LOCUS       NM_001981               5163 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens epidermal growth factor receptor pathway substrate 15
            (EPS15), transcript variant 1, mRNA.
ACCESSION   NM_001981
VERSION     NM_001981.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5163)
  AUTHORS   Wang,Q., Hou,K., Yang,J., Li,H., Li,C., Zhang,Y., Tian,J., Li,C.,
            Guo,B., Jia,S. and Luo,Y.
  TITLE     Modified iPOND revealed the role of mutant p53 in promoting
            helicase function and telomere maintenance
  JOURNAL   Aging (Albany NY) 15 (19), 10767-10784 (2023)
   PUBMED   37827695
  REMARK    GeneRIF: Modified iPOND revealed the role of mutant p53 in
            promoting helicase function and telomere maintenance.
REFERENCE   2  (bases 1 to 5163)
  AUTHORS   Kliche,J., Garvanska,D.H., Simonetti,L., Badgujar,D.,
            Dobritzsch,D., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Large-scale phosphomimetic screening identifies phospho-modulated
            motif-based protein interactions
  JOURNAL   Mol Syst Biol 19 (7), e11164 (2023)
   PUBMED   37219487
REFERENCE   3  (bases 1 to 5163)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 5163)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   5  (bases 1 to 5163)
  AUTHORS   Yang,S., Li,L., Chen,D., Xiao,M. and Xian,L.
  TITLE     EPS15-NTRK1: a novel NTRK1 oncogenic fusion in patient with lung
            adenocarcinoma
  JOURNAL   J Cancer Res Clin Oncol 146 (12), 3389-3392 (2020)
   PUBMED   33037466
  REMARK    GeneRIF: EPS15-NTRK1: a novel NTRK1 oncogenic fusion in patient
            with lung adenocarcinoma.
REFERENCE   6  (bases 1 to 5163)
  AUTHORS   Matsuda,M., Ota,S., Tanimura,R., Nakamura,H., Matuoka,K.,
            Takenawa,T., Nagashima,K. and Kurata,T.
  TITLE     Interaction between the amino-terminal SH3 domain of CRK and its
            natural target proteins
  JOURNAL   J Biol Chem 271 (24), 14468-14472 (1996)
   PUBMED   8662907
REFERENCE   7  (bases 1 to 5163)
  AUTHORS   Benmerah,A., Begue,B., Dautry-Varsat,A. and Cerf-Bensussan,N.
  TITLE     The ear of alpha-adaptin interacts with the COOH-terminal domain of
            the Eps 15 protein
  JOURNAL   J Biol Chem 271 (20), 12111-12116 (1996)
   PUBMED   8662627
REFERENCE   8  (bases 1 to 5163)
  AUTHORS   Schumacher,C., Knudsen,B.S., Ohuchi,T., Di Fiore,P.P.,
            Glassman,R.H. and Hanafusa,H.
  TITLE     The SH3 domain of Crk binds specifically to a conserved
            proline-rich motif in Eps15 and Eps15R
  JOURNAL   J Biol Chem 270 (25), 15341-15347 (1995)
   PUBMED   7797522
REFERENCE   9  (bases 1 to 5163)
  AUTHORS   Wong,W.T., Kraus,M.H., Carlomagno,F., Zelano,A., Druck,T.,
            Croce,C.M., Huebner,K. and Di Fiore,P.P.
  TITLE     The human eps15 gene, encoding a tyrosine kinase substrate, is
            conserved in evolution and maps to 1p31-p32
  JOURNAL   Oncogene 9 (6), 1591-1597 (1994)
   PUBMED   8183552
REFERENCE   10 (bases 1 to 5163)
  AUTHORS   Bernard,O.A., Mauchauffe,M., Mecucci,C., Van den Berghe,H. and
            Berger,R.
  TITLE     A novel gene, AF-1p, fused to HRX in t(1;11)(p32;q23), is not
            related to AF-4, AF-9 nor ENL
  JOURNAL   Oncogene 9 (4), 1039-1045 (1994)
   PUBMED   8134107
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z29064.1, CD657119.1 and
            AL671986.7.
            
            On Nov 23, 2018 this sequence version replaced NM_001981.2.
            
            Summary: This gene encodes a protein that is part of the EGFR
            pathway. The protein is present at clatherin-coated pits and is
            involved in receptor-mediated endocytosis of EGF. Notably, this
            gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous
            leukemias. Alternative splicing results in multiple transcript
            variants encoding distinct isoforms. [provided by RefSeq, May
            2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (A). Isoform A mainly
            localizes to clathrin-coated pits at the plasma membrane.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.30770.1,
                                           SRR1803617.23096.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371733.8/ ENSP00000360798.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1362              Z29064.1           58-1419
            1363-1365           CD657119.1         195-197
            1366-2908           Z29064.1           1423-2965
            2909-5163           AL671986.7         48348-50602         c
FEATURES             Location/Qualifiers
     source          1..5163
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..5163
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /note="epidermal growth factor receptor pathway substrate
                     15"
                     /db_xref="GeneID:2060"
                     /db_xref="HGNC:HGNC:3419"
                     /db_xref="MIM:600051"
     exon            1..68
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..2726
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /note="isoform A is encoded by transcript variant 1; ALL1
                     fused gene from chromosome 1; epidermal growth factor
                     receptor substrate 15; protein AF-1p"
                     /codon_start=1
                     /product="epidermal growth factor receptor substrate 15
                     isoform A"
                     /protein_id="NP_001972.1"
                     /db_xref="CCDS:CCDS557.1"
                     /db_xref="GeneID:2060"
                     /db_xref="HGNC:HGNC:3419"
                     /db_xref="MIM:600051"
                     /translation="MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLK
                     KSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPR
                     FHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKL
                     PVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTW
                     VVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGK
                     LSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKNIIGSSPVADFSAIKE
                     LDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQ
                     QVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKA
                     REELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQ
                     LNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPEL
                     LPSGVTDENEVTTAVTEKVCSELDNNRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDP
                     FVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFRQSTDPFATSSTDPFSAANNSSI
                     TSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESFGGGFADFSTLSKVNNEDPFR
                     SATSSSVSNVVITKNVFEETSVKSEDEPPALPPKIGTPTRPCPLPPGKRSINKLDSPD
                     PFKLNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNKEADPSNFANFSAYPSEEDMI
                     EWAKRESEREEEQRLARLNQQEQEDLELAIALSKSEISEA"
     exon            69..110
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            111..200
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            201..248
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            249..344
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            345..410
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            411..536
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            537..596
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            597..686
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            687..832
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            833..989
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1075
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1148
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1310
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1508
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1712
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1826
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1917
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..1953
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2087
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2154
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2231
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2394
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2579
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..5163
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4165..4170
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /note="hexamer: AATAAA"
     polyA_site      4189
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /note="major polyA site"
     regulatory      4992..4997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /note="hexamer: AATAAA"
     polyA_site      5018
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
     regulatory      5139..5144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
                     /note="hexamer: AATAAA"
     polyA_site      5163
                     /gene="EPS15"
                     /gene_synonym="AF-1P; AF1P; MLLT5"
ORIGIN      
        1 gtcttccttc ccctcccttg catgatggaa acaccatggc tgcggcggcc cagctctctc
       61 tgacacagtt atcaagtggg aatcctgtat atgaaaaata ctatagacag gttgatacag
      121 gcaatactgg aagggtgttg gcttctgatg ctgctgcttt cctgaaaaaa tcagggcttc
      181 cagacttgat acttggaaag atttgggatt tagccgacac agatggcaaa ggtatcctga
      241 acaaacaaga attctttgtt gctttgcgtc ttgtggcatg tgcccagaat ggattggaag
      301 tttcactaag tagtttgaac ctggctgttc ctccaccaag atttcatgat accagtagtc
      361 ctttgctaat cagtggaacc tctgcagctg agctcccatg ggctgtaaaa cctgaagata
      421 aggccaaata tgatgcaata tttgatagtt taagcccagt gaatggattt ctgtctggtg
      481 ataaagtgaa accagtgttg ctcaactcta agttacctgt ggatatcctt ggaagagttt
      541 gggagttgag tgatattgac catgatggaa tgcttgacag agatgagttt gcagttgcca
      601 tgtttttggt atactgtgca ctggagaaag aacctgtgcc aatgtccttg cctccagcct
      661 tggtgccacc atctaagaga aaaacgtggg ttgtatcccc tgcagaaaaa gctaaatatg
      721 atgaaatctt cctgaaaact gataaagata tggacggatt tgtgtctgga ttggaggtcc
      781 gtgaaatatt cttgaaaaca ggtttacctt ctaccttact agcccatata tggtcattat
      841 gcgacacaaa ggactgtggg aagctttcaa aggatcagtt tgccttggct tttcacttaa
      901 tcagtcagaa gttaatcaag ggcattgatc ctcctcacgt tcttactcct gaaatgattc
      961 caccatcaga cagggccagt ttacaaaaga acatcatagg atcaagtcct gttgcagatt
     1021 tctctgctat taaggaacta gatactctta acaatgaaat agttgaccta cagagggaaa
     1081 agaataatgt ggaacaggac cttaaggaga aggaagatac tattaaacag aggacaagtg
     1141 aggttcagga tcttcaagat gaagttcaaa gggagaatac taatctgcaa aaactacagg
     1201 cccagaaaca gcaggtacag gaactccttg atgaactgga tgagcagaaa gcccagctgg
     1261 aggagcaact caaggaagtc agaaagaaat gtgctgagga ggcccaactg atctcttctc
     1321 tgaaagctga attaactagt caggaatcgc agatctccac ttacgaagaa gaattggcaa
     1381 aagctagaga agagctgagc cgtctacagc aagaaacagc agaattggag gagagtgtag
     1441 agtcagggaa ggctcagttg gaacctcttc agcagcacct acaagattca caacaggaaa
     1501 ttagttcaat gcaaatgaaa ctgatggaaa tgaaagattt ggaaaatcat aatagtcagt
     1561 taaattggtg cagtagccca cacagcattc ttgtaaacgg agctacagat tattgcagcc
     1621 tcagcaccag cagcagtgaa acagccaacc ttaatgaaca tgttgaaggc cagagcaacc
     1681 tagagtctga gcccatacac caggaatctc cagcaagaag tagtcctgaa ctactgcctt
     1741 ctggtgtgac tgatgaaaat gaggtgacta cagctgttac tgaaaaagtt tgttctgaac
     1801 tcgacaataa tagacattca aaagaggaag atccatttaa tgtagactca agttcgctga
     1861 caggtccagt tgcagataca aacttggatt ttttccagtc tgatcctttt gttggcagtg
     1921 atcctttcaa ggatgatcct tttggaaaaa tcgatccatt tggtggtgat cctttcaaag
     1981 gttcagatcc atttgcatca gactgtttct tcaggcaatc tactgatcct tttgccactt
     2041 caagcactga ccctttcagt gcagccaaca atagcagtat tacatcggta gaaacgttga
     2101 agcacaatga tccttttgct cctggtggaa cagttgttgc agcaagcgat tcagccacag
     2161 acccctttgc ttctgttttt gggaatgaat catttggagg tggatttgct gacttcagca
     2221 cattgtcaaa ggtcaacaat gaagatcctt ttcgttcagc cacatcgagc tctgtcagca
     2281 acgtagtgat tacaaaaaat gtatttgagg aaacatcggt caaaagtgaa gatgaacccc
     2341 cagcactgcc accaaagatc ggaactccaa caagaccctg ccctctacca cctgggaaaa
     2401 gatccatcaa caaattggat tctcctgatc cctttaaact gaatgatcca tttcagcctt
     2461 tcccaggcaa cgatagcccc aaagaaaaag atcctgaaat attttgtgat ccattcactt
     2521 ctgctactac cactaccaat aaagaggctg atccaagcaa ttttgccaac ttcagtgctt
     2581 atccctctga agaagatatg atcgaatggg ccaagaggga aagtgagaga gaggaagagc
     2641 agaggcttgc ccgactaaat cagcaggaac aagaagactt agaactggct attgcactca
     2701 gcaaatctga gatatcagaa gcatgaagaa ttctcttgtt ctttggcaac aatatagtat
     2761 tcttcttcct gaatactgaa actatttaca atgtgtatca aaactacctg tgagcatggg
     2821 aatacaaaag gtttgagatt cctgtaaatg tgacaaaatt ttaggatttt ttttttttct
     2881 tcattacaga ttcgtctttt tttttttttc ttataaaagc cgtaacccag tcagacaaat
     2941 tcaccttcac ttaggcccct gttctggtat acatttactg tgagcttttg cctgcctgtg
     3001 ctattttact tgtaaagcta gagcacccaa gcttctgcct tctggaatat agagaaatag
     3061 tttcaccctg cactaccctg ttctgtagtt attctgatga tagccagtga ggttcttaaa
     3121 gtttgcagta ttctcccctg attggaatgg ttgagtgagg gtaagggaaa gaatatctta
     3181 tttcttttat gattggtgca aattggctaa agtgcatttt taaatttcct ctacttaatt
     3241 tgtttttcag agataaggaa aaatattttg cacagattta ctccactatg gaaaagggat
     3301 gctgtaggtt gaaccattat agcctcagat tcgatctttt cctaactaaa aatattaaag
     3361 cctcatgtgt gaaataaatt tttaaaaaga tttatctgga tttagagaat tttagatcaa
     3421 cagatacctc tcagtgtgtt tgctaattaa taaaaatcag tttcttacaa ataaagtttg
     3481 taagaaaatg ttcattttaa gtgatagata gtggagaaaa tttatcacct aaaatatacc
     3541 catcagtata aggcaagcaa aagtcttaac atggcagcca ttctgccttt gccgtggccc
     3601 tgtcctgttt agttcttagt gggttaattt ttgtactttt gcagaagaaa cttcagcaag
     3661 ctagaactgg aaggtacttt aatttttcat atatatttgt tttttttttt ttaatgaagg
     3721 ctcatttact tgaaatgtaa aaactttcac tgaatacaaa tagaaaaagt gatgtgtttt
     3781 atatcatatt gctttttgtc catctttgtg gtttagttta tttactcact tcatgttttt
     3841 cacctataaa attgtcaagc tagcaaaaaa actcttgttt ttttaattgg gagagaagag
     3901 acctgccaga ttatcagacc tcttcatgtt aaaagaccat ctcctgtaaa actgacctag
     3961 tggacaagct gaatttgaaa tagactgtga agtaagctgt aacttgtcat tttaattttg
     4021 tttaacacgg ttactgactt agatgatgta ttaaatacca agataaagaa aaatgcacct
     4081 aaaatctaat tagaattctc tgggtcaaca agtcaaggtg gtattgatct gtgttaatct
     4141 gagtaactta ttgcctagcc tataaataaa ttccaaaata tccaattcat ttcttcttga
     4201 aatggtgctt gttttgtttt ctttccatta cacaattaga ctcctacagt ttaaaacaaa
     4261 ctttaaacca ctatcttgca ctgctaactt ttttctacct ttgtaaatag aaacatttct
     4321 gcataaaagt catacatatg aagcaagggc tgaatcataa tcacaaggct taattttgat
     4381 aaacgaatcc agtgacctaa ggattttctg caaaatttga ctgggagttg tgataggtgg
     4441 tatttttgtt tattttcttc ctcttactcc ttaggataaa ggtaagttga cttgaacaac
     4501 tttcttttgc actgggaaaa taagcaaatg tttaaatgct tcaaaaaaat tttcaattaa
     4561 actcaaatat taaatatcta taacttataa acaccaactt tcaatgtaat aaatgtatcc
     4621 taatcttatg tatgtttaac tggattacat agatttttat cttttgttaa aatgtgtata
     4681 ccccgtggac caacataata ttaaagtatg tatatattat ataaatatat atgtatatgt
     4741 gctcgcttgt gtaggatgaa tgtcttagag tcgtttgtgg tattttatgt tgttgactct
     4801 ggctccaggg cctgtgcttg aaaaggacag ataagtattg cccagagcta agtggcacta
     4861 cttacaaagt tttaaatgtc ttctacatac tgattcatgt ttatttgagc tctctttata
     4921 gaattttctc ttaaagtttc aaacctctaa gttgtagcct gtaattatga gaacagtaaa
     4981 ctttaagtaa taataaagaa tcccatccat atatccaatt tgcaattgag ttttgcatgg
     5041 ttctctgatt atgtccatgc tgtgtccaag gaggagtagg tacatacaat cagcacagat
     5101 taatatatgt aaagggtttg ggacagcacc tggtatagaa taaataataa atgtaaacta
     5161 tta
//
