LOCUS       NM_024794               1838 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens epoxide hydrolase 3 (EPHX3), transcript variant 1,
            mRNA.
ACCESSION   NM_024794
VERSION     NM_024794.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1838)
  AUTHORS   Morisseau,C., Kodani,S.D., Kamita,S.G., Yang,J., Lee,K.S.S. and
            Hammock,B.D.
  TITLE     Relative Importance of Soluble and Microsomal Epoxide Hydrolases
            for the Hydrolysis of Epoxy-Fatty Acids in Human Tissues
  JOURNAL   Int J Mol Sci 22 (9), 4993 (2021)
   PUBMED   34066758
  REMARK    GeneRIF: Relative Importance of Soluble and Microsomal Epoxide
            Hydrolases for the Hydrolysis of Epoxy-Fatty Acids in Human
            Tissues.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1838)
  AUTHORS   Stott-Miller,M., Zhao,S., Wright,J.L., Kolb,S., Bibikova,M.,
            Klotzle,B., Ostrander,E.A., Fan,J.B., Feng,Z. and Stanford,J.L.
  TITLE     Validation study of genes with hypermethylated promoter regions
            associated with prostate cancer recurrence
  JOURNAL   Cancer Epidemiol Biomarkers Prev 23 (7), 1331-1339 (2014)
   PUBMED   24718283
  REMARK    GeneRIF: These results validate the association between promoter
            hypermethylation of ABHD9 and HOXD3 and prostate cancer recurrence
REFERENCE   3  (bases 1 to 1838)
  AUTHORS   Decker,M., Adamska,M., Cronin,A., Di Giallonardo,F., Burgener,J.,
            Marowsky,A., Falck,J.R., Morisseau,C., Hammock,B.D., Gruzdev,A.,
            Zeldin,D.C. and Arand,M.
  TITLE     EH3 (ABHD9): the first member of a new epoxide hydrolase family
            with high activity for fatty acid epoxides
  JOURNAL   J Lipid Res 53 (10), 2038-2045 (2012)
   PUBMED   22798687
  REMARK    GeneRIF: The identification of two human epoxide hydrolases: EH3
            and EH4.
REFERENCE   4  (bases 1 to 1838)
  AUTHORS   Bagryantseva,Y., Novotna,B., Rossner,P. Jr., Chvatalova,I.,
            Milcova,A., Svecova,V., Lnenickova,Z., Solansky,I. and Sram,R.J.
  TITLE     Oxidative damage to biological macromolecules in Prague bus drivers
            and garagemen: impact of air pollution and genetic polymorphisms
  JOURNAL   Toxicol Lett 199 (1), 60-68 (2010)
   PUBMED   20723587
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 1838)
  AUTHORS   Cottrell,S., Jung,K., Kristiansen,G., Eltze,E., Semjonow,A.,
            Ittmann,M., Hartmann,A., Stamey,T., Haefliger,C. and Weiss,G.
  TITLE     Discovery and validation of 3 novel DNA methylation markers of
            prostate cancer prognosis
  JOURNAL   J Urol 177 (5), 1753-1758 (2007)
   PUBMED   17437806
  REMARK    GeneRIF: methylation of the ABHD9 is significantly associated with
            prostate cancer prognosis.
REFERENCE   6  (bases 1 to 1838)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004257.1, AK026061.1 and BC115002.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024794.2.
            
            Transcript Variant: This variant (1) has an alternate 5'UTR.
            Transcript variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026061.1, BC132958.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221730.8/ ENSP00000221730.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC004257.1         39731-39758         c
            29-1475             AK026061.1         1-1447
            1476-1782           BC115002.1         1322-1628
            1783-1838           AK026061.1         1755-1810
FEATURES             Location/Qualifiers
     source          1..1838
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..1838
                     /gene="EPHX3"
                     /gene_synonym="ABHD9; EH3"
                     /note="epoxide hydrolase 3"
                     /db_xref="GeneID:79852"
                     /db_xref="HGNC:HGNC:23760"
                     /db_xref="MIM:617400"
     exon            1..480
                     /gene="EPHX3"
                     /gene_synonym="ABHD9; EH3"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..1320
                     /gene="EPHX3"
                     /gene_synonym="ABHD9; EH3"
                     /EC_number="3.3.2.10"
                     /note="abhydrolase domain containing 9; abhydrolase
                     domain-containing protein 9"
                     /codon_start=1
                     /product="epoxide hydrolase 3"
                     /protein_id="NP_079070.1"
                     /db_xref="CCDS:CCDS12327.1"
                     /db_xref="GeneID:79852"
                     /db_xref="HGNC:HGNC:23760"
                     /db_xref="MIM:617400"
                     /translation="MPELVVTALLAPSRLSLKLLRAFMWSLVFSVALVAAAVYGCIAL
                     THVLCRPRRGCCGRRRSASPACLSDPSLGEHGFLNLKSSGLRLHYVSAGRGNGPLMLF
                     LHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAPRDVDCYTIDLLLVDIKDVIL
                     GLGYSKCILVAHDWGALLAWHFSIYYPSLVERMVVVSGAPMSVYQDYSLHHISQFFRS
                     HYMFLFQLPWLPEKLLSMSDFQILKTTLTHRKTGIPCLTPSELEAFLYNFSQPGGLTG
                     PLNYYRNLFRNFPLEPQELTTPTLLLWGEKDTYLELGLVEAIGSRFVPGRLEAHILPG
                     IGHWIPQSNPQEMHQYMWAFLQDLLD"
     exon            481..566
                     /gene="EPHX3"
                     /gene_synonym="ABHD9; EH3"
                     /inference="alignment:Splign:2.1.0"
     exon            567..724
                     /gene="EPHX3"
                     /gene_synonym="ABHD9; EH3"
                     /inference="alignment:Splign:2.1.0"
     exon            725..853
                     /gene="EPHX3"
                     /gene_synonym="ABHD9; EH3"
                     /inference="alignment:Splign:2.1.0"
     exon            854..957
                     /gene="EPHX3"
                     /gene_synonym="ABHD9; EH3"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1094
                     /gene="EPHX3"
                     /gene_synonym="ABHD9; EH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1838
                     /gene="EPHX3"
                     /gene_synonym="ABHD9; EH3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1814..1819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPHX3"
                     /gene_synonym="ABHD9; EH3"
                     /note="hexamer: AATGAA"
     polyA_site      1838
                     /gene="EPHX3"
                     /gene_synonym="ABHD9; EH3"
                     /note="major polyA site"
ORIGIN      
        1 acccttgttt cctgtccctg tcgcgcccag gtgtttacct ggcactcagg tgagtggtgc
       61 gctctggctg ttttctgtcg gagccgcccg cctcttcctt cagcgcgtcc cacaaatccc
      121 gacggcacgg aggggcccca ggccaagggc gatgggcccc tgagccctga caccgcttcg
      181 ccgctgctgc aggtgcccct ggccggcagc gccgccgtgg tcccggagcg cggcgacatg
      241 ccggagctgg tggtgaccgc gctgctggcg ccgtcgcgcc tgtcgctgaa gctgctgcgc
      301 gccttcatgt ggagcctggt gttctcggtg gcgctggtgg ccgcggcggt ctacggctgc
      361 atagcgctca cgcacgtgct gtgccggccc cggcgcggct gctgcgggcg ccgtcggagc
      421 gcgtcccccg cctgcctgag cgacccctcg ctgggtgagc acggtttcct gaacctcaag
      481 agctcgggcc tgcgtctgca ctatgtctcg gctggacgag gtaacggacc cctcatgctg
      541 tttctgcacg gcttccctga gaactggttc tcctggcgtt accagctccg ggagttccag
      601 agccgcttcc atgttgtggc tgtggacttg cgaggctatg gcccctcgga tgcacctcgg
      661 gatgtggact gctacacaat cgacctgctg ctggtggaca tcaaagatgt catcctaggc
      721 ctgggttact cgaagtgcat ccttgtggcc catgactggg gtgccctcct tgcctggcat
      781 ttctccatct actacccatc cctggtcgag cggatggttg tggtcagtgg tgcccccatg
      841 tcggtgtacc aagactattc cctgcaccac atcagccagt tcttccgttc ccactacatg
      901 ttcctgttcc agctgccctg gctgcccgag aagctgctgt ctatgtctga ctttcagatt
      961 ctgaagacca ccctcaccca ccgcaagaca ggcatcccat gcttgacccc cagcgagctc
     1021 gaggccttcc tttataactt ctcacagcct ggtggcctca ctgggcccct caactactac
     1081 cgaaacctct tcaggaactt ccccctggaa ccccaggagc tgaccacacc cacattgctg
     1141 ctgtgggggg agaaggacac ttacttggag ctggggctgg tggaagccat cggcagccgc
     1201 tttgtgccgg gccgcttgga ggcccacatc ctgccaggca tagggcattg gatcccacag
     1261 agcaaccccc aggagatgca ccagtacatg tgggccttct tgcaagacct gctggactag
     1321 tggtccttgc tggcctgccc aggaggcatg gatactcagg aaggaacaca cacccattat
     1381 ctgtgtgtgc ctgggagtcc atacaatgtc catacatggg tgaactcttg aatcgctcat
     1441 aggcatggga ctcctggatc ccacacaagc gcacctatgg gtgcctcggg acacaccaac
     1501 ccctatactc acacacaggc atggatgcat gtgtgtgtaa caaacacttt gaccctggga
     1561 actgggtata cctctcttcc agtggagcca gatgccgaga ccgagtgtcc cacctcctcc
     1621 cttcctgggg cctcactctg cgctttgcca aagtcgcttc tctgccatag ctgcacagac
     1681 cttaaaccct gaccttcctg tccctgcctt cgacctcctg cctgggtctt cagctcagtg
     1741 ctactctgaa tacaatactg ctgaccacat ttggctactt cagcttaaat gtatgttaat
     1801 tgaaatgaaa tacaatgaaa atgcagtgct cagtccca
//
