LOCUS       NM_001253697            8544 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens erbb2 interacting protein (ERBIN), transcript variant
            1, mRNA.
ACCESSION   NM_001253697
VERSION     NM_001253697.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8544)
  AUTHORS   Zhang,Z., Xu,X., Zhang,D., Zhao,S., Wang,C., Zhang,G., Chen,W.,
            Liu,J., Gong,H., Rixiati,Y., Li,S., Shen,T. and Li,J.
  TITLE     Targeting Erbin-mitochondria axis in platelets/megakaryocytes
            promotes B cell-mediated antitumor immunity
  JOURNAL   Cell Metab 36 (3), 541-556 (2024)
   PUBMED   38232736
  REMARK    GeneRIF: Targeting Erbin-mitochondria axis in
            platelets/megakaryocytes promotes B cell-mediated antitumor
            immunity.
REFERENCE   2  (bases 1 to 8544)
  AUTHORS   Peng,X., Zhao,L., Yao,L., Dong,J., Wu,W. and Luo,T.
  TITLE     Exosomal ERBB2IP contributes to tumor growth via elevating PSAT1
            expression in non-small cell lung carcinoma
  JOURNAL   Thorac Cancer 14 (19), 1812-1823 (2023)
   PUBMED   37192746
  REMARK    GeneRIF: Exosomal ERBB2IP contributes to tumor growth via elevating
            PSAT1 expression in non-small cell lung carcinoma.
REFERENCE   3  (bases 1 to 8544)
  AUTHORS   Shen,T., Liu,J.L., Wang,C.Y., Rixiati,Y., Li,S., Cai,L.D.,
            Zhao,Y.Y. and Li,J.M.
  TITLE     Targeting Erbin in B cells for therapy of lung metastasis of
            colorectal cancer
  JOURNAL   Signal Transduct Target Ther 6 (1), 115 (2021)
   PUBMED   33707428
  REMARK    GeneRIF: Targeting Erbin in B cells for therapy of lung metastasis
            of colorectal cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8544)
  AUTHORS   Jang,H., Stevens,P., Gao,T. and Galperin,E.
  TITLE     The leucine-rich repeat signaling scaffolds Shoc2 and Erbin:
            cellular mechanism and role in disease
  JOURNAL   FEBS J 288 (3), 721-739 (2021)
   PUBMED   32558243
  REMARK    GeneRIF: The leucine-rich repeat signaling scaffolds Shoc2 and
            Erbin: cellular mechanism and role in disease.
            Review article
REFERENCE   5  (bases 1 to 8544)
  AUTHORS   Jaulin-Bastard,F., Arsanto,J.P., Le Bivic,A., Navarro,C., Vely,F.,
            Saito,H., Marchetto,S., Hatzfeld,M., Santoni,M.J., Birnbaum,D. and
            Borg,J.P.
  TITLE     Interaction between Erbin and a Catenin-related protein in
            epithelial cells
  JOURNAL   J Biol Chem 277 (4), 2869-2875 (2002)
   PUBMED   11711544
REFERENCE   6  (bases 1 to 8544)
  AUTHORS   Favre,B., Fontao,L., Koster,J., Shafaatian,R., Jaunin,F.,
            Saurat,J.H., Sonnenberg,A. and Borradori,L.
  TITLE     The hemidesmosomal protein bullous pemphigoid antigen 1 and the
            integrin beta 4 subunit bind to ERBIN. Molecular cloning of
            multiple alternative splice variants of ERBIN and analysis of their
            tissue expression
  JOURNAL   J Biol Chem 276 (35), 32427-32436 (2001)
   PUBMED   11375975
REFERENCE   7  (bases 1 to 8544)
  AUTHORS   Saito,H., Santoni,M.J., Arsanto,J.P., Jaulin-Bastard,F., Le
            Bivic,A., Marchetto,S., Audebert,S., Isnardon,D., Adelaide,J.,
            Birnbaum,D. and Borg,J.P.
  TITLE     Lano, a novel LAP protein directly connected to MAGUK proteins in
            epithelial cells
  JOURNAL   J Biol Chem 276 (34), 32051-32055 (2001)
   PUBMED   11440998
REFERENCE   8  (bases 1 to 8544)
  AUTHORS   Huang,Y.Z., Wang,Q., Xiong,W.C. and Mei,L.
  TITLE     Erbin is a protein concentrated at postsynaptic membranes that
            interacts with PSD-95
  JOURNAL   J Biol Chem 276 (22), 19318-19326 (2001)
   PUBMED   11279080
REFERENCE   9  (bases 1 to 8544)
  AUTHORS   Jaulin-Bastard,F., Saito,H., Le Bivic,A., Ollendorff,V.,
            Marchetto,S., Birnbaum,D. and Borg,J.P.
  TITLE     The ERBB2/HER2 receptor differentially interacts with ERBIN and
            PICK1 PSD-95/DLG/ZO-1 domain proteins
  JOURNAL   J Biol Chem 276 (18), 15256-15263 (2001)
   PUBMED   11278603
REFERENCE   10 (bases 1 to 8544)
  AUTHORS   Borg,J.P., Marchetto,S., Le Bivic,A., Ollendorff,V.,
            Jaulin-Bastard,F., Saito,H., Fournier,E., Adelaide,J., Margolis,B.
            and Birnbaum,D.
  TITLE     ERBIN: a basolateral PDZ protein that interacts with the mammalian
            ERBB2/HER2 receptor
  JOURNAL   Nat Cell Biol 2 (7), 407-414 (2000)
   PUBMED   10878805
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DR000131.1, AF276423.1,
            BC144075.1, AB033051.2, BP342103.1, N67861.1 and AC025442.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001253697.1.
            
            Summary: This gene is a member of the leucine-rich repeat and PDZ
            domain (LAP) family. The encoded protein contains 17 leucine-rich
            repeats and one PDZ domain. It binds to the unphosphorylated form
            of the ERBB2 protein and regulates ERBB2 function and localization.
            It has also been shown to affect the Ras signaling pathway by
            disrupting Ras-Raf interaction. Alternatively spliced transcript
            variants encoding multiple isoforms have been observed for this
            gene. [provided by RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF276423.1, SRR14038191.1845876.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284037.10/ ENSP00000284037.4
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               DR000131.1         43-188
            147-853             AF276423.1         1-707
            854-1226            BC144075.1         656-1028
            1227-1377           AF276423.1         1081-1231
            1378-3547           AB033051.2         1089-3258
            3548-4356           AF276423.1         3402-4210
            4357-6476           AB033051.2         3945-6064
            6477-6767           BP342103.1         294-584
            6768-7021           N67861.1           1-254               c
            7022-8544           AC025442.6         27328-28850
FEATURES             Location/Qualifiers
     source          1..8544
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q12.3"
     gene            1..8544
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /note="erbb2 interacting protein"
                     /db_xref="GeneID:55914"
                     /db_xref="HGNC:HGNC:15842"
                     /db_xref="MIM:606944"
     exon            1..232
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            233..280
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            281..478
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             290..4528
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     densin-180-like protein; protein LAP2; epididymis
                     secretory protein Li 78"
                     /codon_start=1
                     /product="erbin isoform 1"
                     /protein_id="NP_001240626.1"
                     /db_xref="CCDS:CCDS58953.1"
                     /db_xref="GeneID:55914"
                     /db_xref="HGNC:HGNC:15842"
                     /db_xref="MIM:606944"
                     /translation="MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTF
                     EKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKN
                     GIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRL
                     TKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANR
                     LTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLK
                     NITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYL
                     QQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQ
                     LTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDNESFNPSLW
                     EEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDE
                     ETNEDSGRDLKPHEDQQDINKDVGVKTSESTTTVKSKVDEREKYMIGNSVQKISEPEA
                     EISPGSLPVTANMKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQP
                     KVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCS
                     PVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKFKAHDKKDFNLPEYDLNVEER
                     LVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEIMERSKTQDIVLGTSFLSI
                     NSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHDSDCSVDLGISKSTEDL
                     SPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVKITSAVDGKNIVRSK
                     SATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRGPTSGPQSAPQIY
                     GPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQSYAKHSANMNF
                     SNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSVSSTASVNL
                     GDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNASRPQSAR
                     PSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQVLRHI
                     EAKKLEKKHPQTSSSGDPCQDGIFISGQQNYSSATLSHKDVPPDSLMKMPLSNGQMGQ
                     PLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQ
                     EIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQA
                     NGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS"
     exon            479..596
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            597..675
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            676..765
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            766..822
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            823..886
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            887..961
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1106
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1179
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1309
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1425
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1495
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1595
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1717
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1891
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2077
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2192
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2376
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..3922
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3923..4045
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4046..4252
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4253..4345
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4346..4420
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4421..8544
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      6509
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /note="major polyA site"
     regulatory      7840..7845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /note="hexamer: AATAAA"
     polyA_site      7863
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
     regulatory      8521..8526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /note="hexamer: AATAAA"
     polyA_site      8544
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
ORIGIN      
        1 ggcggagatc ctcgttgggg ctgggaaact cctgcaaaac tcgagaccag gaagccagcc
       61 cgcaccccaa cccccaccaa agccacctac tcttcttctg tgggaggcca gtccacatcc
      121 gctctcaccc gagagagata ttcagctgga tccaaagtga ctgatgaagg gaaggaaatc
      181 atgtcaagcg aagccttgaa aaagctgccc tgagacggtg tcccgccgaa agaatgttgg
      241 ctcaattaag aaacatcagg gagataaatt caacccagtg tgtctaaaaa tgactacaaa
      301 acgaagtttg tttgtgcggt tggtaccatg tcgctgtcta cgaggggaag aggagactgt
      361 cactactctt gattattctc attgcagctt agaacaagtt ccgaaagaga tttttacttt
      421 tgaaaaaacc ttggaggaac tctatttaga tgctaatcag attgaagagc ttccaaagca
      481 actttttaac tgtcagtctt tacacaaact gagtttgcca gacaatgatt taacaacgtt
      541 accagcatcc attgcaaacc ttattaatct cagggaactg gatgtcagca agaatggaat
      601 acaggagttt ccagaaaata taaaaaattg taaagttttg acaattgtgg aggccagtgt
      661 aaaccctatt tccaagctcc ctgatggatt ttctcagctg ttaaacctaa cccagttgta
      721 tctgaatgat gcttttcttg agttcttgcc agcaaatttt ggcagattaa ctaaactcca
      781 aatattagag cttagagaaa accagttaaa aatgttgcct aaaactatga atagactgac
      841 ccagctggaa agactggatt tgggaagtaa cgaattcacg gaagtgcctg aagtacttga
      901 gcaactaagt ggattgaaag agttttggat ggatgctaat agactgactt ttattccagg
      961 gtttattggt agtttgaaac agctcacata tttggatgtt tctaaaaata atattgaaat
     1021 ggttgaagaa ggaatttcaa catgtgaaaa ccttcaagac ctcctattat caagcaattc
     1081 acttcagcag cttcctgaga ctattggttc gttgaagaat ataacaacgc ttaaaataga
     1141 tgaaaaccag ttaatgtatc tgccagactc tataggaggg ttaatatcag tagaagaact
     1201 ggattgtagt ttcaatgaag ttgaagcttt gccttcatct attgggcagc ttactaactt
     1261 aagaactttt gctgctgatc ataattactt acagcagttg cccccagaga ttggaagctg
     1321 gaaaaatata actgtgctgt ttctccattc caataaactt gagacacttc cagaggaaat
     1381 gggtgatatg caaaaattaa aagtcattaa tttaagtgat aatagattaa agaatttacc
     1441 ctttagcttt acaaagctac agcaattgac agctatgtgg ctctcagata atcagtccaa
     1501 acccctgata cctcttcaaa aagaaactga ttcagagacc cagaaaatgg tgcttaccaa
     1561 ctacatgttc cctcaacagc caaggactga ggatgttatg tttatatcag ataatgaaag
     1621 ttttaaccct tcattgtggg aggaacagag gaaacagcgg gctcaagttg catttgaatg
     1681 tgatgaagac aaagatgaaa gggaggcacc tcccagggag ggaaatttaa aaagatatcc
     1741 aacaccatac ccagatgagc ttaagaatat ggtcaaaact gttcaaacca ttgtacatag
     1801 attaaaagat gaagagacca atgaagactc aggaagagat ttgaaaccac atgaagatca
     1861 acaagatata aataaagatg tgggtgtgaa gacctcagaa agtactacta cagtaaaaag
     1921 caaagttgat gaaagagaaa aatatatgat aggaaactct gtacagaaga tcagtgaacc
     1981 tgaagctgag attagtcctg ggagtttacc agtgactgca aatatgaaag cctctgagaa
     2041 cttgaagcat attgttaacc atgatgatgt ttttgaggaa tctgaagaac tttcttctga
     2101 tgaagagatg aaaatggcgg agatgcgacc accattaatt gaaacctcta ttaaccagcc
     2161 aaaagtcgta gcacttagta ataacaaaaa agatgataca aaggaaacag attctttatc
     2221 agatgaagtt acacacaata gcaatcagaa taacagcaat tgttcttctc catctcggat
     2281 gtctgattca gtttctctta atactgatag tagtcaagac acctcactct gctctccagt
     2341 gaaacaaact catattgata ttaattccaa aatcaggcaa gaagatgaaa attttaacag
     2401 ccttttacaa aatggagata ttttaaacag ttcaacagag gaaaagttca aagctcatga
     2461 taaaaaagat tttaacttac ctgaatatga tttgaatgtt gaagagcgat tagttctaat
     2521 tgagaaaagt gttgactcaa cagccacagc tgatgacact cacaaattag atcatatcaa
     2581 tatgaatctt aataaactta taactaatga tacatttcaa ccagagatca tggaaagatc
     2641 aaaaacacag gatattgtgc ttggaacaag ctttttaagc attaattcta aagaggaaac
     2701 tgagcacttg gaaaatggaa acaagtatcc taatttggaa tccgtaaata aggtaaatgg
     2761 acattctgag gaaacttccc agtctcctaa taggactgaa ccacatgaca gtgattgttc
     2821 tgttgactta ggtatttcca aaagcactga agatctctcc cctcagaaaa gtggtccagt
     2881 tggatctgtt gtgaaatctc atagcataac taatatggag attggagggc taaaaatcta
     2941 tgatattctt agtgataatg gacctcagca gccaagtaca accgttaaaa tcacatctgc
     3001 tgttgatgga aaaaatatag tcaggagcaa gtctgccaca ctgttgtatg atcaaccatt
     3061 gcaggtattt actggttctt cctcatcttc tgatttaata tcaggaacaa aggcaatttt
     3121 caagtttgat tcaaatcata atcccgaaga gccaaatata ataagaggcc ccacaagtgg
     3181 cccacaatct gcacctcaaa tatatggtcc tccacagtat aatatccaat acagtagcag
     3241 tgctgcagtc aaagacactt tgtggcactc caaacaaaat ccccaaatag accatgccag
     3301 ttttcctcct cagctccttc ctagatcaga gagcacagaa aatcaaagtt atgctaaaca
     3361 ttctgccaat atgaatttct ctaatcataa caatgttcga gctaatactg cataccattt
     3421 acatcagaga cttggcccag caagacatgg ggaaatgtgg gccatctcac caaacgaccg
     3481 acttattcct gcagtaactc gaagtacaat ccagcgacaa agtagtgtgt cctccacagc
     3541 ctctgtaaat cttggtgatc caggctctac aaggcgggct cagattcctg aaggagatta
     3601 tttatcatac agagagttcc actcagcggg aagaactcct ccaatgatgc caggatcaca
     3661 gagacccctt tctgcacgaa catacagcat agatggtcca aatgcatcaa gacctcagag
     3721 tgctcgaccc tctattaatg aaataccaga gagaactatg tcagttagtg atttcaatta
     3781 ttcacggact agtccttcaa aaagaccaaa tgcaagggtt ggttctgagc attctttatt
     3841 agatcctcca ggaaaaagta aagttcctcg tgactggaga gaacaagtac ttcgacatat
     3901 tgaagccaaa aagttagaaa agaagcatcc ccagacatcc agttcaggag atccttgtca
     3961 agatggtata ttcatttcag gacagcagaa ctactcatca gccacactta gtcacaaaga
     4021 tgttcctcca gacagcttga tgaaaatgcc tttgagtaat ggacagatgg gccagcctct
     4081 caggcctcag gcaaattata gtcaaataca tcacccccct caggcatctg tggcaaggca
     4141 tccctctaga gaacaactaa ttgattactt gatgctgaaa gtggcccacc agcctccata
     4201 tacacagccc cattgttctc ctagacaagg ccatgaactg gcaaaacaag agattcgagt
     4261 gagggttgaa aaggatccag aacttggatt tagcatatca ggtggtgtcg ggggtagagg
     4321 aaacccattc agacctgatg atgatggtat atttgtaaca agggtacaac ctgaaggacc
     4381 agcatcaaaa ttactgcagc caggtgataa aattattcag gctaatggct acagttttat
     4441 aaatattgaa catggacaag cagtgtcctt gctaaaaact ttccagaata cagttgaact
     4501 catcattgta cgagaagttt cctcataagc actgtggaca aaaaaagcgg ggaagacagc
     4561 aagatttatt ggaagatact tacaggggaa attaatattt tgactatttt tatatataaa
     4621 gaagaactca aaaaattatg ttcaaatttg tacattaatg aaataatgga acttgtggtt
     4681 agagggaaag aaccactgta cagaatataa aggagactgt tgaattcata ccatataaaa
     4741 cttgttaggt ttttaaacat agcaatcaag gctacaaaaa caaacctgtg ttgtttttgt
     4801 atagattgta ggtttatttt tggatttcat atacatgact gaactgtgtg caaggcaata
     4861 gttagccttg attttagccc agagacagat ggcagagcta tctctctcat agcttttatg
     4921 cccttatttt tattcaactg gtattaatgt ttttctcctg aaactacttt ttttgatgtg
     4981 ggcaagagat ttgaagtgtt ggcttttgct atgtgcatat tgaattgaag agtgagtagg
     5041 tgaaggtggt gctggtgggt tcactttcca aggccagact aaaacagtta ttttctataa
     5101 aaatctggaa gcaaagaatg gggatgggga gagctacgtg gtagtatgtt tttattagga
     5161 gaataatgca ataaaatatg taatgtcttt tttataaagc aaaaaagaca ataattgcat
     5221 ttatgagctc ggcaggatct gttcttgtca tagccattga ctatacattt gctactggtg
     5281 attcagtttt taatttttta gtcacaggaa atttttaact ctactgtaga tgcatgtcca
     5341 tgcattttct gtgttatgga aatccactga tttttttttt tttttcaaat ggtggtactt
     5401 gcaatctgtt ttataattag tgctccattt aaatctaatt tataattttt attttaagca
     5461 gcaaatgaaa caaaaatggc cagttttaag attgtgttgc ctgtaacaca aaatgttacg
     5521 aaggtttagg aaagcctctt tgatttttgt ttggccttgc attgccttgg taaagtaaaa
     5581 ggaaacagta cacttggagc taggaaacca aagcaagctt tgtgaaactg gcacagtgat
     5641 agagaattgc tgtggagagt tatagagcaa agggatgggt ccttgaggcc tgccagtgtg
     5701 taaaggtgtt caaataaagg gctgtttcta caggtaacat taaatgtgaa ctcaacactt
     5761 ccagagtctt taaagggttt ctatgtgtat cagtgtaata gtgttttacc accaactgcc
     5821 tttctttgtt cctagttact gtaacaaata tttgatgata gaggtttatt aattttgttt
     5881 atccagacca ttaattttat ttgtttttgt tctatgtaat caaataaaat ttgagtaaca
     5941 tgtaatggta aggattaatg catggttatt tggaccagaa aaaagtgcca tagaagacca
     6001 ataactgttt agttgaggct agtctggaac ctttcattag agcaatattt ggttattgca
     6061 cttcattttt atttactaag aaatgcaatt tgggaatttt taatctgtta tgctttgttt
     6121 atcaaccttg attttaatta agacttttat aagactagct taaaacacca accaacatta
     6181 tttttgcaaa agtgagttgg actcactttc cattcttgct agtcagagta agtaggcagc
     6241 acttttaaaa atatgtgaac tcaaatattg cacttctttc aagatgttat caattggtta
     6301 ttgtactgta tagttttaat aattttgatt gaaacccttt aacaactctt tgtaaatttt
     6361 aactcatttt agttgatttt cagtactatt tacataggaa ttgattttta tggatatagt
     6421 agaagaaatg tgctgtattt tgataaaatt cacttattgt atgtgtgttg taatctaaaa
     6481 aaaaaaagaa tgacaaacag cttctttaag acaagtctcg gtgttccctt tattcttagt
     6541 ttgtttttaa atattaattt tggcattcta aaatagctaa catttctttt attgatttca
     6601 gattttcaca ggcacattct acttttaatc agaaatatat ttaataagta taattgtgaa
     6661 gttttcaact actttacctt gaaccacata taccaattat aattttggaa aaggaattaa
     6721 gcctcacgga acaatggatc ttcagcaaac cttaacttca ttgtctgcac attacattga
     6781 agtattataa atgcaacaga tgttatatgc actggcattt tatcctactc tagttagtta
     6841 aaattttata gtattcttgc aacacataaa gttgcgtaag aaactttacc aagaggagta
     6901 ttatagccaa gttttctttg aaagtattgg aaaactaaaa ttaaatgaca aggactttga
     6961 attagaattt tgctgtaata aagtttcaaa atttgaataa aataattaaa ttttttgagg
     7021 aagtggagaa gacattttta gtttatatat tgttgagtaa attgtagtta aggcctatac
     7081 ccataactaa ctttagtaag tattatatag caattcatca aaaccacaac tgtcttttag
     7141 tgattttgtc tttaagagta atttcttact ctaaccagta aaaaaataat actgatcaga
     7201 gtaatttata cggcatacaa tagttgatac aatctaaaga tttatgctaa ttaaggaatt
     7261 atcacttcat ctgaatcaat gaaattctaa aattccctac atatttattt tgtaaatatt
     7321 cttctgacct ctttggactg gatatgaaga tatatatata tacacttaat tcttttaaac
     7381 acaaaacttg ccataagcag aaccaaactt ttaagtatta atttgctgca cttaaaaaat
     7441 cccattagca gctatgtaat atttttatca accaacattt attcattcca aatttttgta
     7501 tatatctaga tgaagtaaca catagaggat agataacaaa ctaatgatgt ttaaactggt
     7561 ttatttacaa aattcggggt tagagaaatt ctcatgaaaa atatacaatt tttttttagc
     7621 attaaaaccc tgtatatcta ggtgtggaag aagtgtagtt tatctcaaat tattattatt
     7681 tacttctaaa gggaggcatt aagatgggaa atgtttctct gatggagatt gacgtgtgaa
     7741 atctatttgg aagggtattt ttttcactca gtctgttgca ttcttacagc cttctgtttt
     7801 aatgttcagt gaataggttt cttatgaaat ggacattgaa ataaaaatta tgattcaaga
     7861 gcattaattg atgaacaagt gaacaagatg cctctttaaa aaaaaaaaag aaaaagtaat
     7921 ctagacaggc agccaactca gacctttggg tattcctttg tttctaaata aggaccttca
     7981 gaaaaagttg accatattct acctaaagct gctaattctt tacagaattc ataagcccag
     8041 gggatagtaa gtagtcattt agttttggaa agttcttaag agaatgctat cttctacagt
     8101 ctcatgaagc agtttttcaa gattagaatc tgtggtcagc tataacgtac agtcctaata
     8161 tccaaccacc tgagaagctc atcctaagct gagaaagcct aaaatgttag agaatgttta
     8221 gagaaaacac ctgaaatttt ttttaagaga acaacctagg ttttattgta gagaacaatc
     8281 aaaatactcc tgaacctttc tatagaatct ttaggagaga ggctgacaaa aagaatcctt
     8341 ctgttacaac tttcttttct aatgtaacaa ccagggacaa tggtgatctg tcacgcatct
     8401 gcccatctag cttctcaatc ggcccacggt tttatttcag gataaaattt gagaaactag
     8461 tatcactggg gaaggaagaa acctaagctg taaaattatg cttttcccct caagggattc
     8521 aataaagctt atttttcatg aaaa
//
