LOCUS       NM_004445               3999 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens EPH receptor B6 (EPHB6), transcript variant 1, mRNA.
ACCESSION   NM_004445 XM_006715881
VERSION     NM_004445.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3999)
  AUTHORS   Yu,H., Qin,X.K., Yin,K.W., Li,Z.M., Ni,E.D., Yang,J.M., Liu,X.H.,
            Zhou,A.J., Li,S.J., Gao,T.M., Li,Y. and Li,J.M.
  TITLE     EphB6 deficiency in intestinal neurons promotes tumor growth in
            colorectal cancer by neurotransmitter GABA signaling
  JOURNAL   Carcinogenesis 44 (8-9), 682-694 (2023)
   PUBMED   37294054
  REMARK    GeneRIF: EphB6 deficiency in intestinal neurons promotes tumor
            growth in colorectal cancer by neurotransmitter GABA signaling.
REFERENCE   2  (bases 1 to 3999)
  AUTHORS   Salokas,K., Liu,X., Ohman,T., Chowdhury,I., Gawriyski,L.,
            Keskitalo,S. and Varjosalo,M.
  TITLE     Physical and functional interactome atlas of human receptor
            tyrosine kinases
  JOURNAL   EMBO Rep 23 (6), e54041 (2022)
   PUBMED   35384245
REFERENCE   3  (bases 1 to 3999)
  AUTHORS   Mason,E.O., Goldgur,Y., Robev,D., Freywald,A., Nikolov,D.B. and
            Himanen,J.P.
  TITLE     Structure of the EphB6 receptor ectodomain
  JOURNAL   PLoS One 16 (3), e0247335 (2021)
   PUBMED   33770085
  REMARK    GeneRIF: Structure of the EphB6 receptor ectodomain.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3999)
  AUTHORS   Li,Y., Luo,Z.Y., Hu,Y.Y., Bi,Y.W., Yang,J.M., Zou,W.J., Song,Y.L.,
            Li,S., Shen,T., Li,S.J., Huang,L., Zhou,A.J., Gao,T.M. and Li,J.M.
  TITLE     The gut microbiota regulates autism-like behavior by mediating
            vitamin B6 homeostasis in EphB6-deficient mice
  JOURNAL   Microbiome 8 (1), 120 (2020)
   PUBMED   32819434
  REMARK    GeneRIF: The gut microbiota regulates autism-like behavior by
            mediating vitamin B6 homeostasis in EphB6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3999)
  AUTHORS   Truitt,L. and Freywald,A.
  TITLE     Dancing with the dead: Eph receptors and their kinase-null partners
  JOURNAL   Biochem Cell Biol 89 (2), 115-129 (2011)
   PUBMED   21455264
  REMARK    Review article
REFERENCE   6  (bases 1 to 3999)
  AUTHORS   Holder,N. and Klein,R.
  TITLE     Eph receptors and ephrins: effectors of morphogenesis
  JOURNAL   Development 126 (10), 2033-2044 (1999)
   PUBMED   10207129
  REMARK    Review article
REFERENCE   7  (bases 1 to 3999)
  AUTHORS   Hock,B., Bohme,B., Karn,T., Yamamoto,T., Kaibuchi,K., Holtrich,U.,
            Holland,S., Pawson,T., Rubsamen-Waigmann,H. and Strebhardt,K.
  TITLE     PDZ-domain-mediated interaction of the Eph-related receptor
            tyrosine kinase EphB3 and the ras-binding protein AF6 depends on
            the kinase activity of the receptor
  JOURNAL   Proc Natl Acad Sci U S A 95 (17), 9779-9784 (1998)
   PUBMED   9707552
REFERENCE   8  (bases 1 to 3999)
  AUTHORS   Zhou,R.
  TITLE     The Eph family receptors and ligands
  JOURNAL   Pharmacol Ther 77 (3), 151-181 (1998)
   PUBMED   9576626
  REMARK    Review article
REFERENCE   9  (bases 1 to 3999)
  AUTHORS   Flanagan,J.G. and Vanderhaeghen,P.
  TITLE     The ephrins and Eph receptors in neural development
  JOURNAL   Annu Rev Neurosci 21, 309-345 (1998)
   PUBMED   9530499
  REMARK    Review article
REFERENCE   10 (bases 1 to 3999)
  AUTHORS   Matsuoka,H., Iwata,N., Ito,M., Shimoyama,M., Nagata,A., Chihara,K.,
            Takai,S. and Matsui,T.
  TITLE     Expression of a kinase-defective Eph-like receptor in the normal
            human brain
  JOURNAL   Biochem Biophys Res Commun 235 (3), 487-492 (1997)
   PUBMED   9207182
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL532843.3, BX419816.2,
            AC245427.3, CN283345.1, BC110607.1 and CN283348.1.
            
            On or before Oct 9, 2018 this sequence version replaced
            XM_006715881.2, NM_004445.5.
            
            Summary: This gene encodes a member of a family of transmembrane
            proteins that function as receptors for ephrin-B family proteins.
            Unlike other members of this family, the encoded protein does not
            contain a functional kinase domain. Activity of this protein can
            influence cell adhesion and migration. Expression of this gene is
            downregulated during tumor progression, suggesting that the protein
            may suppress tumor invasion and metastasis. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jul
            2013].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            CCDS Note: The coding region has been updated to include an
            additional codon based on a 3-nt insertion that is present in the
            GRCh38 reference genome sequence.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.251975.1,
                                           SRR1803613.238982.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000652003.1/ ENSP00000498670.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-291               AL532843.3         117-407
            292-391             BX419816.2         250-349
            392-392             AC245427.3         152233-152233
            393-688             CN283345.1         318-613
            689-1259            BC110607.1         124-694
            1260-1262           CN283348.1         318-320
            1263-1713           BC110607.1         695-1145
            1714-1714           AC245427.3         156598-156598
            1715-2491           BC110607.1         1147-1923
            2492-2606           AC245427.3         158708-158822
            2607-2659           AC245427.3         159097-159149
            2660-3946           BC110607.1         2092-3378
            3947-3999           AC245427.3         162141-162193
FEATURES             Location/Qualifiers
     source          1..3999
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..3999
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /note="EPH receptor B6"
                     /db_xref="GeneID:2051"
                     /db_xref="HGNC:HGNC:3396"
                     /db_xref="MIM:602757"
     exon            1..310
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            311..445
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            446..562
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            563..640
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            641..841
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     CDS             742..3810
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /EC_number="2.7.10.1"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; ephrin type-B receptor 6; tyrosine-protein
                     kinase-defective receptor EPH-6; human kinase-defective
                     Eph-family receptor protein"
                     /codon_start=1
                     /product="ephrin type-B receptor 6 isoform a precursor"
                     /protein_id="NP_004436.4"
                     /db_xref="CCDS:CCDS5873.2"
                     /db_xref="GeneID:2051"
                     /db_xref="HGNC:HGNC:3396"
                     /db_xref="MIM:602757"
                     /translation="MATEGAAQLGNRVAGMVCSLWVLLLVSSVLALEEVLLDTTGETS
                     EIGWLTYPPGGWDEVSVLDDQRRLTRTFEACHVAGAPPGTGQDNWLQTHFVERRGAQR
                     AHIRLHFSVRACSSLGVSGGTCRETFTLYYRQAEEPDSPDSVSSWHLKRWTKVDTIAA
                     DESFPSSSSSSSSSSSSAAWAVGPHGAGQRAGLQLNVKERSFGPLTQRGFYVAFQDTG
                     ACLALVAVRLFSYTCPAVLRSFASFPETQASGAGGASLVAAVGTCVAHAEPEEDGVGG
                     QAGGSPPRLHCNGEGKWMVAVGGCRCQPGYQPARGDKACQACPRGLYKASAGNAPCSP
                     CPARSHAPNPAAPVCPCLEGFYRASSDPPEAPCTGPPSAPQELWFEVQGSALMLHWRL
                     PRELGGRGDLLFNVVCKECEGRQEPASGGGGTCHRCRDEVHFDPRQRGLTESRVLVGG
                     LRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVPVVHQVSRASNSITVS
                     WPQPDQTNGNILDYQLRYYDQAEDESHSFTLTSETNTATVTQLSPGHIYGFQVRARTA
                     AGHGPYGGKVYFQTLPQGELSSQLPERLSLVIGSILGALAFLLLAAITVLAVVFQRKR
                     RGTGYTEQLQQYSSPGLGVKYYIDPSTYEDPCQAIRELAREVDPAYIKIEEVIGTGSF
                     GEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQFQHPNILRLEGVVT
                     KSRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRSLS
                     AHSVLVNSHLVCKVARLGHSPQGPSCLLRWAAPEVIAHGKHTTSSDVWSFGILMWEVM
                     SYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVA
                     AFDKMIRKPDTLQAGGDPGERPSQALLTPVALDFPCLDSPQAWLSAIGLECYQDNFSK
                     FGLCTFSDVAQLSLEDLPALGITLAGHQKKLLHHIQLLQQHLRQQGSVEV"
     exon            842..906
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1690
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1846
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2203
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2328
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2491
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2606
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2659
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2779
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..3027
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3028..3201
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3202..3351
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3352..3545
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3546..3701
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3702..3999
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3974..3979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /note="hexamer: ATTAAA"
     polyA_site      3999
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /note="major polyA site"
ORIGIN      
        1 gggctgcgtt cgctccagcc gcggctctac agcagcgggc ggcgggaccc gggacccagc
       61 ttggcgacgg cgatctcgac gcgggccccc aggatctccc ggcgccccac ctctggagca
      121 gcccctgccg ccagcgtcag gtccaccccg gaatcccagg gactctcggc gccgaacgga
      181 cccgggccgg gtgcaacggg gtccccggac tggagaagac gcgggtggca ccgtgcgagc
      241 tccaggagcc ccgggtccac tgcgaggcct cggggggcgc agacctgcag agactgcggc
      301 caacgggaag aaataaaggg attatagtcc acccaattca cagacttctg agactcagac
      361 acgaggagag atagagaacc gccaatctct aaatcaacaa gcaaaggagg tgccaagcct
      421 gtttgtcttc attgtgacac tggagtctag atgctgggaa gtccaagatc agggtgccgg
      481 catggtcagt tcctggcgaa gcctctcttc taggtttcag actgccctct tctttgttgt
      541 gtcctcgaat ggcagaaaaa ggggtggctg ttggaggaag ggaggagagt aaatgaagag
      601 aaagaactgg aataacccct tgcagaaaaa aaaaaaaagg gaagcaagct tagctgtaca
      661 ccctgagtct tgcaaaagct gcagccccac ccaggagcag ggtggtggct ggggcgatgg
      721 tggacgccct gaagatgtcc catggctact gaaggggctg cccagttagg gaacagagtg
      781 gcgggcatgg tgtgtagcct atgggtgctg ctcctggtgt cttcagttct ggctctggaa
      841 gaggtattgc tggacaccac cggagagaca tctgagattg gctggctcac ctacccacca
      901 ggggggtggg acgaggtgag tgttctggac gaccagcgac gcctgactcg gacctttgag
      961 gcatgtcatg tggcaggggc ccctccaggc accgggcagg acaattggtt gcagacacac
     1021 tttgtggagc ggcgcggggc ccagagggcg cacattcgac tccacttctc tgtgcgggca
     1081 tgctccagcc tgggtgtgag cggcggcacc tgccgggaga ccttcaccct ttactaccgt
     1141 caggctgagg agcccgacag ccctgacagc gtttcctcct ggcacctcaa acgctggacc
     1201 aaggtggaca caattgcagc agacgagagc tttccctcct cctcctcctc ctcctcctcc
     1261 tcttcttcct ctgcagcgtg ggctgtggga ccccacgggg ctgggcagcg ggctggactg
     1321 caactgaacg tcaaagagcg gagctttggg cctctcaccc aacgcggctt ctacgtggcc
     1381 ttccaggaca cgggggcctg cctggccctg gtcgctgtca ggctcttctc ctacacctgc
     1441 cctgccgtgc tccgatcctt tgcttccttt ccagagacgc aggccagtgg ggctgggggg
     1501 gcctccctgg tggcagctgt gggcacctgt gtggctcatg cagagccaga ggaggatgga
     1561 gtagggggcc aggcaggagg cagccccccc aggctgcact gcaacgggga gggcaagtgg
     1621 atggtagctg tcgggggctg ccgctgccag cctggatacc aaccagcacg aggagacaag
     1681 gcctgccaag cctgcccacg ggggctctat aaggcttctg ctgggaatgc tccctgctca
     1741 ccatgccctg cccgcagtca cgctcccaac ccagcagccc ccgtttgccc ctgcctggag
     1801 ggcttctacc gggccagttc cgacccacca gaggccccct gcactggtcc tccatcggct
     1861 ccccaggagc tttggtttga ggtgcaaggc tcagcactca tgctacactg gcgcctgcct
     1921 cgggagctgg ggggtcgagg ggacctgctc ttcaatgtcg tgtgcaagga gtgtgaaggc
     1981 cgccaggaac ctgccagcgg tggtgggggc acttgtcacc gctgcaggga tgaggtccac
     2041 ttcgaccctc gccagagagg cctgactgag agccgagtgt tagtgggggg actccgggca
     2101 cacgtaccct acatcttaga ggtgcaggct gttaatgggg tgtctgagct cagccctgac
     2161 cctcctcagg ctgcagccat caatgtcagc accagccatg aagtgccctc tgctgtccct
     2221 gtggtgcacc aggtgagccg ggcatccaac agcatcacgg tgtcctggcc gcagcccgac
     2281 cagaccaatg ggaacatcct ggactatcag ctccgctact atgaccaggc agaagacgaa
     2341 tcccactcct tcaccctgac cagcgagacc aacactgcca ccgtgacaca gctgagccct
     2401 ggccacatct atggtttcca ggtgcgggcc cggactgctg ccggccacgg cccctacggg
     2461 ggcaaagtct atttccagac acttcctcaa ggggagctgt cttcccagct tccagaaaga
     2521 ctctccttgg tgatcggctc catcctgggg gctttggcct tcctcctgct ggcagccatc
     2581 accgtgctgg cggtcgtctt ccagcggaag cggcgtggga ctggctacac agagcagctg
     2641 cagcaataca gcagcccagg actcggggtg aagtattaca tcgacccctc cacctacgag
     2701 gacccctgtc aggccatccg agaacttgcc cgggaagtcg atcctgctta tatcaagatt
     2761 gaggaggtca ttgggacagg ctcttttgga gaagtgcgcc agggccgcct gcagccacgg
     2821 ggacggaggg agcagactgt ggccatccag gccctgtggg ccgggggcgc cgaaagcctg
     2881 cagatgacct tcctgggccg ggccgcagtg ctgggtcagt tccagcaccc caacatcctg
     2941 cggctggagg gcgtggtcac caagagccga cccctcatgg tgctgacgga gttcatggag
     3001 cttggccccc tggacagctt cctcaggcag cgggagggcc agttcagcag cctgcagctg
     3061 gtggccatgc agcggggagt ggctgctgcc atgcagtacc tgtccagctt tgccttcgtc
     3121 catcgctcgc tgtctgccca cagcgtgctg gtgaatagcc acttggtgtg caaggtggcc
     3181 cgtcttggcc acagtcctca gggcccaagt tgtttgcttc gctgggcagc cccagaggtc
     3241 attgcacatg gaaagcatac aacatccagt gatgtctgga gctttgggat actcatgtgg
     3301 gaagtgatga gttatggaga acggccttac tgggacatga gtgagcagga ggtactaaat
     3361 gcaatagagc aggagttccg gctgcccccg cctccaggct gtcctcctgg attacatcta
     3421 cttatgttgg acacttggca gaaggaccgt gcccggcggc ctcattttga ccagctggtg
     3481 gctgcatttg acaagatgat ccgcaagcca gataccctgc aggctggcgg ggacccaggg
     3541 gaaaggcctt cccaggccct tctgacccct gtggccctgg actttccttg tctggactca
     3601 ccccaggcct ggctttcagc cattggactg gagtgctacc aggacaactt ctccaagttt
     3661 ggcctctgta ccttcagtga tgtggctcag ctcagcctag aagacctgcc tgccctgggc
     3721 atcaccctgg ctggccacca gaagaagctg ctgcaccaca tccagctcct tcagcaacac
     3781 ctgaggcagc agggctcagt ggaggtctga gaatgacgat acccgtgact cagccctgga
     3841 cactggtccg agaagggaca tgtgggacgt gagccgggct ccaacagcct ctgtgagaga
     3901 tgccccacac caaacccaac cctcccgatg gctgcattcc ctggtcctcc gcctctccac
     3961 cagccccctc ctcattaaag ggaaagaagg gaatttgca
//
