LOCUS       NM_001005862            4858 bp    mRNA    linear   PRI 11-MAR-2025
DEFINITION  Homo sapiens erb-b2 receptor tyrosine kinase 2 (ERBB2), transcript
            variant 2, mRNA.
ACCESSION   NM_001005862
VERSION     NM_001005862.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4858)
  AUTHORS   Phillips,J.B., Park,S.S., Lin,C.H., Cho,J., Lim,S., Aurora,R.,
            Kim,J.H., Angajala,A., Park,B., Stone,J.K., Wang,B., Kahn,A.G.,
            Lim,S.S., Kim,J.H., Ahn,E.E. and Tan,M.
  TITLE     SON is an essential RNA splicing factor promoting ErbB2 and ErbB3
            expression in breast cancer
  JOURNAL   Br J Cancer 131 (9), 1437-1449 (2024)
   PUBMED   39313574
  REMARK    GeneRIF: SON is an essential RNA splicing factor promoting ErbB2
            and ErbB3 expression in breast cancer.
REFERENCE   2  (bases 1 to 4858)
  AUTHORS   Liu,X., Song,Y., Cheng,P., Liang,B. and Xing,D.
  TITLE     Targeting HER2 in solid tumors: Unveiling the structure and novel
            epitopes
  JOURNAL   Cancer Treat Rev 130, 102826 (2024)
   PUBMED   39270365
  REMARK    GeneRIF: Targeting HER2 in solid tumors: Unveiling the structure
            and novel epitopes.
            Review article
REFERENCE   3  (bases 1 to 4858)
  AUTHORS   Saravani,S., Nemati Rezvani,H., Shahraki,M. and Kadeh,H.
  TITLE     A Comparison of Immunohistochemical Expression of Epidermal Growth
            Factor Receptor and Human Epidermal Growth Factor Receptor 2 in
            Dental Follicles with Different Radiographic Sizes
  JOURNAL   Iran J Med Sci 49 (8), 508-514 (2024)
   PUBMED   39205824
  REMARK    GeneRIF: A Comparison of Immunohistochemical Expression of
            Epidermal Growth Factor Receptor and Human Epidermal Growth Factor
            Receptor 2 in Dental Follicles with Different Radiographic Sizes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4858)
  AUTHORS   Yang,H., Wang,X., Blanco-Gomez,A., He,L., Garcia-Sancha,N.,
            Corchado-Cobos,R., Perez-Baena,M.J., Jimenez-Navas,A., Wang,P.,
            Inman,J.L., Snijders,A.M., Threadgill,D.W., Balmain,A., Chang,H.,
            Perez-Losada,J. and Mao,J.H.
  TITLE     A susceptibility gene signature for ERBB2-driven mammary tumour
            development and metastasis in collaborative cross mice
  JOURNAL   EBioMedicine 106, 105260 (2024)
   PUBMED   39067134
  REMARK    GeneRIF: A susceptibility gene signature for ERBB2-driven mammary
            tumour development and metastasis in collaborative cross mice.
REFERENCE   5  (bases 1 to 4858)
  AUTHORS   Oh,D.Y. and Bang,Y.J.
  TITLE     HER2-targeted therapies - a role beyond breast cancer
  JOURNAL   Nat Rev Clin Oncol 17 (1), 33-48 (2020)
   PUBMED   31548601
  REMARK    Review article
REFERENCE   6  (bases 1 to 4858)
  AUTHORS   Child,S.J., Miller,M.K. and Geballe,A.P.
  TITLE     Translational control by an upstream open reading frame in the
            HER-2/neu transcript
  JOURNAL   J Biol Chem 274 (34), 24335-24341 (1999)
   PUBMED   10446211
REFERENCE   7  (bases 1 to 4858)
  AUTHORS   Child,S.J., Miller,M.K. and Geballe,A.P.
  TITLE     Cell type-dependent and -independent control of HER-2/neu
            translation
  JOURNAL   Int J Biochem Cell Biol 31 (1), 201-213 (1999)
   PUBMED   10216954
  REMARK    Erratum:[Int J Biochem Cell Biol 1999 Aug;31(8):883-4]
REFERENCE   8  (bases 1 to 4858)
  AUTHORS   Gout,I., Dhand,R., Panayotou,G., Fry,M.J., Hiles,I., Otsu,M. and
            Waterfield,M.D.
  TITLE     Expression and characterization of the p85 subunit of the
            phosphatidylinositol 3-kinase complex and a related p85 beta
            protein by using the baculovirus expression system
  JOURNAL   Biochem J 288 (Pt 2) (Pt 2), 395-405 (1992)
   PUBMED   1334406
REFERENCE   9  (bases 1 to 4858)
  AUTHORS   Peles,E., Lamprecht,R., Ben-Levy,R., Tzahar,E. and Yarden,Y.
  TITLE     Regulated coupling of the Neu receptor to phosphatidylinositol
            3'-kinase and its release by oncogenic activation
  JOURNAL   J Biol Chem 267 (17), 12266-12274 (1992)
   PUBMED   1351056
REFERENCE   10 (bases 1 to 4858)
  AUTHORS   Hall,J.M. and King,M.C.
  TITLE     PCR detection of an MboI polymorphism in the ERBB2 (HER2; NEU) gene
            on chromosome 17q11.2-q12
  JOURNAL   Nucleic Acids Res 19 (9), 2515 (1991)
   PUBMED   1675005
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087491.5 and AC079199.9.
            
            On May 21, 2020 this sequence version replaced NM_001005862.2.
            
            Summary: This gene encodes a member of the epidermal growth factor
            (EGF) receptor family of receptor tyrosine kinases. This protein
            has no ligand binding domain of its own and therefore cannot bind
            growth factors. However, it does bind tightly to other ligand-bound
            EGF receptor family members to form a heterodimer, stabilizing
            ligand binding and enhancing kinase-mediated activation of
            downstream signalling pathways, such as those involving
            mitogen-activated protein kinase and phosphatidylinositol-3 kinase.
            Allelic variations at amino acid positions 654 and 655 of isoform a
            (positions 624 and 625 of isoform b) have been reported, with the
            most common allele, Ile654/Ile655, shown here. Amplification and/or
            overexpression of this gene has been reported in numerous cancers,
            including breast and ovarian tumors. Alternative splicing results
            in several additional transcript variants, some encoding different
            isoforms and others that have not been fully characterized.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.2855139.1,
                                           SRR18074969.1776953.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               AC087491.5         118693-118877
            186-290             AC087491.5         119295-119399
            291-355             AC087491.5         123860-123924
            356-549             AC087491.5         125587-125780
            550-701             AC087491.5         137589-137740
            702-915             AC087491.5         138920-139133
            916-1050            AC087491.5         139917-140051
            1051-1119           AC087491.5         140412-140480
            1120-1235           AC087491.5         140685-140800
            1236-1377           AC087491.5         140939-141080
            1378-1497           AC087491.5         142527-142646
            1498-1624           AC087491.5         142921-143047
            1625-1698           AC087491.5         145885-145958
            1699-1789           AC087491.5         146045-146135
            1790-1989           AC087491.5         146339-146538
            1990-2122           AC087491.5         146900-147032
            2123-2213           AC087491.5         147114-147204
            2214-2374           AC087491.5         147919-148079
            2375-2422           AC087491.5         150386-150433
            2423-2561           AC087491.5         153918-154056
            2562-2684           AC087491.5         154137-154259
            2685-2783           AC087491.5         154511-154609
            2784-2969           AC087491.5         155325-155510
            2970-3125           AC087491.5         155648-155803
            3126-3201           AC087491.5         155926-156001
            3202-3348           AC087491.5         156306-156452
            3349-3404           AC087491.5         157161-157216
            3405-3446           AC079199.9         71077-71118
            3447-3635           AC079199.9         71274-71462
            3636-3888           AC079199.9         71754-72006
            3889-4858           AC079199.9         72148-73117
FEATURES             Location/Qualifiers
     source          1..4858
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..4858
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /note="erb-b2 receptor tyrosine kinase 2"
                     /db_xref="GeneID:2064"
                     /db_xref="HGNC:HGNC:3430"
                     /db_xref="MIM:164870"
     exon            1..185
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            186..290
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            291..355
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            356..549
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            550..701
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             567..4244
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /EC_number="2.7.10.1"
                     /note="isoform b is encoded by transcript variant 2;
                     herstatin; receptor tyrosine-protein kinase erbB-2;
                     neuroblastoma/glioblastoma derived oncogene homolog; c-erb
                     B2/neu protein; proto-oncogene Neu; proto-oncogene
                     c-ErbB-2; metastatic lymph node gene 19 protein; tyrosine
                     kinase-type cell surface receptor HER2; v-erb-b2 avian
                     erythroblastic leukemia viral oncogene homolog 2; v-erb-b2
                     erythroblastic leukemia viral oncogene homolog 2,
                     neuro/glioblastoma derived oncogene homolog; v-erb-b2
                     avian erythroblastic leukemia viral oncoprotein 2; human
                     epidermal growth factor receptor 2"
                     /codon_start=1
                     /product="receptor tyrosine-protein kinase erbB-2 isoform
                     b"
                     /protein_id="NP_001005862.1"
                     /db_xref="CCDS:CCDS45667.1"
                     /db_xref="GeneID:2064"
                     /db_xref="HGNC:HGNC:3430"
                     /db_xref="MIM:164870"
                     /translation="MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFL
                     QDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGA
                     SPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSR
                     ACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPK
                     HSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLST
                     DVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEF
                     AGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDL
                     SVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
                     PWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQ
                     ECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFC
                     VARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSI
                     ISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQM
                     RILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDE
                     AYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQ
                     IAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPI
                     KWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQP
                     PICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDS
                     TFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLT
                     LGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTV
                     PLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPG
                     KNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPP
                     STFKGTPTAENPEYLGLDVPV"
     exon            702..915
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1050
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1119
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1235
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1377
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1497
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1624
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1698
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1789
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1989
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2122
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2213
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2374
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2422
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2561
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2684
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2783
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..2969
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3125
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3126..3201
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3202..3348
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3349..3446
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3447..3635
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3636..3888
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3889..4858
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4757..4762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /note="hexamer: AATAAA"
     polyA_site      4777
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /note="major polyA site"
     regulatory      4841..4846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
                     /note="hexamer: AATATA"
     polyA_site      4858
                     /gene="ERBB2"
                     /gene_synonym="c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu;
                     HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2"
ORIGIN      
        1 gttctttatt ctactctccg ctgaagtcca cacagtttaa attaaagttc ccggattttt
       61 gtgggcgcct gccccgcccc tcgtccccct gctgtgtcca tatatcgagg cgatagggtt
      121 aagggaaggc ggacgcctga tgggttaatg agcaaactga agtgttttcc atgatctttt
      181 ttgagtcgca attgaagtac cacctcccga gggtgattgc ttccccatgc ggggtagaac
      241 ctttgctgtc ctgttcacca ctctacctcc agcacagaat ttggcttatg cctactcaat
      301 gtgaagatga tgaggatgaa aacctttgtg atgatccact tccacttaat gaatggtggc
      361 aaagcaaagc tatattcaag accacatgca aagctactcc ctgagcaaag agtcacagat
      421 aaaacggggg caccagtaga atggccagga caaacgcagt gcagcacaga gactcagacc
      481 ctggcagcca tgcctgcgca ggcagtgatg agagtgacat gtactgttgt ggacatgcac
      541 aaaagtgagt gtgcaccggc acagacatga agctgcggct ccctgccagt cccgagaccc
      601 acctggacat gctccgccac ctctaccagg gctgccaggt ggtgcaggga aacctggaac
      661 tcacctacct gcccaccaat gccagcctgt ccttcctgca ggatatccag gaggtgcagg
      721 gctacgtgct catcgctcac aaccaagtga ggcaggtccc actgcagagg ctgcggattg
      781 tgcgaggcac ccagctcttt gaggacaact atgccctggc cgtgctagac aatggagacc
      841 cgctgaacaa taccacccct gtcacagggg cctccccagg aggcctgcgg gagctgcagc
      901 ttcgaagcct cacagagatc ttgaaaggag gggtcttgat ccagcggaac ccccagctct
      961 gctaccagga cacgattttg tggaaggaca tcttccacaa gaacaaccag ctggctctca
     1021 cactgataga caccaaccgc tctcgggcct gccacccctg ttctccgatg tgtaagggct
     1081 cccgctgctg gggagagagt tctgaggatt gtcagagcct gacgcgcact gtctgtgccg
     1141 gtggctgtgc ccgctgcaag gggccactgc ccactgactg ctgccatgag cagtgtgctg
     1201 ccggctgcac gggccccaag cactctgact gcctggcctg cctccacttc aaccacagtg
     1261 gcatctgtga gctgcactgc ccagccctgg tcacctacaa cacagacacg tttgagtcca
     1321 tgcccaatcc cgagggccgg tatacattcg gcgccagctg tgtgactgcc tgtccctaca
     1381 actacctttc tacggacgtg ggatcctgca ccctcgtctg ccccctgcac aaccaagagg
     1441 tgacagcaga ggatggaaca cagcggtgtg agaagtgcag caagccctgt gcccgagtgt
     1501 gctatggtct gggcatggag cacttgcgag aggtgagggc agttaccagt gccaatatcc
     1561 aggagtttgc tggctgcaag aagatctttg ggagcctggc atttctgccg gagagctttg
     1621 atggggaccc agcctccaac actgccccgc tccagccaga gcagctccaa gtgtttgaga
     1681 ctctggaaga gatcacaggt tacctataca tctcagcatg gccggacagc ctgcctgacc
     1741 tcagcgtctt ccagaacctg caagtaatcc ggggacgaat tctgcacaat ggcgcctact
     1801 cgctgaccct gcaagggctg ggcatcagct ggctggggct gcgctcactg agggaactgg
     1861 gcagtggact ggccctcatc caccataaca cccacctctg cttcgtgcac acggtgccct
     1921 gggaccagct ctttcggaac ccgcaccaag ctctgctcca cactgccaac cggccagagg
     1981 acgagtgtgt gggcgagggc ctggcctgcc accagctgtg cgcccgaggg cactgctggg
     2041 gtccagggcc cacccagtgt gtcaactgca gccagttcct tcggggccag gagtgcgtgg
     2101 aggaatgccg agtactgcag gggctcccca gggagtatgt gaatgccagg cactgtttgc
     2161 cgtgccaccc tgagtgtcag ccccagaatg gctcagtgac ctgttttgga ccggaggctg
     2221 accagtgtgt ggcctgtgcc cactataagg accctccctt ctgcgtggcc cgctgcccca
     2281 gcggtgtgaa acctgacctc tcctacatgc ccatctggaa gtttccagat gaggagggcg
     2341 catgccagcc ttgccccatc aactgcaccc actcctgtgt ggacctggat gacaagggct
     2401 gccccgccga gcagagagcc agccctctga cgtccatcat ctctgcggtg gttggcattc
     2461 tgctggtcgt ggtcttgggg gtggtctttg ggatcctcat caagcgacgg cagcagaaga
     2521 tccggaagta cacgatgcgg agactgctgc aggaaacgga gctggtggag ccgctgacac
     2581 ctagcggagc gatgcccaac caggcgcaga tgcggatcct gaaagagacg gagctgagga
     2641 aggtgaaggt gcttggatct ggcgcttttg gcacagtcta caagggcatc tggatccctg
     2701 atggggagaa tgtgaaaatt ccagtggcca tcaaagtgtt gagggaaaac acatccccca
     2761 aagccaacaa agaaatctta gacgaagcat acgtgatggc tggtgtgggc tccccatatg
     2821 tctcccgcct tctgggcatc tgcctgacat ccacggtgca gctggtgaca cagcttatgc
     2881 cctatggctg cctcttagac catgtccggg aaaaccgcgg acgcctgggc tcccaggacc
     2941 tgctgaactg gtgtatgcag attgccaagg ggatgagcta cctggaggat gtgcggctcg
     3001 tacacaggga cttggccgct cggaacgtgc tggtcaagag tcccaaccat gtcaaaatta
     3061 cagacttcgg gctggctcgg ctgctggaca ttgacgagac agagtaccat gcagatgggg
     3121 gcaaggtgcc catcaagtgg atggcgctgg agtccattct ccgccggcgg ttcacccacc
     3181 agagtgatgt gtggagttat ggtgtgactg tgtgggagct gatgactttt ggggccaaac
     3241 cttacgatgg gatcccagcc cgggagatcc ctgacctgct ggaaaagggg gagcggctgc
     3301 cccagccccc catctgcacc attgatgtct acatgatcat ggtcaaatgt tggatgattg
     3361 actctgaatg tcggccaaga ttccgggagt tggtgtctga attctcccgc atggccaggg
     3421 acccccagcg ctttgtggtc atccagaatg aggacttggg cccagccagt cccttggaca
     3481 gcaccttcta ccgctcactg ctggaggacg atgacatggg ggacctggtg gatgctgagg
     3541 agtatctggt accccagcag ggcttcttct gtccagaccc tgccccgggc gctgggggca
     3601 tggtccacca caggcaccgc agctcatcta ccaggagtgg cggtggggac ctgacactag
     3661 ggctggagcc ctctgaagag gaggccccca ggtctccact ggcaccctcc gaaggggctg
     3721 gctccgatgt atttgatggt gacctgggaa tgggggcagc caaggggctg caaagcctcc
     3781 ccacacatga ccccagccct ctacagcggt acagtgagga ccccacagta cccctgccct
     3841 ctgagactga tggctacgtt gcccccctga cctgcagccc ccagcctgaa tatgtgaacc
     3901 agccagatgt tcggccccag cccccttcgc cccgagaggg ccctctgcct gctgcccgac
     3961 ctgctggtgc cactctggaa aggcccaaga ctctctcccc agggaagaat ggggtcgtca
     4021 aagacgtttt tgcctttggg ggtgccgtgg agaaccccga gtacttgaca ccccagggag
     4081 gagctgcccc tcagccccac cctcctcctg ccttcagccc agccttcgac aacctctatt
     4141 actgggacca ggacccacca gagcgggggg ctccacccag caccttcaaa gggacaccta
     4201 cggcagagaa cccagagtac ctgggtctgg acgtgccagt gtgaaccaga aggccaagtc
     4261 cgcagaagcc ctgatgtgtc ctcagggagc agggaaggcc tgacttctgc tggcatcaag
     4321 aggtgggagg gccctccgac cacttccagg ggaacctgcc atgccaggaa cctgtcctaa
     4381 ggaaccttcc ttcctgcttg agttcccaga tggctggaag gggtccagcc tcgttggaag
     4441 aggaacagca ctggggagtc tttgtggatt ctgaggccct gcccaatgag actctagggt
     4501 ccagtggatg ccacagccca gcttggccct ttccttccag atcctgggta ctgaaagcct
     4561 tagggaagct ggcctgagag gggaagcggc cctaagggag tgtctaagaa caaaagcgac
     4621 ccattcagag actgtccctg aaacctagta ctgcccccca tgaggaagga acagcaatgg
     4681 tgtcagtatc caggctttgt acagagtgct tttctgttta gtttttactt tttttgtttt
     4741 gtttttttaa agatgaaata aagacccagg gggagaatgg gtgttgtatg gggaggcaag
     4801 tgtggggggt ccttctccac acccactttg tccatttgca aatatatttt ggaaaaca
//
