LOCUS       NM_022350               5131 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens endoplasmic reticulum aminopeptidase 2 (ERAP2),
            transcript variant 1, mRNA.
ACCESSION   NM_022350
VERSION     NM_022350.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5131)
  AUTHORS   Saeterstad,S., Ostvik,A.E., Hansen,M.D., Bruland,T. and van Beelen
            Granlund,A.
  TITLE     The effect of rs2910686 on ERAP2 expression in IBD and epithelial
            inflammatory response
  JOURNAL   J Transl Med 22 (1), 750 (2024)
   PUBMED   39123229
  REMARK    GeneRIF: The effect of rs2910686 on ERAP2 expression in IBD and
            epithelial inflammatory response.
            Erratum:[J Transl Med. 2024 Sep 20;22(1):849. doi:
            10.1186/s12967-024-05645-2.. PMID: 39304925]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5131)
  AUTHORS   Mesahel,R.M.I., Fotoh,D.S., Hadhoud,M.M. and Ali Assar,M.F.
  TITLE     A study of the association between single nucleotide polymorphisms
            of the endoplasmic reticulum aminopeptidase 2 (ERAP2) gene and the
            risk of ankylosing spondylitis in Egyptians
  JOURNAL   Mol Biol Rep 51 (1), 614 (2024)
   PUBMED   38704785
  REMARK    GeneRIF: A study of the association between single nucleotide
            polymorphisms of the endoplasmic reticulum aminopeptidase 2 (ERAP2)
            gene and the risk of ankylosing spondylitis in Egyptians.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5131)
  AUTHORS   Venema,W.J., Hiddingh,S., van Loosdregt,J., Bowes,J., Balliu,B., de
            Boer,J.H., Ossewaarde-van Norel,J., Thompson,S.D., Langefeld,C.D.,
            de Ligt,A., van der Veken,L.T., Krijger,P.H.L., de Laat,W. and
            Kuiper,J.J.W.
  TITLE     A cis-regulatory element regulates ERAP2 expression through
            autoimmune disease risk SNPs
  JOURNAL   Cell Genom 4 (1), 100460 (2024)
   PUBMED   38190099
  REMARK    GeneRIF: A cis-regulatory element regulates ERAP2 expression
            through autoimmune disease risk SNPs.
REFERENCE   4  (bases 1 to 5131)
  AUTHORS   Tedeschi,V., Paldino,G., Alba,J., Molteni,E., Paladini,F.,
            Scrivo,R., Congia,M., Cauli,A., Caccavale,R., Paroli,M., Di
            Franco,M., Tuosto,L., Sorrentino,R., D'Abramo,M. and Fiorillo,M.T.
  TITLE     ERAP1 and ERAP2 Haplotypes Influence Suboptimal
            HLA-B*27:05-Restricted Anti-Viral CD8+ T Cell Responses
            Cross-Reactive to Self-Epitopes
  JOURNAL   Int J Mol Sci 24 (17), 13335 (2023)
   PUBMED   37686141
  REMARK    GeneRIF: ERAP1 and ERAP2 Haplotypes Influence Suboptimal
            HLA-B*27:05-Restricted Anti-Viral CD8+ T Cell Responses
            Cross-Reactive to Self-Epitopes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5131)
  AUTHORS   Saveanu,L., Carroll,O., Lindo,V., Del Val,M., Lopez,D.,
            Lepelletier,Y., Greer,F., Schomburg,L., Fruci,D., Niedermann,G. and
            van Endert,P.M.
  TITLE     Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase
            complexes in the endoplasmic reticulum
  JOURNAL   Nat Immunol 6 (7), 689-697 (2005)
   PUBMED   15908954
REFERENCE   6  (bases 1 to 5131)
  AUTHORS   Tanioka,T., Hattori,A., Mizutani,S. and Tsujimoto,M.
  TITLE     Regulation of the human leukocyte-derived arginine
            aminopeptidase/endoplasmic reticulum-aminopeptidase 2 gene by
            interferon-gamma
  JOURNAL   FEBS J 272 (4), 916-928 (2005)
   PUBMED   15691326
REFERENCE   7  (bases 1 to 5131)
  AUTHORS   Tanioka,T., Hattori,A., Masuda,S., Nomura,Y., Nakayama,H.,
            Mizutani,S. and Tsujimoto,M.
  TITLE     Human leukocyte-derived arginine aminopeptidase. The third member
            of the oxytocinase subfamily of aminopeptidases
  JOURNAL   J Biol Chem 278 (34), 32275-32283 (2003)
   PUBMED   12799365
REFERENCE   8  (bases 1 to 5131)
  AUTHORS   York,I.A., Chang,S.C., Saric,T., Keys,J.A., Favreau,J.M.,
            Goldberg,A.L. and Rock,K.L.
  TITLE     The ER aminopeptidase ERAP1 enhances or limits antigen presentation
            by trimming epitopes to 8-9 residues
  JOURNAL   Nat Immunol 3 (12), 1177-1184 (2002)
   PUBMED   12436110
REFERENCE   9  (bases 1 to 5131)
  AUTHORS   Saric,T., Chang,S.C., Hattori,A., York,I.A., Markant,S., Rock,K.L.,
            Tsujimoto,M. and Goldberg,A.L.
  TITLE     An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims
            precursors to MHC class I-presented peptides
  JOURNAL   Nat Immunol 3 (12), 1169-1176 (2002)
   PUBMED   12436109
REFERENCE   10 (bases 1 to 5131)
  AUTHORS   Hattori,A., Matsumoto,K., Mizutani,S. and Tsujimoto,M.
  TITLE     Genomic organization of the human adipocyte-derived leucine
            aminopeptidase gene and its relationship to the placental leucine
            aminopeptidase/oxytocinase gene
  JOURNAL   J Biochem 130 (2), 235-241 (2001)
   PUBMED   11481040
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AV688559.1, AF191545.1,
            AK312864.1, AC008850.7 and CA311579.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 25, 2019 this sequence version replaced NM_022350.4.
            
            Summary: This gene encodes a zinc metalloaminopeptidase of the M1
            protease family that resides in the endoplasmic reticulum and
            functions in N-terminal trimming antigenic epitopes for
            presentation by major histocompatibility complex (MHC) class I
            molecules. Certain mutations in this gene are associated with the
            inflammatory arthritis syndrome ankylosing spondylitis and
            pre-eclampsia. This gene is located adjacent to a closely related
            aminopeptidase gene on chromosome 5. [provided by RefSeq, Jul
            2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1 and 2 both encode the same protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB109031.1, SRR14038196.2725563.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000437043.8/ ENSP00000400376.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AV688559.1         562-592
            32-299              AF191545.1         4-271
            300-1013            AK312864.1         313-1026
            1014-3290           AF191545.1         986-3262
            3291-4670           AC008850.7         128144-129523       c
            4671-5131           CA311579.1         31-491              c
FEATURES             Location/Qualifiers
     source          1..5131
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q15"
     gene            1..5131
                     /gene="ERAP2"
                     /gene_synonym="L-RAP; LRAP"
                     /note="endoplasmic reticulum aminopeptidase 2"
                     /db_xref="GeneID:64167"
                     /db_xref="HGNC:HGNC:29499"
                     /db_xref="MIM:609497"
     exon            1..28
                     /gene="ERAP2"
                     /gene_synonym="L-RAP; LRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            29..725
                     /gene="ERAP2"
                     /gene_synonym="L-RAP; LRAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..3033
                     /gene="ERAP2"
                     /gene_synonym="L-RAP; LRAP"
                     /EC_number="3.4.11.-"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leukocyte-derived arginine aminopeptidase"
                     /codon_start=1
                     /product="endoplasmic reticulum aminopeptidase 2 isoform
                     1"
                     /protein_id="NP_071745.1"
                     /db_xref="CCDS:CCDS4086.1"
                     /db_xref="GeneID:64167"
                     /db_xref="HGNC:HGNC:29499"
                     /db_xref="MIM:609497"
                     /translation="MFHSSAMVNSHRKPMFNIHRGFYCLTAILPQICICSQFSVPSSY
                     HFTEDPGAFPVATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVS
                     NATQFIILHSKDLEITNATLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHL
                     KYYVAMDFQAKLGDGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKA
                     NFSIKIRRESRHIALSNMPKVKTIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSG
                     FTSSGVKVSIYASPDKRNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPG
                     AMENWGLITYRETSLLFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLK
                     EGFAKYMELIAVNATYPELQFDDYFLNVCFEVITKDSLNSSRPISKPAETPTQIQEMF
                     DEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDF
                     TSGGVCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVKQDGCSLRLQQERF
                     LQGVFQEDPEWRALQERYLWHIPLTYSTSSSNVIHRHILKSKTDTLDLPEKTSWVKFN
                     VDSNGYYIVHYEGHGWDQLITQLNQNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALD
                     MTYYLQHETSSPALLEGLSYLESFYHMMDRRNISDISENLKRYLLQYFKPVIDRQSWS
                     DKGSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWMESSGKLNIPTDVLKIVYSVG
                     AQTTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGMEGKVIKTQNLA
                     ALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEV
                     KLFFESLEAQGSHLDIFQTVLETITKNIKWLEKNLPTLRTWLMVNT"
     exon            726..864
                     /gene="ERAP2"
                     /gene_synonym="L-RAP; LRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            865..999
                     /gene="ERAP2"
                     /gene_synonym="L-RAP; LRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1120
                     /gene="ERAP2"
                     /gene_synonym="L-RAP; LRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1275
                     /gene="ERAP2"
                     /gene_synonym="L-RAP; LRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1389
                     /gene="ERAP2"
                     /gene_synonym="L-RAP; LRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1521
                     /gene="ERAP2"
                     /gene_synonym="L-RAP; LRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1653
                     /gene="ERAP2"
                     /gene_synonym="L-RAP; LRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1722
                     /gene="ERAP2"
                     /gene_synonym="L-RAP; LRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1898
                     /gene="ERAP2"
                     /gene_synonym="L-RAP; LRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..1978
                     /gene="ERAP2"
                     /gene_synonym="L-RAP; LRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2162
                     /gene="ERAP2"
                     /gene_synonym="L-RAP; LRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2319
                     /gene="ERAP2"
                     /gene_synonym="L-RAP; LRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2504
                     /gene="ERAP2"
                     /gene_synonym="L-RAP; LRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2666
                     /gene="ERAP2"
                     /gene_synonym="L-RAP; LRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2807
                     /gene="ERAP2"
                     /gene_synonym="L-RAP; LRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..2889
                     /gene="ERAP2"
                     /gene_synonym="L-RAP; LRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..5131
                     /gene="ERAP2"
                     /gene_synonym="L-RAP; LRAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5112..5117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERAP2"
                     /gene_synonym="L-RAP; LRAP"
                     /note="hexamer: AATAGA"
     polyA_site      5131
                     /gene="ERAP2"
                     /gene_synonym="L-RAP; LRAP"
                     /note="major polyA site"
ORIGIN      
        1 agtcaaatct gcagcagcat gatttaagat taaattcatg tattgaaaat attgttcaga
       61 ccccatgtga cataactgga gccagtgcag tgccatgaag aactacgaga ttagcctgga
      121 tattaacttg tcttctagag aatagatttc atgttccatt cttctgcaat ggttaattca
      181 cacagaaaac caatgtttaa cattcacaga ggattttact gcttaacagc catcttgccc
      241 caaatatgca tttgttctca gttctcagtg ccatctagtt atcacttcac tgaggatcct
      301 ggggctttcc cagtagccac taatggggaa cgatttcctt ggcaggagct aaggctcccc
      361 agtgtggtca ttcctctcca ttatgacctc tttgtccacc ccaatctcac ctctctggac
      421 tttgttgcat ctgagaagat cgaagtcttg gtcagcaatg ctacccagtt tatcatcttg
      481 cacagcaaag atcttgaaat cacgaatgcc acccttcagt cagaggaaga ttcaagatac
      541 atgaaaccag gaaaagaact gaaagttttg agttaccctg ctcatgaaca aattgcactg
      601 ctggttccag agaaacttac gcctcacctg aaatactatg tggctatgga cttccaagcc
      661 aagttaggtg atggctttga agggttttat aaaagcacat acagaactct tggtggtgaa
      721 acaagaattc ttgcagtaac agattttgag ccaacccagg cacgcatggc tttcccttgc
      781 tttgatgaac cgttgttcaa agccaacttt tcaatcaaga tacgaagaga gagcaggcat
      841 attgcactat ccaacatgcc aaaggttaag acaattgaac ttgaaggagg tcttttggaa
      901 gatcactttg aaactactgt aaaaatgagt acataccttg tagcctacat agtttgtgat
      961 ttccactctc tgagtggctt cacttcatca ggggtcaagg tgtccatcta tgcatcccca
     1021 gacaaacgga atcaaacaca ttatgctttg caggcatcac tgaagctact tgatttttat
     1081 gaaaagtact ttgatatcta ctatccactc tccaaactgg atttaattgc tattcctgac
     1141 tttgcacctg gagccatgga aaattggggc ctcattacat atagggagac gtcactgctt
     1201 tttgacccca agacctcttc tgcttccgat aaactgtggg tcaccagagt catagcccat
     1261 gaactggcgc accagtggtt tggcaacctg gtcacaatgg aatggtggaa tgatatttgg
     1321 cttaaggagg gttttgcaaa atacatggaa cttatcgctg ttaatgctac atatccagag
     1381 ctgcaatttg atgactattt tttgaatgtg tgttttgaag taattacaaa agattcattg
     1441 aattcatccc gccctatctc caaaccagcg gaaaccccga ctcaaataca ggaaatgttt
     1501 gatgaagttt cctataacaa gggagcttgt attttgaata tgctcaagga ttttctgggt
     1561 gaggagaaat tccagaaagg aataattcag tacttaaaga agttcagcta tagaaatgct
     1621 aagaatgatg acttgtggag cagtctgtca aatagttgtt tagaaagtga ttttacatct
     1681 ggtggagttt gtcattcgga tcccaagatg acaagtaaca tgctcgcctt tctgggggaa
     1741 aatgcagagg tcaaagagat gatgactaca tggactctcc agaaaggaat ccccctgctg
     1801 gtggttaaac aagacgggtg ttcactccga ctgcaacagg agcgcttcct ccagggggtt
     1861 ttccaggaag accctgaatg gagggccctg caggagaggt acctgtggca tatcccattg
     1921 acctactcca cgagttcttc taatgtgatc cacagacaca ttctaaaatc aaagacagat
     1981 actctggatc tacctgaaaa gaccagttgg gtgaaattta atgtggactc aaatggttac
     2041 tacatcgttc actatgaggg tcatggatgg gaccaactca ttacacagct gaatcagaac
     2101 cacacacttc tcagacctaa ggacagagta ggtctgattc atgatgtgtt tcagctagtt
     2161 ggtgcaggga gactgaccct agacaaagct cttgacatga cttactacct ccaacatgaa
     2221 acaagcagcc ccgcacttct cgaaggtctg agttacttgg aatcgtttta ccacatgatg
     2281 gacagaagga atatttcaga tatctctgaa aacctcaagc gttaccttct tcagtatttt
     2341 aagccagtga ttgacaggca aagctggagt gacaagggct cagtctggga caggatgctc
     2401 cgctcggctc tcttgaagct ggcctgtgac ctgaaccatg ctccttgcat ccagaaagct
     2461 gctgaactct tctcccagtg gatggaatcc agtggaaaat taaatatacc aacagatgtt
     2521 ttaaagattg tgtattctgt gggtgctcag acaacagcag gatggaatta ccttttagag
     2581 caatatgaac tgtcaatgtc aagtgctgaa caaaacaaaa ttctgtatgc tttgtcaacg
     2641 agcaagcatc aggaaaagtt actgaagtta attgaactag gaatggaagg aaaggttatc
     2701 aagacacaga acttggcagc tctccttcat gcgattgcca gacgtccaaa ggggcagcaa
     2761 ctagcatggg attttgtaag agaaaattgg acccatcttc tgaaaaaatt tgacttgggc
     2821 tcatatgaca taaggatgat catctctggc acaacagctc acttttcttc caaggataag
     2881 ttgcaagagg tgaaactatt ttttgaatct cttgaggctc aaggatcaca tctggatatt
     2941 tttcaaactg ttctggaaac gataaccaaa aatataaaat ggctggagaa gaatcttccg
     3001 actctgagga cttggctaat ggttaatact taaatggtca atagaaaaag taggctgggc
     3061 gcggtggctc acgcctgtaa tcccagcact ttgggaggct gagaagggcg gatcacgagg
     3121 tcaggagatg gagaccatcc tggctaacac ggtgagaccc cgtctccgct aaaaatacaa
     3181 aaaattagcc gggcatggtg gcaggtgcct gtagtcccag ctactcggca ggctgcagca
     3241 ggaaaatggc ataaacccgg gaggtggagc ttgcagtgag ccgagattgc accactgcat
     3301 tccagcctgg gtgactgagc gagactctgt ctcaaaaaaa aaaaaaaaaa aaaaaagaaa
     3361 aagaaaaaga aaagaaaaga aaaggtacat cagacatgac tgcctgcatg aagtcaaaca
     3421 gggtaacacc agtgaagctc aagtcaagag ctgtggatat tttgtctaac caacaagaag
     3481 tctcaagaaa tcaggcagtg cagctgcctg ctctcagcta tcgtatccag ccaaaagatg
     3541 catgatgatg gagtggtggg ggaaggccag ttcagtatcc tatttaaaag taaacttcct
     3601 gaataatgga tatatgtgga gatacagaca tagatatata gatacagctg taattattta
     3661 gcctcaagtg actttctcca ttgcttcacg ctatgccact attttgcttc tttaattttt
     3721 ttaaccttgc ttagtattct atagtttgcc caaccagttt tacgtccaag gaaaattagc
     3781 caatgcataa aatatacaaa ctatgaaagg caaggatcag gaaaccagag actttgccac
     3841 caaatctcag attattagaa actaggtgtc agggtttatc aagaaggcca ggaaggcctt
     3901 ttgggttaag ccttacattc atgaagaacc tcaagggtag atttttgaga gcattccaaa
     3961 tgaatggtct ctggtcaaat gaatgaatgg tcaaatgaat aaatctgccc tcacagagat
     4021 acaaaaggaa aaggaatata attcatacca tttggtttaa gccttacatt catgaagtac
     4081 ctcaagggta gatttttgag atcattccaa atgaagtcga atctgccctc acagagacac
     4141 aagaaaggaa tataattcat acactattgc atttttaata aatcttttga aatttgcaga
     4201 attagattgt attgtgtatt ttcggttaaa tgataattga atgtaaatat ttagatgcag
     4261 caccatattt tataacccag ctttagcatt tcttcatatt ttaaggaaac cccccacctc
     4321 cttcttttaa gggcgcttct tgctctctga aatgccctgc taaatgcttc tcttaattat
     4381 ttgaataagg tagtttggaa taaagaaaga aaagatcact ctacatacag atagtaaact
     4441 taatttgtga tcctatatat gagacagtat aaaaatacag ataagtttta gaaagactca
     4501 aaacaatatg taaatgactg atgtttgcat tattaaggaa gacttgggat gttgggtcaa
     4561 gaggggaaag tgttagtcaa tccactttgg agcaatatca tgaaggtcaa ttataattcc
     4621 atataccttt ctttgatgcc acagtcagag atagaataca gtttgggtgg ccatggatgt
     4681 gccccaatac agtacacatt ttttggttaa atttgttttc agatcatttc atggaatctt
     4741 tgaagtatct ttgactctaa ctttgacttg gtggtggacc ttccttggtt tttataacac
     4801 ctaagagata tcctttagaa ttacatgtat tttagcataa ggaaattgaa aaagtaaaac
     4861 atactggttt ttttcaacaa gaccatatgt aaattaaata gtgaaatgtg tatgagtttc
     4921 agtagaactg taccatcaac aatgtttcca taaatatgca gagttctttc ttttgtattg
     4981 ttatttacaa tattgttaaa ttgaatgcat ttgcaatttc taggattcta aagaattgag
     5041 tacagaaagt agcaatttta ttatttgatg ataatatgag aattactgtg ccaatactgt
     5101 tttgataaat aaatagattt ttaaaaataa a
//
