LOCUS       NM_033255               3106 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens epithelial stromal interaction 1 (EPSTI1), transcript
            variant 2, mRNA.
ACCESSION   NM_033255
VERSION     NM_033255.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3106)
  AUTHORS   Bei,Y.R., Zhang,S.C., Song,Y., Tang,M.L., Zhang,K.L., Jiang,M.,
            He,R.C., Wu,S.G., Liu,X.H., Wu,L.M., Dai,X.Y. and Hu,Y.W.
  TITLE     EPSTI1 promotes monocyte adhesion to endothelial cells in vitro via
            upregulating VCAM-1 and ICAM-1 expression
  JOURNAL   Acta Pharmacol Sin 44 (1), 71-80 (2023)
   PUBMED   35778487
  REMARK    GeneRIF: EPSTI1 promotes monocyte adhesion to endothelial cells in
            vitro via upregulating VCAM-1 and ICAM-1 expression.
REFERENCE   2  (bases 1 to 3106)
  AUTHORS   Wang,X., Cheng,W., Zeng,X., Dou,X., Zhou,Z. and Pei,Q.
  TITLE     EPSTI1 as an immune biomarker predicts the prognosis of patients
            with stage III colon cancer
  JOURNAL   Front Immunol 13, 987394 (2022)
   PUBMED   36330510
  REMARK    GeneRIF: EPSTI1 as an immune biomarker predicts the prognosis of
            patients with stage III colon cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3106)
  AUTHORS   Kari,A., M,Z., Aili,Z., Adili,A., Hairula,N. and Abuduhaer,A.
  TITLE     Knockdown of EPSTI1 alleviates lipopolysaccharide-induced
            inflammatory injury through regulation of NF-kappaB signaling in a
            cellular pneumonia model
  JOURNAL   Allergol Immunopathol (Madr) 50 (3), 106-112 (2022)
   PUBMED   35527663
  REMARK    GeneRIF: Knockdown of EPSTI1 alleviates lipopolysaccharide-induced
            inflammatory injury through regulation of NF-kappaB signaling in a
            cellular pneumonia model.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3106)
  AUTHORS   Fan,M., Arai,M., Tawada,A., Chiba,T., Fukushima,R., Uzawa,K.,
            Shiiba,M., Kato,N., Tanzawa,H. and Takiguchi,Y.
  TITLE     Contrasting functions of the epithelial-stromal interaction 1 gene,
            in human oral and lung squamous cell cancers
  JOURNAL   Oncol Rep 47 (1) (2022)
   PUBMED   34738627
  REMARK    GeneRIF: Contrasting functions of the epithelialstromal interaction
            1 gene, in human oral and lung squamous cell cancers.
REFERENCE   5  (bases 1 to 3106)
  AUTHORS   Chen,B., Wei,W., Huang,X., Xie,X., Kong,Y., Dai,D., Yang,L.,
            Wang,J., Tang,H. and Xie,X.
  TITLE     circEPSTI1 as a Prognostic Marker and Mediator of Triple-Negative
            Breast Cancer Progression
  JOURNAL   Theranostics 8 (14), 4003-4015 (2018)
   PUBMED   30083277
  REMARK    GeneRIF: circEPSTI1,a significantly upregulated circRNA, which is
            derived from the EPSTI1 (epithelial stromal interaction 1) gene
            locus, is an independent prognostic marker for triple-negative
            breast cancer patient survival.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3106)
  AUTHORS   Li,T., Lu,H., Shen,C., Lahiri,S.K., Wason,M.S., Mukherjee,D., Yu,L.
            and Zhao,J.
  TITLE     Identification of epithelial stromal interaction 1 as a novel
            effector downstream of Kruppel-like factor 8 in breast cancer
            invasion and metastasis
  JOURNAL   Oncogene 33 (39), 4746-4755 (2014)
   PUBMED   24096480
  REMARK    GeneRIF: A novel KLF8 to EPSTI1 to VCP to NF-kappaB signaling
            mechanism potentially critical for breast cancer invasion and
            metastasis.
REFERENCE   7  (bases 1 to 3106)
  AUTHORS   de Neergaard,M., Kim,J., Villadsen,R., Fridriksdottir,A.J.,
            Rank,F., Timmermans-Wielenga,V., Langerod,A., Borresen-Dale,A.L.,
            Petersen,O.W. and Ronnov-Jessen,L.
  TITLE     Epithelial-stromal interaction 1 (EPSTI1) substitutes for
            peritumoral fibroblasts in the tumor microenvironment
  JOURNAL   Am J Pathol 176 (3), 1229-1240 (2010)
   PUBMED   20133812
  REMARK    GeneRIF: These observations implicate EPSTI1 as a hitherto
            unappreciated regulator of tumor cell properties.
REFERENCE   8  (bases 1 to 3106)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   9  (bases 1 to 3106)
  AUTHORS   Ishii,T., Onda,H., Tanigawa,A., Ohshima,S., Fujiwara,H., Mima,T.,
            Katada,Y., Deguchi,H., Suemura,M., Miyake,T., Miyatake,K.,
            Kawase,I., Zhao,H., Tomiyama,Y., Saeki,Y. and Nojima,H.
  TITLE     Isolation and expression profiling of genes upregulated in the
            peripheral blood cells of systemic lupus erythematosus patients
  JOURNAL   DNA Res 12 (6), 429-439 (2005)
   PUBMED   16769699
REFERENCE   10 (bases 1 to 3106)
  AUTHORS   Nielsen,H.L., Ronnov-Jessen,L., Villadsen,R. and Petersen,O.W.
  TITLE     Identification of EPSTI1, a novel gene induced by
            epithelial-stromal interaction in human breast cancer
  JOURNAL   Genomics 79 (5), 703-710 (2002)
   PUBMED   11991720
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL445217.3 and AL137878.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_033255.4.
            
            Summary: The protein encoded by this gene has been shown to promote
            tumor invasion and metastasis in some invasive cancer cells when
            overexpressed. Expression of this gene has been shown to be
            upregulated by direct binding of the Kruppel like factor 8 protein
            to promoter sequences. The translated protein interacts with the
            amino terminal region of the valosin containing protein gene
            product, resulting in the nuclear translocation of the nuclear
            factor kappa B subunit 1 gene product, and activation of target
            genes. Overexpression of this gene has been observed in some breast
            cancers and in some individuals with systemic lupus erythematosus
            (SLE). [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (2) lacks two alternate coding
            exons, which results in a frameshift, compared to variant 1. The
            encoded isoform (2) is shorter and has a distinct C-terminus,
            compared to isoform 1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.179378.1, AK292461.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313624.12/ ENSP00000318643.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               AL445217.3         36834-37097         c
            265-323             AL445217.3         15468-15526         c
            324-407             AL445217.3         13950-14033         c
            408-481             AL445217.3         8922-8995           c
            482-565             AL445217.3         8111-8194           c
            566-639             AL137878.11        86062-86135         c
            640-733             AL137878.11        58450-58543         c
            734-817             AL137878.11        49655-49738         c
            818-891             AL137878.11        32424-32497         c
            892-991             AL137878.11        27123-27222         c
            992-3106            AL137878.11        18502-20616         c
FEATURES             Location/Qualifiers
     source          1..3106
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.11"
     gene            1..3106
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /note="epithelial stromal interaction 1"
                     /db_xref="GeneID:94240"
                     /db_xref="HGNC:HGNC:16465"
                     /db_xref="MIM:607441"
     exon            1..264
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1000
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     epithelial-stromal interaction protein 1; epithelial
                     stromal interaction 1 (breast)"
                     /codon_start=1
                     /product="epithelial-stromal interaction protein 1 isoform
                     2"
                     /protein_id="NP_150280.1"
                     /db_xref="CCDS:CCDS9387.1"
                     /db_xref="GeneID:94240"
                     /db_xref="HGNC:HGNC:16465"
                     /db_xref="MIM:607441"
                     /translation="MNTRNRVVNSGLGASPASRPTRDPQDPSGRQGELSPVEDQREGL
                     EAAPKGPSRESVVHAGQRRTSAYTLIAPNINRRNEIQRIAEQELANLEKWKEQNRAKP
                     VHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQ
                     REKSNKLEEKKRLQENLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSST
                     WARSWAYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRRVNNA
                     FLDRLQGKSQPGGLEQSGGCWNMNSGNSWGI"
     exon            265..323
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /inference="alignment:Splign:2.1.0"
     exon            324..407
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /inference="alignment:Splign:2.1.0"
     exon            408..481
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /inference="alignment:Splign:2.1.0"
     exon            482..565
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /inference="alignment:Splign:2.1.0"
     exon            566..639
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..733
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..817
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..891
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /inference="alignment:Splign:2.1.0"
     exon            892..991
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /inference="alignment:Splign:2.1.0"
     exon            992..3106
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1485..1490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /note="hexamer: AATAAA"
     polyA_site      1508
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /note="major polyA site"
     regulatory      1985..1990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /note="hexamer: AATAAA"
     polyA_site      2005
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
     regulatory      3073..3078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /note="hexamer: AATAAA"
     polyA_site      3106
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
ORIGIN      
        1 atcttgagac tcgctaagcg tcccagccgc atccctcccg cagcgacggc ggcccgggac
       61 ccgcgggctg tgaaccatga acacccgcaa tagagtggtg aactccgggc tcggcgcctc
      121 ccctgcctcc cgcccgaccc gggatcccca ggacccttct gggcggcaag gggagctgag
      181 ccccgtggaa gaccagagag agggtttgga ggcagcccct aagggccctt cgcgggagag
      241 cgtcgtgcac gcgggccaga ggcgcacaag tgcatacacc ttgatagcac caaatataaa
      301 ccggagaaat gagatacaaa gaattgcgga gcaggagctg gccaacctgg agaagtggaa
      361 ggagcagaac agagctaaac cggttcacct ggtgcccaga cggctaggtg gaagccagtc
      421 agaaactgaa gtcagacaga aacaacaact ccagctgatg caatctaaat acaagcaaaa
      481 gctaaaaaga gaagaatctg taagaatcaa gaaggaagct gaagaagctg aactccaaaa
      541 aatgaaggca attcagagag agaagagcaa taaactggag gagaaaaaaa gacttcaaga
      601 aaaccttaga agagaagcat ttagagagca tcagcaatac aaaaccgctg agttcttgag
      661 caaactgaac acagaatcgc cagacagaag tgcctgtcaa agtgctgttt gtggcccaca
      721 atcctcaaca tgggccagaa gctgggctta cagagattct ctaaaggcag aagaaaacag
      781 aaaattgcaa aagatgaagg atgaacaaca tcaaaagagt gaattactgg aactgaaacg
      841 gcagcagcaa gagcaagaaa gagccaaaat ccaccagact gaacacagga gggtaaataa
      901 tgcttttctg gaccgactcc aaggcaaaag tcaaccaggt ggcctcgagc aatctggagg
      961 ctgttggaat atgaatagcg gtaacagctg gggtatatga gaaaatattg actcctatct
     1021 ggccttcatc aactgacctc gaaaagcctc atgagatgct ttttcttaat gtgattttgt
     1081 tcagcctcac tgtttttacc ttaatttcaa ctgcccacac acttgaccgt gcagtcagga
     1141 gtgactggct tctccttgtc ctcatttatg catgtttgga ggagctgatt cctgaactca
     1201 tatttaatct ctactgccag ggaaatgcta cattattttt ctaattggaa gtataattag
     1261 agtgatgttg gtagggtaga aaaagaggga gtcacttgat gctttcaggt taatcagagc
     1321 tatgggtgct acaggcttgt ctttctaagt gacatattct tatctaattc tcagatcagg
     1381 ttttgaaagc tttgggggtc tttttagatt ttaatcccta ctttctttat ggtacaaata
     1441 tgtacaaaag aaaaaggtct tatattcttt tacacaaatt tataaataaa ttttgaactc
     1501 cttctgtata aatgggtcat ttttattttt aatgaaaagt tattggggtt ttctctcttg
     1561 aagggtctca ttttaattcc cttttccagg ccgtatagat caaatatagt actgtcatta
     1621 ctgttggctc ttgttttggt cttgacttac taatagtgtt accctgattt tcagaggggg
     1681 acagtttatc tccagaaagg ccaatgtttg tatacacatc agctagacac aaatatagac
     1741 atcatatgta gtttgtacat gtttcagaaa cttgtttttt ctttgctctg tgtaacctat
     1801 ttcctattgc tagttcagtt ggctttctta ttcacttctg tgaccctgaa ccagttctca
     1861 gaccctagag tgtaagagca ttgattttct acgctgtgta atctagctca atccctctgt
     1921 cccctccgcc tcaccgtccc ccagccacca cattgtatag caaaagcatt acattcaatc
     1981 ctagaataaa ggtaaataca acaaatcatc tttgcagctg gacaactaat aatactttgc
     2041 agcattaaga gatcttctgt gttaccagtc actctgttga aatgaacttt ccgaatctct
     2101 ttattcagga aaacatgggg ttttgaaatt cttgggccaa gagacataac tgaggggttc
     2161 gcagagctag gcaagggtgc actaggaaag ggccacattg gtgggtgggg ggtaacagag
     2221 aacagatggt gtcaggaagt ttctctggag taaataatgt ggatattctt ggtttccctc
     2281 tcctccgcca gctgaagctg tgttagtgct gttgacacta atataaaatg tttggtccat
     2341 ttgaaatcct tgtcattgcc ttatatgggg gaaactcaat cccccagcct gtgttggaaa
     2401 tatcaccaaa ctgattgtaa atgtgcggct gtagcagaca ttttagtgtg gtggtgtgca
     2461 gccatttcgg ccctacacct gccagcctgg ctaccttaca gttgtgttcc gatttttgcg
     2521 tctatgcttg gtgtgcctca cttgctgcat tttccagcat gcaaccagga gttgacgtag
     2581 gaaaaaggga tgctttctta ctttggaagc tctcagggaa gttggtgtca atttctcctc
     2641 cactgcctgg cctaccctgc actcccaaag attttgtgca gatgggtagt tccatttttt
     2701 aaaaattgtg cagatatgga aaattgtgac ttacttcatg accagaacta tctagaatat
     2761 gtgtgggggt ataaacatct tgcttaacca aatatctatg taggcagagg taaccaggag
     2821 agaagcaaga cttgctgcct aaaggagccc accattttac ttttcacatt taatctgcca
     2881 cgttgaatca attggaataa aacctgactc gcaggtgact ggacaggaaa tcccaaagtt
     2941 ccaccatttc tatgcttaat tttaatgtcc ccccgctttt ttttttgtag aaaataaaaa
     3001 caagaaaatc gttccaatgt aagatgtttg ttatagaaac tttaggcaat acaggtgtgt
     3061 aataaaatgt ttaataaact tctaaacact tttgtatttg gattta
//
