LOCUS       NM_017957               3879 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens epsin 3 (EPN3), mRNA.
ACCESSION   NM_017957
VERSION     NM_017957.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3879)
  AUTHORS   Li,Y., Zhang,P., Tang,G., Zhong,J., Wang,Z. and Zhu,B.
  TITLE     Lowering expression of Epsin-3 inhibits migration and invasion of
            lung adenocarcinoma cells by inhibiting the epithelial-mesenchymal
            transition
  JOURNAL   Sci Rep 14 (1), 17069 (2024)
   PUBMED   39048677
  REMARK    GeneRIF: Lowering expression of Epsin-3 inhibits migration and
            invasion of lung adenocarcinoma cells by inhibiting the
            epithelial-mesenchymal transition.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3879)
  AUTHORS   Ahmed,H., Paterson,I., Aziz,S.A., Cremona,O., Robinson,M.,
            Carrozzo,M. and Valentine,R.A.
  TITLE     Expression of Epsin3 and its interaction with Notch signalling in
            oral epithelial dysplasia and oral squamous cell carcinoma
  JOURNAL   J Oral Pathol Med 52 (8), 710-717 (2023)
   PUBMED   37339783
  REMARK    GeneRIF: Expression of Epsin3 and its interaction with Notch
            signalling in oral epithelial dysplasia and oral squamous cell
            carcinoma.
REFERENCE   3  (bases 1 to 3879)
  AUTHORS   Meng,J., Zhang,C., Zhu,N., Zhang,C., Liu,M., Han,Z. and Li,Y.
  TITLE     EPN3 plays oncogenic role in non-small cell lung cancer by
            activating the JAK1/2-STAT3 pathway
  JOURNAL   Environ Toxicol 38 (8), 1968-1979 (2023)
   PUBMED   37186036
  REMARK    GeneRIF: EPN3 plays oncogenic role in non-small cell lung cancer by
            activating the JAK1/2-STAT3 pathway.
REFERENCE   4  (bases 1 to 3879)
  AUTHORS   Wang,Y., Song,W., Kan,P., Huang,C., Ma,Z., Wu,Q., Yao,X. and
            Zhang,B.
  TITLE     Overexpression of Epsin 3 enhances migration and invasion of glioma
            cells by inducing epithelial-mesenchymal transition
  JOURNAL   Oncol Rep 40 (5), 3049-3059 (2018)
   PUBMED   30226603
  REMARK    GeneRIF: These results suggested that EPN3 enhances the migration
            and invasion of glioblastoma cells by activating the transcription
            factors Slug, Twist and ZEB1, but not Snail 1 or ZEB2, to induce
            EMT in glioma cells; EPN3 involvement in the Notch and
            WNT/betacatenin signaling pathways may contribute to this process.
REFERENCE   5  (bases 1 to 3879)
  AUTHORS   Hellwig,B., Madjar,K., Edlund,K., Marchan,R., Cadenas,C.,
            Heimes,A.S., Almstedt,K., Lebrecht,A., Sicking,I., Battista,M.J.,
            Micke,P., Schmidt,M., Hengstler,J.G. and Rahnenfuhrer,J.
  TITLE     Epsin Family Member 3 and Ribosome-Related Genes Are Associated
            with Late Metastasis in Estrogen Receptor-Positive Breast Cancer
            and Long-Term Survival in Non-Small Cell Lung Cancer Using a
            Genome-Wide Identification and Validation Strategy
  JOURNAL   PLoS One 11 (12), e0167585 (2016)
   PUBMED   27926932
  REMARK    GeneRIF: High expression of epsin (EPN3) was associated with
            increased risk of late metastasis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3879)
  AUTHORS   Coon,B.G., Burgner,J., Camonis,J.H. and Aguilar,R.C.
  TITLE     The epsin family of endocytic adaptors promotes fibrosarcoma
            migration and invasion
  JOURNAL   J Biol Chem 285 (43), 33073-33081 (2010)
   PUBMED   20709745
REFERENCE   7  (bases 1 to 3879)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 3879)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   9  (bases 1 to 3879)
  AUTHORS   Spradling,K.D., McDaniel,A.E., Lohi,J. and Pilcher,B.K.
  TITLE     Epsin 3 is a novel extracellular matrix-induced transcript specific
            to wounded epithelia
  JOURNAL   J Biol Chem 276 (31), 29257-29267 (2001)
   PUBMED   11359770
REFERENCE   10 (bases 1 to 3879)
  AUTHORS   Spradling,K.D., Burke,T.J., Lohi,J. and Pilcher,B.K.
  TITLE     Cloning and initial characterization of human epsin 3, a novel
            matrix-induced keratinocyte specific transcript
  JOURNAL   J Invest Dermatol 115 (2), 332 (2000)
   PUBMED   10951261
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC388544.1, AK000785.1, DA392550.1, AF324241.1, BM981734.1,
            BU539570.1 and CA944655.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017957.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000785.1, AK292977.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268933.8/ ENSP00000268933.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 DC388544.1         49-51
            4-306               AK000785.1         1-303
            307-529             DA392550.1         318-540
            530-2485            AF324241.1         143-2098
            2486-2933           BM981734.1         15-462              c
            2934-3615           BU539570.1         41-722
            3616-3879           CA944655.1         18-281              c
FEATURES             Location/Qualifiers
     source          1..3879
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..3879
                     /gene="EPN3"
                     /note="epsin 3"
                     /db_xref="GeneID:55040"
                     /db_xref="HGNC:HGNC:18235"
                     /db_xref="MIM:607264"
     exon            1..251
                     /gene="EPN3"
                     /inference="alignment:Splign:2.1.0"
     exon            252..949
                     /gene="EPN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             388..2286
                     /gene="EPN3"
                     /note="EPS-15-interacting protein 3"
                     /codon_start=1
                     /product="epsin-3"
                     /protein_id="NP_060427.2"
                     /db_xref="CCDS:CCDS11570.1"
                     /db_xref="GeneID:55040"
                     /db_xref="HGNC:HGNC:18235"
                     /db_xref="MIM:607264"
                     /translation="MTTSALRRQVKNIVHNYSEAEIKVREATSNDPWGPPSSLMSEIA
                     DLTFNTVAFTEVMGMLWRRLNDSGKNWRHVYKALTLLDYLLKTGSERVAHQCRENLYT
                     IQTLKDFQYIDRDGKDQGVNVREKVKQVMALLKDEERLRQERTHALKTKERMALEGIG
                     IGSGQLGFSRRYGEDYSRSRGSPSSYNSSSSSPRYTSDLEQARPQTSGEEELQLQLAL
                     AMSREEAEKPVPPASHRDEDLQLQLALRLSRQEHEKEVRSWQGDGSPMANGAGAVVHH
                     QRDREPEREERKEEEKLKTSQSSILDLADIFVPALAPPSTHCSADPWDIPGFRPNTEA
                     SGSSWGPSADPWSPIPSGTVLSRSQPWDLTPMLSSSEPWGRTPVLPAGPPTTDPWALN
                     SPHHKLPSTGADPWGASLETSDTPGGASTFDPFAKPPESTETKEGLEQALPSGKPSSP
                     VELDLFGDPSPSSKQNGTKEPDALDLGILGEALTQPSKEARACRTPESFLGPSASSLV
                     NLDSLVKAPQVAKTRNPFLTGLSAPSPTNPFGAGEPGRPTLNQMRTGSPALGLAGGPV
                     GAPLGSMTYSASLPLPLSSVPAGLTLPASVSVFPQAGAFAPQPLLPTPSSAGPRPPPP
                     QTGTNPFL"
     exon            950..1068
                     /gene="EPN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1149
                     /gene="EPN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1278
                     /gene="EPN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1366
                     /gene="EPN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1636
                     /gene="EPN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1741
                     /gene="EPN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1972
                     /gene="EPN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..3879
                     /gene="EPN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2472..2477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPN3"
                     /note="hexamer: AATAAA"
     polyA_site      2490
                     /gene="EPN3"
                     /note="major polyA site"
     regulatory      2904..2909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPN3"
                     /note="hexamer: AATAAA"
     polyA_site      2933
                     /gene="EPN3"
                     /note="major polyA site"
     regulatory      3858..3863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPN3"
                     /note="hexamer: AGTAAA"
     polyA_site      3879
                     /gene="EPN3"
                     /note="major polyA site"
ORIGIN      
        1 ggagtgctgc ctggcgctgg ctaggaggca aacgcacgcg ggaagagctg ctacccattc
       61 cagggaccct gccgctgccc ctctgagggg tctgcacctc ctgggagcag gtgggtctct
      121 gggacgaggg tccatggtgg atggctctgg agacgctccc gaggctgtgc cgtcccgctg
      181 ctgcacaggt cggagggtca ccgcagaggc tactcgggct ggggctgggg ccgagggagc
      241 ccgcactgga gccccatgtg gaacccaagg atgcagctgc tctgctaaca cggcagccca
      301 tccttcaaga ctgtgacctc gccacagtgg ccctcagccc tccacctccg gcgggggcga
      361 gggccaccca cctccaagtc tccagccatg acgacctccg cactccggcg ccaggtgaag
      421 aacatcgtgc acaactactc cgaggcagaa atcaaggtgc gcgaggccac cagcaatgac
      481 ccctggggcc cccctagttc gctcatgtcc gagatcgctg acctgacctt caacacagtg
      541 gccttcaccg aagtcatggg catgctgtgg cggcggctca atgacagcgg caagaactgg
      601 cggcacgtgt acaaggctct aacattgctg gactacctgc tcaagacggg ctccgagcgg
      661 gtggcccacc agtgccgcga gaacctctac accatccaga cactcaagga cttccagtac
      721 atcgaccgcg acggcaagga ccagggcgtc aacgtgcgcg agaaggtcaa gcaggtgatg
      781 gccctgctca aggatgagga gcggctgcgg caggagcgaa cccacgccct caagaccaag
      841 gagcgcatgg cactggaggg catcggcatt ggcagtgggc agctgggctt cagccgccgc
      901 tacggcgagg actacagccg ctcccggggc tccccgtcct cctacaactc ctcctcttcg
      961 tcaccccgct atacctccga cctggagcag gcccggcctc agacgtcagg ggaagaggaa
     1021 ctgcagctgc agctggccct cgccatgagc cgtgaggagg cagagaagcc tgtcccccca
     1081 gcctcccaca gggacgagga cctgcagctg cagctggctc tgcgcctgag ccggcaggag
     1141 cacgagaagg aggtgaggtc ctggcagggt gatggctccc ccatggccaa tggtgcaggg
     1201 gccgtggtcc accatcagcg ggacagagag cctgagagag aagagagaaa ggaggaggag
     1261 aagctaaaaa ccagccagtc ctccatcctg gacttggctg acatcttcgt acctgccctg
     1321 gccccgccct ccacacactg ctctgctgac ccatgggaca tcccaggttt taggccgaac
     1381 acagaggcca gtggatcctc ctgggggcct tctgcagacc cctggtctcc gatcccctca
     1441 ggaaccgtcc tgtcccgaag ccagccctgg gatctgactc ccatgctctc ctcctctgag
     1501 ccctggggca ggaccccagt gctgcctgct gggcccccca ccacagaccc ctgggccctg
     1561 aactctcccc accacaaact ccccagcact ggggctgacc cttggggagc ctccctggag
     1621 acctccgaca cacctggtgg tgcctcgacc tttgacccat ttgccaaacc tccagaatcc
     1681 acagagacca aggaggggct ggagcaggcc ctgccctctg ggaagcccag cagccctgtg
     1741 gagctggacc tgtttggaga ccccagcccc agttccaagc aaaatggcac gaaggagcca
     1801 gatgccctgg acctgggcat actaggggaa gcactaaccc agccaagcaa agaggcccga
     1861 gcttgccgga ctcccgagtc cttcctgggt ccctcagctt cctccttggt caaccttgac
     1921 tcgttggtca aggcacccca ggttgcaaag acccggaacc ccttcctgac aggtctcagc
     1981 gctccgtccc ccaccaaccc gttcggcgcg ggcgagccgg gcaggccgac gctaaaccag
     2041 atgcgcaccg gctcgccggc gctgggcctg gcaggcgggc ctgtgggggc gcccctgggc
     2101 tccatgacct acagcgcctc tctgcccctc ccgctcagca gcgtgccagc tggcttgacc
     2161 ctccccgcct cggttagcgt cttcccgcag gccggagcct tcgcaccgca gccgctgctg
     2221 cccacgccga gctcagccgg gccgcggccc ccgcccccgc agaccggcac caaccccttc
     2281 ctctgagccc cgccccgtcc cataccggcc tgcgcctgcg ccggacgctc cgcggccccg
     2341 cctccggacc cggggctggg cggggcgccg gtgctagtgg aacgccgagc cagtggcggc
     2401 tggtatcccg cggcggctct ggaagctgga cgcggaccac ggcccgggag ctagaaactg
     2461 aacgcccgca taataaagac tggaaccctc gttctcagct ctcaccaagt ggactttttg
     2521 cggggtgtgg cggccgggtc tcgaccacag cgtggatcac cggctgttta ggaaactgca
     2581 gctgcacaac gtggggtgca aaactgcccc gcttccttta cagctcttct caaccctcac
     2641 ctccatcccc cgtcacccag gcaccttcgc ttccagatgc tgccaggctg tcactcaatt
     2701 cggtcatttc attcatttat cacacatggg cactggggtt gggctaacag caagagacaa
     2761 taggcctttg ttcctattta ttgggtactg cttacgtgct aagcagatca gtttatttaa
     2821 tgcttgcaac gactctctga ggtagaaaat attgttaatt ccgttcagga tcccggctac
     2881 ataatctgtg gggctcaata caaaataaaa atgtaggggc tccttgttca aaatcgtatg
     2941 aagaatttca aaacagggac aacagagcat gaaaccaagc gcaaagccca ctgcagtgcg
     3001 attgcacagg tatctcacct tgcagccggc actactccca tttttcaggc aaggaaaccg
     3061 tggctcagag aggttgaatg gcatgctcaa agtcacaaag ctggcatggg gcggggctgg
     3121 aactcaagag tcagacagtc tggctccaag gcctggagat cccaggctgg gccccagatt
     3181 taattcagca aatattgact gactgctgtg gacaaagtgc tgggctcacc ttggagggat
     3241 ccaacctcca ggagctcgag cgcagcaggg tagacaagcc aggggcacgt gatgcggctg
     3301 tggcagaagc caagtgcagg agctcccagg ctcctttgtt ttactgagtc accttaaatg
     3361 taactctgcc ctctcccttg cttcgccaag gctagcgaga aactcagtct tagccacaca
     3421 ggaggaatcg gaccccttct gggggtttat gtggagtctg ggaaaccaag ggtggggtga
     3481 ggcctggtac tcaatccagg aggggcccct atgaccaccc tcgcctgttt ttcttctcaa
     3541 tgctccctga tcactggacc actggacact gatgtgtcct cagtgcttgg ggtctggctc
     3601 tgcaggcagc ctgcagccag cctccatccc cctttcaggg acaaatggcc ttccaccaga
     3661 gtcggtgagt ggagaggcac aatgccactc cccttcctga ggtgggggta ggggaaggga
     3721 gtcccacaat gcagttacaa acaggatgga caagaacacc tgctcaggag tcagacttac
     3781 agggttcaaa gttctgctcc aaggtttgac cctaacaaga atcacttagt aataagtggt
     3841 tatgctctgt gaccttgagt aaattactta ccctctcca
//
