LOCUS       NM_001258374            3216 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens epidermal growth factor receptor pathway substrate 15
            like 1 (EPS15L1), transcript variant 1, mRNA.
ACCESSION   NM_001258374
VERSION     NM_001258374.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3216)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3216)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 3216)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3216)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3216)
  AUTHORS   Muller,P.M., Rademacher,J., Bagshaw,R.D., Wortmann,C., Barth,C.,
            van Unen,J., Alp,K.M., Giudice,G., Eccles,R.L., Heinrich,L.E.,
            Pascual-Vargas,P., Sanchez-Castro,M., Brandenburg,L., Mbamalu,G.,
            Tucholska,M., Spatt,L., Czajkowski,M.T., Welke,R.W., Zhang,S.,
            Nguyen,V., Rrustemi,T., Trnka,P., Freitag,K., Larsen,B., Popp,O.,
            Mertins,P., Gingras,A.C., Roth,F.P., Colwill,K., Bakal,C.,
            Pertz,O., Pawson,T., Petsalaki,E. and Rocks,O.
  TITLE     Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals
            spatially organized RAC1 signalling from integrin adhesions
  JOURNAL   Nat Cell Biol 22 (4), 498-511 (2020)
   PUBMED   32203420
REFERENCE   6  (bases 1 to 3216)
  AUTHORS   Ueki,N., Oda,T., Kondo,M., Yano,K., Noguchi,T. and Muramatsu,M.
  TITLE     Selection system for genes encoding nuclear-targeted proteins
  JOURNAL   Nat Biotechnol 16 (13), 1338-1342 (1998)
   PUBMED   9853615
REFERENCE   7  (bases 1 to 3216)
  AUTHORS   Chen,H., Fre,S., Slepnev,V.I., Capua,M.R., Takei,K., Butler,M.H.,
            Di Fiore,P.P. and De Camilli,P.
  TITLE     Epsin is an EH-domain-binding protein implicated in
            clathrin-mediated endocytosis
  JOURNAL   Nature 394 (6695), 793-797 (1998)
   PUBMED   9723620
REFERENCE   8  (bases 1 to 3216)
  AUTHORS   Coda,L., Salcini,A.E., Confalonieri,S., Pelicci,G., Sorkina,T.,
            Sorkin,A., Pelicci,P.G. and Di Fiore,P.P.
  TITLE     Eps15R is a tyrosine kinase substrate with characteristics of a
            docking protein possibly involved in coated pits-mediated
            internalization
  JOURNAL   J Biol Chem 273 (5), 3003-3012 (1998)
   PUBMED   9446614
REFERENCE   9  (bases 1 to 3216)
  AUTHORS   Carbone,R., Fre,S., Iannolo,G., Belleudi,F., Mancini,P.,
            Pelicci,P.G., Torrisi,M.R. and Di Fiore,P.P.
  TITLE     eps15 and eps15R are essential components of the endocytic pathway
  JOURNAL   Cancer Res 57 (24), 5498-5504 (1997)
   PUBMED   9407958
REFERENCE   10 (bases 1 to 3216)
  AUTHORS   Salcini,A.E., Confalonieri,S., Doria,M., Santolini,E., Tassi,E.,
            Minenkova,O., Cesareni,G., Pelicci,P.G. and Di Fiore,P.P.
  TITLE     Binding specificity and in vivo targets of the EH domain, a novel
            protein-protein interaction module
  JOURNAL   Genes Dev 11 (17), 2239-2249 (1997)
   PUBMED   9303539
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008764.9 and AC020917.4.
            
            On Aug 31, 2019 this sequence version replaced NM_001258374.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067114.1, AK296473.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000455140.7/ ENSP00000393313.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AC008764.9         19155-19212         c
            59-100              AC020917.4         129025-129066       c
            101-190             AC020917.4         128739-128828       c
            191-238             AC020917.4         127709-127756       c
            239-334             AC020917.4         124617-124712       c
            335-397             AC020917.4         123784-123846       c
            398-523             AC020917.4         121212-121337       c
            524-583             AC020917.4         115549-115608       c
            584-817             AC020917.4         111930-112163       c
            818-975             AC020917.4         108166-108323       c
            976-1132            AC020917.4         104795-104951       c
            1133-1218           AC020917.4         104399-104484       c
            1219-1291           AC020917.4         100620-100692       c
            1292-1453           AC020917.4         91435-91596         c
            1454-1651           AC020917.4         90580-90777         c
            1652-1816           AC020917.4         89168-89332         c
            1817-1940           AC020917.4         82191-82314         c
            1941-1991           AC020917.4         80798-80848         c
            1992-2128           AC020917.4         79151-79287         c
            2129-2189           AC020917.4         73018-73078         c
            2190-2272           AC020917.4         71976-72058         c
            2273-2405           AC020917.4         63969-64101         c
            2406-2611           AC020917.4         48626-48831         c
            2612-3216           AC020917.4         42094-42698         c
FEATURES             Location/Qualifiers
     source          1..3216
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..3216
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /note="epidermal growth factor receptor pathway substrate
                     15 like 1"
                     /db_xref="GeneID:58513"
                     /db_xref="HGNC:HGNC:24634"
                     /db_xref="MIM:616826"
     exon            1..58
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..2758
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /note="isoform 1 is encoded by transcript variant 1;
                     epidermal growth factor receptor substrate EPS15R;
                     eps15-related protein"
                     /codon_start=1
                     /product="epidermal growth factor receptor substrate
                     15-like 1 isoform 1"
                     /protein_id="NP_001245303.1"
                     /db_xref="CCDS:CCDS58654.1"
                     /db_xref="GeneID:58513"
                     /db_xref="HGNC:HGNC:24634"
                     /db_xref="MIM:616826"
                     /translation="MAAPLIPLSQQIPTGNSLYESYYKQVDPAYTGRVGASEAALFLK
                     KSGLSDIILGKIWDLADPEGKGFLDKQGFYVALRLVACAQSGHEVTLSNLNLSMPPPK
                     FHDTSSPLMVTPPSAEAHWAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLP
                     LDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSALPPSLIPPSKRKKTV
                     FPGAVPVLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSLKQTQPTVNWVVPVADK
                     MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFA
                     LAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPGPDSSGSLGSGEFTGVKELDDISQE
                     IAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLD
                     EMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRL
                     QQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQ
                     VLDGAHGASLTDLANLSEGVSLAERGSFGAMDDPFKNKALLFSNNTQELHPDPFQTED
                     PFKSDPFKGADPFKGDPFQNDPFAEQQTTSTDPFGGDPFKESDPFRGSATDDFFKKQT
                     KNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSVSSKGSDPFGTLDPFGSGSFNSAEG
                     FADFSQMSKPPPSGPFTSSLGGAGFSDDPFKSKQDTPALPPKKPAPPRPKPPSGKSTP
                     VSQLGSADFPEAPDPFQPLGADSGDPFQSKKGFGDPFSGKDPFVPSSAAKPSKASASG
                     FADFTSFGNEEQQLAWAKRESEKAEQERLARLRRQEQEDLELAIALSKADMPAA"
     exon            59..100
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /inference="alignment:Splign:2.1.0"
     exon            101..190
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /inference="alignment:Splign:2.1.0"
     exon            191..238
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /inference="alignment:Splign:2.1.0"
     exon            239..334
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /inference="alignment:Splign:2.1.0"
     exon            335..397
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /inference="alignment:Splign:2.1.0"
     exon            398..523
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /inference="alignment:Splign:2.1.0"
     exon            524..583
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /inference="alignment:Splign:2.1.0"
     exon            584..817
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /inference="alignment:Splign:2.1.0"
     exon            818..975
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1132
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1218
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1291
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1453
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1651
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1816
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1940
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..1991
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2128
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2189
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2272
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2405
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2611
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..3216
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3195..3200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /note="hexamer: TATAAA"
     polyA_site      3216
                     /gene="EPS15L1"
                     /gene_synonym="EPS15R"
                     /note="major polyA site"
ORIGIN      
        1 gctcggagcc cgagtccgcg ggaagatggc ggcgccgctc atccccctct cccagcagat
       61 tcccactgga aattcgttgt atgaatctta ttacaagcag gtcgatccgg catacacagg
      121 gagggtgggg gcgagtgaag ctgcgctttt tctaaagaag tctggcctct cggacattat
      181 ccttgggaag atatgggact tggccgatcc agaaggtaaa gggttcttgg acaaacaggg
      241 tttctatgtt gcactgagac tggtggcctg tgcacagagt ggccatgaag ttaccttgag
      301 caatctgaat ttgagcatgc caccgcctaa atttcacgac accagcagcc ctctgatggt
      361 cacaccgccc tctgcagagg cccactgggc tgtgagggtg gaagaaaagg ccaaatttga
      421 tgggattttt gaaagcctct tgcccatcaa tggtttgctc tctggagaca aagtcaagcc
      481 agtcctcatg aactcaaagc tgcctcttga tgtcctgggc agggtctggg acctcagtga
      541 cattgacaag gatgggcact tggatcgaga tgagttcgct gtggccatgc acttggtgta
      601 ccgagccctg gagaaggagc ccgtgccctc cgccctgccc ccgtccctca tcccaccctc
      661 caagagaaag aagactgtgt tccctggcgc cgtccccgtc ctgcctgcca gccccccacc
      721 aaaagacagc ctccgctcca cgccgtccca cggcagcgtc agcagcctca acagcacagg
      781 gagcctgtcc cccaagcaca gcctcaagca aacacagcca acagtgaact gggtggtgcc
      841 cgtggcagac aagatgcgat ttgatgagat attcctgaag accgacctgg acctggatgg
      901 ctacgtgagt ggccaggagg tgaaggagat cttcatgcac tcgggcctca cccagaacct
      961 tctagcacac atatgggccc tggccgatac gaggcaaacg gggaagttaa gcaaagacca
     1021 attcgcgtta gctatgtatt tcattcagca gaaggtcagt aaaggcatcg accctcctca
     1081 agtcctctcg ccggacatgg tcccgccttc ggagagaggc acgcccggcc cggacagttc
     1141 aggctctctc ggctccgggg agtttactgg cgtgaaggag cttgatgaca tcagtcaaga
     1201 gattgcccag ttacaaagag agaaatattc actggaacaa gacattcgag aaaaggaaga
     1261 ggcaatcaga cagaaaacca gcgaggtgca ggaattacaa aatgacctag accgggaaac
     1321 aagcagtttg caggagctcg aggctcagaa acaggatgct caagaccgcc tggacgagat
     1381 ggaccagcag aaggccaagc tccgagacat gctgagcgac gtccggcaga agtgccagga
     1441 tgagactcag atgatctcat cactgaaaac gcaaatccaa tctcaggaat ctgacttaaa
     1501 gtcccaggaa gacgatctga accgagccaa gtcggagctg aaccgattgc agcaggagga
     1561 aacccagctg gagcagagca ttcaggctgg gcgagtccag ctggaaacca tcatcaagtc
     1621 cctgaagtca acgcaagacg aaatcaacca ggcaaggagc aaactttccc agctgcatga
     1681 aagccgccag gaggcccaca ggagcctgga gcagtatgac caggtgctcg atggagccca
     1741 tggtgccagc ctgaccgacc tggccaacct gagcgaaggc gtctccctgg cagagagggg
     1801 cagttttgga gccatggatg atcctttcaa aaataaagcc ttgttattta gcaacaacac
     1861 gcaagagttg catccggatc ctttccagac agaagacccc ttcaaatctg acccatttaa
     1921 aggagctgac cccttcaaag gcgacccgtt ccagaatgac ccctttgcag aacagcagac
     1981 aacttcaaca gatccatttg gaggggaccc tttcaaagaa agtgacccat tccgtggctc
     2041 tgccactgac gacttcttca agaaacagac aaagaatgac ccatttacct cggatccatt
     2101 cacgaaaaac ccttccttac cttcgaagct cgaccccttt gaatccagtg atcccttttc
     2161 atcctccagt gtctcctcaa aaggatcaga tccctttgga accttagatc ccttcggaag
     2221 tgggtccttc aatagtgctg aaggctttgc cgacttcagc cagatgtcca agcccccacc
     2281 ttctggccct ttcacctcct ccttgggagg ggcaggattc tcagatgacc cctttaaaag
     2341 taaacaggac actcctgctc tgcctccgaa gaaacctgct cctccacggc ctaaaccgcc
     2401 cagcggtaaa agtacacctg taagccagct tggttccgca gactttcccg aggcccccga
     2461 tccattccag ccactcgggg ctgacagcgg cgacccgttc caaagtaaaa aggggtttgg
     2521 ggacccgttt agtggaaaag acccatttgt cccctcctct gcagctaaac cttctaaggc
     2581 ctctgcctcg ggctttgcag acttcacctc ttttggcaat gaggagcagc agctggcgtg
     2641 ggccaagcgg gagagcgaga aggcggaaca ggagaggctg gcgcggctgc ggcggcagga
     2701 gcaggaggac ctggaactgg ccatcgcgct cagcaaggct gacatgcctg ccgcctaggc
     2761 gagggccgtg tgtaggcggg acagggcacg ggcgggttcc agagaggggg cagtgcagat
     2821 gtctatatat acacacacac accgtcgcca ccgtactcca aggaccggga ctcgggggct
     2881 tgttcagggt gagcagactc ggctgcaaga cctggaaagg tcacatctcc tggggaagcc
     2941 cttacagagg ccttggccac cacttctgca ggtccgtctc tccactgtgc catccccccc
     3001 ggggctgact gcctcccgct cttcctctgg ggacgaacac acagcggtca gtcgaggaga
     3061 ggaagcaccc agggcttccc cgcctcctcc ctactcatag ctgcagacat ccccacccgc
     3121 cctcccacgc atcagtcaga cactccccca gtggtgtatg cactcgttgt ataaaatgaa
     3181 gtttgaatga ttaatataaa atattttaat acaaaa
//
