LOCUS       NM_181532                826 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens ES cell expressed Ras (ERAS), mRNA.
ACCESSION   NM_181532
VERSION     NM_181532.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 826)
  AUTHORS   Pudewell,S., Lissy,J., Nakhaeizadeh,H., Taha,M.S., Akbarzadeh,M.,
            Rezaei Adariani,S., Nakhaei-Rad,S., Li,J., Kordes,C.,
            Haussinger,D., Piekorz,R.P., Cortese-Krott,M.M. and Ahmadian,M.R.
  TITLE     Physical Interaction between Embryonic Stem Cell-Expressed Ras
            (ERas) and Arginase-1 in Quiescent Hepatic Stellate Cells
  JOURNAL   Cells 11 (3), 508 (2022)
   PUBMED   35159317
  REMARK    GeneRIF: Physical Interaction between Embryonic Stem Cell-Expressed
            Ras (ERas) and Arginase-1 in Quiescent Hepatic Stellate Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 826)
  AUTHORS   Liu,Y., Qin,P., Wu,R., Du,L. and Li,F.
  TITLE     ERas regulates cell proliferation and epithelial-mesenchymal
            transition by affecting Erk/Akt signaling pathway in pancreatic
            cancer
  JOURNAL   Hum Cell 33 (4), 1186-1196 (2020)
   PUBMED   32700262
  REMARK    GeneRIF: ERas regulates cell proliferation and
            epithelial-mesenchymal transition by affecting Erk/Akt signaling
            pathway in pancreatic cancer.
REFERENCE   3  (bases 1 to 826)
  AUTHORS   Pan,J. and Zhao,L.X.
  TITLE     Epithelial-mesenchymal transition suppresses ERas to activate
            autophagy in retinal pigment epithelial cells in proliferative
            vitreoretinopathy
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (9), 4627-4634 (2020)
   PUBMED   32432726
  REMARK    GeneRIF: Epithelial-mesenchymal transition suppresses ERas to
            activate autophagy in retinal pigment epithelial cells in
            proliferative vitreoretinopathy.
REFERENCE   4  (bases 1 to 826)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 826)
  AUTHORS   Suarez-Cabrera,C., de la Pena,B., Gonzalez,L.L., Page,A.,
            Martinez-Fernandez,M., Casanova,M.L., Paramio,J.M.,
            Rojo-Sebastian,A., Moreno-Bueno,G., Maroto,A., Ramirez,A. and
            Navarro,M.
  TITLE     The Ras-related gene ERAS is involved in human and murine breast
            cancer
  JOURNAL   Sci Rep 8 (1), 13038 (2018)
   PUBMED   30158566
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 826)
  AUTHORS   Miyamoto,S., Yasui,Y., Kim,M., Sugie,S., Murakami,A.,
            Ishigamori-Suzuki,R. and Tanaka,T.
  TITLE     A novel rasH2 mouse carcinogenesis model that is highly susceptible
            to 4-NQO-induced tongue and esophageal carcinogenesis is useful for
            preclinical chemoprevention studies
  JOURNAL   Carcinogenesis 29 (2), 418-426 (2008)
   PUBMED   18174262
  REMARK    GeneRIF: rasH2 may have a role in susceptibility to
            chemically-induced tongue and esophageal neoplasms
REFERENCE   7  (bases 1 to 826)
  AUTHORS   Yasuda,K., Yashiro,M., Sawada,T., Ohira,M. and Hirakawa,K.
  TITLE     ERas oncogene expression and epigenetic regulation by histone
            acetylation in human cancer cells
  JOURNAL   Anticancer Res 27 (6B), 4071-4075 (2007)
   PUBMED   18225573
REFERENCE   8  (bases 1 to 826)
  AUTHORS   Kameda,T. and Thomson,J.A.
  TITLE     Human ERas gene has an upstream premature polyadenylation signal
            that results in a truncated, noncoding transcript
  JOURNAL   Stem Cells 23 (10), 1535-1540 (2005)
   PUBMED   16081664
  REMARK    GeneRIF: Studies on ERas gene expression.
REFERENCE   9  (bases 1 to 826)
  AUTHORS   Takahashi,K., Mitsui,K. and Yamanaka,S.
  TITLE     Role of ERas in promoting tumour-like properties in mouse embryonic
            stem cells
  JOURNAL   Nature 423 (6939), 541-545 (2003)
   PUBMED   12774123
  REMARK    GeneRIF: transforming oncogene ERas is important in the tumour-like
            growth properties of embryonic stem cells
REFERENCE   10 (bases 1 to 826)
  AUTHORS   Miyoshi,J., Kagimoto,M., Soeda,E. and Sakaki,Y.
  TITLE     The human c-Ha-ras2 is a processed pseudogene inactivated by
            numerous base substitutions
  JOURNAL   Nucleic Acids Res 12 (4), 1821-1828 (1984)
   PUBMED   6322122
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY043532.1 and BC101642.1.
            
            On Dec 5, 2012 this sequence version replaced NM_181532.2.
            
            Summary: This gene encodes a constitutively active member of the
            small GTPase Ras protein family. The encoded protein activates the
            phosphatidylinositol 3-kinase signal transduction pathway in
            undifferentiated stem cells, but is not expressed in differentiated
            cells. This gene may be involved in cancer and chemotherapy
            resistance. [provided by RefSeq, Dec 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HY043532.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000636362.1/ ENSP00000490793.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-443               HY043532.1         2-444
            444-826             BC101642.1         384-766
FEATURES             Location/Qualifiers
     source          1..826
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.23"
     gene            1..826
                     /gene="ERAS"
                     /gene_synonym="HRAS2; HRASP"
                     /note="ES cell expressed Ras"
                     /db_xref="GeneID:3266"
                     /db_xref="HGNC:HGNC:5174"
                     /db_xref="MIM:300437"
     exon            1..37
                     /gene="ERAS"
                     /gene_synonym="HRAS2; HRASP"
                     /inference="alignment:Splign:2.1.0"
     exon            38..826
                     /gene="ERAS"
                     /gene_synonym="HRAS2; HRASP"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..782
                     /gene="ERAS"
                     /gene_synonym="HRAS2; HRASP"
                     /EC_number="3.6.5.2"
                     /note="v-Ha-ras Harvey rat sarcoma viral oncogene homolog
                     pseudogene; GTPase ERas; small GTPase protein E-Ras;
                     v-Ha-ras Harvey rat sarcoma viral oncogene homolog 2;
                     embryonic stem cell-expressed Ras"
                     /codon_start=1
                     /product="GTPase ERas precursor"
                     /protein_id="NP_853510.1"
                     /db_xref="CCDS:CCDS35246.1"
                     /db_xref="GeneID:3266"
                     /db_xref="HGNC:HGNC:5174"
                     /db_xref="MIM:300437"
                     /translation="MELPTKPGTFDLGLATWSPSFQGETHRAQARRRDVGRQLPEYKA
                     VVVGASGVGKSALTIQLNHQCFVEDHDPTIQDSYWKELTLDSGDCILNVLDTAGQAIH
                     RALRDQCLAVCDGVLGVFALDDPSSLIQLQQIWATWGPHPAQPLVLVGNKCDLVTTAG
                     DAHAAAAALAHSWGAHFVETSAKTRQGVEEAFSLLVHEIQRVQEAMAKEPMARSCREK
                     TRHQKATCHCGCSVA"
ORIGIN      
        1 agagcgtccc agcgcgcccg cctccccacg gacacagagc ctgctgccca cgtctcttcc
       61 ctgagctgcc tgctggggtc atggagctgc caacaaagcc tggcaccttc gacctgggcc
      121 tggccacatg gagcccttcc ttccaggggg aaacccaccg ggctcaggca cgccgcaggg
      181 atgttggcag gcagctgcct gagtacaagg ctgtggtggt gggcgccagt ggcgtgggca
      241 agagtgcgct gaccatccag ctgaaccacc agtgcttcgt ggaggaccac gaccccacca
      301 tccaggattc ctactggaag gagttgaccc tggacagtgg ggactgcatt ctgaatgtgc
      361 tggacacagc agggcaggcc atccataggg ccctgcgtga ccagtgcctg gctgtctgtg
      421 atggtgtgct gggcgtcttc gctctcgatg acccctcgtc tctgatccag ctgcagcaga
      481 tatgggccac ctggggccct caccccgccc agccccttgt cctcgtgggc aacaagtgtg
      541 accttgtgac cactgctgga gatgctcatg ccgctgctgc agccctcgca cacagctggg
      601 gggcccactt cgtggagacc tcggccaaaa cacggcaagg cgtggaggag gccttttccc
      661 tgctggtcca tgagatccag agggtccagg aggccatggc gaaggagccc atggcaaggt
      721 cctgtaggga gaagacccgg caccagaagg ccacctgcca ctgtggctgc tctgtggcct
      781 gaaggtcttg gccaagaaat gtagaccttt ccccaggcca gggtga
//
