LOCUS       NM_001280794            3934 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens EPH receptor B6 (EPHB6), transcript variant 2, mRNA.
ACCESSION   NM_001280794
VERSION     NM_001280794.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3934)
  AUTHORS   Yu,H., Qin,X.K., Yin,K.W., Li,Z.M., Ni,E.D., Yang,J.M., Liu,X.H.,
            Zhou,A.J., Li,S.J., Gao,T.M., Li,Y. and Li,J.M.
  TITLE     EphB6 deficiency in intestinal neurons promotes tumor growth in
            colorectal cancer by neurotransmitter GABA signaling
  JOURNAL   Carcinogenesis 44 (8-9), 682-694 (2023)
   PUBMED   37294054
  REMARK    GeneRIF: EphB6 deficiency in intestinal neurons promotes tumor
            growth in colorectal cancer by neurotransmitter GABA signaling.
REFERENCE   2  (bases 1 to 3934)
  AUTHORS   Salokas,K., Liu,X., Ohman,T., Chowdhury,I., Gawriyski,L.,
            Keskitalo,S. and Varjosalo,M.
  TITLE     Physical and functional interactome atlas of human receptor
            tyrosine kinases
  JOURNAL   EMBO Rep 23 (6), e54041 (2022)
   PUBMED   35384245
REFERENCE   3  (bases 1 to 3934)
  AUTHORS   Mason,E.O., Goldgur,Y., Robev,D., Freywald,A., Nikolov,D.B. and
            Himanen,J.P.
  TITLE     Structure of the EphB6 receptor ectodomain
  JOURNAL   PLoS One 16 (3), e0247335 (2021)
   PUBMED   33770085
  REMARK    GeneRIF: Structure of the EphB6 receptor ectodomain.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3934)
  AUTHORS   Li,Y., Luo,Z.Y., Hu,Y.Y., Bi,Y.W., Yang,J.M., Zou,W.J., Song,Y.L.,
            Li,S., Shen,T., Li,S.J., Huang,L., Zhou,A.J., Gao,T.M. and Li,J.M.
  TITLE     The gut microbiota regulates autism-like behavior by mediating
            vitamin B6 homeostasis in EphB6-deficient mice
  JOURNAL   Microbiome 8 (1), 120 (2020)
   PUBMED   32819434
  REMARK    GeneRIF: The gut microbiota regulates autism-like behavior by
            mediating vitamin B6 homeostasis in EphB6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3934)
  AUTHORS   Truitt,L. and Freywald,A.
  TITLE     Dancing with the dead: Eph receptors and their kinase-null partners
  JOURNAL   Biochem Cell Biol 89 (2), 115-129 (2011)
   PUBMED   21455264
  REMARK    Review article
REFERENCE   6  (bases 1 to 3934)
  AUTHORS   Holder,N. and Klein,R.
  TITLE     Eph receptors and ephrins: effectors of morphogenesis
  JOURNAL   Development 126 (10), 2033-2044 (1999)
   PUBMED   10207129
  REMARK    Review article
REFERENCE   7  (bases 1 to 3934)
  AUTHORS   Hock,B., Bohme,B., Karn,T., Yamamoto,T., Kaibuchi,K., Holtrich,U.,
            Holland,S., Pawson,T., Rubsamen-Waigmann,H. and Strebhardt,K.
  TITLE     PDZ-domain-mediated interaction of the Eph-related receptor
            tyrosine kinase EphB3 and the ras-binding protein AF6 depends on
            the kinase activity of the receptor
  JOURNAL   Proc Natl Acad Sci U S A 95 (17), 9779-9784 (1998)
   PUBMED   9707552
REFERENCE   8  (bases 1 to 3934)
  AUTHORS   Zhou,R.
  TITLE     The Eph family receptors and ligands
  JOURNAL   Pharmacol Ther 77 (3), 151-181 (1998)
   PUBMED   9576626
  REMARK    Review article
REFERENCE   9  (bases 1 to 3934)
  AUTHORS   Flanagan,J.G. and Vanderhaeghen,P.
  TITLE     The ephrins and Eph receptors in neural development
  JOURNAL   Annu Rev Neurosci 21, 309-345 (1998)
   PUBMED   9530499
  REMARK    Review article
REFERENCE   10 (bases 1 to 3934)
  AUTHORS   Matsuoka,H., Iwata,N., Ito,M., Shimoyama,M., Nagata,A., Chihara,K.,
            Takai,S. and Matsui,T.
  TITLE     Expression of a kinase-defective Eph-like receptor in the normal
            human brain
  JOURNAL   Biochem Biophys Res Commun 235 (3), 487-492 (1997)
   PUBMED   9207182
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC245427.3.
            
            On Aug 14, 2020 this sequence version replaced NM_001280794.2.
            
            Summary: This gene encodes a member of a family of transmembrane
            proteins that function as receptors for ephrin-B family proteins.
            Unlike other members of this family, the encoded protein does not
            contain a functional kinase domain. Activity of this protein can
            influence cell adhesion and migration. Expression of this gene is
            downregulated during tumor progression, suggesting that the protein
            may suppress tumor invasion and metastasis. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jul
            2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks
            an exon in the 5' coding region, and initiates translation at a
            downstream in-frame start codon, compared to variant 1. The encoded
            isoform (b) has a shorter N-terminus, compared to isoform a. Both
            variants 2 and 3 encode the same isoform (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056159.1, SRR14038192.3307019.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-310               AC245427.3         146176-146485
            311-445             AC245427.3         152152-152286
            446-562             AC245427.3         153117-153233
            563-640             AC245427.3         153856-153933
            641-841             AC245427.3         154227-154427
            842-1625            AC245427.3         155066-155849
            1626-1781           AC245427.3         156575-156730
            1782-2138           AC245427.3         157060-157416
            2139-2263           AC245427.3         157581-157705
            2264-2426           AC245427.3         158006-158168
            2427-2541           AC245427.3         158708-158822
            2542-2594           AC245427.3         159097-159149
            2595-2714           AC245427.3         159341-159460
            2715-2962           AC245427.3         159592-159839
            2963-3136           AC245427.3         160074-160247
            3137-3286           AC245427.3         160917-161066
            3287-3480           AC245427.3         161314-161507
            3481-3636           AC245427.3         161630-161785
            3637-3934           AC245427.3         161896-162193
FEATURES             Location/Qualifiers
     source          1..3934
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..3934
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /note="EPH receptor B6"
                     /db_xref="GeneID:2051"
                     /db_xref="HGNC:HGNC:3396"
                     /db_xref="MIM:602757"
     exon            1..310
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            311..445
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            446..562
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            563..640
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            641..841
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1625
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     CDS             1556..3745
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /EC_number="2.7.10.1"
                     /note="isoform b is encoded by transcript variant 2;
                     ephrin type-B receptor 6; tyrosine-protein
                     kinase-defective receptor EPH-6; human kinase-defective
                     Eph-family receptor protein"
                     /codon_start=1
                     /product="ephrin type-B receptor 6 isoform b"
                     /protein_id="NP_001267723.2"
                     /db_xref="CCDS:CCDS75672.1"
                     /db_xref="GeneID:2051"
                     /db_xref="HGNC:HGNC:3396"
                     /db_xref="MIM:602757"
                     /translation="MVAVGGCRCQPGYQPARGDKACQACPRGLYKASAGNAPCSPCPA
                     RSHAPNPAAPVCPCLEGFYRASSDPPEAPCTGPPSAPQELWFEVQGSALMLHWRLPRE
                     LGGRGDLLFNVVCKECEGRQEPASGGGGTCHRCRDEVHFDPRQRGLTESRVLVGGLRA
                     HVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVPVVHQVSRASNSITVSWPQ
                     PDQTNGNILDYQLRYYDQAEDESHSFTLTSETNTATVTQLSPGHIYGFQVRARTAAGH
                     GPYGGKVYFQTLPQGELSSQLPERLSLVIGSILGALAFLLLAAITVLAVVFQRKRRGT
                     GYTEQLQQYSSPGLGVKYYIDPSTYEDPCQAIRELAREVDPAYIKIEEVIGTGSFGEV
                     RQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQFQHPNILRLEGVVTKSR
                     PLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRSLSAHS
                     VLVNSHLVCKVARLGHSPQGPSCLLRWAAPEVIAHGKHTTSSDVWSFGILMWEVMSYG
                     ERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAFD
                     KMIRKPDTLQAGGDPGERPSQALLTPVALDFPCLDSPQAWLSAIGLECYQDNFSKFGL
                     CTFSDVAQLSLEDLPALGITLAGHQKKLLHHIQLLQQHLRQQGSVEV"
     exon            1626..1781
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..2138
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2263
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2426
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2541
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2594
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2714
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2715..2962
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3136
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..3286
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3287..3480
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3481..3636
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3637..3934
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3909..3914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /note="hexamer: ATTAAA"
     polyA_site      3934
                     /gene="EPHB6"
                     /gene_synonym="HEP"
                     /note="major polyA site"
ORIGIN      
        1 gggctgcgtt cgctccagcc gcggctctac agcagcgggc ggcgggaccc gggacccagc
       61 ttggcgacgg cgatctcgac gcgggccccc aggatctccc ggcgccccac ctctggagca
      121 gcccctgccg ccagcgtcag gtccaccccg gaatcccagg gactctcggc gccgaacgga
      181 cccgggccgg gtgcaacggg gtccccggac tggagaagac gcgggtggca ccgtgcgagc
      241 tccaggagcc ccgggtccac tgcgaggcct cggggggcgc agacctgcag agactgcggc
      301 caacgggaag aaataaaggg attatagtcc acccaattca cagacttctg agactcagac
      361 acgaggagag atagagaacc gccaatctct aaatcaacaa gcaaaggagg tgccaagcct
      421 gtttgtcttc attgtgacac tggagtctag atgctgggaa gtccaagatc agggtgccgg
      481 catggtcagt tcctggcgaa gcctctcttc taggtttcag actgccctct tctttgttgt
      541 gtcctcgaat ggcagaaaaa ggggtggctg ttggaggaag ggaggagagt aaatgaagag
      601 aaagaactgg aataacccct tgcagaaaaa aaaaaaaagg gaagcaagct tagctgtaca
      661 ccctgagtct tgcaaaagct gcagccccac ccaggagcag ggtggtggct ggggcgatgg
      721 tggacgccct gaagatgtcc catggctact gaaggggctg cccagttagg gaacagagtg
      781 gcgggcatgg tgtgtagcct atgggtgctg ctcctggtgt cttcagttct ggctctggaa
      841 gtgggacgag gtgagtgttc tggacgacca gcgacgcctg actcggacct ttgaggcatg
      901 tcatgtggca ggggcccctc caggcaccgg gcaggacaat tggttgcaga cacactttgt
      961 ggagcggcgc ggggcccaga gggcgcacat tcgactccac ttctctgtgc gggcatgctc
     1021 cagcctgggt gtgagcggcg gcacctgccg ggagaccttc accctttact accgtcaggc
     1081 tgaggagccc gacagccctg acagcgtttc ctcctggcac ctcaaacgct ggaccaaggt
     1141 ggacacaatt gcagcagacg agagctttcc ctcctcctcc tcctcctcct cctcctcttc
     1201 ttcctctgca gcgtgggctg tgggacccca cggggctggg cagcgggctg gactgcaact
     1261 gaacgtcaaa gagcggagct ttgggcctct cacccaacgc ggcttctacg tggccttcca
     1321 ggacacgggg gcctgcctgg ccctggtcgc tgtcaggctc ttctcctaca cctgccctgc
     1381 cgtgctccga tcctttgctt cctttccaga gacgcaggcc agtggggctg ggggggcctc
     1441 cctggtggca gctgtgggca cctgtgtggc tcatgcagag ccagaggagg atggagtagg
     1501 gggccaggca ggaggcagcc cccccaggct gcactgcaac ggggagggca agtggatggt
     1561 agctgtcggg ggctgccgct gccagcctgg ataccaacca gcacgaggag acaaggcctg
     1621 ccaagcctgc ccacgggggc tctataaggc ttctgctggg aatgctccct gctcaccatg
     1681 ccctgcccgc agtcacgctc ccaacccagc agcccccgtt tgcccctgcc tggagggctt
     1741 ctaccgggcc agttccgacc caccagaggc cccctgcact ggtcctccat cggctcccca
     1801 ggagctttgg tttgaggtgc aaggctcagc actcatgcta cactggcgcc tgcctcggga
     1861 gctggggggt cgaggggacc tgctcttcaa tgtcgtgtgc aaggagtgtg aaggccgcca
     1921 ggaacctgcc agcggtggtg ggggcacttg tcaccgctgc agggatgagg tccacttcga
     1981 ccctcgccag agaggcctga ctgagagccg agtgttagtg gggggactcc gggcacacgt
     2041 accctacatc ttagaggtgc aggctgttaa tggggtgtct gagctcagcc ctgaccctcc
     2101 tcaggctgca gccatcaatg tcagcaccag ccatgaagtg ccctctgctg tccctgtggt
     2161 gcaccaggtg agccgggcat ccaacagcat cacggtgtcc tggccgcagc ccgaccagac
     2221 caatgggaac atcctggact atcagctccg ctactatgac caggcagaag acgaatccca
     2281 ctccttcacc ctgaccagcg agaccaacac tgccaccgtg acacagctga gccctggcca
     2341 catctatggt ttccaggtgc gggcccggac tgctgccggc cacggcccct acgggggcaa
     2401 agtctatttc cagacacttc ctcaagggga gctgtcttcc cagcttccag aaagactctc
     2461 cttggtgatc ggctccatcc tgggggcttt ggccttcctc ctgctggcag ccatcaccgt
     2521 gctggcggtc gtcttccagc ggaagcggcg tgggactggc tacacagagc agctgcagca
     2581 atacagcagc ccaggactcg gggtgaagta ttacatcgac ccctccacct acgaggaccc
     2641 ctgtcaggcc atccgagaac ttgcccggga agtcgatcct gcttatatca agattgagga
     2701 ggtcattggg acaggctctt ttggagaagt gcgccagggc cgcctgcagc cacggggacg
     2761 gagggagcag actgtggcca tccaggccct gtgggccggg ggcgccgaaa gcctgcagat
     2821 gaccttcctg ggccgggccg cagtgctggg tcagttccag caccccaaca tcctgcggct
     2881 ggagggcgtg gtcaccaaga gccgacccct catggtgctg acggagttca tggagcttgg
     2941 ccccctggac agcttcctca ggcagcggga gggccagttc agcagcctgc agctggtggc
     3001 catgcagcgg ggagtggctg ctgccatgca gtacctgtcc agctttgcct tcgtccatcg
     3061 ctcgctgtct gcccacagcg tgctggtgaa tagccacttg gtgtgcaagg tggcccgtct
     3121 tggccacagt cctcagggcc caagttgttt gcttcgctgg gcagccccag aggtcattgc
     3181 acatggaaag catacaacat ccagtgatgt ctggagcttt gggatactca tgtgggaagt
     3241 gatgagttat ggagaacggc cttactggga catgagtgag caggaggtac taaatgcaat
     3301 agagcaggag ttccggctgc ccccgcctcc aggctgtcct cctggattac atctacttat
     3361 gttggacact tggcagaagg accgtgcccg gcggcctcat tttgaccagc tggtggctgc
     3421 atttgacaag atgatccgca agccagatac cctgcaggct ggcggggacc caggggaaag
     3481 gccttcccag gcccttctga cccctgtggc cctggacttt ccttgtctgg actcacccca
     3541 ggcctggctt tcagccattg gactggagtg ctaccaggac aacttctcca agtttggcct
     3601 ctgtaccttc agtgatgtgg ctcagctcag cctagaagac ctgcctgccc tgggcatcac
     3661 cctggctggc caccagaaga agctgctgca ccacatccag ctccttcagc aacacctgag
     3721 gcagcagggc tcagtggagg tctgagaatg acgatacccg tgactcagcc ctggacactg
     3781 gtccgagaag ggacatgtgg gacgtgagcc gggctccaac agcctctgtg agagatgccc
     3841 cacaccaaac ccaaccctcc cgatggctgc attccctggt cctccgcctc tccaccagcc
     3901 ccctcctcat taaagggaaa gaagggaatt tgca
//
