LOCUS       NM_173567               1436 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens epoxide hydrolase 4 (EPHX4), mRNA.
ACCESSION   NM_173567
VERSION     NM_173567.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1436)
  AUTHORS   Shen,N., Gao,G., Lu,X., Jin,J., Lin,L., Qian,M. and Qin,Y.
  TITLE     Comprehensive analysis of the immune implication of EPHX4 gene in
            laryngeal squamous cell carcinoma
  JOURNAL   Braz J Otorhinolaryngol 90 (4), 101411 (2024)
   PUBMED   38663041
  REMARK    GeneRIF: Comprehensive analysis of the immune implication of EPHX4
            gene in laryngeal squamous cell carcinoma.
REFERENCE   2  (bases 1 to 1436)
  AUTHORS   Morisseau,C., Kodani,S.D., Kamita,S.G., Yang,J., Lee,K.S.S. and
            Hammock,B.D.
  TITLE     Relative Importance of Soluble and Microsomal Epoxide Hydrolases
            for the Hydrolysis of Epoxy-Fatty Acids in Human Tissues
  JOURNAL   Int J Mol Sci 22 (9), 4993 (2021)
   PUBMED   34066758
  REMARK    GeneRIF: Relative Importance of Soluble and Microsomal Epoxide
            Hydrolases for the Hydrolysis of Epoxy-Fatty Acids in Human
            Tissues.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1436)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1436)
  AUTHORS   Decker,M., Adamska,M., Cronin,A., Di Giallonardo,F., Burgener,J.,
            Marowsky,A., Falck,J.R., Morisseau,C., Hammock,B.D., Gruzdev,A.,
            Zeldin,D.C. and Arand,M.
  TITLE     EH3 (ABHD9): the first member of a new epoxide hydrolase family
            with high activity for fatty acid epoxides
  JOURNAL   J Lipid Res 53 (10), 2038-2045 (2012)
   PUBMED   22798687
  REMARK    GeneRIF: The identification of two human epoxide hydrolases: EH3
            and EH4.
REFERENCE   5  (bases 1 to 1436)
  AUTHORS   Bagryantseva,Y., Novotna,B., Rossner,P. Jr., Chvatalova,I.,
            Milcova,A., Svecova,V., Lnenickova,Z., Solansky,I. and Sram,R.J.
  TITLE     Oxidative damage to biological macromolecules in Prague bus drivers
            and garagemen: impact of air pollution and genetic polymorphisms
  JOURNAL   Toxicol Lett 199 (1), 60-68 (2010)
   PUBMED   20723587
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1436)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB475492.1, BC041475.1, AK074822.1 and AC104836.2.
            
            On Nov 23, 2018 this sequence version replaced NM_173567.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.50840.1,
                                           SRR1660807.55026.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370383.5/ ENSP00000359410.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DB475492.1         10-25
            17-1056             BC041475.1         1-1040
            1057-1057           AK074822.1         1026-1026
            1058-1434           BC041475.1         1042-1418
            1435-1436           AC104836.2         11941-11942
FEATURES             Location/Qualifiers
     source          1..1436
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.1"
     gene            1..1436
                     /gene="EPHX4"
                     /gene_synonym="ABHD7; EH4; EPHXRP"
                     /note="epoxide hydrolase 4"
                     /db_xref="GeneID:253152"
                     /db_xref="HGNC:HGNC:23758"
                     /db_xref="MIM:617401"
     exon            1..326
                     /gene="EPHX4"
                     /gene_synonym="ABHD7; EH4; EPHXRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1184
                     /gene="EPHX4"
                     /gene_synonym="ABHD7; EH4; EPHXRP"
                     /note="abhydrolase domain containing 7; epoxide
                     hydrolase-related protein; abhydrolase domain-containing
                     protein 7"
                     /codon_start=1
                     /product="epoxide hydrolase 4"
                     /protein_id="NP_775838.3"
                     /db_xref="CCDS:CCDS736.1"
                     /db_xref="GeneID:253152"
                     /db_xref="HGNC:HGNC:23758"
                     /db_xref="MIM:617401"
                     /translation="MARLRDCLPRLMLTLRSLLFWSLVYCYCGLCASIHLLKLLWSLG
                     KGPAQTFRRPAREHPPACLSDPSLGTHCYVRIKDSGLRFHYVAAGERGKPLMLLLHGF
                     PEFWYSWRYQLREFKSEYRVVALDLRGYGETDAPIHRQNYKLDCLITDIKDILDSLGY
                     SKCVLIGHDWGGMIAWLIAICYPEMVMKLIVINFPHPNVFTEYILRHPAQLLKSSYYY
                     FFQIPWFPEFMFSINDFKVLKHLFTSHSTGIGRKGCQLTTEDLEAYIYVFSQPGALSG
                     PINHYRNIFSCLPLKHHMVTTPTLLLWGENDAFMEVEMAEVTKIYVKNYFRLTILSEA
                     SHWLQQDQPDIVNKLIWTFLKEETRKKD"
     exon            327..412
                     /gene="EPHX4"
                     /gene_synonym="ABHD7; EH4; EPHXRP"
                     /inference="alignment:Splign:2.1.0"
     exon            413..570
                     /gene="EPHX4"
                     /gene_synonym="ABHD7; EH4; EPHXRP"
                     /inference="alignment:Splign:2.1.0"
     exon            571..699
                     /gene="EPHX4"
                     /gene_synonym="ABHD7; EH4; EPHXRP"
                     /inference="alignment:Splign:2.1.0"
     exon            700..803
                     /gene="EPHX4"
                     /gene_synonym="ABHD7; EH4; EPHXRP"
                     /inference="alignment:Splign:2.1.0"
     exon            804..952
                     /gene="EPHX4"
                     /gene_synonym="ABHD7; EH4; EPHXRP"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1436
                     /gene="EPHX4"
                     /gene_synonym="ABHD7; EH4; EPHXRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1302..1307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPHX4"
                     /gene_synonym="ABHD7; EH4; EPHXRP"
                     /note="hexamer: AATAAA"
     polyA_site      1334
                     /gene="EPHX4"
                     /gene_synonym="ABHD7; EH4; EPHXRP"
                     /note="major polyA site"
     regulatory      1411..1416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPHX4"
                     /gene_synonym="ABHD7; EH4; EPHXRP"
                     /note="hexamer: AATATA"
     polyA_site      1436
                     /gene="EPHX4"
                     /gene_synonym="ABHD7; EH4; EPHXRP"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgtcgag aggcgacggc gggctggcct ggcgcgctgc ggcgctcgct cacccgctcc
       61 cgaggaaggg cagtgggccc cgccgccgcc tcccaatggc gaggctgcgg gattgcctgc
      121 cccgcctgat gctcacgctc cggtccctgc tcttctggtc cctggtctac tgctactgcg
      181 ggctctgcgc ctccatccac ctgctcaaac ttttgtggag cctcggcaag gggccggcgc
      241 agaccttccg gcggcccgcc cgggagcacc ctcccgcgtg cctgagcgac ccctccttgg
      301 gcacccactg ctacgtgcgg atcaaggatt cagggttaag atttcactat gttgctgctg
      361 gagaaagagg caaaccactt atgctgctgc ttcatggatt tccagaattc tggtattctt
      421 ggcgttacca actgagagaa tttaaaagtg aatatcgagt tgtagcactg gatttgagag
      481 gttatggaga aacagatgct cccattcatc gacagaatta taaattggat tgtctaatta
      541 cagatataaa ggatatttta gattctttag ggtatagcaa atgtgttctt attggccatg
      601 actggggggg catgattgct tggctaattg ccatctgtta tcctgaaatg gtgatgaagc
      661 ttattgttat taacttccct catccaaatg tatttacaga atatatttta cgacaccctg
      721 ctcagctgtt gaaatccagt tattattact tcttccaaat accatggttc ccagaattta
      781 tgttctcaat aaatgatttc aaggttttga aacatctgtt taccagtcac agcactggca
      841 ttggaagaaa aggatgccaa ttaacaacag aggatcttga agcttatatt tatgtctttt
      901 ctcagcctgg agcattaagt ggcccaatta accattaccg aaatatcttc agctgcctgc
      961 ctctcaaaca tcacatggtg accactccaa cactactact gtggggagag aatgacgcat
     1021 tcatggaggt tgagatggct gaagtcacaa agatttatgt taaaaactat ttcaggctaa
     1081 ctattttgtc agaagccagt cattggcttc agcaagacca acctgacata gtgaacaaat
     1141 tgatatggac atttctaaaa gaagaaacaa gaaaaaaaga ttgacttttc tttatcttct
     1201 atgaagggtc tgtaatgaaa tctctaaata atttttaaaa attgttcatc aacttcttta
     1261 tgttttatta gaaaaaaact gttttaatgt gctttatcat aaataaatat cctgacaaat
     1321 ggtattgaaa aaaatctgag atcatgtgaa catataatac aatgttgatt ttcttctggt
     1381 gtattttgca cagacaagca tctgccttaa aatatataca cttgtacaaa aaggaa
//
