LOCUS       XM_047435590            5129 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens erb-b2 receptor tyrosine kinase 2 (ERBB2),
            transcript variant X1, mRNA.
ACCESSION   XM_047435590
VERSION     XM_047435590.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000017.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5129
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
     gene            1..5129
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /note="erb-b2 receptor tyrosine kinase 2; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 101 ESTs, 606 long SRA reads, 7 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 4 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:2064"
                     /db_xref="HGNC:HGNC:3430"
                     /db_xref="MIM:164870"
     CDS             793..4515
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /codon_start=1
                     /product="receptor tyrosine-protein kinase erbB-2 isoform
                     X1"
                     /protein_id="XP_047291546.1"
                     /db_xref="GeneID:2064"
                     /db_xref="HGNC:HGNC:3430"
                     /db_xref="MIM:164870"
                     /translation="MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGN
                     LELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVL
                     DNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHK
                     NNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPT
                     DCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTF
                     GASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEH
                     LREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEIT
                     GYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
                     ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGP
                     GPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEA
                     DQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDD
                     KGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELV
                     EPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVL
                     RENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREN
                     RGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLD
                     IDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAR
                     EIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFV
                     VIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHH
                     RHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPT
                     HDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAAR
                     PAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDN
                     LYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV"
ORIGIN      
        1 gttctttatt ctactctccg ctgaagtcca cacagtttaa attaaagttc ccggattttt
       61 gtgggcgcct gccccgcccc tcgtccccct gctgtgtcca tatatcgagg cgatagggtt
      121 aagggaaggc ggacgcctga tgggttaatg agcaaactga agtgttttcc atgatctttt
      181 ttgagtcgca attgaagtac cacctcccga gggtgattgc ttccccatgc ggggtagaac
      241 ctttgctgtc ctgttcacca ctctacctcc agcacagaat ttggcttatg cctactcaat
      301 gtgaagatga tgaggatgaa aacctttgtg atgatccact tccacttaat gaatggttcc
      361 tcgtctcctc ttccttggac caaaagtcag aggcaagaat gccctcattc ataccccagt
      421 ggtctatacc tccagcagca agtcgagtga gcaagtgatg tcctgaaagg cccagtggat
      481 cagtggaatg aagcgggcag gaagacttag tgctcctgaa acaaggaatc cagaatccag
      541 gagaaggatg gctcagtggg gctttcaagg gacaagtggc aaagcaaagc tatattcaag
      601 accacatgca aagctactcc ctgagcaaag agtcacagat aaaacggggg caccagtaga
      661 atggccagga caaacgcagt gcagcacaga gactcagacc ctggcagcca tgcctgcgca
      721 ggcagtgatg agagtgacat gtactgttgt ggacatgcac aaaagtgaga tacttcaaag
      781 attccagaag atatgccccg ggggtcctgg aagccacaag tgtgcaccgg cacagacatg
      841 aagctgcggc tccctgccag tcccgagacc cacctggaca tgctccgcca cctctaccag
      901 ggctgccagg tggtgcaggg aaacctggaa ctcacctacc tgcccaccaa tgccagcctg
      961 tccttcctgc aggatatcca ggaggtgcag ggctacgtgc tcatcgctca caaccaagtg
     1021 aggcaggtcc cactgcagag gctgcggatt gtgcgaggca cccagctctt tgaggacaac
     1081 tatgccctgg ccgtgctaga caatggagac ccgctgaaca ataccacccc tgtcacaggg
     1141 gcctccccag gaggcctgcg ggagctgcag cttcgaagcc tcacagagat cttgaaagga
     1201 ggggtcttga tccagcggaa cccccagctc tgctaccagg acacgatttt gtggaaggac
     1261 atcttccaca agaacaacca gctggctctc acactgatag acaccaaccg ctctcgggcc
     1321 tgccacccct gttctccgat gtgtaagggc tcccgctgct ggggagagag ttctgaggat
     1381 tgtcagagcc tgacgcgcac tgtctgtgcc ggtggctgtg cccgctgcaa ggggccactg
     1441 cccactgact gctgccatga gcagtgtgct gccggctgca cgggccccaa gcactctgac
     1501 tgcctggcct gcctccactt caaccacagt ggcatctgtg agctgcactg cccagccctg
     1561 gtcacctaca acacagacac gtttgagtcc atgcccaatc ccgagggccg gtatacattc
     1621 ggcgccagct gtgtgactgc ctgtccctac aactaccttt ctacggacgt gggatcctgc
     1681 accctcgtct gccccctgca caaccaagag gtgacagcag aggatggaac acagcggtgt
     1741 gagaagtgca gcaagccctg tgcccgagtg tgctatggtc tgggcatgga gcacttgcga
     1801 gaggtgaggg cagttaccag tgccaatatc caggagtttg ctggctgcaa gaagatcttt
     1861 gggagcctgg catttctgcc ggagagcttt gatggggacc cagcctccaa cactgccccg
     1921 ctccagccag agcagctcca agtgtttgag actctggaag agatcacagg ttacctatac
     1981 atctcagcat ggccggacag cctgcctgac ctcagcgtct tccagaacct gcaagtaatc
     2041 cggggacgaa ttctgcacaa tggcgcctac tcgctgaccc tgcaagggct gggcatcagc
     2101 tggctggggc tgcgctcact gagggaactg ggcagtggac tggccctcat ccaccataac
     2161 acccacctct gcttcgtgca cacggtgccc tgggaccagc tctttcggaa cccgcaccaa
     2221 gctctgctcc acactgccaa ccggccagag gacgagtgtg tgggcgaggg cctggcctgc
     2281 caccagctgt gcgcccgagg gcactgctgg ggtccagggc ccacccagtg tgtcaactgc
     2341 agccagttcc ttcggggcca ggagtgcgtg gaggaatgcc gagtactgca ggggctcccc
     2401 agggagtatg tgaatgccag gcactgtttg ccgtgccacc ctgagtgtca gccccagaat
     2461 ggctcagtga cctgttttgg accggaggct gaccagtgtg tggcctgtgc ccactataag
     2521 gaccctccct tctgcgtggc ccgctgcccc agcggtgtga aacctgacct ctcctacatg
     2581 cccatctgga agtttccaga tgaggagggc gcatgccagc cttgccccat caactgcacc
     2641 cactcctgtg tggacctgga tgacaagggc tgccccgccg agcagagagc cagccctctg
     2701 acgtccatca tctctgcggt ggttggcatt ctgctggtcg tggtcttggg ggtggtcttt
     2761 gggatcctca tcaagcgacg gcagcagaag atccggaagt acacgatgcg gagactgctg
     2821 caggaaacgg agctggtgga gccgctgaca cctagcggag cgatgcccaa ccaggcgcag
     2881 atgcggatcc tgaaagagac ggagctgagg aaggtgaagg tgcttggatc tggcgctttt
     2941 ggcacagtct acaagggcat ctggatccct gatggggaga atgtgaaaat tccagtggcc
     3001 atcaaagtgt tgagggaaaa cacatccccc aaagccaaca aagaaatctt agacgaagca
     3061 tacgtgatgg ctggtgtggg ctccccatat gtctcccgcc ttctgggcat ctgcctgaca
     3121 tccacggtgc agctggtgac acagcttatg ccctatggct gcctcttaga ccatgtccgg
     3181 gaaaaccgcg gacgcctggg ctcccaggac ctgctgaact ggtgtatgca gattgccaag
     3241 gggatgagct acctggagga tgtgcggctc gtacacaggg acttggccgc tcggaacgtg
     3301 ctggtcaaga gtcccaacca tgtcaaaatt acagacttcg ggctggctcg gctgctggac
     3361 attgacgaga cagagtacca tgcagatggg ggcaaggtgc ccatcaagtg gatggcgctg
     3421 gagtccattc tccgccggcg gttcacccac cagagtgatg tgtggagtta tggtgtgact
     3481 gtgtgggagc tgatgacttt tggggccaaa ccttacgatg ggatcccagc ccgggagatc
     3541 cctgacctgc tggaaaaggg ggagcggctg ccccagcccc ccatctgcac cattgatgtc
     3601 tacatgatca tggtcaaatg ttggatgatt gactctgaat gtcggccaag attccgggag
     3661 ttggtgtctg aattctcccg catggccagg gacccccagc gctttgtggt catccagaat
     3721 gaggacttgg gcccagccag tcccttggac agcaccttct accgctcact gctggaggac
     3781 gatgacatgg gggacctggt ggatgctgag gagtatctgg taccccagca gggcttcttc
     3841 tgtccagacc ctgccccggg cgctgggggc atggtccacc acaggcaccg cagctcatct
     3901 accaggagtg gcggtgggga cctgacacta gggctggagc cctctgaaga ggaggccccc
     3961 aggtctccac tggcaccctc cgaaggggct ggctccgatg tatttgatgg tgacctggga
     4021 atgggggcag ccaaggggct gcaaagcctc cccacacatg accccagccc tctacagcgg
     4081 tacagtgagg accccacagt acccctgccc tctgagactg atggctacgt tgcccccctg
     4141 acctgcagcc cccagcctga atatgtgaac cagccagatg ttcggcccca gcccccttcg
     4201 ccccgagagg gccctctgcc tgctgcccga cctgctggtg ccactctgga aaggcccaag
     4261 actctctccc cagggaagaa tggggtcgtc aaagacgttt ttgcctttgg gggtgccgtg
     4321 gagaaccccg agtacttgac accccaggga ggagctgccc ctcagcccca ccctcctcct
     4381 gccttcagcc cagccttcga caacctctat tactgggacc aggacccacc agagcggggg
     4441 gctccaccca gcaccttcaa agggacacct acggcagaga acccagagta cctgggtctg
     4501 gacgtgccag tgtgaaccag aaggccaagt ccgcagaagc cctgatgtgt cctcagggag
     4561 cagggaaggc ctgacttctg ctggcatcaa gaggtgggag ggccctccga ccacttccag
     4621 gggaacctgc catgccagga acctgtccta aggaaccttc cttcctgctt gagttcccag
     4681 atggctggaa ggggtccagc ctcgttggaa gaggaacagc actggggagt ctttgtggat
     4741 tctgaggccc tgcccaatga gactctaggg tccagtggat gccacagccc agcttggccc
     4801 tttccttcca gatcctgggt actgaaagcc ttagggaagc tggcctgaga ggggaagcgg
     4861 ccctaaggga gtgtctaaga acaaaagcga cccattcaga gactgtccct gaaacctagt
     4921 actgcccccc atgaggaagg aacagcaatg gtgtcagtat ccaggctttg tacagagtgc
     4981 ttttctgttt agtttttact ttttttgttt tgttttttta aagatgaaat aaagacccag
     5041 ggggagaatg ggtgttgtat ggggaggcaa gtgtgggggg tccttctcca cacccacttt
     5101 gtccatttgc aaatatattt tggaaaaca
//
