LOCUS       NM_005235              12097 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens erb-b2 receptor tyrosine kinase 4 (ERBB4), transcript
            variant JM-a/CVT-1, mRNA.
ACCESSION   NM_005235
VERSION     NM_005235.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12097)
  AUTHORS   Li,X., Zhang,H., Li,W., Tuo,H., He,B. and Jiang,H.
  TITLE     The role and mechanism of NRG1/ErbB4 in inducing the
            differentiation of induced pluripotent stem cells into
            cardiomyocytes
  JOURNAL   BMC Cardiovasc Disord 24 (1), 559 (2024)
   PUBMED   39407109
  REMARK    GeneRIF: The role and mechanism of NRG1/ErbB4 in inducing the
            differentiation of induced pluripotent stem cells into
            cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12097)
  AUTHORS   Singh,P.K., Kim,S. and Smith,A.W.
  TITLE     HER4 is a high-affinity dimerization partner for all EGFR/HER/ErbB
            family proteins
  JOURNAL   Protein Sci 33 (10), e5171 (2024)
   PUBMED   39276020
  REMARK    GeneRIF: HER4 is a high-affinity dimerization partner for all
            EGFR/HER/ErbB family proteins.
REFERENCE   3  (bases 1 to 12097)
  AUTHORS   Adashek,J.J., Pandya,C., Maragakis,N.J., De,P., Cohen,P.R., Kato,S.
            and Kurzrock,R.
  TITLE     Neuregulin-1 and ALS19 (ERBB4): at the crossroads of amyotrophic
            lateral sclerosis and cancer
  JOURNAL   BMC Med 22 (1), 74 (2024)
   PUBMED   38369520
  REMARK    GeneRIF: Neuregulin-1 and ALS19 (ERBB4): at the crossroads of
            amyotrophic lateral sclerosis and cancer.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 12097)
  AUTHORS   Li,R., Wang,Y., Yang,L., Zhong,P., Huang,G., Liang,Q. and Yu,X.
  TITLE     Genetic variants of ERBB4 gene and risk of gestational diabetes
            mellitus: a susceptibility and diagnostic nomogram study
  JOURNAL   Front Endocrinol (Lausanne) 14, 1283539 (2023)
   PUBMED   38149095
  REMARK    GeneRIF: Genetic variants of ERBB4 gene and risk of gestational
            diabetes mellitus: a susceptibility and diagnostic nomogram study.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 12097)
  AUTHORS   Tang,R., Cui,H., Dou,R., Tao,L., Tan,L., Guo,T. and Luo,D.
  TITLE     ErbB4 affects Th1/Th17 cell differentiation and promotes psoriasis
            progression
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (12), 1-5 (2023)
   PUBMED   38063127
  REMARK    GeneRIF: ErbB4 affects Th1/Th17 cell differentiation and promotes
            psoriasis progression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 12097)
  AUTHORS   Barbacci,E.G., Guarino,B.C., Stroh,J.G., Singleton,D.H.,
            Rosnack,K.J., Moyer,J.D. and Andrews,G.C.
  TITLE     The structural basis for the specificity of epidermal growth factor
            and heregulin binding
  JOURNAL   J Biol Chem 270 (16), 9585-9589 (1995)
   PUBMED   7721889
  REMARK    Erratum:[J Biol Chem 1995 Nov 24;270(47):28494]
REFERENCE   7  (bases 1 to 12097)
  AUTHORS   Zimonjic,D.B., Alimandi,M., Miki,T., Popescu,N.C. and Kraus,M.H.
  TITLE     Localization of the human HER4/erbB-4 gene to chromosome 2
  JOURNAL   Oncogene 10 (6), 1235-1237 (1995)
   PUBMED   7700649
REFERENCE   8  (bases 1 to 12097)
  AUTHORS   Nagata,K., Kohda,D., Hatanaka,H., Ichikawa,S., Matsuda,S.,
            Yamamoto,T., Suzuki,A. and Inagaki,F.
  TITLE     Solution structure of the epidermal growth factor-like domain of
            heregulin-alpha, a ligand for p180erbB-4
  JOURNAL   EMBO J 13 (15), 3517-3523 (1994)
   PUBMED   8062828
REFERENCE   9  (bases 1 to 12097)
  AUTHORS   Culouscou,J.M., Plowman,G.D., Carlton,G.W., Green,J.M. and
            Shoyab,M.
  TITLE     Characterization of a breast cancer cell differentiation factor
            that specifically activates the HER4/p180erbB4 receptor
  JOURNAL   J Biol Chem 268 (25), 18407-18410 (1993)
   PUBMED   7689552
REFERENCE   10 (bases 1 to 12097)
  AUTHORS   Siddique,N. and Siddique,T.
  TITLE     Amyotrophic Lateral Sclerosis Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301623
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC096765.3, AI793060.1,
            L07868.1, CR627023.1, AC012069.10 and BQ015804.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005235.2.
            
            Summary: This gene is a member of the Tyr protein kinase family and
            the epidermal growth factor receptor subfamily. It encodes a
            single-pass type I membrane protein with multiple cysteine rich
            domains, a transmembrane domain, a tyrosine kinase domain, a
            phosphotidylinositol-3 kinase binding site and a PDZ domain binding
            motif. The protein binds to and is activated by neuregulins and
            other factors and induces a variety of cellular responses including
            mitogenesis and differentiation. Multiple proteolytic events allow
            for the release of a cytoplasmic fragment and an extracellular
            fragment. Mutations in this gene have been associated with cancer.
            Alternatively spliced variants which encode different protein
            isoforms have been described; however, not all variants have been
            fully characterized. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (JM-a/CYT-1) represents the longer
            transcript and encodes the longer isoform (JM-a/CYT-1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L07868.1, BC112199.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342788.9/ ENSP00000342235.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               AC096765.3         80317-80490         c
            175-239             AI793060.1         214-278
            240-4570            L07868.1           1-4331
            4571-4571           CR627023.1         181-181
            4572-4704           L07868.1           4332-4464
            4705-11965          AC012069.10        58518-65778         c
            11966-12097         BQ015804.1         19-150              c
FEATURES             Location/Qualifiers
     source          1..12097
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q34"
     gene            1..12097
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /note="erb-b2 receptor tyrosine kinase 4"
                     /db_xref="GeneID:2066"
                     /db_xref="HGNC:HGNC:3432"
                     /db_xref="MIM:600543"
     exon            1..354
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..4199
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /EC_number="2.7.10.1"
                     /note="isoform JM-a/CVT-1 precursor is encoded by
                     transcript variant JM-a/CVT-1; receptor tyrosine-protein
                     kinase erbB-4; tyrosine kinase-type cell surface receptor
                     HER4; avian erythroblastic leukemia viral (v-erb-b2)
                     oncogene homolog 4; proto-oncogene-like protein c-ErbB-4;
                     v-erb-a erythroblastic leukemia viral oncogene homolog 4;
                     v-erb-b2 avian erythroblastic leukemia viral oncogene
                     homolog 4; human epidermal growth factor receptor 4"
                     /codon_start=1
                     /product="receptor tyrosine-protein kinase erbB-4 isoform
                     JM-a/CVT-1 precursor"
                     /protein_id="NP_005226.1"
                     /db_xref="CCDS:CCDS2394.1"
                     /db_xref="GeneID:2066"
                     /db_xref="HGNC:HGNC:3432"
                     /db_xref="MIM:600543"
                     /translation="MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQ
                     QYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENL
                     RIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADT
                     IHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCD
                     GRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLE
                     HNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKAC
                     DGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVF
                     RTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSL
                     KEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCS
                     SDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGL
                     LTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQG
                     CNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKK
                     KRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPE
                     GETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQL
                     MPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNH
                     VKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELM
                     TFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAA
                     EFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNI
                     PPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTI
                     PEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELD
                     EEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVN
                     EPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEY
                     STKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV"
     exon            355..506
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            507..693
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            694..828
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            829..894
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1013
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1155
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1269
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1396
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1470
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1561
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1761
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1894
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..1988
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2143
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2218
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2351
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2474
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2573
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2759
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            2760..2915
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            2916..2991
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            2992..3138
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..3236
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            3237..3407
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            3408..3455
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            3456..3753
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     exon            3754..12097
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12076..12081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /note="hexamer: AATAAA"
     polyA_site      12097
                     /gene="ERBB4"
                     /gene_synonym="ALS19; HER4; p180erbB4"
                     /note="major polyA site"
ORIGIN      
        1 acagtccggc ccagagcgcc aagcgcacac accgagcaca ctcccacacg cgcacacacg
       61 cgctcacact cgccccctcc tcgggccccg gccctggacc cgcgggcgcg gactcggtcg
      121 cccgccctgg gagtcgccac accgcgcgcg ccgcgcccgc ccccctcgca cccccacgcg
      181 cgcccggctg ggggatctcc tccgcgtgcc cgaaaggggg atatgccatt tggacatgta
      241 attgtcagca cgggatctga gacttccaaa aaatgaagcc ggcgacagga ctttgggtct
      301 gggtgagcct tctcgtggcg gcggggaccg tccagcccag cgattctcag tcagtgtgtg
      361 caggaacgga gaataaactg agctctctct ctgacctgga acagcagtac cgagccttgc
      421 gcaagtacta tgaaaactgt gaggttgtca tgggcaacct ggagataacc agcattgagc
      481 acaaccggga cctctccttc ctgcggtctg ttcgagaagt cacaggctac gtgttagtgg
      541 ctcttaatca gtttcgttac ctgcctctgg agaatttacg cattattcgt gggacaaaac
      601 tttatgagga tcgatatgcc ttggcaatat ttttaaacta cagaaaagat ggaaactttg
      661 gacttcaaga acttggatta aagaacttga cagaaatcct aaatggtgga gtctatgtag
      721 accagaacaa attcctttgt tatgcagaca ccattcattg gcaagatatt gttcggaacc
      781 catggccttc caacttgact cttgtgtcaa caaatggtag ttcaggatgt ggacgttgcc
      841 ataagtcctg tactggccgt tgctggggac ccacagaaaa tcattgccag actttgacaa
      901 ggacggtgtg tgcagaacaa tgtgacggca gatgctacgg accttacgtc agtgactgct
      961 gccatcgaga atgtgctgga ggctgctcag gacctaagga cacagactgc tttgcctgca
     1021 tgaatttcaa tgacagtgga gcatgtgtta ctcagtgtcc ccaaaccttt gtctacaatc
     1081 caaccacctt tcaactggag cacaatttca atgcaaagta cacatatgga gcattctgtg
     1141 tcaagaaatg tccacataac tttgtggtag attccagttc ttgtgtgcgt gcctgcccta
     1201 gttccaagat ggaagtagaa gaaaatggga ttaaaatgtg taaaccttgc actgacattt
     1261 gcccaaaagc ttgtgatggc attggcacag gatcattgat gtcagctcag actgtggatt
     1321 ccagtaacat tgacaaattc ataaactgta ccaagatcaa tgggaatttg atctttctag
     1381 tcactggtat tcatggggac ccttacaatg caattgaagc catagaccca gagaaactga
     1441 acgtctttcg gacagtcaga gagataacag gtttcctgaa catacagtca tggccaccaa
     1501 acatgactga cttcagtgtt ttttctaacc tggtgaccat tggtggaaga gtactctata
     1561 gtggcctgtc cttgcttatc ctcaagcaac agggcatcac ctctctacag ttccagtccc
     1621 tgaaggaaat cagcgcagga aacatctata ttactgacaa cagcaacctg tgttattatc
     1681 ataccattaa ctggacaaca ctcttcagca caatcaacca gagaatagta atccgggaca
     1741 acagaaaagc tgaaaattgt actgctgaag gaatggtgtg caaccatctg tgttccagtg
     1801 atggctgttg gggacctggg ccagaccaat gtctgtcgtg tcgccgcttc agtagaggaa
     1861 ggatctgcat agagtcttgt aacctctatg atggtgaatt tcgggagttt gagaatggct
     1921 ccatctgtgt ggagtgtgac ccccagtgtg agaagatgga agatggcctc ctcacatgcc
     1981 atggaccggg tcctgacaac tgtacaaagt gctctcattt taaagatggc ccaaactgtg
     2041 tggaaaaatg tccagatggc ttacaggggg caaacagttt cattttcaag tatgctgatc
     2101 cagatcggga gtgccaccca tgccatccaa actgcaccca agggtgtaac ggtcccacta
     2161 gtcatgactg catttactac ccatggacgg gccattccac tttaccacaa catgctagaa
     2221 ctcccctgat tgcagctgga gtaattggtg ggctcttcat tctggtcatt gtgggtctga
     2281 catttgctgt ttatgttaga aggaagagca tcaaaaagaa aagagccttg agaagattct
     2341 tggaaacaga gttggtggaa ccattaactc ccagtggcac agcacccaat caagctcaac
     2401 ttcgtatttt gaaagaaact gagctgaaga gggtaaaagt ccttggctca ggtgcttttg
     2461 gaacggttta taaaggtatt tgggtacctg aaggagaaac tgtgaagatt cctgtggcta
     2521 ttaagattct taatgagaca actggtccca aggcaaatgt ggagttcatg gatgaagctc
     2581 tgatcatggc aagtatggat catccacacc tagtccggtt gctgggtgtg tgtctgagcc
     2641 caaccatcca gctggttact caacttatgc cccatggctg cctgttggag tatgtccacg
     2701 agcacaagga taacattgga tcacaactgc tgcttaactg gtgtgtccag atagctaagg
     2761 gaatgatgta cctggaagaa agacgactcg ttcatcggga tttggcagcc cgtaatgtct
     2821 tagtgaaatc tccaaaccat gtgaaaatca cagattttgg gctagccaga ctcttggaag
     2881 gagatgaaaa agagtacaat gctgatggag gaaagatgcc aattaaatgg atggctctgg
     2941 agtgtataca ttacaggaaa ttcacccatc agagtgacgt ttggagctat ggagttacta
     3001 tatgggaact gatgaccttt ggaggaaaac cctatgatgg aattccaacg cgagaaatcc
     3061 ctgatttatt agagaaagga gaacgtttgc ctcagcctcc catctgcact attgacgttt
     3121 acatggtcat ggtcaaatgt tggatgattg atgctgacag tagacctaaa tttaaggaac
     3181 tggctgctga gttttcaagg atggctcgag accctcaaag atacctagtt attcagggtg
     3241 atgatcgtat gaagcttccc agtccaaatg acagcaagtt ctttcagaat ctcttggatg
     3301 aagaggattt ggaagatatg atggatgctg aggagtactt ggtccctcag gctttcaaca
     3361 tcccacctcc catctatact tccagagcaa gaattgactc gaataggagt gaaattggac
     3421 acagccctcc tcctgcctac acccccatgt caggaaacca gtttgtatac cgagatggag
     3481 gttttgctgc tgaacaagga gtgtctgtgc cctacagagc cccaactagc acaattccag
     3541 aagctcctgt ggcacagggt gctactgctg agatttttga tgactcctgc tgtaatggca
     3601 ccctacgcaa gccagtggca ccccatgtcc aagaggacag tagcacccag aggtacagtg
     3661 ctgaccccac cgtgtttgcc ccagaacgga gcccacgagg agagctggat gaggaaggtt
     3721 acatgactcc tatgcgagac aaacccaaac aagaatacct gaatccagtg gaggagaacc
     3781 cttttgtttc tcggagaaaa aatggagacc ttcaagcatt ggataatccc gaatatcaca
     3841 atgcatccaa tggtccaccc aaggccgagg atgagtatgt gaatgagcca ctgtacctca
     3901 acacctttgc caacaccttg ggaaaagctg agtacctgaa gaacaacata ctgtcaatgc
     3961 cagagaaggc caagaaagcg tttgacaacc ctgactactg gaaccacagc ctgccacctc
     4021 ggagcaccct tcagcaccca gactacctgc aggagtacag cacaaaatat ttttataaac
     4081 agaatgggcg gatccggcct attgtggcag agaatcctga atacctctct gagttctccc
     4141 tgaagccagg cactgtgctg ccgcctccac cttacagaca ccggaatact gtggtgtaag
     4201 ctcagttgtg gttttttagg tggagagaca cacctgctcc aatttcccca cccccctctc
     4261 tttctctggt ggtcttcctt ctaccccaag gccagtagtt ttgacacttc ccagtggaag
     4321 atacagagat gcaatgatag ttatgtgctt acctaacttg aacattagag ggaaagactg
     4381 aaagagaaag ataggaggaa ccacaatgtt tcttcatttc tctgcatggg ttggtcagga
     4441 gaatgaaaca gctagagaag gaccagaaaa tgtaaggcaa tgctgcctac tatcaaacta
     4501 gctgtcactt tttttctttt tctttttctt tctttgtttc tttcttcctc ttcttttttt
     4561 tttttttttt taaagcagat ggttgaaaca cccatgctat ctgttcctat ctgcaggaac
     4621 tgatgtgtgc atatttagca tccctggaaa tcataataaa gtttccatta gaacaaaaga
     4681 ataacatttt ctataacata tgatggtgtc tgaaattgag aatccagttt ctttccccag
     4741 cagtttctgt cctagcaagt aagaatggcc aactcaactt tcataattta aaaatctcca
     4801 ttaaagttat aactagtaat tatgttttca acactttttg gtttttttca ttttgttttg
     4861 ctctgaccga ttcctttata tttgctcccc tatttttggc tttaatttct aattgcaaag
     4921 atgtttacat caaagcttct tcacagaatt taagcaagaa atattttaat atagtgaaat
     4981 ggccactact ttaagtatac aatctttaaa ataagaaagg gaggctaata tttttcatgc
     5041 tatcaaatta tcttcaccct catcctttac atttttcaac attttttttt ctccataaat
     5101 gacactactt gataggccgt tggttgtctg aagagtagaa gggaaactaa gagacagttc
     5161 tctgtggttc aggaaaacta ctgatacttt caggggtggc ccaatgaggg aatccattga
     5221 actggaagaa acacactgga ttgggtatgt ctacctggca gatactcaga aatgtagttt
     5281 gcacttaagc tgtaatttta tttgttcttt ttctgaactc cattttggat tttgaatcaa
     5341 gcaatatgga agcaaccagc aaattaacta atttaagtac atttttaaaa aaagagctaa
     5401 gataaagact gtggaaatgc caaaccaagc aaattaggaa ccttgcaacg gtatccaggg
     5461 actatgatga gaggccagca cattatcttc atatgtcacc tttgctacgc aaggaaattt
     5521 gttcagttcg tatacttcgt aagaaggaat gcgagtaagg attggcttga attccatgga
     5581 atttctagta tgagactatt tatatgaagt agaaggtaac tctttgcaca taaattggta
     5641 taataaaaag aaaaacacaa acattcaaag cttagggata ggtccttggg tcaaaagttg
     5701 taaataaatg tgaaacatct tctcatgcaa ttattttatt atccaacaca ctaatctttt
     5761 gatactttat ataattccct ttcttcatat actgcatcca gtactagaac catcattatt
     5821 atgtatcatt ttgaaagaat acctgatgag atgaaggatg agaacaaatg acagagatga
     5881 gtctccaagt aaagggggcc tcacatcaat aattaggaaa cttagatata agtcgccctt
     5941 ttctgaaaat tctaccccaa gtcatttaga tttttaaaaa atatttctaa tgttaaaata
     6001 ttgggaccaa attagaatca atagtataag attaattaat tagagtaaaa atatctatta
     6061 aggcagagaa agtttagaga aaaaaatcca aagaaatttg tgtttcttcc tattctgaac
     6121 aagtaaatcc atccatccat ccatccaaac ctcctttatc taactgtgtc tactaaaagc
     6181 accatgtttt gtggggaaca ctcagataaa tggaatatca tcctcaactt caaaattcta
     6241 tgatctagga gatttaatta aaatgacatt ttaatttttc tatgcgttcc aacaatcaga
     6301 ttgcatagtc tcttttgtga atagctgtca tataatcagt tgtactgtaa gatatctcct
     6361 ttaaactcat ttgggatata agttaaacat ccttcaaatt gttgatgttg acaaacagga
     6421 taatttcaat aatattattc aaacataaac tggtctagga gaatattgca tcactgacta
     6481 attagcctat ctagagtcta acttcaccat taaaccaaaa gcagatggtg gtccttggcc
     6541 aagaatattg gagacattgg agttggtttt tttctaagct ataagaagtg aggcgagctg
     6601 aaaaagtatg gtagagcagg agaagggttt gtgagattcc ttctagtgaa gttcaccctc
     6661 aaacttttca ggggtaaaga cacagagtga ttcaggggcc acaatctaat agctcagggc
     6721 tctcctatcc attcagagaa gtctctagga aaagggatct catatcagta cttatgaaaa
     6781 attgaatata agcctccctt tctaaataaa tctgcatcga gtcatcacag ccctcttttt
     6841 ggatactata ccttgatttt ttttttctga tttacaatat gcatatggtt tctactgggc
     6901 tatagaaagc agaatcactc attttggaga aggaaaaaat gaatagttaa aacaaacttt
     6961 taactgttaa ggtaacagaa atgtatttag tgaatgtctc tttcctccta agaacacaag
     7021 acttctacat gttgggtaat acctagagat gcatgtagga ataatccaaa atgacccaaa
     7081 tgctttataa tagcaccact ttataattct tttgaatgat ttctgtagta tataattgac
     7141 ttcagttgtt tgagtgtttt ttgttttatt tttgtccccc ctgggaaaac atatttcagc
     7201 atgtataaga gggagaaaaa aagtttcatt ccttccagag aataacttat ttagtccagt
     7261 agggtagaat tttaaaatgt cagttaaagt cttcaaagtg cttgggggga tatcagattc
     7321 cagaggccaa ttgtagcaat tgaaatttgc agaatcaatt atgtaaatct gagacaaatt
     7381 agtattaaaa ttacacggag tatatttttt aaatcaccca actttgtaga ttatacctat
     7441 tttgggcagg tatggaaaaa ttttgcagtt aaatgattgc ctaaagaaag tggtaaacag
     7501 gtgaggaaag atggcctctg atctaggata gatccagaac cacaaagcat ctgcaccaca
     7561 aaaggtgtta gactaccaag cagctcctgg ttttctgcat agtattagta gcacagctta
     7621 ggatgagaat cctttctcca gtaacattct taaaatagca tgaaaaacaa cgcaaaactc
     7681 aaatttctat taaaacacac aaactaaaat caagtgattc ttttttgtag attagggaga
     7741 aggactgaat atctaattta agagaaggaa tagtgtttaa gtgttatagt gtgtgagcta
     7801 ataccttcta aaggaaagac atggcatgaa gattgtgcat acttacaatg ctaaggaaaa
     7861 atcaagaaaa ggactgtgtg aggctctgct actagatgaa gttggaagga ctattaatgt
     7921 gcttcttgaa gtatcaaaaa tgaaaagaaa attaaaattg tttaagcctg acagggaagg
     7981 atgtaaatac aagtttttct agagctctct aacctttatt tcaaaactgg aattattcat
     8041 ccatctgtaa ttgttgataa tttaactagt atatgtagtt cataaggtaa tagaaaaggt
     8101 gatcatgaaa gcatgtatat aactggacag aaccacgata atgctataag atgtagattt
     8161 agttaggtta tcagatgtta aatgatttta atattattaa ataaatcaaa ctagaaaact
     8221 aaccacaagt ataatgtaac aaagttaaat gcaggatata aaaatgtagg atggattttg
     8281 catagtaaaa agataagttt gccatttaaa attgttgttt gttgggttta gctgaaagta
     8341 ggcatatatg gttccacttg ggaaaacttg ctttaaagca ttacaatgaa caattttttc
     8401 tcattctctt attcctttat cactttttaa atgtaaagaa aattgtattt atttattttt
     8461 ttaaataaac accaccttgc agaatttaat aggcaaacat gttacatatg actaagtaag
     8521 ggtcttcaag atgaagtaaa gaaaatgtaa atgttctatt accttatgca gagacaaaaa
     8581 aaaaaaggag tggtgtcatt tagctagcaa acaaacaaaa tacagttaat tggtgatatg
     8641 tcctttcttt tctcactatg ccctcttgcc tccaaaaatg acaacaaaga atcacaattt
     8701 ttctgataaa taaatgctaa accaagcgtt tcaaactatt gcattgccat tcttttggac
     8761 tttagttatt agaatgatga ttgttatagg gcaaatgaga aatccatgtg catcagcttc
     8821 tagttgttaa aaaaaccaga taaattaact tctactgtat actgtgggca gaggatccta
     8881 gagctgatcc tacaacatca gcttctagtt gttaaaaaaa aaaaaagaaa cagataaatt
     8941 aacttctact gtatatactg tgggcagagg atcttactgt gcctctgttt gtgtacatgg
     9001 acttcggtgt gtatcagttt gaaggacagc cttgccccat gtaaacatat aaatgcagat
     9061 tggtatcgcc tggttgctat ttgcttaaga acaaatatta tacagatgag atcaggcata
     9121 attttaaaag atcattatca gtggagacct cattattact gatattacaa tggggccagt
     9181 ttttatactt ctgggtagaa ttaataaaat ttttctgatc ccagagatct gagttctctc
     9241 tgcagttgga aacaagaagc tgttgtgggc attgtgtcgg gccaggggcc cttgtgtttg
     9301 tgtgggcaaa tatcttttag cagtgtgagc tgcttttttc ttttcattaa aagtctctct
     9361 aaaataatag aaatttcaga tactcggttc aagtctcact gattttgtag aggtccaaaa
     9421 atgtaggatc tgtcactttt gcaggcccct gcctcaccta attcctggcc aggtgacatt
     9481 ttgggcagaa gtaaatgctt ctatagtcac aagctaaaat gactctaagc cccaatttca
     9541 cggggggtat tcacatgctt cctctggaaa atactctttg acagtcagct ttgcaagtaa
     9601 gtgattacct tgttaggaat caaagaaaaa tgtatttctc tctgaccttt agaggaaaat
     9661 agaatccttc ccttttttgc ccattgacac aactggcact gctctcttcc ctttctacca
     9721 ccctggttca aagtagtccc ccgatgctgt cctgttcctt tcttaagcca tagtggatct
     9781 ctgagatcct acaccccact ttgtgaaaca ctgacttcat ctttgccctc gaatgcctga
     9841 ttttttcata agagattcta gcaatttgga cactgtttaa gtgaactatc aaactaccgc
     9901 atagagaata tttaagctat taaaattatg gtttcccatg aagatcaatt ctctgtgtcc
     9961 ttccctatag gaatttgaga cgagttagcc ctgtgatgaa tcttgaaact cacatatgtc
    10021 cacatacact tggtagaact tcgatttaat ctttacataa aagctgtaca tataaccaag
    10081 aagttatttt tgccagtaaa ttaacttatt tgctttattc atcttatttg gttcctaatc
    10141 gtaaatattt tgtagctgct gtaaattttt ttctcccaaa tgaggagtct tattatcata
    10201 aaggtaaagg ctattcagct ttgataacca cctgcaattc ttttttggat cattcatcca
    10261 tctaacaaat acataatgag gacagttcat gttaatgaaa atccatgttg tttaatagaa
    10321 tgccatcctt tacctacttt tgctctttat ggacgttttt cttttcatgc tctagtgagc
    10381 tttccctata tcatgagaag tggttatatt tgtgcaaata tacaaatata ggaaaacaaa
    10441 gattcatacc tgtaggcaat agtctaactt gtccaaacca ctttgccttt actgctattt
    10501 ttatccccaa tgcgtagata tttcccccag gcctatagcc tttgtgaagg aaagcaaatc
    10561 atacctcctg tatattgaca cgaatctggt tttcaaatgt catttccaga ttttttagtt
    10621 aattgggggt tgtccttttc ccttaatgtg agagtcattt tcctgtatat ttctggatct
    10681 ctcaggggct gggagggggg agtgagggga ctacaaccat agcactccaa gaaccctttt
    10741 gggattactc cagtaatcaa ctacgaaagt tattttctaa atgtagatat gtaaggtgtt
    10801 cttttaaagt aaggtacttt gaaatatgta gcataaactg gtactgctgt taaatgggtc
    10861 gattattaaa cggagcagct gtgtgagggc agctaacttt gaatgcctgt ctccctggct
    10921 ggtgtgtctc cttctcatgt tgagagcacc agggattgcg tggctgcatg ctgaaaccgc
    10981 attttcccat ggtgtatgac tagttcatct ctttcttgag caccattaca agaagatcaa
    11041 atgaaaatga gatcaatgtg gaagacaatt catagcacaa aaaaagtcat cttaaatcta
    11101 ctctcaaaca ttcatcttat acatgcatca aagtaattta ctgacatcag tttgggtgag
    11161 agagggagtc actttactga aaaggcagag gcttaaggtg tatacatttg tactcacttc
    11221 cttattttct taacttgtaa gcagaaaaca agccctctct cttgtgaagt atcttcaaag
    11281 gattggggtg caaaaatacc ttgctggtaa gccatcaatg ttttatttaa atccctgcat
    11341 tcaaagttag ctgccttttt gaaataaaca aacaaaaaat actactgtat gtttgaaaat
    11401 gtgaatagta tttttatagc ttgttaaaga catggctagt tgcatttgta aataagtata
    11461 atgttgcttt gattttcttt tgtggacatc tttatttgga acataattgt ctttagggtt
    11521 gatttgtata taagtaattg gcctgtgatt gtttcttttt tggttggaag ttatcatttt
    11581 gacattactt gtgattctgt gttcagcact attgtgatgt gttcaacctc tgcactcgct
    11641 tacacaatag gatatgccaa ttgtgtgtgg tgtaatgtta ttttgatttt tttccatgtt
    11701 attgatgaag gatcatgcac ctaacacata ctaacttttt taatgttagg catattttta
    11761 gtatactttc tcttattctt tcttctcctc caacctttta cccatcctcc ttcctttccc
    11821 tcattcctgt tgttatttga gaatgaggga gaaacagtat tttacattta tgtaattagg
    11881 cttttccgtt agttctcaag gatcctcttt tggctcttgg gaaagaattg tacctgtaca
    11941 aggcaattat agaatgcgaa ctgctttgcc tcattccata ctgatcatcc cagctgaaca
    12001 atttgaaaac tgttctgcct ttttgttaca tgaatctgtc agaaatatat ttttaattta
    12061 atataaatga aattcaataa aatatgaaac aaacgtt
//
