LOCUS       NM_001130677            3255 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens elongin BC and polycomb repressive complex 2
            associated protein (EPOP), mRNA.
ACCESSION   NM_001130677
VERSION     NM_001130677.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3255)
  AUTHORS   Liefke,R., Karwacki-Neisius,V. and Shi,Y.
  TITLE     EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin
            Landscape
  JOURNAL   Mol Cell 64 (4), 659-672 (2016)
   PUBMED   27863226
  REMARK    Erratum:[Mol Cell. 2017 Jan 5;65(1):202. doi:
            10.1016/j.molcel.2016.12.006.. PMID: 28061330]
REFERENCE   2  (bases 1 to 3255)
  AUTHORS   Beringer,M., Pisano,P., Di Carlo,V., Blanco,E., Chammas,P.,
            Vizan,P., Gutierrez,A., Aranda,S., Payer,B., Wierer,M. and Di
            Croce,L.
  TITLE     EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem
            Cells
  JOURNAL   Mol Cell 64 (4), 645-658 (2016)
   PUBMED   27863225
REFERENCE   3  (bases 1 to 3255)
  AUTHORS   Alekseyenko,A.A., Gorchakov,A.A., Kharchenko,P.V. and Kuroda,M.I.
  TITLE     Reciprocal interactions of human C10orf12 and C17orf96 with PRC2
            revealed by BioTAP-XL cross-linking and affinity purification
  JOURNAL   Proc Natl Acad Sci U S A 111 (7), 2488-2493 (2014)
   PUBMED   24550272
REFERENCE   4  (bases 1 to 3255)
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006449.19.
            
            On May 17, 2019 this sequence version replaced NM_001130677.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1163655.464319.1,
                                        SRR6380201.138676.21 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000621654.2/ ENSP00000484710.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC006449.19        119938-119960       c
            24-3255             AC006449.19        116706-119937       c
FEATURES             Location/Qualifiers
     source          1..3255
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..3255
                     /gene="EPOP"
                     /gene_synonym="C17orf96; PRR28"
                     /note="elongin BC and polycomb repressive complex 2
                     associated protein"
                     /db_xref="GeneID:100170841"
                     /db_xref="HGNC:HGNC:34493"
                     /db_xref="MIM:617795"
     exon            1..3255
                     /gene="EPOP"
                     /gene_synonym="C17orf96; PRR28"
                     /inference="alignment:Splign:2.1.0"
     CDS             463..1602
                     /gene="EPOP"
                     /gene_synonym="C17orf96; PRR28"
                     /note="proline rich 28; uncharacterized protein C17orf96;
                     proline-rich protein 28"
                     /codon_start=1
                     /product="elongin BC and Polycomb repressive complex
                     2-associated protein"
                     /protein_id="NP_001124149.1"
                     /db_xref="CCDS:CCDS45661.1"
                     /db_xref="GeneID:100170841"
                     /db_xref="HGNC:HGNC:34493"
                     /db_xref="MIM:617795"
                     /translation="METLCPAPRLAVPASPRGSPCSPTPRKPCRGTQEFSPLCLRALA
                     FCALAKPRASSLGPGPGELAARSPVLRGPQAPLRPGGWAPDGLKHLWAPTGRPGVPNT
                     AAGEDADVAACPRRGEEEEGGGGFPHFGVRSCAPPGRCPAPPHPRESTTSFASAPPRP
                     APGLEPQRGPAASPPQEPSSRPPSPPAGLSTEPAGPGTAPRPFLPGQPAEVDGNPPPA
                     APEAPAASPSTASPAPAAPGDLRQEHFDRLIRRSKLWCYAKGFALDTPSLRRGPERPP
                     AKGPARGAAKKRRLPAPPPRTAQPRRPAPTLPTTSTFSLLNCFPCPPALVVGEDGDLK
                     PASSLRLQGDSKPPPAHPLWRWQMGGPAVPEPPGLKFWGINMDES"
     regulatory      3230..3235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPOP"
                     /gene_synonym="C17orf96; PRR28"
                     /note="hexamer: CATAAA"
     polyA_site      3255
                     /gene="EPOP"
                     /gene_synonym="C17orf96; PRR28"
                     /note="major polyA site"
ORIGIN      
        1 agttctctat aacgcggtct ccgggagcca gcggggaaga aagaaaccga gcgggcggaa
       61 ggcgccctcc ccgccgcctg ggcccgggca ccgggtgccg ggcccggggt ccttcccgcc
      121 tcccgcggcc gccggccgct ttgtttcccc tgcctctgcg cttcgggcga ctcgagaggg
      181 tctcccgccg gggttgcgaa ggggacgcgg cggcagaagg gcggccgacc ccgccgggac
      241 tcacagggac ccaggagtcc ggccgccggg agggccgcgt gaggagagcg aagagggagc
      301 ccgagctctg cggccccggg tggcgggccg ggggcgcccg tgagcagaga cctccccgtc
      361 gacggggggc gatgttcccc tcacccgtgg gctcttcggg cagccagggc atcccgccgc
      421 tgggacctgg acccgctcag tgggcacccc tcaggctgct ccatggagac cctgtgccct
      481 gcgccccgcc tggcagtgcc ggcgtccccg cgagggtcgc cctgctcccc cacgccccgg
      541 aagccgtgtc gggggaccca ggaattctct ccgctgtgcc tgcgtgccct cgccttctgc
      601 gcccttgcca agccccgggc gtcctctctg ggcccggggc ctggggagct ggcggcgcgg
      661 tccccagtgc tgcggggccc tcaggccccc ctgcgccctg gcggctgggc cccggatggc
      721 ctgaagcacc tctgggcacc gaccgggcgg cccggcgttc ctaacaccgc cgccggcgag
      781 gatgcggacg tcgcagcgtg cccccgccgc ggagaggagg aagagggcgg aggcggtttc
      841 ccgcacttcg gcgttcgctc ctgtgcacct ccgggccgct gccctgcgcc cccgcaccct
      901 cgggaatcta cgaccagctt cgcctcggcc ccgcctcgcc cggccccggg tctcgagcct
      961 cagcgtggcc cagccgccag cccgcctcag gaacccagtt cccggcctcc gtcgccacct
     1021 gcgggcctct ccaccgagcc cgcgggtccc gggacggcgc cgcggccgtt cctgcccggc
     1081 cagcctgccg aagtcgatgg aaaccccccg ccggccgccc ccgaggctcc agcggccagc
     1141 ccctcgacgg ccagcccggc tccggccgca cccggagatc tccgccagga acatttcgat
     1201 cgtctgatcc gccggtcgaa actttggtgt tacgcgaagg gcttcgcctt ggacactccg
     1261 agtttgcgcc gggggccaga gcggccgcct gcgaaagggc cggctcgggg agccgccaag
     1321 aaacgccggc tgccggcgcc ccctccgcgc accgcgcagc cccgccgccc tgcaccgacg
     1381 ctccccacca cgagcacctt cagcctcctc aactgcttcc cctgcccccc ggccctggtg
     1441 gtgggggaag acggagacct aaagccggca tcctcgcttc gcctccaggg agactctaag
     1501 cccccgcccg cccacccgct gtggaggtgg cagatggggg gtcccgctgt ccctgagccc
     1561 cctggcctca aattctgggg gatcaacatg gatgaaagct gaccgtggga cttctgccaa
     1621 aggggaaaag ttgggaccat ggccaaaccg cgggcttgag gagggagccc cgtttctcac
     1681 atttgtcccc ttcctttaca ttttaggagc tgtgggcaga gggacctaaa taacagtgat
     1741 cttcattcaa gcacctaagt tttcggggtg acagtccctc cccctcatcc tttgcagagg
     1801 aacccagggc tggagtcggg agaaggctga tgacatagat tccaatccct gcctccttcc
     1861 atctcggacc gttggaggca gggcctgcac cccagtggga gcaaaggagg ccaccgctca
     1921 aagacacccc cccacccaaa aaaaagggga gaagagagag acctcggtga tggacaaacc
     1981 ggttgttact gtgtctgtgg gcgagcctgg ggtgcggggc tgtggtgggg gtggggagat
     2041 gattggcagc tccctggggg catcccccac ccccactgtc caggccttta accctttgct
     2101 cccctcaggc cttccctaac gctccaagca ccgctggagc ctttaatggg tgagggaact
     2161 tgggtaagag gaagatcacc cccttcctgt cccctttcta ggccccctca agtgcaggtg
     2221 acccttaatt ggtgagatct tcagcctcag ccgccgacct ttcccttttg tccagttttg
     2281 gagttcccgt tttttccttg tttgctttcc gagtgtaagg tctggccggt gagaaagatt
     2341 tcccccaacc ttgattaatc agccccctcc cccaacttac ttcccttagg acgggtaggg
     2401 ctgagggacc tcctctcctg gaaagtgctt actttgcctg gggaaggggc tagacactgt
     2461 cccagggaaa gtaatagaag gtggaagaaa tcaataaaat cagaccaaac aagtcgcctt
     2521 tcgagggcct ccaccgattt atggatgaga gggggtggag gtggaaggca ggcccaagtc
     2581 cattctttgg acacccaaac tcagccccct taaagagtgg aaacaaaaca agctgcactt
     2641 tgcagaggtg gtaaatgaaa ggactcttgg cctaacttca agagtcccct ggggtttgaa
     2701 ggggcaaagt ttgagtctgg atggaacctg ggctgaggta ccttaagctt ccccccgcaa
     2761 caccccagcc tcagggattg cgggagttgt cagagatctg atggatccga aaggggcagg
     2821 gccaggggat taggtttggg gtcagaggtt ctgttttcca ggggaggggt gagataggcc
     2881 tggatcatgc cctctgccat gccctccagc taggaggatc ttgagtcaga gaggattgga
     2941 agtgctttct cctccaccca ggtgaggtca ggggagctta ggtcttaggg agatggcaag
     3001 ttgaggtatg aagggaagct ggggcttttg gagctgccga acaactgagg gacccagtgc
     3061 gccttccatc ccgcactagt gaatagcgcc ccctcttccc ccgaaaacga ggtgcgagag
     3121 gaacaattcc cacgctgggg aaggacttgt ctccttttct gtgaaaatgc tttgtaaaaa
     3181 gttgttattg tttgcataga gcagattctt gagaaaaact gttttggacc ataaaagttt
     3241 tgtttgtttt aaaaa
//
