LOCUS       NM_001982               5615 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens erb-b2 receptor tyrosine kinase 3 (ERBB3), transcript
            variant 1, mRNA.
ACCESSION   NM_001982
VERSION     NM_001982.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5615)
  AUTHORS   Phillips,J.B., Park,S.S., Lin,C.H., Cho,J., Lim,S., Aurora,R.,
            Kim,J.H., Angajala,A., Park,B., Stone,J.K., Wang,B., Kahn,A.G.,
            Lim,S.S., Kim,J.H., Ahn,E.E. and Tan,M.
  TITLE     SON is an essential RNA splicing factor promoting ErbB2 and ErbB3
            expression in breast cancer
  JOURNAL   Br J Cancer 131 (9), 1437-1449 (2024)
   PUBMED   39313574
  REMARK    GeneRIF: SON is an essential RNA splicing factor promoting ErbB2
            and ErbB3 expression in breast cancer.
REFERENCE   2  (bases 1 to 5615)
  AUTHORS   Mishra,R., Kilroy,M.K., Feroz,W., Patel,H. and Garrett,J.T.
  TITLE     HER3 V104 mutations regulate cell signaling, growth, and drug
            sensitivity in cancer
  JOURNAL   Mol Carcinog 63 (8), 1528-1541 (2024)
   PUBMED   38751013
  REMARK    GeneRIF: HER3 V104 mutations regulate cell signaling, growth, and
            drug sensitivity in cancer.
REFERENCE   3  (bases 1 to 5615)
  AUTHORS   Blas,P.E., Rodriguez,E.S.R., Williams,H.L., Levin,M.K.,
            Bell,J.S.K., Pierobon,M., Barrett,A.S., Petricoin,E.F. and
            O'Shaughnessy,J.A.
  TITLE     Targeting HER2/HER3 co-mutations in metastatic breast cancer: Case
            reports of exceptional responders to trastuzumab and pertuzumab
            therapy
  JOURNAL   Cancer Rep (Hoboken) 7 (3), e1954 (2024)
   PUBMED   38441358
  REMARK    GeneRIF: Targeting HER2/HER3 co-mutations in metastatic breast
            cancer: Case reports of exceptional responders to trastuzumab and
            pertuzumab therapy.
REFERENCE   4  (bases 1 to 5615)
  AUTHORS   Kim,M., Lee,H.H., Won,S.D., Jang,Y., Kim,B.G., Cho,N.H., Choi,Y.D.,
            Chung,J.S. and Han,H.H.
  TITLE     Deciphering the Role of ERBB3 Isoforms in Renal Cell Carcinoma: A
            Comprehensive Genomic and Transcriptomic Analysis
  JOURNAL   Medicina (Kaunas) 60 (1), 181 (2024)
   PUBMED   38276060
  REMARK    GeneRIF: Deciphering the Role of ERBB3 Isoforms in Renal Cell
            Carcinoma: A Comprehensive Genomic and Transcriptomic Analysis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5615)
  AUTHORS   Liu,Y.N., Tsai,M.F., Wu,S.G., Chang,T.H. and Shih,J.Y.
  TITLE     CD44s and CD44v8-10 isoforms confer acquired resistance to
            osimertinib by activating the ErbB3/STAT3 signaling pathway
  JOURNAL   Life Sci 336, 122345 (2024)
   PUBMED   38092140
  REMARK    GeneRIF: CD44s and CD44v8-10 isoforms confer acquired resistance to
            osimertinib by activating the ErbB3/STAT3 signaling pathway.
REFERENCE   6  (bases 1 to 5615)
  AUTHORS   Wallasch,C., Weiss,F.U., Niederfellner,G., Jallal,B., Issing,W. and
            Ullrich,A.
  TITLE     Heregulin-dependent regulation of HER2/neu oncogenic signaling by
            heterodimerization with HER3
  JOURNAL   EMBO J 14 (17), 4267-4275 (1995)
   PUBMED   7556068
REFERENCE   7  (bases 1 to 5615)
  AUTHORS   Alimandi,M., Romano,A., Curia,M.C., Muraro,R., Fedi,P.,
            Aaronson,S.A., Di Fiore,P.P. and Kraus,M.H.
  TITLE     Cooperative signaling of ErbB3 and ErbB2 in neoplastic
            transformation and human mammary carcinomas
  JOURNAL   Oncogene 10 (9), 1813-1821 (1995)
   PUBMED   7538656
REFERENCE   8  (bases 1 to 5615)
  AUTHORS   Sliwkowski,M.X., Schaefer,G., Akita,R.W., Lofgren,J.A.,
            Fitzpatrick,V.D., Nuijens,A., Fendly,B.M., Cerione,R.A.,
            Vandlen,R.L. and Carraway,K.L. 3rd.
  TITLE     Coexpression of erbB2 and erbB3 proteins reconstitutes a high
            affinity receptor for heregulin
  JOURNAL   J Biol Chem 269 (20), 14661-14665 (1994)
   PUBMED   7514177
REFERENCE   9  (bases 1 to 5615)
  AUTHORS   Plowman,G.D., Whitney,G.S., Neubauer,M.G., Green,J.M.,
            McDonald,V.L., Todaro,G.J. and Shoyab,M.
  TITLE     Molecular cloning and expression of an additional epidermal growth
            factor receptor-related gene
  JOURNAL   Proc Natl Acad Sci U S A 87 (13), 4905-4909 (1990)
   PUBMED   2164210
REFERENCE   10 (bases 1 to 5615)
  AUTHORS   Kraus,M.H., Issing,W., Miki,T., Popescu,N.C. and Aaronson,S.A.
  TITLE     Isolation and characterization of ERBB3, a third member of the
            ERBB/epidermal growth factor receptor family: evidence for
            overexpression in a subset of human mammary tumors
  JOURNAL   Proc Natl Acad Sci U S A 86 (23), 9193-9197 (1989)
   PUBMED   2687875
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC347955.1, BC082992.1,
            BU674508.1 and AA524528.1.
            
            On Nov 30, 2019 this sequence version replaced NM_001982.3.
            
            Summary: This gene encodes a member of the epidermal growth factor
            receptor (EGFR) family of receptor tyrosine kinases. This
            membrane-bound protein has a neuregulin binding domain but not an
            active kinase domain. It therefore can bind this ligand but not
            convey the signal into the cell through protein phosphorylation.
            However, it does form heterodimers with other EGF receptor family
            members which do have kinase activity. Heterodimerization leads to
            the activation of pathways which lead to cell proliferation or
            differentiation. Amplification of this gene and/or overexpression
            of its protein have been reported in numerous cancers, including
            prostate, bladder, and breast tumors. Alternate transcriptional
            splice variants encoding different isoforms have been
            characterized. One isoform lacks the intermembrane region and is
            secreted outside the cell. This form acts to modulate the activity
            of the membrane-bound form. Additional splice variants have also
            been reported, but they have not been thoroughly characterized.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082992.1, M34309.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267101.8/ ENSP00000267101.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DC347955.1         79-99
            22-4943             BC082992.1         1-4922
            4944-5309           BU674508.1         154-519
            5310-5615           AA524528.1         11-316              c
FEATURES             Location/Qualifiers
     source          1..5615
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.2"
     gene            1..5615
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /note="erb-b2 receptor tyrosine kinase 3"
                     /db_xref="GeneID:2065"
                     /db_xref="HGNC:HGNC:3431"
                     /db_xref="MIM:190151"
     exon            1..218
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..4165
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; receptor tyrosine-protein kinase erbB-3;
                     proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type
                     cell surface receptor HER3; v-erb-b2 avian erythroblastic
                     leukemia viral oncogene homolog 3; human epidermal growth
                     factor receptor 3"
                     /codon_start=1
                     /product="receptor tyrosine-protein kinase erbB-3 isoform
                     1 precursor"
                     /protein_id="NP_001973.2"
                     /db_xref="CCDS:CCDS31833.1"
                     /db_xref="GeneID:2065"
                     /db_xref="HGNC:HGNC:3431"
                     /db_xref="MIM:190151"
                     /translation="MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAEN
                     QYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNL
                     RVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDT
                     IDWRDIVRDRDAEIVVKDNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHC
                     FGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNP
                     HTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGT
                     GSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVRE
                     ITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEIS
                     AGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGG
                     CWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCN
                     GSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCKGP
                     ELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLGGTFLYWRGRRIQNKRAMRRYLE
                     RGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVC
                     IKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDH
                     VRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVA
                     DLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAG
                     LRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDP
                     PRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEEDNLATTTLGSA
                     LSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMP
                     RGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPL
                     SPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRRR
                     RHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEY
                     MNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATD
                     SAFDNPDYWHSRLFPKANAQRT"
     exon            219..370
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..557
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            558..683
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            684..749
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            750..868
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1010
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1124
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1245
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1319
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1410
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1616
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1749
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1840
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1995
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2049
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2191
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2311
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2410
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2596
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2752
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2828
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2829..2975
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2976..3073
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..3265
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3266..3337
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3338..3638
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3639..5615
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5590..5595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /note="hexamer: AATAAA"
     polyA_site      5615
                     /gene="ERBB3"
                     /gene_synonym="c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK;
                     HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
                     VSCN1"
                     /note="major polyA site"
ORIGIN      
        1 gcaatttgca acctccgctg ccgtcgccgc agcagccacc aattcgccag cggttcaggt
       61 ggctcttgcc tcgatgtcct agcctagggg cccccgggcc ggacttggct gggctccctt
      121 caccctctgc ggagtcatga gggcgaacga cgctctgcag gtgctgggct tgcttttcag
      181 cctggcccgg ggctccgagg tgggcaactc tcaggcagtg tgtcctggga ctctgaatgg
      241 cctgagtgtg accggcgatg ctgagaacca ataccagaca ctgtacaagc tctacgagag
      301 gtgtgaggtg gtgatgggga accttgagat tgtgctcacg ggacacaatg ccgacctctc
      361 cttcctgcag tggattcgag aagtgacagg ctatgtcctc gtggccatga atgaattctc
      421 tactctacca ttgcccaacc tccgcgtggt gcgagggacc caggtctacg atgggaagtt
      481 tgccatcttc gtcatgttga actataacac caactccagc cacgctctgc gccagctccg
      541 cttgactcag ctcaccgaga ttctgtcagg gggtgtttat attgagaaga acgataagct
      601 ttgtcacatg gacacaattg actggaggga catcgtgagg gaccgagatg ctgagatagt
      661 ggtgaaggac aatggcagaa gctgtccccc ctgtcatgag gtttgcaagg ggcgatgctg
      721 gggtcctgga tcagaagact gccagacatt gaccaagacc atctgtgctc ctcagtgtaa
      781 tggtcactgc tttgggccca accccaacca gtgctgccat gatgagtgtg ccgggggctg
      841 ctcaggccct caggacacag actgctttgc ctgccggcac ttcaatgaca gtggagcctg
      901 tgtacctcgc tgtccacagc ctcttgtcta caacaagcta actttccagc tggaacccaa
      961 tccccacacc aagtatcagt atggaggagt ttgtgtagcc agctgtcccc ataactttgt
     1021 ggtggatcaa acatcctgtg tcagggcctg tcctcctgac aagatggaag tagataaaaa
     1081 tgggctcaag atgtgtgagc cttgtggggg actatgtccc aaagcctgtg agggaacagg
     1141 ctctgggagc cgcttccaga ctgtggactc gagcaacatt gatggatttg tgaactgcac
     1201 caagatcctg ggcaacctgg actttctgat caccggcctc aatggagacc cctggcacaa
     1261 gatccctgcc ctggacccag agaagctcaa tgtcttccgg acagtacggg agatcacagg
     1321 ttacctgaac atccagtcct ggccgcccca catgcacaac ttcagtgttt tttccaattt
     1381 gacaaccatt ggaggcagaa gcctctacaa ccggggcttc tcattgttga tcatgaagaa
     1441 cttgaatgtc acatctctgg gcttccgatc cctgaaggaa attagtgctg ggcgtatcta
     1501 tataagtgcc aataggcagc tctgctacca ccactctttg aactggacca aggtgcttcg
     1561 ggggcctacg gaagagcgac tagacatcaa gcataatcgg ccgcgcagag actgcgtggc
     1621 agagggcaaa gtgtgtgacc cactgtgctc ctctggggga tgctggggcc caggccctgg
     1681 tcagtgcttg tcctgtcgaa attatagccg aggaggtgtc tgtgtgaccc actgcaactt
     1741 tctgaatggg gagcctcgag aatttgccca tgaggccgaa tgcttctcct gccacccgga
     1801 atgccaaccc atggagggca ctgccacatg caatggctcg ggctctgata cttgtgctca
     1861 atgtgcccat tttcgagatg ggccccactg tgtgagcagc tgcccccatg gagtcctagg
     1921 tgccaagggc ccaatctaca agtacccaga tgttcagaat gaatgtcggc cctgccatga
     1981 gaactgcacc caggggtgta aaggaccaga gcttcaagac tgtttaggac aaacactggt
     2041 gctgatcggc aaaacccatc tgacaatggc tttgacagtg atagcaggat tggtagtgat
     2101 tttcatgatg ctgggcggca cttttctcta ctggcgtggg cgccggattc agaataaaag
     2161 ggctatgagg cgatacttgg aacggggtga gagcatagag cctctggacc ccagtgagaa
     2221 ggctaacaaa gtcttggcca gaatcttcaa agagacagag ctaaggaagc ttaaagtgct
     2281 tggctcgggt gtctttggaa ctgtgcacaa aggagtgtgg atccctgagg gtgaatcaat
     2341 caagattcca gtctgcatta aagtcattga ggacaagagt ggacggcaga gttttcaagc
     2401 tgtgacagat catatgctgg ccattggcag cctggaccat gcccacattg taaggctgct
     2461 gggactatgc ccagggtcat ctctgcagct tgtcactcaa tatttgcctc tgggttctct
     2521 gctggatcat gtgagacaac accggggggc actggggcca cagctgctgc tcaactgggg
     2581 agtacaaatt gccaagggaa tgtactacct tgaggaacat ggtatggtgc atagaaacct
     2641 ggctgcccga aacgtgctac tcaagtcacc cagtcaggtt caggtggcag attttggtgt
     2701 ggctgacctg ctgcctcctg atgataagca gctgctatac agtgaggcca agactccaat
     2761 taagtggatg gcccttgaga gtatccactt tgggaaatac acacaccaga gtgatgtctg
     2821 gagctatggt gtgacagttt gggagttgat gaccttcggg gcagagccct atgcagggct
     2881 acgattggct gaagtaccag acctgctaga gaagggggag cggttggcac agccccagat
     2941 ctgcacaatt gatgtctaca tggtgatggt caagtgttgg atgattgatg agaacattcg
     3001 cccaaccttt aaagaactag ccaatgagtt caccaggatg gcccgagacc caccacggta
     3061 tctggtcata aagagagaga gtgggcctgg aatagcccct gggccagagc cccatggtct
     3121 gacaaacaag aagctagagg aagtagagct ggagccagaa ctagacctag acctagactt
     3181 ggaagcagag gaggacaacc tggcaaccac cacactgggc tccgccctca gcctaccagt
     3241 tggaacactt aatcggccac gtgggagcca gagcctttta agtccatcat ctggatacat
     3301 gcccatgaac cagggtaatc ttggggagtc ttgccaggag tctgcagttt ctgggagcag
     3361 tgaacggtgc ccccgtccag tctctctaca cccaatgcca cggggatgcc tggcatcaga
     3421 gtcatcagag gggcatgtaa caggctctga ggctgagctc caggagaaag tgtcaatgtg
     3481 taggagccgg agcaggagcc ggagcccacg gccacgcgga gatagcgcct accattccca
     3541 gcgccacagt ctgctgactc ctgttacccc actctcccca cccgggttag aggaagagga
     3601 tgtcaacggt tatgtcatgc cagatacaca cctcaaaggt actccctcct cccgggaagg
     3661 caccctttct tcagtgggtc tcagttctgt cctgggtact gaagaagaag atgaagatga
     3721 ggagtatgaa tacatgaacc ggaggagaag gcacagtcca cctcatcccc ctaggccaag
     3781 ttcccttgag gagctgggtt atgagtacat ggatgtgggg tcagacctca gtgcctctct
     3841 gggcagcaca cagagttgcc cactccaccc tgtacccatc atgcccactg caggcacaac
     3901 tccagatgaa gactatgaat atatgaatcg gcaacgagat ggaggtggtc ctgggggtga
     3961 ttatgcagcc atgggggcct gcccagcatc tgagcaaggg tatgaagaga tgagagcttt
     4021 tcaggggcct ggacatcagg ccccccatgt ccattatgcc cgcctaaaaa ctctacgtag
     4081 cttagaggct acagactctg cctttgataa ccctgattac tggcatagca ggcttttccc
     4141 caaggctaat gcccagagaa cgtaactcct gctccctgtg gcactcaggg agcatttaat
     4201 ggcagctagt gcctttagag ggtaccgtct tctccctatt ccctctctct cccaggtccc
     4261 agcccctttt ccccagtccc agacaattcc attcaatctt tggaggcttt taaacatttt
     4321 gacacaaaat tcttatggta tgtagccagc tgtgcacttt cttctctttc ccaaccccag
     4381 gaaaggtttt ccttattttg tgtgctttcc cagtcccatt cctcagcttc ttcacaggca
     4441 ctcctggaga tatgaaggat tactctccat atcccttcct ctcaggctct tgactacttg
     4501 gaactaggct cttatgtgtg cctttgtttc ccatcagact gtcaagaaga ggaaagggag
     4561 gaaacctagc agaggaaagt gtaattttgg tttatgactc ttaaccccct agaaagacag
     4621 aagcttaaaa tctgtgaaga aagaggttag gagtagatat tgattactat cataattcag
     4681 cacttaacta tgagccaggc atcatactaa acttcaccta cattatctca cttagtcctt
     4741 tatcatcctt aaaacaattc tgtgacatac atattatctc attttacaca aagggaagtc
     4801 gggcatggtg gctcatgcct gtaatctcag cactttggga ggctgaggca gaaggattac
     4861 ctgaggcaag gagtttgaga ccagcttagc caacatagta agacccccat ctctttaaaa
     4921 aaaaaaaaaa aaaaaaaaaa aaaactttag aactgggtgc agtggctcat gcctgtaatc
     4981 ccagccagca ctttgggagg ctgagatggg aagatcactt gagcccagaa ttagagataa
     5041 gcctatggaa acatagcaag acactgtctc tacaggggaa aaaaaaaaaa gaaactgagc
     5101 cttaaagaga tgaaataaat taagcagtag atccaggatg caaaatcctc ccaattcctg
     5161 tgcatgtgct cttattgtaa ggtgccaaga aaaactgatt taagttacag cccttgttta
     5221 aggggcactg tttcttgttt ttgcactgaa tcaagtctaa ccccaacagc cacatcctcc
     5281 tatacctaga catctcatct caggaagtgg tggtgggggt agtcagaagg aaaaataact
     5341 ggacatcttt gtgtaaacca taatccacat gtgccgtaaa tgatcttcac tccttatccg
     5401 agggcaaatt cacaaggatc cccaagatcc acttttagaa gccattctca tccagcagtg
     5461 agaagcttcc aggtaggaca gaaaaaagat ccagcttcag ctgcacacct ctgtcccctt
     5521 ggatggggaa ctaagggaaa acgtctgttg tatcactgaa gttttttgtt ttgtttttat
     5581 acgtgtctga ataaaaatgc caaagttttt tttca
//
