Inoue,M., Ohtsuka,T. and Takai,Y.
  TITLE     Physical and functional interaction of the active zone proteins,
            CAST, RIM1, and Bassoon, in neurotransmitter release
  JOURNAL   J Cell Biol 164 (2), 301-311 (2004)
   PUBMED   14734538
REFERENCE   7  (bases 1 to 6239)
  AUTHORS   Deguchi-Tawarada,M., Inoue,E., Takao-Rikitsu,E., Inoue,M.,
            Ohtsuka,T. and Takai,Y.
  TITLE     CAST2: identification and characterization of a protein
            structurally related to the presynaptic cytomatrix protein CAST
  JOURNAL   Genes Cells 9 (1), 15-23 (2004)
   PUBMED   14723704
REFERENCE   8  (bases 1 to 6239)
  AUTHORS   Ko,J., Na,M., Kim,S., Lee,J.R. and Kim,E.
  TITLE     Interaction of the ERC family of RIM-binding proteins with the
            liprin-alpha family of multidomain proteins
  JOURNAL   J Biol Chem 278 (43), 42377-42385 (2003)
   PUBMED   12923177
  REMARK    GeneRIF: In vitro results indicate that ERC2/CAST, an active
            zone-specific isoform, interacts with all of the known isoforms of
            liprin-alpha and that liprin-alpha1 associates with both ERC2 and
            ERC1b
REFERENCE   9  (bases 1 to 6239)
  AUTHORS   Wang,Y., Liu,X., Biederer,T. and Sudhof,T.C.
  TITLE     A family of RIM-binding proteins regulated by alternative splicing:
            Implications for the genesis of synaptic active zones
  JOURNAL   Proc Natl Acad Sci U S A 99 (22), 14464-14469 (2002)
   PUBMED   12391317
REFERENCE   10 (bases 1 to 6239)
  AUTHORS   Ohtsuka,T., Takao-Rikitsu,E., Inoue,E., Inoue,M., Takeuchi,M.,
            Matsubara,K., Deguchi-Tawarada,M., Satoh,K., Morimoto,K.,
            Nakanishi,H. and Takai,Y.
  TITLE     Cast: a novel protein of the cytomatrix at the active zone of
            synapses that forms a ternary complex with RIM1 and munc13-1
  JOURNAL   J Cell Biol 158 (3), 577-590 (2002)
   PUBMED   12163476
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC098478.2, AB002376.2,
            AA826430.1 and BC060881.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015576.2.
            
            Summary: This gene encodes a protein that belongs to the
            Rab3-interacting molecule (RIM)-binding protein family. Members of
            this protein family form part of the cytomatrix at the active zone
            (CAZ) complex and function as regulators of neurotransmitter
            release. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the supported protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB002376.2, BC112391.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000288221.11/ ENSP00000288221.6
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AC098478.2         72286-72389         c
            105-4281            AB002376.2         1-4177
            4282-4522           AA826430.1         1-241
            4523-6239           BC060881.1         1770-3486
FEATURES             Location/Qualifiers
     source          1..6239
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.3"
     gene            1..6239
                     /gene="ERC2"
                     /gene_synonym="CAST; CAST1; ELKSL; SPBC110; Spc110"
                     /note="ELKS/RAB6-interacting/CAST family member 2"
                     /db_xref="GeneID:26059"
                     /db_xref="HGNC:HGNC:31922"
                     /db_xref="MIM:617250"
     exon            1..220
                     /gene="ERC2"
                     /gene_synonym="CAST; CAST1; ELKSL; SPBC110; Spc110"
                     /inference="alignment:Splign:2.1.0"
     exon            221..1017
                     /gene="ERC2"
                     /gene_synonym="CAST; CAST1; ELKSL; SPBC110; Spc110"
                     /inference="alignment:Splign:2.1.0"
     CDS             361..3234
                     /gene="ERC2"
                     /gene_synonym="CAST; CAST1; ELKSL; SPBC110; Spc110"
                     /note="CAZ-associated structural protein; cytomatrix
                     protein p110"
                     /codon_start=1
                     /product="ERC protein 2"
                     /protein_id="NP_056391.1"
                     /db_xref="CCDS:CCDS46851.1"
                     /db_xref="GeneID:26059"
                     /db_xref="HGNC:HGNC:31922"
                     /db_xref="MIM:617250"
                     /translation="MYGSARTITNLEGSPSRSPRLPRSPRLGHRRTSSGGGGGTGKTL
                     SMENIQSLNAAYATSGPMYLSDHEGVASTTYPKGTMTLGRATNRAVYGGRVTAMGSSP
                     NIASAGLSHTDVLSYTDQHGGLTGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRE
                     NDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEEN
                     QHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKE
                     LFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAE
                     AESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLER
                     NIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESEL
                     LALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNK
                     KTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLK
                     DRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKD
                     LKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLE
                     AQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEK
                     NDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQ
                     HLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQ
                     EALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQLKQQTQNRMKLMAD
                     NYDDDHHHYHHHHHHHHHRSPGRSQHSNHRPSPDQDDEEGIWA"
     exon            1018..1434
                     /gene="ERC2"
                     /gene_synonym="CAST; CAST1; ELKSL; SPBC110; Spc110"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1509
                     /gene="ERC2"
                     /gene_synonym="CAST; CAST1; ELKSL; SPBC110; Spc110"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1665
                     /gene="ERC2"
                     /gene_synonym="CAST; CAST1; ELKSL; SPBC110; Spc110"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1833
                     /gene="ERC2"
                     /gene_synonym="CAST; CAST1; ELKSL; SPBC110; Spc110"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..2001
                     /gene="ERC2"
                     /gene_synonym="CAST; CAST1; ELKSL; SPBC110; Spc110"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2139
                     /gene="ERC2"
                     /gene_synonym="CAST; CAST1; ELKSL; SPBC110; Spc110"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2280
                     /gene="ERC2"
                     /gene_synonym="CAST; CAST1; ELKSL; SPBC110; Spc110"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2421
                     /gene="ERC2"
                     /gene_synonym="CAST; CAST1; ELKSL; SPBC110; Spc110"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2615
                     /gene="ERC2"
                     /gene_synonym="CAST; CAST1; ELKSL; SPBC110; Spc110"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..2627
                     /gene="ERC2"
                     /gene_synonym="CAST; CAST1; ELKSL; SPBC110; Spc110"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2763
                     /gene="ERC2"
                     /gene_synonym="CAST; CAST1; ELKSL; SPBC110; Spc110"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2924
                     /gene="ERC2"
                     /gene_synonym="CAST; CAST1; ELKSL; SPBC110; Spc110"
                     /inference="alignment:Splign:2.1.0"
     exon            2925..3072
                     /gene="ERC2"
                     /gene_synonym="CAST; CAST1; ELKSL; SPBC110; Spc110"
                     /inference="alignment:Splign:2.1.0"
     exon            3073..3207
                     /gene="ERC2"
                     /gene_synonym="CAST; CAST1; ELKSL; SPBC110; Spc110"
                     /inference="alignment:Splign:2.1.0"
     exon            3208..3273
                     /gene="ERC2"
                     /gene_synonym="CAST; CAST1; ELKSL; SPBC110; Spc110"
                     /inference="alignment:Splign:2.1.0"
     exon            3274..6239
                     /gene="ERC2"
                     /gene_synonym="CAST; CAST1; ELKSL; SPBC110; Spc110"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6217..6222
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERC2"
                     /gene_synonym="CAST; CAST1; ELKSL; SPBC110; Spc110"
                     /note="hexamer: AATAAA"
     polyA_site      6239
                     /gene="ERC2"
                     /gene_synonym="CAST; CAST1; ELKSL; SPBC110; Spc110"
                     /note="major polyA site"
ORIGIN      
        1 gcgcctggcc ctggccctcc gagcagtgtc ctcctccttc ccttctttcc tccctccctg
       61 ttccccgccc cgcttctcct cctcttcctc cgcctcccgc tcctgctcgc tcggtctccg
      121 gctccggcgc cggctcctgc tcctcctggc cgcccggggc caaggcgacg agaggttgta
      181 aaaatccatg tgggacggcc ccggggcgag catcggaaag atctctgagt ggagttattt
      241 tctggtacgg actgtgaaaa gaatgcggtg aaaattctgg acaatcgtgg aaatattagc
      301 tcaaacccca acttaatata gcatttcttc tcttcagtaa cacctcataa tacaagaaaa
      361 atgtatggaa gtgcaagaac aatcaccaat ctggaaggta gcccttccag atcccctcgt
      421 ttgccaaggt ctcctcgttt gggccaccga agaacaagta gtgggggagg tggaggaaca
      481 ggcaagactc tgtctatgga gaatatccag tccctcaatg cagcctatgc tacgtctgga
      541 cccatgtatc tgagtgatca tgaaggggtg gcttcaacaa cctacccaaa gggcactatg
      601 actctgggaa gggctacaaa tcgagctgta tatggaggcc gtgtcacagc catggggagt
      661 agtcccaata ttgcttctgc tggactttcc cacacagatg tcctttcata cacagatcaa
      721 catggtgggc tgactggctc atcccatcat caccaccacc aggtcccctc catgttgagg
      781 caggtaagag acagcacaat gttagatctt caggcccagc tgaaagaact gcagagagag
      841 aatgacctcc tccggaaaga gctagacatc aaggacagca aattgggatc ttccatgaac
      901 agtattaaga ctttctggag tcctgagctt aagaaggaga gagtcttgag gaaagaagag
      961 gcagcgcgga tgtctgtcct caaggagcag atgagggttt cccatgaaga aaatcagcac
     1021 ctacagttga caatccaggc ccttcaagat gagctgcgaa cccagagaga cctcaaccac
     1081 ctcctccagc aagagagtgg caaccgagga gcggagcact tcaccatcga gctgaccgag
     1141 gagaacttta ggcggctcca agccgagcat gacaggcagg ctaaggagct gttccttttg
     1201 aggaagacat tagaggaaat ggagctgaga attgaaacgc agaaacaaac cctcaatgcc
     1261 cgagatgagt caattaaaaa acttcttgag atgttgcaaa gtaaaggctt gccatccaaa
     1321 agcctggagg atgacaatga gcgaacgcgg cggatggcag aggctgagtc tcaggtcagc
     1381 cacttggaag tgattttaga tcagaaagag aaggaaaaca tacatcttag agaggaattg
     1441 caccgaagaa gccaacttca gccggagcca gccaagacga aggctctcca gactgtcatc
     1501 gaaatgaagg acacaaaaat cgcttcattg gaacgaaaca taagggatct tgaggatgag
     1561 atccagatgt taaaagccaa tggtgtgctg aacactgagg accgcgaaga agagatcaaa
     1621 caaattgagg tttacaaaag tcactccaag tttatgaaga ccaagattga tcagctgaag
     1681 caggaacttt caaagaaaga gtcggaactt cttgccttac aaacaaagct tgaaaccctc
     1741 agcaatcaaa attcagattg caagcaacac attgaagtgc tcaaagagtc acttactgcc
     1801 aaagaacaga gggctgccat ccttcagact gaggtagatg cgctgagatt acgactggaa
     1861 gaaaaagaat ctttcctcaa taaaaaaaca aaacagctac aggacctcac agaagagaag
     1921 gggacactgg ccggtgaaat tcgtgacatg aaagatatgt tagaagtgaa ggaaagaaaa
     1981 atcaatgttc ttcagaaaaa gattgaaaac ttgcaagaac aacttaggga taaagacaag
     2041 caactgacca acctgaaaga cagagtgaag tccttgcaga cggattccag taatacagat
     2101 actgcactgg cgacgctaga ggaagctctg tcagagaagg agagaataat tgagcgcttg
     2161 aaagaacagc gagaaagaga tgatcgggaa agactagaag agatagaatc cttccgaaaa
     2221 gagaacaaag acctgaaaga gaaggtcaat gctttacagg ctgaactgac tgagaaagag
     2281 tctagtttaa ttgacctcaa agaacatgca tcttcattag cctctgcggg gctgaaaagg
     2341 gattccaaat taaaatctct agaaatagcc attgaacaaa agaaagagga atgtagcaaa
     2401 ttggaagcac agttaaaaaa ggcacataat attgaagatg actccaggat gaaccctgag
     2461 tttgcagacc aaataaaaca gctcgataaa gaggcgtctt actaccgcga cgagtgtggc
     2521 aaggcccaag cggaagtgga ccggttgctg gagatcctca aggaggtgga gaatgagaag
     2581 aatgacaagg acaagaagat cgcagaactg gagagcttga ctctcaggca tatgaaagat
     2641 cagaataaga aggtggccaa cctcaagcac aatcaacagt tggaaaagaa gaaaaatgct
     2701 cagttactag aagaagtgcg caggcgagaa gacagcatgg ctgacaactc acagcatttg
     2761 cagatagagg aactgatgaa tgcactggag aagaccagac aggaactgga tgccaccaaa
     2821 gcacgcctcg cctccacaca acagtccctg gccgaaaaag aagcgcactt ggccaacctc
     2881 cggattgaga ggaggaaaca gctggaggag atcctggaga tgaaacagga agcactactt
     2941 gcagccatca gtgaaaaaga tgcaaacatt gccttgctgg aattgtctgc ctccaaaaag
     3001 aaaaagacgc aggaagaagt catggccctc aagcgggaaa aagaccgact agtacatcaa
     3061 ttaaagcagc agacccagaa cagaatgaag ttgatggcag acaactatga tgatgaccat
     3121 caccattacc accaccacca ccatcaccac caccatcgat ctcctgggag gtcgcaacat
     3181 tccaatcaca ggccctctcc ggaccaggat gacgaggagg gcatatgggc atagccgggc
     3241 ctgtaaacca aagttccagt tttgttttga gggctattag aagggctgaa taaagggaac
     3301 atgcagctct gcagcaatat tctgataatg tattgcagtg cggctcacat cactgtccac
     3361 caccacctgg agcggctcat cagaactgaa ggggagtttt cacttacctt attgagcgtg
     3421 attctgttct acttgatatt tccttcacca cctcatgtca tttctcatgg atttggttat
     3481 gatggaaagg aagaatgcag aggaggagaa aagtgacaga tcctccattt ttgttgggat
     3541 gcgggcattt tgaatgtgat catctttgct gaatgtcatt atttgataac attttgttta
     3601 tgttacttaa acatcattgg ataaatttga actccatggg attttatctg tggattcagc
     3661 ttctgttgga caactagcct catctccagt atcctgctgg ttcactctaa ttggtcattc
     3721 ctaatgcatt agattatcaa aaagtataaa ttcgctgtga gtgagtggtg ttggcagtgt
     3781 ttgtatacca tgatgcatgg agtgtttgac gaagaaacaa aaaacaccaa aaattgcgag
     3841 cctttaccct cctctatttc tttaatctgt tgtttgaaga accgcatttt gagggtgtaa
     3901 ccagtagtca cctctgggcc aggttggaaa agaaatcaat tttttaaacc actaatgctt
     3961 gccaagaaat cgccttatga gaacatggtg tgtgtctctg acaatgcgtg gcacatctaa
     4021 attgatcatt cataatttta tctacccagt catgtactgg agagtggcaa aagtctgagg
     4081 cacctgcata tctctagtcc ctgtgttctg cacatcccca cggtggggac gccaccaagc
     4141 ctcagactct taccatcccg gtgcatgcag gtctccatga agaagctggg actcattcac
     4201 atttcaagat ccaaatgctg tgcaaacagt gtaagcttag attttctgta aatgaagggt
     4261 catttctctt tttttttttt tttaaagaaa atgtgtctgc aacatggatt ccaaagcatt
     4321 ttcagcatca aacatgaaaa cattgatgaa tgaggaacaa tcacaaaagc tgtgtctctg
     4381 tatatagctc tacacaacat gtatgtggat acagtcatta tttaaagcac atgccaggga
     4441 aaaagaccaa attttgaggt cttttacata cagtgatatg gtactaagga gaattaaact
     4501 cctactgctt cctctgaata ttaagaaaca atttaaattg ttataacttc ataaaactca
     4561 tgactgagtc tggcaaacat gtgcaactct tgtattgctc cattttcttg tcaatggaag
     4621 aaacccttcc acgtgtatgc aagtgggaga tgaaaacctg catttttaaa ggacaaacag
     4681 tgaatttaag catgagtggc cttaataaat atagttgtct ttctttgctg ctgtggaaag
     4741 gattctaaac agatgtccct gaagtcttgc attgaattta gtcattatta ttacttttta
     4801 aaatgttggt gcaattaact ctggacctct cttgtgagcc atagagatat ttaaaagaca
     4861 aacaccttat ttgtcgggga agatgaaacc gtccctgagt tgcaccattc tttcttggtg
     4921 cattcgcggt taagatactc aagcaggttt cttgcttctg gctttgttct tgtcatcagt
     4981 aagtataaca aactatgtaa tgcttatgtg ttgcataaac aatccaaatg cattcatgtt
     5041 ttaaaagttt gtcctttaac tatcagaggg atctaggtct tggttagaga agtaagcaga
     5101 gttctttgca agcttattta gcacattttg acacaatgtt gcactgaaaa cccaggccac
     5161 aaatgtgtcc cagtgaacag tttggatgtc ctcaaagaag tggttctcac tgcctcctac
     5221 aaccaggtct tgacctgaac tctgcaactg aatacttgaa gtaggaagta ggaaatccag
     5281 tagggaaaat agggtccttg aaacagaaaa aaaaaaccaa cccatgtata gctagctatt
     5341 tctatgtatg tgccaatttt gtcacagctc ttgtttggag ggatcatttt ctgcccaact
     5401 ttcattggtt aaaatattac tgatcttacc tttatgaggt cgtataattt agtcccttaa
     5461 aaattaaatt ctctctaaca taacaacctt tcccatttcg tgtaatattc tctgatgttt
     5521 gggggttacc aaaaatatcc ctttttcaca tattaagaat agtctctggg tttacaacaa
     5581 acactgtgat gttgggaagc tatttccttt gcgcaaactt taacaggttt tcttctaatc
     5641 ataacatagt tgaaaaaaga agtttgggct aacatttagg agaagttggt cttactttgt
     5701 gcaaaagcag gcttgtgctt tataccccat ttgatttcga tgtacagtct caattttgta
     5761 tttaatgatt tttgtgtatc cagtatgcac gttaacagcg tgtcaacttt catttgaaag
     5821 tgggtttcaa tttacttttt aaacagtgtt tatgacgaga cctcagatgt gttgacgtaa
     5881 gctctatctg caatgttttt gtgtagagtg gcgattgaat gctgcccagg gtcagtgtat
     5941 ctaattcccc gagaccctcg tttgatagtg cttcttgtaa tatttcttca agtgagtggc
     6001 atgtgggttg tgatattgac catgtgatta tggacatcga tatgaaaaat aaataaataa
     6061 aactaaggaa ccctggaaac taccagtggg catgtattag ccagtcattg taacctcgtg
     6121 tctagtagaa caatgtacaa ggtatgtaca gttcataaat ttgttgtcat gtgtatgaga
     6181 agtactttgt gctgatcgcc ttatttatat tcatcaaata aaccttgttt ctttctgaa
//
