LOCUS       XM_017000616            5070 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens epidermal growth factor receptor pathway
            substrate 15 (EPS15), transcript variant X1, mRNA.
ACCESSION   XM_017000616
VERSION     XM_017000616.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017000616.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5070
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..5070
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /note="epidermal growth factor receptor pathway substrate
                     15; Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 2 mRNAs, 48 ESTs, 1873 long SRA reads, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 81 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:2060"
                     /db_xref="HGNC:HGNC:3419"
                     /db_xref="MIM:600051"
     CDS             36..2633
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /codon_start=1
                     /product="epidermal growth factor receptor substrate 15
                     isoform X1"
                     /protein_id="XP_016856105.1"
                     /db_xref="GeneID:2060"
                     /db_xref="HGNC:HGNC:3419"
                     /db_xref="MIM:600051"
                     /translation="MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLK
                     KSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPR
                     FHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKL
                     PVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTV
                     SISGSVRLIPSSASAKESYHSLPSVGILPTKAPLRQWVVSPAEKAKYDEIFLKTDKDM
                     DGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGI
                     DPPHVLTPEMIPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQD
                     LKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLK
                     EVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESG
                     KAQLEPLQQHLQDSQQEISSARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKE
                     EDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFAS
                     DCFFRQSTDPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDSATDPFAS
                     VFGNESFGGGFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPAL
                     PPKIGTPTRPCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDPFTS
                     ATTTTNKEADPSNFANFSAYPSEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAIA
                     LSKSEISEA"
ORIGIN      
        1 gtcttccttc ccctcccttg catgatggaa acaccatggc tgcggcggcc cagctctctc
       61 tgacacagtt atcaagtggg aatcctgtat atgaaaaata ctatagacag gttgatacag
      121 gcaatactgg aagggtgttg gcttctgatg ctgctgcttt cctgaaaaaa tcagggcttc
      181 cagacttgat acttggaaag atttgggatt tagccgacac agatggcaaa ggtatcctga
      241 acaaacaaga attctttgtt gctttgcgtc ttgtggcatg tgcccagaat ggattggaag
      301 tttcactaag tagtttgaac ctggctgttc ctccaccaag atttcatgat accagtagtc
      361 ctttgctaat cagtggaacc tctgcagctg agctcccatg ggctgtaaaa cctgaagata
      421 aggccaaata tgatgcaata tttgatagtt taagcccagt gaatggattt ctgtctggtg
      481 ataaagtgaa accagtgttg ctcaactcta agttacctgt ggatatcctt ggaagagttt
      541 gggagttgag tgatattgac catgatggaa tgcttgacag agatgagttt gcagttgcca
      601 tgtttttggt atactgtgca ctggagaaag aacctgtgcc aatgtccttg cctccagcct
      661 tggtgccacc atctaagaga aaaacggtca gtatatcagg ctctgtgcgg ttgatcccct
      721 cttcagcatc agccaaggaa tcttaccact ccttaccatc tgtaggcatt ttacctacca
      781 aagcaccatt aagacagtgg gttgtatccc ctgcagaaaa agctaaatat gatgaaatct
      841 tcctgaaaac tgataaagat atggacggat ttgtgtctgg attggaggtc cgtgaaatat
      901 tcttgaaaac aggtttacct tctaccttac tagcccatat atggtcatta tgcgacacaa
      961 aggactgtgg gaagctttca aaggatcagt ttgccttggc ttttcactta atcagtcaga
     1021 agttaatcaa gggcattgat cctcctcacg ttcttactcc tgaaatgatt ccaccatcag
     1081 acagggccag tttacaaaag aacatcatag gatcaagtcc tgttgcagat ttctctgcta
     1141 ttaaggaact agatactctt aacaatgaaa tagttgacct acagagggaa aagaataatg
     1201 tggaacagga ccttaaggag aaggaagata ctattaaaca gaggacaagt gaggttcagg
     1261 atcttcaaga tgaagttcaa agggagaata ctaatctgca aaaactacag gcccagaaac
     1321 agcaggtaca ggaactcctt gatgaactgg atgagcagaa agcccagctg gaggagcaac
     1381 tcaaggaagt cagaaagaaa tgtgctgagg aggcccaact gatctcttct ctgaaagctg
     1441 aattaactag tcaggaatcg cagatctcca cttacgaaga agaattggca aaagctagag
     1501 aagagctgag ccgtctacag caagaaacag cagaattgga ggagagtgta gagtcaggga
     1561 aggctcagtt ggaacctctt cagcagcacc tacaagattc acaacaggaa attagttcag
     1621 caagaagtag tcctgaacta ctgccttctg gtgtgactga tgaaaatgag gtgactacag
     1681 ctgttactga aaaagtttgt tctgaactcg acaataatag acattcaaaa gaggaagatc
     1741 catttaatgt agactcaagt tcgctgacag gtccagttgc agatacaaac ttggattttt
     1801 tccagtctga tccttttgtt ggcagtgatc ctttcaagga tgatcctttt ggaaaaatcg
     1861 atccatttgg tggtgatcct ttcaaaggtt cagatccatt tgcatcagac tgtttcttca
     1921 ggcaatctac tgatcctttt gccacttcaa gcactgaccc tttcagtgca gccaacaata
     1981 gcagtattac atcggtagaa acgttgaagc acaatgatcc ttttgctcct ggtggaacag
     2041 ttgttgcagc aagcgattca gccacagacc cctttgcttc tgtttttggg aatgaatcat
     2101 ttggaggtgg atttgctgac ttcagcacat tgtcaaaggt caacaatgaa gatccttttc
     2161 gttcagccac atcgagctct gtcagcaacg tagtgattac aaaaaatgta tttgaggaaa
     2221 catcggtcaa aagtgaagat gaacccccag cactgccacc aaagatcgga actccaacaa
     2281 gaccctgccc tctaccacct gggaaaagat ccatcaacaa attggattct cctgatccct
     2341 ttaaactgaa tgatccattt cagcctttcc caggcaacga tagccccaaa gaaaaagatc
     2401 ctgaaatatt ttgtgatcca ttcacttctg ctactaccac taccaataaa gaggctgatc
     2461 caagcaattt tgccaacttc agtgcttatc cctctgaaga agatatgatc gaatgggcca
     2521 agagggaaag tgagagagag gaagagcaga ggcttgcccg actaaatcag caggaacaag
     2581 aagacttaga actggctatt gcactcagca aatctgagat atcagaagca tgaagaattc
     2641 tcttgttctt tggcaacaat atagtattct tcttcctgaa tactgaaact atttacaatg
     2701 tgtatcaaaa ctacctgtga gcatgggaat acaaaaggtt tgagattcct gtaaatgtga
     2761 caaaatttta ggattttttt tttttcttca ttacagattc gtcttttttt ttttttctta
     2821 taaaagccgt aacccagtca gacaaattca ccttcactta ggcccctgtt ctggtataca
     2881 tttactgtga gcttttgcct gcctgtgcta ttttacttgt aaagctagag cacccaagct
     2941 tctgccttct ggaatataga gaaatagttt caccctgcac taccctgttc tgtagttatt
     3001 ctgatgatag ccagtgaggt tcttaaagtt tgcagtattc tcccctgatt ggaatggttg
     3061 agtgagggta agggaaagaa tatcttattt cttttatgat tggtgcaaat tggctaaagt
     3121 gcatttttaa atttcctcta cttaatttgt ttttcagaga taaggaaaaa tattttgcac
     3181 agatttactc cactatggaa aagggatgct gtaggttgaa ccattatagc ctcagattcg
     3241 atcttttcct aactaaaaat attaaagcct catgtgtgaa ataaattttt aaaaagattt
     3301 atctggattt agagaatttt agatcaacag atacctctca gtgtgtttgc taattaataa
     3361 aaatcagttt cttacaaata aagtttgtaa gaaaatgttc attttaagtg atagatagtg
     3421 gagaaaattt atcacctaaa atatacccat cagtataagg caagcaaaag tcttaacatg
     3481 gcagccattc tgcctttgcc gtggccctgt cctgtttagt tcttagtggg ttaatttttg
     3541 tacttttgca gaagaaactt cagcaagcta gaactggaag gtactttaat ttttcatata
     3601 tatttgtttt ttttttttta atgaaggctc atttacttga aatgtaaaaa ctttcactga
     3661 atacaaatag aaaaagtgat gtgttttata tcatattgct ttttgtccat ctttgtggtt
     3721 tagtttattt actcacttca tgtttttcac ctataaaatt gtcaagctag caaaaaaact
     3781 cttgtttttt taattgggag agaagagacc tgccagatta tcagacctct tcatgttaaa
     3841 agaccatctc ctgtaaaact gacctagtgg acaagctgaa tttgaaatag actgtgaagt
     3901 aagctgtaac ttgtcatttt aattttgttt aacacggtta ctgacttaga tgatgtatta
     3961 aataccaaga taaagaaaaa tgcacctaaa atctaattag aattctctgg gtcaacaagt
     4021 caaggtggta ttgatctgtg ttaatctgag taacttattg cctagcctat aaataaattc
     4081 caaaatatcc aattcatttc ttcttgaaat ggtgcttgtt ttgttttctt tccattacac
     4141 aattagactc ctacagttta aaacaaactt taaaccacta tcttgcactg ctaacttttt
     4201 tctacctttg taaatagaaa catttctgca taaaagtcat acatatgaag caagggctga
     4261 atcataatca caaggcttaa ttttgataaa cgaatccagt gacctaagga ttttctgcaa
     4321 aatttgactg ggagttgtga taggtggtat ttttgtttat tttcttcctc ttactcctta
     4381 ggataaaggt aagttgactt gaacaacttt cttttgcact gggaaaataa gcaaatgttt
     4441 aaatgcttca aaaaaatttt caattaaact caaatattaa atatctataa cttataaaca
     4501 ccaactttca atgtaataaa tgtatcctaa tcttatgtat gtttaactgg attacataga
     4561 tttttatctt ttgttaaaat gtgtataccc cgtggaccaa cataatatta aagtatgtat
     4621 atattatata aatatatatg tatatgtgct cgcttgtgta ggatgaatgt cttagagtcg
     4681 tttgtggtat tttatgttgt tgactctggc tccagggcct gtgcttgaaa aggacagata
     4741 agtattgccc agagctaagt ggcactactt acaaagtttt aaatgtcttc tacatactga
     4801 ttcatgttta tttgagctct ctttatagaa ttttctctta aagtttcaaa cctctaagtt
     4861 gtagcctgta attatgagaa cagtaaactt taagtaataa taaagaatcc catccatata
     4921 tccaatttgc aattgagttt tgcatggttc tctgattatg tccatgctgt gtccaaggag
     4981 gagtaggtac atacaatcag cacagattaa tatatgtaaa gggtttggga cagcacctgg
     5041 tatagaataa ataataaatg taaactatta
//
