LOCUS       NM_001382797            4458 bp    mRNA    linear   PRI 11-MAR-2025
DEFINITION  Homo sapiens erb-b2 receptor tyrosine kinase 2 (ERBB2), transcript
            variant 22, mRNA.
ACCESSION   NM_001382797
VERSION     NM_001382797.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4458)
  AUTHORS   Phillips,J.B., Park,S.S., Lin,C.H., Cho,J., Lim,S., Aurora,R.,
            Kim,J.H., Angajala,A., Park,B., Stone,J.K., Wang,B., Kahn,A.G.,
            Lim,S.S., Kim,J.H., Ahn,E.E. and Tan,M.
  TITLE     SON is an essential RNA splicing factor promoting ErbB2 and ErbB3
            expression in breast cancer
  JOURNAL   Br J Cancer 131 (9), 1437-1449 (2024)
   PUBMED   39313574
  REMARK    GeneRIF: SON is an essential RNA splicing factor promoting ErbB2
            and ErbB3 expression in breast cancer.
REFERENCE   2  (bases 1 to 4458)
  AUTHORS   Liu,X., Song,Y., Cheng,P., Liang,B. and Xing,D.
  TITLE     Targeting HER2 in solid tumors: Unveiling the structure and novel
            epitopes
  JOURNAL   Cancer Treat Rev 130, 102826 (2024)
   PUBMED   39270365
  REMARK    GeneRIF: Targeting HER2 in solid tumors: Unveiling the structure
            and novel epitopes.
            Review article
REFERENCE   3  (bases 1 to 4458)
  AUTHORS   Saravani,S., Nemati Rezvani,H., Shahraki,M. and Kadeh,H.
  TITLE     A Comparison of Immunohistochemical Expression of Epidermal Growth
            Factor Receptor and Human Epidermal Growth Factor Receptor 2 in
            Dental Follicles with Different Radiographic Sizes
  JOURNAL   Iran J Med Sci 49 (8), 508-514 (2024)
   PUBMED   39205824
  REMARK    GeneRIF: A Comparison of Immunohistochemical Expression of
            Epidermal Growth Factor Receptor and Human Epidermal Growth Factor
            Receptor 2 in Dental Follicles with Different Radiographic Sizes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4458)
  AUTHORS   Yang,H., Wang,X., Blanco-Gomez,A., He,L., Garcia-Sancha,N.,
            Corchado-Cobos,R., Perez-Baena,M.J., Jimenez-Navas,A., Wang,P.,
            Inman,J.L., Snijders,A.M., Threadgill,D.W., Balmain,A., Chang,H.,
            Perez-Losada,J. and Mao,J.H.
  TITLE     A susceptibility gene signature for ERBB2-driven mammary tumour
            development and metastasis in collaborative cross mice
  JOURNAL   EBioMedicine 106, 105260 (2024)
   PUBMED   39067134
  REMARK    GeneRIF: A susceptibility gene signature for ERBB2-driven mammary
            tumour development and metastasis in collaborative cross mice.
REFERENCE   5  (bases 1 to 4458)
  AUTHORS   Oh,D.Y. and Bang,Y.J.
  TITLE     HER2-targeted therapies - a role beyond breast cancer
  JOURNAL   Nat Rev Clin Oncol 17 (1), 33-48 (2020)
   PUBMED   31548601
  REMARK    Review article
REFERENCE   6  (bases 1 to 4458)
  AUTHORS   Child,S.J., Miller,M.K. and Geballe,A.P.
  TITLE     Translational control by an upstream open reading frame in the
            HER-2/neu transcript
  JOURNAL   J Biol Chem 274 (34), 24335-24341 (1999)
   PUBMED   10446211
REFERENCE   7  (bases 1 to 4458)
  AUTHORS   Child,S.J., Miller,M.K. and Geballe,A.P.
  TITLE     Cell type-dependent and -independent control of HER-2/neu
            translation
  JOURNAL   Int J Biochem Cell Biol 31 (1), 201-213 (1999)
   PUBMED   10216954
  REMARK    Erratum:[Int J Biochem Cell Biol 1999 Aug;31(8):883-4]
REFERENCE   8  (bases 1 to 4458)
  AUTHORS   Gout,I., Dhand,R., Panayotou,G., Fry,M.J., Hiles,I., Otsu,M. and
            Waterfield,M.D.
  TITLE     Expression and characterization of the p85 subunit of the
            phosphatidylinositol 3-kinase complex and a related p85 beta
            protein by using the baculovirus expression system
  JOURNAL   Biochem J 288 (Pt 2) (Pt 2), 395-405 (1992)
   PUBMED   1334406
REFERENCE   9  (bases 1 to 4458)
  AUTHORS   Peles,E., Lamprecht,R., Ben-Levy,R., Tzahar,E. and Yarden,Y.
  TITLE     Regulated coupling of the Neu receptor to phosphatidylinositol
            3'-kinase and its release by oncogenic activation
  JOURNAL   J Biol Chem 267 (17), 12266-12274 (1992)
   PUBMED   1351056
REFERENCE   10 (bases 1 to 4458)
  AUTHORS   Hall,J.M. and King,M.C.
  TITLE     PCR detection of an MboI polymorphism in the ERBB2 (HER2; NEU) gene
            on chromosome 17q11.2-q12
  JOURNAL   Nucleic Acids Res 19 (9), 2515 (1991)
   PUBMED   1675005
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087491.5 and AC079199.9.
            
            Summary: This gene encodes a member of the epidermal growth factor
            (EGF) receptor family of receptor tyrosine kinases. This protein
            has no ligand binding domain of its own and therefore cannot bind
            growth factors. However, it does bind tightly to other ligand-bound
            EGF receptor family members to form a heterodimer, stabilizing
            ligand binding and enhancing kinase-mediated activation of
            downstream signalling pathways, such as those involving
            mitogen-activated protein kinase and phosphatidylinositol-3 kinase.
            Allelic variations at amino acid positions 654 and 655 of isoform a
            (positions 624 and 625 of isoform b) have been reported, with the
            most common allele, Ile654/Ile655, shown here. Amplification and/or
            overexpression of this gene has been reported in numerous cancers,
            including breast and ovarian tumors. Alternative splicing results
            in several additional transcript variants, some encoding different
            isoforms and others that have not been fully characterized.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.4312824.1,
                                           SRR7346977.1966104.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               AC087491.5         130663-130910
            249-400             AC087491.5         137589-137740
            401-614             AC087491.5         138920-139133
            615-749             AC087491.5         139917-140051
            750-818             AC087491.5         140412-140480
            819-934             AC087491.5         140685-140800
            935-1076            AC087491.5         140939-141080
            1077-1196           AC087491.5         142527-142646
            1197-1323           AC087491.5         142921-143047
            1324-1397           AC087491.5         145885-145958
            1398-1488           AC087491.5         146045-146135
            1489-1688           AC087491.5         146339-146538
            1689-1821           AC087491.5         146900-147032
            1822-1912           AC087491.5         147114-147204
            1913-2073           AC087491.5         147919-148079
            2074-2121           AC087491.5         150386-150433
            2122-2260           AC087491.5         153918-154056
            2261-2383           AC087491.5         154137-154259
            2384-2569           AC087491.5         155325-155510
            2570-2725           AC087491.5         155648-155803
            2726-2801           AC087491.5         155926-156001
            2802-2948           AC087491.5         156306-156452
            2949-3004           AC087491.5         157161-157216
            3005-3046           AC079199.9         71077-71118
            3047-3235           AC079199.9         71274-71462
            3236-3488           AC079199.9         71754-72006
            3489-4458           AC079199.9         72148-73117
FEATURES             Location/Qualifiers
     source          1..4458
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..4458
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /note="erb-b2 receptor tyrosine kinase 2"
                     /db_xref="GeneID:2064"
                     /db_xref="HGNC:HGNC:3430"
                     /db_xref="MIM:164870"
     exon            1..248
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..3844
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /EC_number="2.7.10.1"
                     /note="isoform s precursor is encoded by transcript
                     variant 22; herstatin; receptor tyrosine-protein kinase
                     erbB-2; neuroblastoma/glioblastoma derived oncogene
                     homolog; c-erb B2/neu protein; proto-oncogene Neu;
                     proto-oncogene c-ErbB-2; metastatic lymph node gene 19
                     protein; tyrosine kinase-type cell surface receptor HER2;
                     v-erb-b2 avian erythroblastic leukemia viral oncogene
                     homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene
                     homolog 2, neuro/glioblastoma derived oncogene homolog;
                     v-erb-b2 avian erythroblastic leukemia viral oncoprotein
                     2; human epidermal growth factor receptor 2"
                     /codon_start=1
                     /product="receptor tyrosine-protein kinase erbB-2 isoform
                     s precursor"
                     /protein_id="NP_001369726.1"
                     /db_xref="GeneID:2064"
                     /db_xref="HGNC:HGNC:3430"
                     /db_xref="MIM:164870"
                     /translation="MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLD
                     MLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIV
                     RGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQ
                     LCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRT
                     VCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNT
                     DTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKC
                     SKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPL
                     QPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGI
                     SWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEG
                     LACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPE
                     CQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQ
                     PCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKI
                     RKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKEAYV
                     MAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAK
                     GMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWM
                     ALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPIC
                     TIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFY
                     RSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGL
                     EPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLP
                     SETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNG
                     VVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTF
                     KGTPTAENPEYLGLDVPV"
     exon            249..400
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            401..614
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            615..749
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            750..818
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            819..934
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1076
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1196
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1323
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1397
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1488
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1688
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1821
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1912
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2073
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2121
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2260
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2383
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2569
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2725
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2801
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2802..2948
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2949..3046
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3047..3235
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3488
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3489..4458
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4357..4362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /note="hexamer: AATAAA"
     polyA_site      4377
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /note="major polyA site"
     regulatory      4441..4446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /note="hexamer: AATATA"
     polyA_site      4458
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
ORIGIN      
        1 cccctccatt gggaccggag aaaccagggg agccccccgg gcagccgcgc gccccttccc
       61 acggggccct ttactgcgcc gcgcgcccgg cccccacccc tcgcagcacc ccgcgccccg
      121 cgccctccca gccgggtcca gccggagcca tggggccgga gccgcagtga gcaccatgga
      181 gctggcggcc ttgtgccgct gggggctcct cctcgccctc ttgccccccg gagccgcgag
      241 cacccaagtg tgcaccggca cagacatgaa gctgcggctc cctgccagtc ccgagaccca
      301 cctggacatg ctccgccacc tctaccaggg ctgccaggtg gtgcagggaa acctggaact
      361 cacctacctg cccaccaatg ccagcctgtc cttcctgcag gatatccagg aggtgcaggg
      421 ctacgtgctc atcgctcaca accaagtgag gcaggtccca ctgcagaggc tgcggattgt
      481 gcgaggcacc cagctctttg aggacaacta tgccctggcc gtgctagaca atggagaccc
      541 gctgaacaat accacccctg tcacaggggc ctccccagga ggcctgcggg agctgcagct
      601 tcgaagcctc acagagatct tgaaaggagg ggtcttgatc cagcggaacc cccagctctg
      661 ctaccaggac acgattttgt ggaaggacat cttccacaag aacaaccagc tggctctcac
      721 actgatagac accaaccgct ctcgggcctg ccacccctgt tctccgatgt gtaagggctc
      781 ccgctgctgg ggagagagtt ctgaggattg tcagagcctg acgcgcactg tctgtgccgg
      841 tggctgtgcc cgctgcaagg ggccactgcc cactgactgc tgccatgagc agtgtgctgc
      901 cggctgcacg ggccccaagc actctgactg cctggcctgc ctccacttca accacagtgg
      961 catctgtgag ctgcactgcc cagccctggt cacctacaac acagacacgt ttgagtccat
     1021 gcccaatccc gagggccggt atacattcgg cgccagctgt gtgactgcct gtccctacaa
     1081 ctacctttct acggacgtgg gatcctgcac cctcgtctgc cccctgcaca accaagaggt
     1141 gacagcagag gatggaacac agcggtgtga gaagtgcagc aagccctgtg cccgagtgtg
     1201 ctatggtctg ggcatggagc acttgcgaga ggtgagggca gttaccagtg ccaatatcca
     1261 ggagtttgct ggctgcaaga agatctttgg gagcctggca tttctgccgg agagctttga
     1321 tggggaccca gcctccaaca ctgccccgct ccagccagag cagctccaag tgtttgagac
     1381 tctggaagag atcacaggtt acctatacat ctcagcatgg ccggacagcc tgcctgacct
     1441 cagcgtcttc cagaacctgc aagtaatccg gggacgaatt ctgcacaatg gcgcctactc
     1501 gctgaccctg caagggctgg gcatcagctg gctggggctg cgctcactga gggaactggg
     1561 cagtggactg gccctcatcc accataacac ccacctctgc ttcgtgcaca cggtgccctg
     1621 ggaccagctc tttcggaacc cgcaccaagc tctgctccac actgccaacc ggccagagga
     1681 cgagtgtgtg ggcgagggcc tggcctgcca ccagctgtgc gcccgagggc actgctgggg
     1741 tccagggccc acccagtgtg tcaactgcag ccagttcctt cggggccagg agtgcgtgga
     1801 ggaatgccga gtactgcagg ggctccccag ggagtatgtg aatgccaggc actgtttgcc
     1861 gtgccaccct gagtgtcagc cccagaatgg ctcagtgacc tgttttggac cggaggctga
     1921 ccagtgtgtg gcctgtgccc actataagga ccctcccttc tgcgtggccc gctgccccag
     1981 cggtgtgaaa cctgacctct cctacatgcc catctggaag tttccagatg aggagggcgc
     2041 atgccagcct tgccccatca actgcaccca ctcctgtgtg gacctggatg acaagggctg
     2101 ccccgccgag cagagagcca gccctctgac gtccatcatc tctgcggtgg ttggcattct
     2161 gctggtcgtg gtcttggggg tggtctttgg gatcctcatc aagcgacggc agcagaagat
     2221 ccggaagtac acgatgcgga gactgctgca ggaaacggag ctggtggagc cgctgacacc
     2281 tagcggagcg atgcccaacc aggcgcagat gcggatcctg aaagagacgg agctgaggaa
     2341 ggtgaaggtg cttggatctg gcgcttttgg cacagtctac aaggaagcat acgtgatggc
     2401 tggtgtgggc tccccatatg tctcccgcct tctgggcatc tgcctgacat ccacggtgca
     2461 gctggtgaca cagcttatgc cctatggctg cctcttagac catgtccggg aaaaccgcgg
     2521 acgcctgggc tcccaggacc tgctgaactg gtgtatgcag attgccaagg ggatgagcta
     2581 cctggaggat gtgcggctcg tacacaggga cttggccgct cggaacgtgc tggtcaagag
     2641 tcccaaccat gtcaaaatta cagacttcgg gctggctcgg ctgctggaca ttgacgagac
     2701 agagtaccat gcagatgggg gcaaggtgcc catcaagtgg atggcgctgg agtccattct
     2761 ccgccggcgg ttcacccacc agagtgatgt gtggagttat ggtgtgactg tgtgggagct
     2821 gatgactttt ggggccaaac cttacgatgg gatcccagcc cgggagatcc ctgacctgct
     2881 ggaaaagggg gagcggctgc cccagccccc catctgcacc attgatgtct acatgatcat
     2941 ggtcaaatgt tggatgattg actctgaatg tcggccaaga ttccgggagt tggtgtctga
     3001 attctcccgc atggccaggg acccccagcg ctttgtggtc atccagaatg aggacttggg
     3061 cccagccagt cccttggaca gcaccttcta ccgctcactg ctggaggacg atgacatggg
     3121 ggacctggtg gatgctgagg agtatctggt accccagcag ggcttcttct gtccagaccc
     3181 tgccccgggc gctgggggca tggtccacca caggcaccgc agctcatcta ccaggagtgg
     3241 cggtggggac ctgacactag ggctggagcc ctctgaagag gaggccccca ggtctccact
     3301 ggcaccctcc gaaggggctg gctccgatgt atttgatggt gacctgggaa tgggggcagc
     3361 caaggggctg caaagcctcc ccacacatga ccccagccct ctacagcggt acagtgagga
     3421 ccccacagta cccctgccct ctgagactga tggctacgtt gcccccctga cctgcagccc
     3481 ccagcctgaa tatgtgaacc agccagatgt tcggccccag cccccttcgc cccgagaggg
     3541 ccctctgcct gctgcccgac ctgctggtgc cactctggaa aggcccaaga ctctctcccc
     3601 agggaagaat ggggtcgtca aagacgtttt tgcctttggg ggtgccgtgg agaaccccga
     3661 gtacttgaca ccccagggag gagctgcccc tcagccccac cctcctcctg ccttcagccc
     3721 agccttcgac aacctctatt actgggacca ggacccacca gagcgggggg ctccacccag
     3781 caccttcaaa gggacaccta cggcagagaa cccagagtac ctgggtctgg acgtgccagt
     3841 gtgaaccaga aggccaagtc cgcagaagcc ctgatgtgtc ctcagggagc agggaaggcc
     3901 tgacttctgc tggcatcaag aggtgggagg gccctccgac cacttccagg ggaacctgcc
     3961 atgccaggaa cctgtcctaa ggaaccttcc ttcctgcttg agttcccaga tggctggaag
     4021 gggtccagcc tcgttggaag aggaacagca ctggggagtc tttgtggatt ctgaggccct
     4081 gcccaatgag actctagggt ccagtggatg ccacagccca gcttggccct ttccttccag
     4141 atcctgggta ctgaaagcct tagggaagct ggcctgagag gggaagcggc cctaagggag
     4201 tgtctaagaa caaaagcgac ccattcagag actgtccctg aaacctagta ctgcccccca
     4261 tgaggaagga acagcaatgg tgtcagtatc caggctttgt acagagtgct tttctgttta
     4321 gtttttactt tttttgtttt gtttttttaa agatgaaata aagacccagg gggagaatgg
     4381 gtgttgtatg gggaggcaag tgtggggggt ccttctccac acccactttg tccatttgca
     4441 aatatatttt ggaaaaca
//
