LOCUS       NM_178040               9308 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens ELKS/RAB6-interacting/CAST family member 1 (ERC1),
            transcript variant epsilon, mRNA.
ACCESSION   NM_178040
VERSION     NM_178040.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9308)
  AUTHORS   Ribolla,L.M., Sala,K., Tonoli,D., Ramella,M., Bracaglia,L.,
            Bonomo,I., Gonnelli,L., Lamarca,A., Brindisi,M., Pierattelli,R.,
            Provenzani,A. and de Curtis,I.
  TITLE     Interfering with the ERC1-LL5beta interaction disrupts plasma
            membrane-Associated platforms and affects tumor cell motility
  JOURNAL   PLoS One 18 (7), e0287670 (2023)
   PUBMED   37437062
  REMARK    GeneRIF: Interfering with the ERC1-LL5beta interaction disrupts
            plasma membrane-Associated platforms and affects tumor cell
            motility.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9308)
  AUTHORS   Liang,M., Jin,G., Xie,X., Zhang,W., Li,K., Niu,F., Yu,C. and Wei,Z.
  TITLE     Oligomerized liprin-alpha promotes phase separation of ELKS for
            compartmentalization of presynaptic active zone proteins
  JOURNAL   Cell Rep 34 (12), 108901 (2021)
   PUBMED   33761347
  REMARK    GeneRIF: Oligomerized liprin-alpha promotes phase separation of
            ELKS for compartmentalization of presynaptic active zone proteins.
            Erratum:[Cell Rep. 2021 Jul 27;36(4):109476. doi:
            10.1016/j.celrep.2021.109476.. PMID: 34320361]
REFERENCE   3  (bases 1 to 9308)
  AUTHORS   Cong,S., Yao,X., Huang,Z., Risacher,S.L., Nho,K., Saykin,A.J. and
            Shen,L.
  CONSRTM   UK Brain Expression Consortium; Alzheimer's Disease Neuroimaging
            Initiative
  TITLE     Volumetric GWAS of medial temporal lobe structures identifies an
            ERC1 locus using ADNI high-resolution T2-weighted MRI data
  JOURNAL   Neurobiol Aging 95, 81-93 (2020)
   PUBMED   32768867
  REMARK    GeneRIF: Volumetric GWAS of medial temporal lobe structures
            identifies an ERC1 locus using ADNI high-resolution T2-weighted MRI
            data.
REFERENCE   4  (bases 1 to 9308)
  AUTHORS   Ohara-Imaizumi,M., Aoyagi,K. and Ohtsuka,T.
  TITLE     Role of the active zone protein, ELKS, in insulin secretion from
            pancreatic beta-cells
  JOURNAL   Mol Metab 27S (Suppl), S81-S91 (2019)
   PUBMED   31500835
  REMARK    GeneRIF: The ELKS forms a potent insulin secretion complex with
            L-type voltage-dependent Ca(2+) channels on the vascular-facing
            plasma membrane of beta-cells, enabling polarized Ca(2+) influx and
            first-phase insulin secretion from islets.
            Review article
REFERENCE   5  (bases 1 to 9308)
  AUTHORS   Ko,J., Na,M., Kim,S., Lee,J.R. and Kim,E.
  TITLE     Interaction of the ERC family of RIM-binding proteins with the
            liprin-alpha family of multidomain proteins
  JOURNAL   J Biol Chem 278 (43), 42377-42385 (2003)
   PUBMED   12923177
  REMARK    GeneRIF: In vitro results indicate that ERC2/CAST, an active
            zone-specific isoform, interacts with all of the known isoforms of
            liprin-alpha and that liprin-alpha1 associates with both ERC2 and
            ERC1b
REFERENCE   6  (bases 1 to 9308)
  AUTHORS   Wang,Y., Liu,X., Biederer,T. and Sudhof,T.C.
  TITLE     A family of RIM-binding proteins regulated by alternative splicing:
            Implications for the genesis of synaptic active zones
  JOURNAL   Proc Natl Acad Sci U S A 99 (22), 14464-14469 (2002)
   PUBMED   12391317
REFERENCE   7  (bases 1 to 9308)
  AUTHORS   Nakata,T., Yokota,T., Emi,M. and Minami,S.
  TITLE     Differential expression of multiple isoforms of the ELKS mRNAs
            involved in a papillary thyroid carcinoma
  JOURNAL   Genes Chromosomes Cancer 35 (1), 30-37 (2002)
   PUBMED   12203787
  REMARK    GeneRIF: Analysis of the gene structure of four isoforms (ELKS
            beta, ELKS gamma, ELKS delta, and ELKS epsilon) in a case of
            papillary thyroid carcinoma reveal that the isoforms are produced
            by alternative splicing.
REFERENCE   8  (bases 1 to 9308)
  AUTHORS   Monier,S., Jollivet,F., Janoueix-Lerosey,I., Johannes,L. and
            Goud,B.
  TITLE     Characterization of novel Rab6-interacting proteins involved in
            endosome-to-TGN transport
  JOURNAL   Traffic 3 (4), 289-297 (2002)
   PUBMED   11929610
REFERENCE   9  (bases 1 to 9308)
  AUTHORS   Yokota,T., Nakata,T., Minami,S., Inazawa,J. and Emi,M.
  TITLE     Genomic organization and chromosomal mapping of ELKS, a gene
            rearranged in a papillary thyroid carcinoma
  JOURNAL   J Hum Genet 45 (1), 6-11 (2000)
   PUBMED   10697956
REFERENCE   10 (bases 1 to 9308)
  AUTHORS   Nakata,T., Kitamura,Y., Shimizu,K., Tanaka,S., Fujimori,M.,
            Yokoyama,S., Ito,K. and Emi,M.
  TITLE     Fusion of a novel gene, ELKS, to RET due to translocation
            t(10;12)(q11;p13) in a papillary thyroid carcinoma
  JOURNAL   Genes Chromosomes Cancer 25 (2), 97-103 (1999)
   PUBMED   10337992
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DR000847.1, AC004803.11,
            AB053471.1, AC004672.1, AC004671.1 and BM984956.1.
            
            On Nov 23, 2018 this sequence version replaced NM_178040.3.
            
            Summary: The protein encoded by this gene is a member of a family
            of RIM-binding proteins. RIMs are active zone proteins that
            regulate neurotransmitter release. This gene has been found fused
            to the receptor-type tyrosine kinase gene RET by gene rearrangement
            due to the translocation t(10;12)(q11;p13) in thyroid papillary
            carcinoma. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (epsilon) encodes the longest
            isoform (epsilon).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AB053471.1, BC132784.1 [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360905.9/ ENSP00000354158.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                DR000847.1         21-59
            40-100              AC004803.11        112102-112162
            101-3243            AB053471.1         26-3168
            3244-3244           AC004672.1         37563-37563         c
            3245-3694           AB053471.1         3170-3619
            3695-8834           AC004671.1         49679-54818
            8835-9308           BM984956.1         21-494              c
FEATURES             Location/Qualifiers
     source          1..9308
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.33"
     gene            1..9308
                     /gene="ERC1"
                     /gene_synonym="Cast2; ELKS; ERC-1; RAB6IP2"
                     /note="ELKS/RAB6-interacting/CAST family member 1"
                     /db_xref="GeneID:23085"
                     /db_xref="HGNC:HGNC:17072"
                     /db_xref="MIM:607127"
     exon            1..100
                     /gene="ERC1"
                     /gene_synonym="Cast2; ELKS; ERC-1; RAB6IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            101..925
                     /gene="ERC1"
                     /gene_synonym="Cast2; ELKS; ERC-1; RAB6IP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..3607
                     /gene="ERC1"
                     /gene_synonym="Cast2; ELKS; ERC-1; RAB6IP2"
                     /note="isoform epsilon is encoded by transcript variant
                     epsilon; RAB6 interacting protein 2"
                     /codon_start=1
                     /product="ELKS/Rab6-interacting/CAST family member 1
                     isoform epsilon"
                     /protein_id="NP_829884.1"
                     /db_xref="CCDS:CCDS8508.1"
                     /db_xref="GeneID:23085"
                     /db_xref="HGNC:HGNC:17072"
                     /db_xref="MIM:607127"
                     /translation="MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGS
                     SVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPYGV
                     RMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKE
                     VLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVV
                     QEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHER
                     QAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTR
                     RLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKIS
                     SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
                     EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKE
                     SLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDML
                     DVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAE
                     KERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHA
                     SSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHL
                     EREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKH
                     KEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAER
                     EMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRA
                     ERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQL
                     KQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHL
                     TTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQE
                     FANAILQQIADHCPDILEQVVNALEESS"
     exon            926..1342
                     /gene="ERC1"
                     /gene_synonym="Cast2; ELKS; ERC-1; RAB6IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1417
                     /gene="ERC1"
                     /gene_synonym="Cast2; ELKS; ERC-1; RAB6IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1573
                     /gene="ERC1"
                     /gene_synonym="Cast2; ELKS; ERC-1; RAB6IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1657
                     /gene="ERC1"
                     /gene_synonym="Cast2; ELKS; ERC-1; RAB6IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1825
                     /gene="ERC1"
                     /gene_synonym="Cast2; ELKS; ERC-1; RAB6IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1993
                     /gene="ERC1"
                     /gene_synonym="Cast2; ELKS; ERC-1; RAB6IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2131
                     /gene="ERC1"
                     /gene_synonym="Cast2; ELKS; ERC-1; RAB6IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2272
                     /gene="ERC1"
                     /gene_synonym="Cast2; ELKS; ERC-1; RAB6IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2413
                     /gene="ERC1"
                     /gene_synonym="Cast2; ELKS; ERC-1; RAB6IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2607
                     /gene="ERC1"
                     /gene_synonym="Cast2; ELKS; ERC-1; RAB6IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2743
                     /gene="ERC1"
                     /gene_synonym="Cast2; ELKS; ERC-1; RAB6IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2875
                     /gene="ERC1"
                     /gene_synonym="Cast2; ELKS; ERC-1; RAB6IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..3036
                     /gene="ERC1"
                     /gene_synonym="Cast2; ELKS; ERC-1; RAB6IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..3181
                     /gene="ERC1"
                     /gene_synonym="Cast2; ELKS; ERC-1; RAB6IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3182..3280
                     /gene="ERC1"
                     /gene_synonym="Cast2; ELKS; ERC-1; RAB6IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3281..3469
                     /gene="ERC1"
                     /gene_synonym="Cast2; ELKS; ERC-1; RAB6IP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3470..9308
                     /gene="ERC1"
                     /gene_synonym="Cast2; ELKS; ERC-1; RAB6IP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9289..9294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERC1"
                     /gene_synonym="Cast2; ELKS; ERC-1; RAB6IP2"
                     /note="hexamer: TATAAA"
     polyA_site      9308
                     /gene="ERC1"
                     /gene_synonym="Cast2; ELKS; ERC-1; RAB6IP2"
                     /note="major polyA site"
ORIGIN      
        1 gcgggcgcct gggccgtgct gtggcggcgg cggcggcggt agtggcggcg gcggcggtgc
       61 ctgggcggca gcagcagcag tagcggcagc cctgaggacg atatggtgta agatacttct
      121 tcaagattgg acagctgggg accttcttct gattaacctt aaaccaactt gtagccatag
      181 agacacctca caaggttccc atttttgttg ttgttgttgt tgattttctg ctcacacctt
      241 tcctgacctt gcaaccatgt atggaagtgc ccgctctgtt gggaaggtgg agccgagcag
      301 ccagagccct gggcgttcac ccaggcttcc acgttcccct cgcttgggtc accgtcgaac
      361 caacagtacg ggagggagtt cgggaagcag tgttggaggt ggcagtggga aaaccctttc
      421 aatggaaaat atacaatctt taaatgctgc ctatgccacc tctggcccta tgtatctaag
      481 tgaccatgaa aatgtgggtt cagaaacacc taaaagcacc atgacacttg gccgttctgg
      541 gggacgtctg ccttacggtg ttcggatgac tgctatgggt agtagcccca atatagctag
      601 cagtggggtt gctagtgaca ccatagcatt tggagagcat cacctccctc ctgtgagtat
      661 ggcatccact gtacctcact cccttcgtca ggcgagagat aacacaatca tggatctgca
      721 gacacagctg aaggaagtat taagagaaaa tgatctcttg cggaaggatg tggaagtaaa
      781 ggagagcaaa ttgagttctt caatgaatag catcaagacc ttctggagcc cagagctgaa
      841 gaaggaacga gccctgagaa aagatgaagc ttccaaaatc accatttgga aggaacagta
      901 cagagttgta caggaggaaa accagcacat gcagatgaca atccaggctc tccaggatga
      961 attgcggatc cagagggacc tgaatcagct gtttcagcag gatagtagca gcaggactgg
     1021 cgaaccttgt gtagcagagc tgacagagga gaactttcag aggcttcatg ctgagcatga
     1081 gcggcaggcc aaagagctgt ttcttcttcg aaagacattg gaggaaatgg agctgcgtat
     1141 tgagactcaa aagcagaccc taaatgctcg ggatgaatcc attaagaagc ttctggaaat
     1201 gttgcagagc aaaggacttt ctgccaaggc taccgaggaa gaccatgaga gaacaagacg
     1261 actggcagag gcagagatgc acgttcatca cctagaaagc cttttggagc agaaggaaaa
     1321 agagaacagt atgttgagag aggagatgca tcgaaggttt gagaatgctc ctgattctgc
     1381 caaaacaaaa gctctgcaaa ctgttattga gatgaaggat tcaaaaattt cctctatgga
     1441 gcgtgggctt cgagacctgg aagaggaaat tcagatgctg aaatcgaatg gtgctttgag
     1501 tactgaggaa agggaagaag aaatgaagca aatggaagtg tatcggagcc attctaaatt
     1561 tatgaaaaat aaggtagaac aactgaagga ggaactaagt tcgaaagagg ctcaatggga
     1621 ggagctgaaa aagaaagcgg ctggtcttca ggctgagatt ggccaggtga aacaggagct
     1681 gtccagaaag gacacagaac tactcgccct gcagacaaag ctagaaacac tcacaaacca
     1741 gttctcagat agtaaacagc acattgaagt gttgaaggag tccttgactg ctaaggagca
     1801 gagggctgcc atcctgcaga ctgaggtgga tgctctccga ttgcgtttgg aagagaagga
     1861 aaccatgttg aataaaaaga caaaacaaat tcaggatatg gctgaagaga aggggacaca
     1921 agctggagag atacatgacc tcaaggacat gttggatgtg aaggagcgga aggttaatgt
     1981 tcttcagaag aagattgaaa atcttcaaga gcagcttaga gacaaggaaa agcagatgag
     2041 cagcttgaaa gaacgggtca aatccttgca ggctgacacc accaacactg acactgcctt
     2101 gacaactttg gaggaggccc ttgcagagaa agagcggaca attgaacgct taaaggagca
     2161 gagggacaga gatgagcgag agaagcaaga ggaaattgat aactacaaaa aagatcttaa
     2221 agacttgaag gaaaaagtca gcctgttgca aggcgacctt tcagagaaag aggcttcact
     2281 tttggatctg aaagagcatg cttcttctct ggcatcctca ggactgaaaa aggactcacg
     2341 gcttaagaca ctagagattg ctttggagca gaagaaggag gagtgtctga aaatggaatc
     2401 acaattgaaa aaggcacatg aggcagcatt ggaagccaga gccagtccag agatgagtga
     2461 ccgaatacag cacttggaga gagagatcac caggtacaaa gatgaatcta gcaaggccca
     2521 ggcagaagtt gatcgactct tagaaatctt gaaggaggtg gaaaatgaga agaatgacaa
     2581 agataagaag atagctgagt tggaaaggca agtgaaagac cagaataaga aggtagcaaa
     2641 tctgaagcac aaggaacagg tggaaaaaaa gaagagtgca caaatgttag aggaggcgcg
     2701 acgacgggag gacaatctca acgacagctc tcagcagcta caggacagtc tccgtaagaa
     2761 ggatgacagg attgaagagc tggaagaagc actaagagaa agtgtacaga taactgcaga
     2821 gcgggaaatg gtgctagcac aagaggaatc agccaggacc aatgctgaaa aacaggtgga
     2881 ggagttactg atggccatgg agaaggtaaa gcaggaacta gaatccatga aagcaaagct
     2941 gtcctccacc cagcagtctc tggcagaaaa ggaaactcac ttgactaatc ttcgggcaga
     3001 gagaaggaaa cacttagagg aagttctgga gatgaagcaa gaagctcttc tggctgccat
     3061 tagtgaaaaa gacgccaata tagctctctt ggagctttcg tcctctaaga agaagaccca
     3121 agaggaagtg gctgccctga agcgggagaa ggatcgtctg gtacagcagc ttaagcagca
     3181 gacgcaaaat cgaatgaagc taatggccga caactacgag gatgaccact tcaaatcctc
     3241 ccattccaat caaacaaatc acaagccctc cccagaccag atcatccagc ccctcttaga
     3301 acttgaccaa aatagaagta aattaaagtt gtacattgga cacctgacaa ccctctgcca
     3361 tgaccgagac cccctgatcc tccgtggact cactccacca gcttcctata acttggacga
     3421 tgaccaggcg gcttgggaga atgagctgca gaagatgacc cgggggcagc ttcaggatga
     3481 gttagagaaa ggtgaacggg acaatgcaga actgcaggag tttgccaacg ccattcttca
     3541 gcagatagca gaccattgtc ccgacatcct agagcaagtg gtcaacgccc tggaagagtc
     3601 ctcttgaccc tgctttatgg ggaagcctga ggtagtcaac ccaggagcca agaaaagaga
     3661 actacgagga acaggtgccc ggaaccttct tggcaccaaa cactacaaac ttcatcccaa
     3721 cttgctcact tgaagaagtg tgattccagc accgtttcta catctgccat cttactctgc
     3781 ctttctgctt tggatgtggt ctctacacta accttcttga tgtccagggt agataaaggg
     3841 tcgaatctct ctgaagaact gccacctggt catcagcagt ggagaactgt gggagctggt
     3901 ggctctgccc tgacagagag ccatggagca gaggagcctc tcacctcctg tcctctgaca
     3961 tgagaatgaa accaggaatg gacttggagt tcaacaggct gagaggatgc ctccaatgga
     4021 ccagagagct gagtgttcta atatcacaat aggtgctttc tcctaaaagg gcaaaaaaca
     4081 atctcaaaaa gattagaaaa agagaagggg ggaagggaag agaaaatcga ctcttctttt
     4141 tactgtctct tctgcttact ttccacatga gatgctttgt accggggagc tgtgagcagg
     4201 cctcacgatg gcttgggagc actcgttctc ccaaggtctg agtcttcatc cagccctgcc
     4261 tgtctgtcgc agccttcctc actctgttcc tcggccagtt aacaagaaga tggtgtgagg
     4321 tgttctccac cagtctctcc tgtttgagac tgttgacgtt atcatactga ggtgttagat
     4381 caaatatctc taattgaaga acatgtgagg ttgaaagagc accagccagg gcaacatagc
     4441 gtgaccctgt ctctacaaaa aattaaaaag agaacataca aagttgacat atgagaccct
     4501 gttgtccccg cctgcagctt tgccccagta acagatgccc gttgctcttg ggctggtttc
     4561 ccctgaacac ctccaagagg ctgcctgcct tgccagcacc cgtgtcctga gctcctgcag
     4621 cccagtggct gctgaagttg tgatccctca ctcaccctgc tagctttgcc cttgactcgt
     4681 cttctctgaa cctcagcctc gtgcattgcc tggaaccttc ttctagcata aatgaaggtt
     4741 tttcctccta cacacattcc ttcctcggtt atttcattca gagaatattt atgaaatgcc
     4801 tactgtgtgc aagtcatcca tccttgaaaa ggccacttct cagtgaggga gagatgtagt
     4861 ggattctgtg agacatacct gctggagttg aagcagtaaa tagcatgtcc ttcccctccc
     4921 cgatcttaag gtgtgttttc tagaaaagtt ccctaatgga attcatgagt ttgggggtct
     4981 cagtcacccg cttgcctgta ggattccatt tgatgattct ggatttttgc tgtttgttat
     5041 tgcccttaga ggggctctga gtatctactt gtgggtggcc atttcctgac atctgcatgt
     5101 acctcgtgga attcagccag cttcatgttg caaatcagaa agctgacccc aagactgcaa
     5161 atcaatgaag gtattggcat tgttaaggac gtagcgtaga caacagcagt cataaataat
     5221 taggcaggaa cttaacccaa atctagttct ttgaccacct ctaccaccag aacccagcag
     5281 acactcacat ctcctgataa gagttgctgg actcgatgtt tttgttttgc attttctcct
     5341 ctccttcccc acttactcag agaatttaaa gtctgtagag tcagcacagc cccatcagtc
     5401 caggaacttc ccaccaccag cccttgactg tcccattaac tgacatggtc agatttccag
     5461 ctccccctac tccctgctgt gaaacaatcc ctctccctgt gagaggaaac tgtggagcgt
     5521 ttcttatcga aggttaaatg gactctgctc ataaacctct tactgagatg cttcctgata
     5581 gccaggctgg ccagagaggg gtgcaggggt tagatagtaa gtggtggtcg tttgtggtca
     5641 gttacctcaa ttctgttcat tgcagtgccc gtaaaccatg tagaaagctc ccagcactga
     5701 aaggcaggag tgttagcatc tcgctttatc caccataacg taaagaactg cggtgtgata
     5761 acagccttca cggggccacg gtggaaccaa gacagcaggc gaggccatgc ctaaacaagt
     5821 ggtctggcac gggcactggc cagctgctct ctccaagcag gtggcccaga tcccacccac
     5881 gtggactttc tcatcaggtg cagcgcctgc cactctcagc cactgggtgt gtcactctcc
     5941 tcttcatctc agcattctcc atcacttccc ctccagaaaa acggatggaa ggaagccctc
     6001 tgtgacactg cttctgagaa gaagcatttc cgggaccgat atcatctgtc tggtctctgt
     6061 gaacagcaag gaatcttctt gaccgttctt gggcactgga ggctggctag gagttcagta
     6121 ataaacgtgg ccttcgtgct gtagggcaga gtggatgcag tttgtagctt tcagagtgtc
     6181 tcattgagtc tagatcattg aaccaacact taaccaaatg tcccactccc atcacactag
     6241 gacttgtcat tccatgcccc tctcctagtg gtcatggttt catatgggca tacaactgct
     6301 actgaagtta tatagccttg aaaactcagt gcaggttgcc cttaattttc cccaaacccc
     6361 tccatcggca agtctagttg ccctttagca cctaaagatc tgcaccccaa accaatgtca
     6421 ccataaagag ggcacgaaga agagtgggtg tgatcccaac ggggttttgt aactgaagaa
     6481 gcccagtgtg agcttctcat cttttcatat acctctaacc cccggtactc attgaatcat
     6541 tgatgaggta tctcaattga gatttgcaag gactttgata ccatttgaaa tggaaaaatt
     6601 ttgaacgggc tttaacatgt ttaagaaata tggatggggc cggccacagt ggctcacgcc
     6661 tgtaatccca gaactctgga aggctgaggc aggcggatca cctgagatca ggagttcgag
     6721 gccagcctgg ccaagatggc aaaaaccccg actctactaa aaatacaaaa ttagccaggc
     6781 gtggtggcgt acgcctgtaa tcccagctac tcaggaggca ggagaatcgc ttgagcctgg
     6841 gaggcagagg ctgcggtgag ccgagatcgt gtcactgcac tccagcctgg gtgacagaga
     6901 ctccatttaa aaaaaaaaaa aaaaaatata tatatatata tatatatata tatatggatg
     6961 ggaatcacca aattcatctc agctctaacc ttttaacctt tgtccttgca ctttacaatc
     7021 taaagatcta cctgtggctc tcagacttcc tcacacttgg gttttagaaa taacttgtaa
     7081 agcagactgg acccaaggcc gccttcagtg tcaagaaggg cattgtgact tgcccctcaa
     7141 tttctgtcca ttgaagtctg gttttccatg aggaacttgc gggctcaccc acccccagag
     7201 tgagagaaga ggaaggcgaa gtcatcacag acacggtctt agccacctgc tgaactaatc
     7261 cctccgctat tgagggtcag ggttgtgagg caaccatcat gtgtcacccc aaaatataaa
     7321 tgtttctgag ccgcccatcc actggcattt ggatttgctg ccagagtcct gttcctccca
     7381 gaaccatccc gccctcctgt tgaccatgtt acttgagtgt aggcccggtg tcaagaccct
     7441 cagagtcttt gaggaaagag ccaagcagag aagaccgctg cgtggagtgt gacaccacat
     7501 ggcatttctc aagcccagcg gaccctgtgt cagcaaatac cagtaattta acatctgctc
     7561 ctggcctcct cttcacctgc ctgggttcgg aactgaggag gaaggatgag aagagactgc
     7621 aatgcagcag gcaccctctg cagagtgagg ccgcccgtcc atcactgcca gccctgggct
     7681 gctcaggagg ggacgtgaac cactcaaagg aatgtcttaa agaggatctg gagtttcccc
     7741 catgcaaatt agggaagaat taggcaagaa aagacataca ttacagggaa atccttctga
     7801 acaaaatggc tgtcttcacc tactcttctt gcaagaaaag acatacatta cagggaaatc
     7861 cttctgaaca aaatggctat cttcacctac tcttcagcaa aaaccgtctc cagacttttt
     7921 agtgtcaaaa atgtaaccaa ctgtctcctg attttttcca atgtgtttgg caagtgctgt
     7981 ggccctgttg taggtacttc tcctgactct tgggggagaa gtggttttag ggattgattt
     8041 gggggagcgg gtttttgtcc catcccacct cctctcttct ttctctgctt gtcgatattg
     8101 tctgtgtgat tcagagaatt ggggcagtta cattgtgtct gttgttgaga ttattaaaag
     8161 attaaaacgt agttgtagaa atgaaaaatt aaacagctgt gttttaaaaa tgcaaaccaa
     8221 tatcttgtta ataaaggaat tcaagctatg gggcagccac actcccctcc tcccaggctg
     8281 gcataggtgg ccctgggctg gcggcttagg aagcatggag cacacttagg gtagtgcctg
     8341 cctgggcaag agacacctgc cgagcaaaag gaacgagaat ctggggctca gagcctcgca
     8401 gttgtgccag gattttccta tacatgttca ggacctctgg gtagaggttt cacagtttgt
     8461 gaccccataa ccaccctcac ccgacgtggg ttctagctca gtgtgcctaa tactgcatgg
     8521 taacctgggc ttgaccctga agcccctgcc tggcaggcca caggacctct cctgcccact
     8581 tggtgctatc tcttccagtg accacccagc acgggtgagc actggccagc ctggagcctg
     8641 caatccaggt ggaacagact gtcctccatg tcagttcctt ctggcttcag gccctcaatt
     8701 atttcccttt gagctttttt agaccctaga tctcctaggc ccaggctctc tcttgacccc
     8761 agagaagcca ctgtcaggaa aggaagtgaa ccctactgaa gccagagaat tcaccccggc
     8821 caaagcaggc cctctgggtc cagcccctca ttccacacca cgccagtatt gcatccatct
     8881 actgcagcta cacatcctga gggcagcacc acccactctg gcctgctggc ccatcgcagg
     8941 actagcccag gcacctgccg ggcattgcag gatatccagt ggggcctgtg actgctccct
     9001 gatgcgtcag aagagaagtg ttgcacttta gtggaggagc tgaggagcac ctgccccctt
     9061 gtagcttgag ttccttttgg taacagtagc agcctccatg gtggtgtctg ggatgcacgt
     9121 gcacccgctg ccttcagctg tatgtgtgtg ttcctgctgg agttgtgtta ctgacaggat
     9181 aatgacatta caaagaaatt gtgttatatt caactttgcc ttgataatta ttgtaaacac
     9241 tttgttcatt ttttcttttt tattcacaaa ctaaatccac caggaaatta taaagttatt
     9301 taaaaacc
//
