LOCUS       NM_014805               8089 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens EPM2A interacting protein 1 (EPM2AIP1), mRNA.
ACCESSION   NM_014805
VERSION     NM_014805.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8089)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 8089)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 8089)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8089)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   5  (bases 1 to 8089)
  AUTHORS   Perera,S., Mrkonjic,M., Rawson,J.B. and Bapat,B.
  TITLE     Functional effects of the MLH1-93G>A polymorphism on MLH1/EPM2AIP1
            promoter activity
  JOURNAL   Oncol Rep 25 (3), 809-815 (2011)
   PUBMED   21206982
  REMARK    GeneRIF: The -93G>A polymorphism modifies the efficiency of
            MLH1/EPM2AIP1 transcription.
REFERENCE   6  (bases 1 to 8089)
  AUTHORS   Walker,L.C., Waddell,N., Ten Haaf,A., Grimmond,S. and Spurdle,A.B.
  CONSRTM   kConFab Investigators
  TITLE     Use of expression data and the CGEMS genome-wide breast cancer
            association study to identify genes that may modify risk in BRCA1/2
            mutation carriers
  JOURNAL   Breast Cancer Res Treat 112 (2), 229-236 (2008)
   PUBMED   18095154
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   7  (bases 1 to 8089)
  AUTHORS   Chan,E.M., Young,E.J., Ianzano,L., Munteanu,I., Zhao,X.,
            Christopoulos,C.C., Avanzini,G., Elia,M., Ackerley,C.A.,
            Jovic,N.J., Bohlega,S., Andermann,E., Rouleau,G.A.,
            Delgado-Escueta,A.V., Minassian,B.A. and Scherer,S.W.
  TITLE     Mutations in NHLRC1 cause progressive myoclonus epilepsy
  JOURNAL   Nat Genet 35 (2), 125-127 (2003)
   PUBMED   12958597
REFERENCE   8  (bases 1 to 8089)
  AUTHORS   Ianzano,L., Zhao,X.C., Minassian,B.A. and Scherer,S.W.
  TITLE     Identification of a novel protein interacting with laforin, the
            EPM2a progressive myoclonus epilepsy gene product
  JOURNAL   Genomics 81 (6), 579-587 (2003)
   PUBMED   12782127
  REMARK    GeneRIF: The EPM2AIP1 gene was identified and characterized in a
            screen for laforin-interacting proteins with a human brain cDNA
            library; the specificity of the interaction was confirmed;
            subcellular colocalization of laforin and EPM2AIP1 protein was
            demonstrated
REFERENCE   9  (bases 1 to 8089)
  AUTHORS   Cai,S., Han,H.J. and Kohwi-Shigematsu,T.
  TITLE     Tissue-specific nuclear architecture and gene expression regulated
            by SATB1
  JOURNAL   Nat Genet 34 (1), 42-51 (2003)
   PUBMED   12692553
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY178832.1 and AC011816.17.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_014805.3.
            
            Summary: The EPM2A gene, which encodes laforin, is mutated in an
            autosomal recessive form of adolescent progressive myoclonus
            epilepsy. The protein encoded by this gene binds to laforin, but
            its function is not known. This gene is intronless. [provided by
            RefSeq, Oct 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1803615.57690.1,
                                        SRR7346977.1761328.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322716.8/ ENSP00000406027.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5394              AY178832.1         174-5567
            5395-7266           AC011816.17        135524-137395       c
            7267-8089           AC011816.17        134701-135523       c
FEATURES             Location/Qualifiers
     source          1..8089
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.2"
     gene            1..8089
                     /gene="EPM2AIP1"
                     /note="EPM2A interacting protein 1"
                     /db_xref="GeneID:9852"
                     /db_xref="HGNC:HGNC:19735"
                     /db_xref="MIM:607911"
     exon            1..8089
                     /gene="EPM2AIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1878
                     /gene="EPM2AIP1"
                     /note="laforin-interacting protein; EPM2A (laforin)
                     interacting protein 1"
                     /codon_start=1
                     /product="EPM2A-interacting protein 1"
                     /protein_id="NP_055620.1"
                     /db_xref="CCDS:CCDS46790.1"
                     /db_xref="GeneID:9852"
                     /db_xref="HGNC:HGNC:19735"
                     /db_xref="MIM:607911"
                     /translation="MWMTPKRSKMEVDEALVFRPEWTQRYLVVEPPEGDGALCLVCRR
                     LIVATRERDVRRHYEAEHEYYERYVADGERAALVERLRQGDLPVASFTPEERAARAGL
                     GLCRLLALKGRGWGEGDFVYQCMEVLLREVLPEHVSVLQGVDLSPDITRQRILSIDRN
                     LRNQLFNRARDFKAYSLALDDQAFVAYENYLLVFIRGVGPELEVQEDLLTIINLTHHF
                     SVGALMSAILESLQTAGLSLQRMVGLTTTHTLRMIGENSGLVSYMREKAVSPNCWNVI
                     HYSGFLHLELLSSYDVDVNQIINTISEWIVLIKTRGVRRPEFQTLLTESESEHGERVN
                     GRCLNNWLRRGKTLKLIFSLRKEMEAFLVSVGATTVHFSDKQWLCDFGFLVDIMEHLR
                     ELSEELRVSKVFAAAAFDHICTFEVKLNLFQRHIEEKNLTDFPALREVVDELKQQNKE
                     DEKIFDPDRYQMVICRLQKEFERHFKDLRFIKKDLELFSNPFNFKPEYAPISVRVELT
                     KLQANTNLWNEYRIKDLGQFYAGLSAESYPIIKGVACKVASLFDSNQICEKAFSYLTR
                     NQHTLSQPLTDEHLQALFRVATTEMEPGWDDLVRERNESNP"
     regulatory      5245..5250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPM2AIP1"
                     /note="hexamer: AATAAA"
     polyA_site      5266
                     /gene="EPM2AIP1"
                     /note="major polyA site"
     regulatory      7245..7250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPM2AIP1"
                     /note="hexamer: AATAAA"
     polyA_site      7266
                     /gene="EPM2AIP1"
     regulatory      8068..8073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPM2AIP1"
                     /note="hexamer: AATAAA"
     polyA_site      8089
                     /gene="EPM2AIP1"
ORIGIN      
        1 ctctcccctt gcggcctttc taacgttggc cctgctcttg tggcctcccg cagaatgtgg
       61 atgacgccca aaagaagcaa gatggaagtc gacgaggctc tagttttccg gcccgagtgg
      121 acccagcgtt atttggtggt ggagcctccg gagggcgatg gggccctgtg cctggtctgt
      181 cgccgcctca tcgtagctac ccgcgaacgc gacgtcaggc gccactacga ggctgagcac
      241 gaatactacg agcggtatgt ggcggacggc gagcgcgcgg ccctggtgga gcgtctgcgt
      301 cagggcgact tgcccgtggc ctccttcact cctgaagaga gagctgctcg tgcaggcctc
      361 gggctctgcc gcctcttggc cttgaagggt cgcggctggg gtgaggggga ctttgtatac
      421 cagtgcatgg aggtgttgct gagagaggta ctgcccgagc atgtaagcgt cctgcaaggc
      481 gttgacttat ctccagatat cacaaggcag aggatcctga gcattgacag gaatctacgc
      541 aaccagcttt ttaaccgagc cagggacttt aaagcctatt ctcttgcctt ggacgaccag
      601 gcttttgtgg cctatgagaa ctacctcctg gtctttatcc gcggtgtagg ccctgagttg
      661 gaggtgcaag aagatcttct gaccataatc aacctgactc atcatttcag tgttggtgcg
      721 ctcatgtcgg caatcctaga gtccctgcag acagcagggc ttagcttgca gagaatggtt
      781 ggactgacca cgacccatac tttgaggatg attggtgaga actcaggact cgtctcatac
      841 atgagagaaa aggccgtaag ccccaactgt tggaatgtca ttcattattc aggatttctt
      901 cacttggaac tgttgagctc ctatgatgta gatgttaatc agatcataaa taccatatcc
      961 gaatggatag ttttgattaa gaccagaggc gttaggcgac ctgaatttca gactttacta
     1021 acggaatctg aatcagagca tggtgaaagg gttaatggac gatgtctgaa caattggctt
     1081 aggagaggga aaactttaaa actaatattc tctctaagaa aagaaatgga agcgttcttg
     1141 gtttcagtag gggcaacaac agtccacttc tcagacaaac aatggctttg tgactttggc
     1201 ttcttggtgg acattatgga acaccttcga gaactcagtg aagaattacg agttagtaaa
     1261 gtctttgctg ctgctgcctt tgaccatatt tgtactttcg aagttaagct gaatttattt
     1321 caaagacata ttgaggaaaa aaatctaaca gactttcctg ccctcagaga agttgttgat
     1381 gagctaaaac agcaaaataa ggaagatgaa aaaatatttg atcctgatag gtatcaaatg
     1441 gtgatctgtc gtctccaaaa agaatttgag agacatttta aggacctcag gttcattaaa
     1501 aaggacttag aacttttttc aaatccattt aactttaaac ctgaatatgc acctatttca
     1561 gtgagggtgg agctaacaaa acttcaggca aacactaatc tttggaatga atacagaatc
     1621 aaagacttgg ggcagtttta tgctggattg tctgctgaat cctacccaat tatcaaaggg
     1681 gttgcctgta aggtggcatc cttgtttgat agtaaccaaa tctgtgaaaa ggctttttca
     1741 tatttgactc gaaaccaaca cactttgagt cagccattaa cagatgagca tctccaagcc
     1801 ctgtttcggg ttgccacaac tgaaatggag cccggttggg atgaccttgt gagagaaaga
     1861 aatgaatcta atccataagg ctttgtagta caagattgaa aaactcaaca agaatttaat
     1921 tctaaaagca aaaattggtt tgagttttca agtttactaa tttggattgt gagaaagtac
     1981 caagtaccag ccgtccaaac tgatcacaat taaaattctg acagttgcct tttttttcat
     2041 ctcaaatggc agcatgggac tgaaacatga gaatgccacc ttttttaaaa cttagtttag
     2101 tgacaaagtc attgtctttt atgatatagt taattttaaa gagatttagt attaatgtga
     2161 gttgaatttg cagtctgttt tttaggtgtt ctgaagataa atgccaaaaa tttcagctct
     2221 tattttaatg gagtgttaaa attctgattc atatagtctt aaattatcaa ctccttaaat
     2281 gtgcttttga accaatttgc agaagctcac atagcaagtt cataagtttc caaaaaggaa
     2341 gcccatacat aacagtggag gtgttttgtc taaccatcaa aatgtttgag actttttttt
     2401 aaacatttct gagttcgaag gtaatactga cagatttctt ccctcttccc tccccatcac
     2461 ccacctcagt gataacacat tactgataga ggaagtcatt agaatcattt ttaagtttca
     2521 gatataggag acttcatgca atttggagat aagactaatt attgggggtt ttccttggat
     2581 ttttttttta ataactgggg gctattttat cagcttgcct attaaaggac tatggtaagt
     2641 atagaatctt aatggttgcc agttagtaat tctttttttt ttttttttta ctgtagacac
     2701 aagtttggcc ctatcaaaaa cgatgaggaa aaaagattgc actccaggat taggaggtgt
     2761 gagatatttt agcttttttg tcttatctgc gtgggtattg ctgctttatt ttaaaaaatc
     2821 ctgcctaaag taaacacttt gttttaaaat gatacagtat cagattttgt tagatgctag
     2881 aaatggattt attctaaaat ttggaactgt cgtacacatt ctatatgtaa gatagcacac
     2941 aagtagaaat atttaaaagc agtcttattc acagattgca gtaattctgt atttctacta
     3001 agataatctg ctttgtgcca aaacagtaat ttccaaactt ctgttcacca tgaaaaggca
     3061 atcttaaagt tcattatgta aaactaatta taaacaggac ccaatttata ttcatagatc
     3121 ctctcaagta ttatacaatt taaaaactct tgttccaaag tcctgtctta actattgaaa
     3181 caccttaatc tgtggttact aatccagcaa attcaaggaa ccaggctatg actaagaatt
     3241 taggtggaat tgatgtctgg gcaattaaaa taaatggcat aagagcttaa aaaccaaagt
     3301 tgtgccagtg gctttcaact agaggcagta acctgtcatt ccagaggatg ctgagaaatg
     3361 tgtaggggca cttttttggt tgtcatattt actaggggct tctgttggca tttaagccta
     3421 aagacactca cccctgcagt gcatgggaca gcctggcaca atgaagaatt agccctccca
     3481 aaatgtagat tattttattt caagggatag ggcagattac cattagaagc aaaattaaaa
     3541 gtacaagctg ggcaaactga cagaatacta gataggagag actaattcca accttctaaa
     3601 tttggctagt aaagtgcaat aaaggcattg ataagttctg ttagctcacc atagcacttg
     3661 taaatcagga attaataatt gaatcagatt taagggctct gtcctgttat acatatttaa
     3721 ggcagaaaaa aagttacatg tcgattaggt acttatcaag aatggtcaag ctgagatttt
     3781 ggttaataga gtaagcttac atatctagag aaacaacata gtggaaaacc gaaaaaaaaa
     3841 aacagaaaaa tctaccggta atttcccaat agctttgaat attcacagca gagctttatt
     3901 acttgagaga aagactggaa gacctgaaag ccacttctgc tttctaaccc cagttcctta
     3961 aatattgaaa tcttgtacat tttgtgaaat tccagtatgt tttgcttaag gtgttaataa
     4021 aattagtttg catcatgtag tcattgagtg agggggagat ataagccaag gattttaaat
     4081 tgacccttag ctatagagaa tttgctataa gctagtcttg tttgtaaaaa aaaaaaaaaa
     4141 aaaagaaaaa gaaaaaagtg tattttactg ttttctgtat taagtaattc tgtaactgca
     4201 tggcagtctt ttttttttta aataaatata gttgttactg gtcctgttgt agcagtgaat
     4261 atagttaaaa tacgtacatt aaaaaaaaaa ttattaggtc cttaccagtt actgtcctat
     4321 agctcattcc tactagtttt cttgacagat ttgtattccc agtgtcccgt attgccactc
     4381 aaattgctct actatgctaa gtccttgtta atagtcttac cctccttgaa acacttgaac
     4441 acttgatgac tttagctttg aggagatacc atctccaggt gtgctttctt agtctttgca
     4501 ggcacctctt cccttcaata tctgttcttc gtatttttaa aaaaatttgt tttagactgc
     4561 cttgttctgt gtcagctcgc tagctgatct catttccttc catggtttcc ttaccattta
     4621 tatgcaaatg actgtcagat tcatatctcc tttctagatc ttccctaatt gatgtatcta
     4681 attgctaaca aatgctcttt gctgtctcag gcactacatg tcattgatct tgcccccaat
     4741 cctgctcctc ctctcatgtt tcctctttga ctaaatggca ttaccactac caaccattca
     4801 tttgtccttt ttaccaattc tccaatgctg ccattttaat tcaggccatc aacctaccta
     4861 aattatagca acagcctcct tattagtctc cctgtttttt atttttattc ctttctacac
     4921 tacaaccaaa ttgctccaaa agacttactg atcatgtcac tgcattgctt tcaccattgc
     4981 tcttagggta caatacaaat ttatcttcat ctttaaggtc tcagtatgcc acttcatcta
     5041 ggaaaccttc attgatgccc tctagattag gtgcccttac tatccattcc ctatacaccc
     5101 tgttctttcc cagacataca cttggcacac tttattgtta ctgcttattg atcactgcta
     5161 gactgtaagc tttgtaaggg cagggaccat ataagccttg ttcactgtta tatctctagt
     5221 gcttagcaca atgcctggca tttcaataaa tgtttggaca aacgaatatt tgtgtagtgt
     5281 tttacaattt ttgaagctct ttcacagtct tatttgacct tcacagtcat tctgccttag
     5341 actgtccatt gggtaacttt tatccacata ttactaattg aaaaatgaag acaagttctt
     5401 tgtaactagg gacctcgttg tattctcaga atttagtgta gtgcttagca tgtgacttaa
     5461 atatgtatta tgtgactgtt aaacaaattg tggttttctc tgttgtatga aaggagagaa
     5521 ggataacaaa ttgcggtttt ccctggtaaa cacagtaagt agtaaactca ggattcaaaa
     5581 ccaaatatac acaccaaatc cactatgtaa tattaagttt gcatatccat gtatagaatc
     5641 ttattttttt ttaccctttg taaacagtgt catatatata tatatatttt tttttttttt
     5701 ttaaatttcc aaaggaacct acatatagag ggaaaagatt agacaactac ttagtgaact
     5761 aaaacaatat gtttttacta aatgttacat ttagtattgg aaaaagataa tgccgcctaa
     5821 gagttaataa tcatttttcc ttttgtaggc atcaacacta ggagaaaatg gcatgctatt
     5881 tacttgctac tttcctttac agatgatttt tggctcttct gggatttaaa agtaagtaaa
     5941 tttaacaaag tagaagactg actcagccct tctggtcact atatattcag ttcacttgtt
     6001 tttacacctg cagaatgtcc ttatcaccca aagggagatg acccaaaagt gacatctagt
     6061 taatgtatac ttctaaagtt tgctgtattc ctttgccttc ttgttcccat gcctctctga
     6121 acttaatttc tgggtaactg aggcttttca ggcttaggtg ggaaagccac acccttagtc
     6181 tgtttcctta agccattttg accaatttat gggattaact agtataatct tagttggagt
     6241 tttagtctga ggcatattaa gtcattcaga gatcttaaca gtaggtgtca tagtcatcca
     6301 gtgatttggt gcttgctgca aaactggctt tttttttttt tttttttttt gaggcggggt
     6361 ctcactttgt cacccaggct ggagtgcaga ggtacaatct cagctcaatg caatctctgc
     6421 cttcctggct caagcaattc tcccactgca gcctcctaag tagctgggaa tacaggtata
     6481 cacgagtaca cccagctaat ttttgtattt ttatgtggag acagggtctt gctgtattcc
     6541 ccaggctagt ctcgaattcc tggactcaag cagtccgccc gcctcgggct cccaaaatgt
     6601 tggtgttata cgtgtgagcc tctgcacccg gcggcaaaac tggcttttaa tcaacctttt
     6661 ggctaaagga tttctctttt tatttatttg taaaaggatt tcccattttt atctttcttt
     6721 ttgatattaa aatgttgcct catcctaccc agtaagtact tgaatttgaa ttctcttcct
     6781 tttcattttt gcctgcaaac tgaccagtct tttctgagtt catctcttct gtacgttttg
     6841 tcaagtgcag tgaacagcaa ctacaaaata ttttgttttt ctgtcttttt ctttagtaaa
     6901 gggtagatga tctgcctttc aggttatctc aaggggcagt ttcacctttc cataatataa
     6961 attacccttg tgtaagttat ttcttccatc ttctgatagc aatttcctga atgcctgcca
     7021 gctaaccatt aagccagtgt tcagtatttt agcattttaa aaaacaaggg accaatttct
     7081 gtgtcagcat gggctagctt gccattgaat aacaaaggca aaatctcact gtctcacaca
     7141 acttttctat tgcaacttgc ctagggactt tggtttagat cataggttgg ccatgatcaa
     7201 actatggtcc atgggcaaaa tctgtctagc tccttattta tctaaataaa gttttactgg
     7261 aatatagcct tgtccattta tttattatct gtggctactt tggttctaca atggcacagc
     7321 tgagtagttg ctacagagtg tgtacatctc acaaaaccta aaatacttat tctgtggccc
     7381 tttacagaga aagttcacca atttgtgctc taagttgcct tcattctggg tctcaggctg
     7441 acaaagcaga taccatcagg agtgtgggtg ctaactttgg gaaatgaaaa aagagtatgg
     7501 caaatcactt aaggactctt aaaggacttt cattggccaa agcaaatcac atagccacat
     7561 taaagttcta ggaggagtgt gatccttgca tatacctggg agaaaaacca gaaatatttg
     7621 gaagacaaca ccactgatta acatcttcat ttatatgctt tcttccaata tattttcaac
     7681 ttgttactga ggtaaaattt aaaagtgtac cgatattaag tgtacacctc agtgggtttt
     7741 tatatatgcc cttgaatgca ccacccaggt caaaatatag aatatttcta gcacttcagt
     7801 aggtgtcctt atgttcccca ggcccccacc aacccctttt atcaccacgg attagttttg
     7861 cctgttttaa aactttatgt aagtgaaata attatatgca ctcttccgtg tcttgttcaa
     7921 cattgtatct gtgagagtaa tccatgttat atgtagtagc agttcatgtt ttacttctgt
     7981 gtagtattcc attgtgtgac tacatcacaa cttacccatt ctaccgttga tagaaattta
     8041 ggttgtttcc agcttgtggt cattatgaat aaagttacta tgaaaatga
//
