LOCUS       NM_001040458            4841 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens endoplasmic reticulum aminopeptidase 1 (ERAP1),
            transcript variant 2, mRNA.
ACCESSION   NM_001040458
VERSION     NM_001040458.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4841)
  AUTHORS   Saad,M.A., Abdul-Sattar,A.B., Abdelal,I.T. and Barak,A.
  TITLE     Association of Endoplasmic Reticulum Aminopeptidase 1 Gene
            Polymorphism with Susceptibility and Severity of Axial
            Spondyloarthritis in Egyptian Population: A Single-center
            Case-Control Study
  JOURNAL   Ann Afr Med 23 (3), 443-451 (2024)
   PUBMED   39034571
  REMARK    GeneRIF: Association of Endoplasmic Reticulum Aminopeptidase 1 Gene
            Polymorphism with Susceptibility and Severity of Axial
            Spondyloarthritis in Egyptian Population: A Single-center
            Case-Control Study.
REFERENCE   2  (bases 1 to 4841)
  AUTHORS   Ma,C., Liu,X.W., Zheng,Y.Y. and Zhang,W.Y.
  TITLE     [Relationship between maternal and fetal ERAP-1 gene polymorphism
            and pre-eclampsia]
  JOURNAL   Zhonghua Fu Chan Ke Za Zhi 59 (6), 434-439 (2024)
   PUBMED   38951078
  REMARK    GeneRIF: [Relationship between maternal and fetal ERAP-1 gene
            polymorphism and pre-eclampsia].
REFERENCE   3  (bases 1 to 4841)
  AUTHORS   Sasaki,T., Razia,S., Kimura-Kataoka,K., Araki,T., Kusaka,A.,
            Takeshita,H. and Fujihara,J.
  TITLE     Association of a single nucleotide polymorphism (rs27434) in the
            ERAP1 gene with plural tissue weight
  JOURNAL   Leg Med (Tokyo) 68, 102419 (2024)
   PUBMED   38342012
  REMARK    GeneRIF: Association of a single nucleotide polymorphism (rs27434)
            in the ERAP1 gene with plural tissue weight.
REFERENCE   4  (bases 1 to 4841)
  AUTHORS   Hassan,S.H., Auda,I.G., Ali,E.N., Alosami,M.H. and Hussein,R.H.
  TITLE     Role of endoplasmic reticulum aminopeptidase-1 gene polymorphism
            (rs13167972) in occurrence susceptibility of ankylosing spondylitis
            in a sample of Iraqi male patients
  JOURNAL   Mol Biol Rep 51 (1), 462 (2024)
   PUBMED   38551779
  REMARK    GeneRIF: Role of endoplasmic reticulum aminopeptidase-1 gene
            polymorphism (rs13167972) in occurrence susceptibility of
            ankylosing spondylitis in a sample of Iraqi male patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4841)
  AUTHORS   Raja,A. and Kuiper,J.J.W.
  TITLE     Evolutionary immuno-genetics of endoplasmic reticulum
            aminopeptidase II (ERAP2)
  JOURNAL   Genes Immun 24 (6), 295-302 (2023)
   PUBMED   37925533
  REMARK    GeneRIF: Evolutionary immuno-genetics of endoplasmic reticulum
            aminopeptidase II (ERAP2).
            Review article
REFERENCE   6  (bases 1 to 4841)
  AUTHORS   Cui,X., Hawari,F., Alsaaty,S., Lawrence,M., Combs,C.A., Geng,W.,
            Rouhani,F.N., Miskinis,D. and Levine,S.J.
  TITLE     Identification of ARTS-1 as a novel TNFR1-binding protein that
            promotes TNFR1 ectodomain shedding
  JOURNAL   J Clin Invest 110 (4), 515-526 (2002)
   PUBMED   12189246
  REMARK    GeneRIF: ARTS-1 has been identified as a novel TNFR1 binding
            protein that promotes TNFR1 shedding.
REFERENCE   7  (bases 1 to 4841)
  AUTHORS   Yamamoto,N., Nakayama,J., Yamakawa-Kobayashi,K., Hamaguchi,H.,
            Miyazaki,R. and Arinami,T.
  TITLE     Identification of 33 polymorphisms in the adipocyte-derived leucine
            aminopeptidase (ALAP) gene and possible association with
            hypertension
  JOURNAL   Hum Mutat 19 (3), 251-257 (2002)
   PUBMED   11857741
  REMARK    GeneRIF: Association has been confirmed between the Lys528Arg
            polymorphism of the adipocyte-derived leucine aminopeptidase gene
            and essential hypertension.
REFERENCE   8  (bases 1 to 4841)
  AUTHORS   Hattori,A., Matsumoto,K., Mizutani,S. and Tsujimoto,M.
  TITLE     Genomic organization of the human adipocyte-derived leucine
            aminopeptidase gene and its relationship to the placental leucine
            aminopeptidase/oxytocinase gene
  JOURNAL   J Biochem 130 (2), 235-241 (2001)
   PUBMED   11481040
REFERENCE   9  (bases 1 to 4841)
  AUTHORS   Hattori,A., Kitatani,K., Matsumoto,H., Miyazawa,S., Rogi,T.,
            Tsuruoka,N., Mizutani,S., Natori,Y. and Tsujimoto,M.
  TITLE     Characterization of recombinant human adipocyte-derived leucine
            aminopeptidase expressed in Chinese hamster ovary cells
  JOURNAL   J Biochem 128 (5), 755-762 (2000)
   PUBMED   11056387
REFERENCE   10 (bases 1 to 4841)
  AUTHORS   Hattori,A., Matsumoto,H., Mizutani,S. and Tsujimoto,M.
  TITLE     Molecular cloning of adipocyte-derived leucine aminopeptidase
            highly related to placental leucine aminopeptidase/oxytocinase
  JOURNAL   J Biochem 125 (5), 931-938 (1999)
   PUBMED   10220586
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA704693.1, DA327238.1,
            AF222340.1 and AC008906.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001040458.2.
            
            Summary: The protein encoded by this gene is an aminopeptidase
            involved in trimming HLA class I-binding precursors so that they
            can be presented on MHC class I molecules. The encoded protein acts
            as a monomer or as a heterodimer with ERAP2. This protein may also
            be involved in blood pressure regulation by inactivation of
            angiotensin II. Three transcript variants encoding two different
            isoforms have been found for this gene.[provided by RefSeq, Oct
            2010].
            
            Transcript Variant: This variant (2) differs in the 3' UTR and
            coding sequence compared to variant 1. The resulting isoform (b)
            has a shorter and distinct C-terminus compared to isoform a.
            Variants 2 and 3 both encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF183569.1, AF222340.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000443439.7/ ENSP00000406304.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DA704693.1         299-319
            22-86               DA327238.1         267-331
            87-3581             AF222340.1         71-3565
            3582-4060           AC008906.5         100631-101109       c
            4061-4841           AF222340.1         4040-4820
FEATURES             Location/Qualifiers
     source          1..4841
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q15"
     gene            1..4841
                     /gene="ERAP1"
                     /gene_synonym="A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP;
                     ERAAP1; PILS-AP; PILSAP"
                     /note="endoplasmic reticulum aminopeptidase 1"
                     /db_xref="GeneID:51752"
                     /db_xref="HGNC:HGNC:18173"
                     /db_xref="MIM:606832"
     exon            1..86
                     /gene="ERAP1"
                     /gene_synonym="A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP;
                     ERAAP1; PILS-AP; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            87..627
                     /gene="ERAP1"
                     /gene_synonym="A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP;
                     ERAAP1; PILS-AP; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..2929
                     /gene="ERAP1"
                     /gene_synonym="A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP;
                     ERAAP1; PILS-AP; PILSAP"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; aminopeptidase regulator of TNFR1 shedding;
                     puromycin-insensitive leucyl-specific aminopeptidase;
                     aminopeptidase PILS; adipocyte-derived leucine
                     aminopeptidase; endoplasmic reticulum aminopeptidase
                     associated with antigen processing; type 1 tumor necrosis
                     factor receptor shedding aminopeptidase regulator"
                     /codon_start=1
                     /product="endoplasmic reticulum aminopeptidase 1 isoform b
                     precursor"
                     /protein_id="NP_001035548.1"
                     /db_xref="CCDS:CCDS47250.1"
                     /db_xref="GeneID:51752"
                     /db_xref="HGNC:HGNC:18173"
                     /db_xref="MIM:606832"
                     /translation="MVFLPLKWSLATMSFLLSSLLALLTVSTPSWCQSTEASPKRSDG
                     TPFPWNKIRLPEYVIPVHYDLLIHANLTTLTFWGTTKVEITASQPTSTIILHSHHLQI
                     SRATLRKGAGERLSEEPLQVLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLSETFH
                     GFYKSTYRTKEGELRILASTQFEPTAARMAFPCFDEPAFKASFSIKIRREPRHLAISN
                     MPLVKSVTVAEGLIEDHFDVTVKMSTYLVAFIISDFESVSKITKSGVKVSVYAVPDKI
                     NQADYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLF
                     DAEKSSASSKLGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHP
                     ELKVGDYFFGKCFDAMEVDALNSSHPVSTPVENPAQIREMFDDVSYDKGACILNMLRE
                     YLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASICPTDGVKGMDGFCSRSQHSSSSS
                     HWHQEGVDVKTMMNTWTLQKGFPLITITVRGRNVHMKQEHYMKGSDGAPDTGYLWHVP
                     LTFITSKSDMVHRFLLKTKTDVLILPEEVEWIKFNVGMNGYYIVHYEDDGWDSLTGLL
                     KGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIMPVFQGLNELIP
                     MYKLMEKRDMNEVETQFKAFLIRLLRDLIDKQTWTDEGSVSERMLRSQLLLLACVHNY
                     QPCVQRAEGYFRKWKESNGNLSLPVDVTLAVFAVGAQSTEGWDFLYSKYQFSLSSTEK
                     SQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQILTLIGRNPVGYPLAWQFLRKN
                     WNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVKGFFSSLKENGSQLRCVQQTIET
                     IEENIGWMDKNFDKIRVWLQSEKLERM"
     exon            628..766
                     /gene="ERAP1"
                     /gene_synonym="A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP;
                     ERAAP1; PILS-AP; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            767..901
                     /gene="ERAP1"
                     /gene_synonym="A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP;
                     ERAAP1; PILS-AP; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1022
                     /gene="ERAP1"
                     /gene_synonym="A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP;
                     ERAAP1; PILS-AP; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1177
                     /gene="ERAP1"
                     /gene_synonym="A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP;
                     ERAAP1; PILS-AP; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1291
                     /gene="ERAP1"
                     /gene_synonym="A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP;
                     ERAAP1; PILS-AP; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1423
                     /gene="ERAP1"
                     /gene_synonym="A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP;
                     ERAAP1; PILS-AP; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1555
                     /gene="ERAP1"
                     /gene_synonym="A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP;
                     ERAAP1; PILS-AP; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1627
                     /gene="ERAP1"
                     /gene_synonym="A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP;
                     ERAAP1; PILS-AP; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1782
                     /gene="ERAP1"
                     /gene_synonym="A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP;
                     ERAAP1; PILS-AP; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1862
                     /gene="ERAP1"
                     /gene_synonym="A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP;
                     ERAAP1; PILS-AP; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..2046
                     /gene="ERAP1"
                     /gene_synonym="A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP;
                     ERAAP1; PILS-AP; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2203
                     /gene="ERAP1"
                     /gene_synonym="A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP;
                     ERAAP1; PILS-AP; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2388
                     /gene="ERAP1"
                     /gene_synonym="A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP;
                     ERAAP1; PILS-AP; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2550
                     /gene="ERAP1"
                     /gene_synonym="A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP;
                     ERAAP1; PILS-AP; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..2691
                     /gene="ERAP1"
                     /gene_synonym="A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP;
                     ERAAP1; PILS-AP; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2773
                     /gene="ERAP1"
                     /gene_synonym="A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP;
                     ERAAP1; PILS-AP; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..4841
                     /gene="ERAP1"
                     /gene_synonym="A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP;
                     ERAAP1; PILS-AP; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4816..4821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERAP1"
                     /gene_synonym="A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP;
                     ERAAP1; PILS-AP; PILSAP"
                     /note="hexamer: AATAAA"
     polyA_site      4841
                     /gene="ERAP1"
                     /gene_synonym="A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP;
                     ERAAP1; PILS-AP; PILSAP"
                     /note="major polyA site"
ORIGIN      
        1 actttcactt tcggtcctgg gggagctagg ccggcggcag tggtggtggc ggcggcgcaa
       61 gggtgagggc ggccccagaa ccccaggtag gtagagcaag aagatggtgt ttctgcccct
      121 caaatggtcc cttgcaacca tgtcatttct actttcctca ctgttggctc tcttaactgt
      181 gtccactcct tcatggtgtc agagcactga agcatctcca aaacgtagtg atgggacacc
      241 atttccttgg aataaaatac gacttcctga gtacgtcatc ccagttcatt atgatctctt
      301 gatccatgca aaccttacca cgctgacctt ctggggaacc acgaaagtag aaatcacagc
      361 cagtcagccc accagcacca tcatcctgca tagtcaccac ctgcagatat ctagggccac
      421 cctcaggaag ggagctggag agaggctatc ggaagaaccc ctgcaggtcc tggaacaccc
      481 ccgtcaggag caaattgcac tgctggctcc cgagcccctc cttgtcgggc tcccgtacac
      541 agttgtcatt cactatgctg gcaatctttc ggagactttc cacggatttt acaaaagcac
      601 ctacagaacc aaggaagggg aactgaggat actagcatca acacaatttg aacccactgc
      661 agctagaatg gcctttccct gctttgatga acctgccttc aaagcaagtt tctcaatcaa
      721 aattagaaga gagccaaggc acctagccat ctccaatatg ccattggtga aatctgtgac
      781 tgttgctgaa ggactcatag aagaccattt tgatgtcact gtgaagatga gcacctatct
      841 ggtggccttc atcatttcag attttgagtc tgtcagcaag ataaccaaga gtggagtcaa
      901 ggtttctgtt tatgctgtgc cagacaagat aaatcaagca gattatgcac tggatgctgc
      961 ggtgactctt ctagaatttt atgaggatta tttcagcata ccgtatcccc tacccaaaca
     1021 agatcttgct gctattcccg actttcagtc tggtgctatg gaaaactggg gactgacaac
     1081 atatagagaa tctgctctgt tgtttgatgc agaaaagtct tctgcatcaa gtaagcttgg
     1141 catcacaatg actgtggccc atgaactggc tcaccagtgg tttgggaacc tggtcactat
     1201 ggaatggtgg aatgatcttt ggctaaatga aggatttgcc aaatttatgg agtttgtgtc
     1261 tgtcagtgtg acccatcctg aactgaaagt tggagattat ttctttggca aatgttttga
     1321 cgcaatggag gtagatgctt taaattcctc acaccctgtg tctacacctg tggaaaatcc
     1381 tgctcagatc cgggagatgt ttgatgatgt ttcttatgat aagggagctt gtattctgaa
     1441 tatgctaagg gagtatctta gtgctgacgc atttaaaagt ggtattgtac agtatctcca
     1501 gaagcatagc tataaaaata caaaaaacga ggacctgtgg gatagtatgg caagtatttg
     1561 ccctacagat ggtgtaaaag ggatggatgg cttttgctct agaagtcaac attcatcttc
     1621 atcctcacat tggcatcagg aaggggtgga tgtgaaaacc atgatgaaca cttggacact
     1681 gcagaagggt tttcccctaa taaccatcac agtgaggggg aggaatgtac acatgaagca
     1741 agagcactac atgaagggct ctgacggcgc cccggacact gggtacctgt ggcatgttcc
     1801 attgacattc atcaccagca aatccgacat ggtccatcga tttttgctaa aaacaaaaac
     1861 agatgtgctc atcctcccag aagaggtgga atggatcaaa tttaatgtgg gcatgaatgg
     1921 ctattacatt gtgcattacg aggatgatgg atgggactct ttgactggcc ttttaaaagg
     1981 aacacacaca gcagtcagca gtaatgatcg ggcgagtctc attaacaatg catttcagct
     2041 cgtcagcatt gggaagctgt ccattgaaaa ggccttggat ttatccctgt acttgaaaca
     2101 tgaaactgaa attatgcccg tgtttcaagg tttgaatgag ctgattccta tgtataagtt
     2161 aatggagaaa agagatatga atgaagtgga aactcaattc aaggccttcc tcatcaggct
     2221 gctaagggac ctcattgata agcagacatg gacagacgag ggctcagtct cagagcgaat
     2281 gctgcggagt caactactac tcctcgcctg tgtgcacaac tatcagccgt gcgtacagag
     2341 ggcagaaggc tatttcagaa agtggaagga atccaatgga aacttgagcc tgcctgtcga
     2401 cgtgaccttg gcagtgtttg ctgtgggggc ccagagcaca gaaggctggg attttcttta
     2461 tagtaaatat cagttttctt tgtccagtac tgagaaaagc caaattgaat ttgccctctg
     2521 cagaacccaa aataaggaaa agcttcaatg gctactagat gaaagcttta agggagataa
     2581 aataaaaact caggagtttc cacaaattct tacactcatt ggcaggaacc cagtaggata
     2641 cccactggcc tggcaatttc tgaggaaaaa ctggaacaaa cttgtacaaa agtttgaact
     2701 tggctcatct tccatagccc acatggtaat gggtacaaca aatcaattct ccacaagaac
     2761 acggcttgaa gaggtaaaag gattcttcag ctctttgaaa gaaaatggtt ctcagctccg
     2821 ttgtgtccaa cagacaattg aaaccattga agaaaacatc ggttggatgg ataagaattt
     2881 tgataaaatc agagtgtggc tgcaaagtga aaagcttgaa cgtatgtaaa aattcctccc
     2941 ttgccaggtt cctgttatct ctaatcacca acattttgtt gagtgtattt tcaaactaga
     3001 gatggctgtt ttggctccaa ctggagatac ttttttccct tcaactcatt ttttgactat
     3061 ccctgtgaaa agaatagctg ttagtttttc atgaatgggc tatcgctacc atgtgttttg
     3121 ttcatcacag gtgttgccct gcaacgtaaa cccaagtgtt gggttccctg ccacagaaga
     3181 ataaagtacc ttattcttct cattttatag tttatgctta agcacccgtg tccaaaaccc
     3241 tgtaccccat gtttatcatt cataaactgt ttcatcagtc tcctcgaaag actctgaata
     3301 gtcgactact gaacaatgaa cacctggatc tgagactaag ccggacgatg actgggttaa
     3361 agctctcccg gctcacccct ccagacccgc tgcccatccc tcttccttgc tccatgccca
     3421 ggggctgact tgtaaaggcc aagtcatcaa gctttcttgc cctttggatg ttggtcagtg
     3481 gggagccgga gagctggagc tggggtcgga ggaggtagta ggtggaggtg ttcttccctg
     3541 attcccttgc gggatgcctc gggctggcct cccctgaggg tcttagctcc gagaggggac
     3601 cctcttttcc acacagcctt ctccacctct ggattttggt aactgctccc tcctcatccc
     3661 ttcaggatta gtggcctcag tgggagtctg gcttttacta gtcctggcgg acttgtggtt
     3721 tctacataat gtgctcgcac ttttgcaaaa aatcttttta tagaaccctc ctcagataat
     3781 tctgagtgag tgtcatctat ttccctgact ggtacagtat ctcttctgaa aaagcagagt
     3841 gcattcaagt ctgtaggaaa acccttttct tagggaggtg attttttttc tctctctgct
     3901 tcttatttgg cctactttac aatttctaac taactagtta ttggcattta ctgacagtaa
     3961 attattgcag tcaccaataa atgatagtac attgtgaaac aaaatatttg ctcatattag
     4021 caaataggac attctttggc tttgaagtct ttctttcttt tgtgaagact tcacacacgg
     4081 ttgcttcagc acacagttgc tgctcaggtt ttatgtatag atgataataa tagaaagcac
     4141 agtttactaa catggtaaac caacggagtt caagtcaagt cagttaatac cctaagaatt
     4201 agattttatt tcttattctg aaaacttgct acacagggac ttatctaacc catagtgtgc
     4261 tctgttgctg acttgattca agttgcagcg tgttttgcgc tgactctaag gtgcggaaat
     4321 cctcacacct ggcaaaggag aattcaaact gaactttttg aatataaggc aaaaacttca
     4381 agataaggga atatgattga tgattggtac gaaaaatgtc aaaatgtgtt cccctaatac
     4441 acgacaaaat agagtgactt ctggacataa atctgccatt tattaaacca ttcactacaa
     4501 caaataaata ggtataaaag tggaattgga atttttatac ttatttgttg tagtgaatgg
     4561 tttaataaaa atagaaatca ctggtaattt ccaccccaaa ctaaactatt tcccttcttt
     4621 taaaaaaata cacaaccaag attttaatgt aaaatatttt gctttaattg tattttatgc
     4681 cttgattaat gaaacatgga aatattgatt ttcagttttg gtcacctgag gaacctatct
     4741 ttgtttgctt ttggaaaagc ccattttcta aacagataca atattgccac aacaatgtgc
     4801 agaaaccttt ttgataataa aaaattgttc tttgcctcta a
//
