LOCUS       NM_004443               4234 bp    mRNA    linear   PRI 26-FEB-2024
DEFINITION  Homo sapiens EPH receptor B3 (EPHB3), mRNA.
ACCESSION   NM_004443
VERSION     NM_004443.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4234)
  AUTHORS   Gao,X., Zhang,R., He,Y., Wang,X., Bao,W., Feng,X., Chai,J. and
            Wang,J.
  TITLE     EphB3 protein is a potential ancillary diagnostic biomarker for
            thyroid cancers
  JOURNAL   Ann Diagn Pathol 69, 152262 (2024)
   PUBMED   38150866
  REMARK    GeneRIF: EphB3 protein is a potential ancillary diagnostic
            biomarker for thyroid cancers.
REFERENCE   2  (bases 1 to 4234)
  AUTHORS   Zhang,F., Shi,H., Xue,H., Li,H., Li,C. and Han,Q.
  TITLE     Up-regulated lncRNA SNHG9 mediates the pathogenesis of dilated
            cardiomyopathy via miR-326/EPHB3 axis
  JOURNAL   J Thromb Thrombolysis 55 (4), 634-648 (2023)
   PUBMED   37004604
  REMARK    GeneRIF: Up-regulated lncRNA SNHG9 mediates the pathogenesis of
            dilated cardiomyopathy via miR-326/EPHB3 axis.
REFERENCE   3  (bases 1 to 4234)
  AUTHORS   Lee,T.H., Heo,J.H., Jeong,J.Y., Lee,G.H., Park,D.S. and Kim,T.H.
  TITLE     Low Expression of EphB2, EphB3, and EphB4 in Bladder Cancer: Novel
            Potential Indicators of Muscular Invasion
  JOURNAL   Yonsei Med J 62 (8), 679-690 (2021)
   PUBMED   34296545
  REMARK    GeneRIF: Low Expression of EphB2, EphB3, and EphB4 in Bladder
            Cancer: Novel Potential Indicators of Muscular Invasion.
REFERENCE   4  (bases 1 to 4234)
  AUTHORS   Jang,B.G., Kim,H.S., Bae,J.M., Kim,W.H., Hyun,C.L. and Kang,G.H.
  TITLE     Expression Profile and Prognostic Significance of EPHB3 in
            Colorectal Cancer
  JOURNAL   Biomolecules 10 (4), 602 (2020)
   PUBMED   32294981
  REMARK    GeneRIF: Expression Profile and Prognostic Significance of EPHB3 in
            Colorectal Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4234)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4234)
  AUTHORS   Zhou,R.
  TITLE     The Eph family receptors and ligands
  JOURNAL   Pharmacol Ther 77 (3), 151-181 (1998)
   PUBMED   9576626
  REMARK    Review article
REFERENCE   7  (bases 1 to 4234)
  AUTHORS   Bergemann,A.D., Zhang,L., Chiang,M.K., Brambilla,R., Klein,R. and
            Flanagan,J.G.
  TITLE     Ephrin-B3, a ligand for the receptor EphB3, expressed at the
            midline of the developing neural tube
  JOURNAL   Oncogene 16 (4), 471-480 (1998)
   PUBMED   9484836
REFERENCE   8  (bases 1 to 4234)
  AUTHORS   Flanagan,J.G. and Vanderhaeghen,P.
  TITLE     The ephrins and Eph receptors in neural development
  JOURNAL   Annu Rev Neurosci 21, 309-345 (1998)
   PUBMED   9530499
  REMARK    Review article
REFERENCE   9  (bases 1 to 4234)
  AUTHORS   Bohme,B., VandenBos,T., Cerretti,D.P., Park,L.S., Holtrich,U.,
            Rubsamen-Waigmann,H. and Strebhardt,K.
  TITLE     Cell-cell adhesion mediated by binding of membrane-anchored ligand
            LERK-2 to the EPH-related receptor human embryonal kinase 2
            promotes tyrosine kinase activity
  JOURNAL   J Biol Chem 271 (40), 24747-24752 (1996)
   PUBMED   8798744
REFERENCE   10 (bases 1 to 4234)
  AUTHORS   Bohme,B., Holtrich,U., Wolf,G., Luzius,H., Grzeschik,K.H.,
            Strebhardt,K. and Rubsamen-Waigmann,H.
  TITLE     PCR mediated detection of a new human receptor-tyrosine-kinase, HEK
            2
  JOURNAL   Oncogene 8 (10), 2857-2862 (1993)
   PUBMED   8397371
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC112643.12, CB993133.1,
            BC052968.1 and X75208.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004443.3.
            
            Summary: Ephrin receptors and their ligands, the ephrins, mediate
            numerous developmental processes, particularly in the nervous
            system. Based on their structures and sequence relationships,
            ephrins are divided into the ephrin-A (EFNA) class, which are
            anchored to the membrane by a glycosylphosphatidylinositol linkage,
            and the ephrin-B (EFNB) class, which are transmembrane proteins.
            The Eph family of receptors are divided into two groups based on
            the similarity of their extracellular domain sequences and their
            affinities for binding ephrin-A and ephrin-B ligands. Ephrin
            receptors make up the largest subgroup of the receptor tyrosine
            kinase (RTK) family. This gene encodes a receptor for ephrin-B
            family members. [provided by RefSeq, Mar 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052968.1, X75208.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330394.3/ ENSP00000332118.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC112643.12        30452-30465
            15-424              CB993133.1         39-448
            425-4099            BC052968.1         394-4068
            4100-4190           X75208.1           3670-3760
            4191-4234           BC052968.1         4154-4197
FEATURES             Location/Qualifiers
     source          1..4234
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.1"
     gene            1..4234
                     /gene="EPHB3"
                     /gene_synonym="EK2; ETK2; HEK2; TYRO6"
                     /note="EPH receptor B3"
                     /db_xref="GeneID:2049"
                     /db_xref="HGNC:HGNC:3394"
                     /db_xref="MIM:601839"
     exon            1..569
                     /gene="EPHB3"
                     /gene_synonym="EK2; ETK2; HEK2; TYRO6"
                     /inference="alignment:Splign:2.1.0"
     CDS             452..3448
                     /gene="EPHB3"
                     /gene_synonym="EK2; ETK2; HEK2; TYRO6"
                     /EC_number="2.7.10.1"
                     /note="ephrin type-B receptor 3; human embryo kinase 2;
                     tyrosine-protein kinase TYRO6; embryonic kinase 2;
                     EPH-like tyrosine kinase 2"
                     /codon_start=1
                     /product="ephrin type-B receptor 3 precursor"
                     /protein_id="NP_004434.2"
                     /db_xref="CCDS:CCDS3268.1"
                     /db_xref="GeneID:2049"
                     /db_xref="HGNC:HGNC:3394"
                     /db_xref="MIM:601839"
                     /translation="MARARPPPPPSPPPGLLPLLPPLLLLPLLLLPAGCRALEETLMD
                     TKWVTSELAWTSHPESGWEEVSGYDEAMNPIRTYQVCNVRESSQNNWLRTGFIWRRDV
                     QRVYVELKFTVRDCNSIPNIPGSCKETFNLFYYEADSDVASASSPFWMENPYVKVDTI
                     APDESFSRLDAGRVNTKVRSFGPLSKAGFYLAFQDQGACMSLISVRAFYKKCASTTAG
                     FALFPETLTGAEPTSLVIAPGTCIPNAVEVSVPLKLYCNGDGEWMVPVGACTCATGHE
                     PAAKESQCRPCPPGSYKAKQGEGPCLPCPPNSRTTSPAASICTCHNNFYRADSDSADS
                     ACTTVPSPPRGVISNVNETSLILEWSEPRDLGGRDDLLYNVICKKCHGAGGASACSRC
                     DDNVEFVPRQLGLTERRVHISHLLAHTRYTFEVQAVNGVSGKSPLPPRYAAVNITTNQ
                     AAPSEVPTLRLHSSSGSSLTLSWAPPERPNGVILDYEMKYFEKSEGIASTVTSQMNSV
                     QLDGLRPDARYVVQVRARTVAGYGQYSRPAEFETTSERGSGAQQLQEQLPLIVGSATA
                     GLVFVVAVVVIAIVCLRKQRHGSDSEYTEKLQQYIAPGMKVYIDPFTYEDPNEAVREF
                     AKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSE
                     ASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLR
                     GIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGG
                     KIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYR
                     LPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLIRNAASLKVIASAQSGMSQ
                     PLLDRTVPDYTTFTTVGDWLDAIKMGRYKESFVSAGFASFDLVAQMTAEDLLRIGVTL
                     AGHQKKILSSIQDMRLQMNQTLPVQV"
     exon            570..634
                     /gene="EPHB3"
                     /gene_synonym="EK2; ETK2; HEK2; TYRO6"
                     /inference="alignment:Splign:2.1.0"
     exon            635..1307
                     /gene="EPHB3"
                     /gene_synonym="EK2; ETK2; HEK2; TYRO6"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1463
                     /gene="EPHB3"
                     /gene_synonym="EK2; ETK2; HEK2; TYRO6"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1805
                     /gene="EPHB3"
                     /gene_synonym="EK2; ETK2; HEK2; TYRO6"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1930
                     /gene="EPHB3"
                     /gene_synonym="EK2; ETK2; HEK2; TYRO6"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2090
                     /gene="EPHB3"
                     /gene_synonym="EK2; ETK2; HEK2; TYRO6"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2199
                     /gene="EPHB3"
                     /gene_synonym="EK2; ETK2; HEK2; TYRO6"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2252
                     /gene="EPHB3"
                     /gene_synonym="EK2; ETK2; HEK2; TYRO6"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2375
                     /gene="EPHB3"
                     /gene_synonym="EK2; ETK2; HEK2; TYRO6"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2623
                     /gene="EPHB3"
                     /gene_synonym="EK2; ETK2; HEK2; TYRO6"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..2839
                     /gene="EPHB3"
                     /gene_synonym="EK2; ETK2; HEK2; TYRO6"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..2989
                     /gene="EPHB3"
                     /gene_synonym="EK2; ETK2; HEK2; TYRO6"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..3183
                     /gene="EPHB3"
                     /gene_synonym="EK2; ETK2; HEK2; TYRO6"
                     /inference="alignment:Splign:2.1.0"
     exon            3184..3339
                     /gene="EPHB3"
                     /gene_synonym="EK2; ETK2; HEK2; TYRO6"
                     /inference="alignment:Splign:2.1.0"
     exon            3340..4234
                     /gene="EPHB3"
                     /gene_synonym="EK2; ETK2; HEK2; TYRO6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4216..4221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPHB3"
                     /gene_synonym="EK2; ETK2; HEK2; TYRO6"
                     /note="hexamer: AATAAA"
     polyA_site      4234
                     /gene="EPHB3"
                     /gene_synonym="EK2; ETK2; HEK2; TYRO6"
                     /note="major polyA site"
ORIGIN      
        1 agcagaagtg agtacgtgag cggcgcagca agatcccagc tcggaccccg gacggcgcgc
       61 gcccccgaag ccccggatcc cagtcgggcc cgcagctgac cgccagatta ctgtgcatcc
      121 cgaatcacga ccacctgcac cctcctgccc cggcccgccc cccaagtcct caggcaccca
      181 gctccccggc gccccggatc ctcctggacc ggtccgtcca gattcccgcg ggaccgacct
      241 gtccgcatcc ccaggaccgc cgggctcggt gcaccgcctc ggtcccggag ccgcccgcct
      301 ggattgcatt ccctcctctc ctggatctcc tgggacccga cgcgagcctg ccccggagcc
      361 cgccgagcgc accctctctc gggtgcctgc agccccgccg gcgcggcccg gcccggcgcg
      421 gcccggctcg gctcctagag ctgccacggc catggccaga gcccgcccgc cgccgccgcc
      481 gtcgccgccg ccggggcttc tgccgctgct ccctccgctg ctgctgctgc cgctgctgct
      541 gctgcccgcc ggctgccggg cgctggaaga gaccctcatg gacacaaaat gggtaacatc
      601 tgagttggcg tggacatctc atccagaaag tgggtgggaa gaggtgagtg gctacgatga
      661 ggccatgaat cccatccgca cataccaggt gtgtaatgtg cgcgagtcaa gccagaacaa
      721 ctggcttcgc acggggttca tctggcggcg ggatgtgcag cgggtctacg tggagctcaa
      781 gttcactgtg cgtgactgca acagcatccc caacatcccc ggctcctgca aggagacctt
      841 caacctcttc tactacgagg ctgacagcga tgtggcctca gcctcctccc ccttctggat
      901 ggagaacccc tacgtgaaag tggacaccat tgcacccgat gagagcttct cgcggctgga
      961 tgccggccgt gtcaacacca aggtgcgcag ctttgggcca ctttccaagg ctggcttcta
     1021 cctggccttc caggaccagg gcgcctgcat gtcgctcatc tccgtgcgcg ccttctacaa
     1081 gaagtgtgca tccaccaccg caggcttcgc actcttcccc gagaccctca ctggggcgga
     1141 gcccacctcg ctggtcattg ctcctggcac ctgcatccct aacgccgtgg aggtgtcggt
     1201 gccactcaag ctctactgca acggcgatgg ggagtggatg gtgcctgtgg gtgcctgcac
     1261 ctgtgccacc ggccatgagc cagctgccaa ggagtcccag tgccgcccct gtccccctgg
     1321 gagctacaag gcgaagcagg gagaggggcc ctgcctccca tgtcccccca acagccgtac
     1381 cacctcccca gccgccagca tctgcacctg ccacaataac ttctaccgtg cagactcgga
     1441 ctctgcggac agtgcctgta ccaccgtgcc atctccaccc cgaggtgtga tctccaatgt
     1501 gaatgaaacc tcactgatcc tcgagtggag tgagccccgg gacctgggtg gccgggatga
     1561 cctcctgtac aatgtcatct gcaagaagtg ccatggggct ggaggggcct cagcctgctc
     1621 acgctgtgat gacaacgtgg agtttgtgcc tcggcagctg ggcctgacgg agcgccgggt
     1681 ccacatcagc catctgctgg cccacacgcg ctacaccttt gaggtgcagg cggtcaacgg
     1741 tgtctcgggc aagagccctc tgccgcctcg ttatgcggcc gtgaatatca ccacaaacca
     1801 ggctgccccg tctgaagtgc ccacactacg cctgcacagc agctcaggca gcagcctcac
     1861 cctatcctgg gcacccccag agcggcccaa cggagtcatc ctggactacg agatgaagta
     1921 ctttgagaag agcgagggca tcgcctccac agtgaccagc cagatgaact ccgtgcagct
     1981 ggacgggctt cggcctgacg cccgctatgt ggtccaggtc cgtgcccgca cagtagctgg
     2041 ctatgggcag tacagccgcc ctgccgagtt tgagaccaca agtgagagag gctctggggc
     2101 ccagcagctc caggagcagc ttcccctcat cgtgggctcc gctacagctg ggcttgtctt
     2161 cgtggtggct gtcgtggtca tcgctatcgt ctgcctcagg aagcagcgac acggctctga
     2221 ttcggagtac acggagaagc tgcagcagta cattgctcct ggaatgaagg tttatattga
     2281 cccttttacc tacgaggacc ctaatgaggc tgttcgggag tttgccaagg agatcgacgt
     2341 gtcctgcgtc aagatcgagg aggtgatcgg agctggggaa tttggggaag tgtgccgtgg
     2401 tcgactgaaa cagcctggcc gccgagaggt gtttgtggcc atcaagacgc tgaaggtggg
     2461 ctacaccgag aggcagcggc gggacttcct aagcgaggcc tccatcatgg gtcagtttga
     2521 tcaccccaat ataatccggc tcgagggcgt ggtcaccaaa agtcggccag ttatgatcct
     2581 cactgagttc atggaaaact gcgccctgga ctccttcctc cggctcaacg atgggcagtt
     2641 cacggtcatc cagctggtgg gcatgttgcg gggcattgct gccggcatga agtacctgtc
     2701 cgagatgaac tatgtgcacc gcgacctggc tgctcgcaac atccttgtca acagcaacct
     2761 ggtctgcaaa gtctcagact ttggcctctc ccgcttcctg gaggatgacc cctccgatcc
     2821 tacctacacc agttccctgg gcgggaagat ccccatccgc tggactgccc cagaggccat
     2881 agcctatcgg aagttcactt ctgctagtga tgtctggagc tacggaattg tcatgtggga
     2941 ggtcatgagc tatggagagc gaccctactg ggacatgagc aaccaggatg tcatcaatgc
     3001 cgtggagcag gattaccggc tgccaccacc catggactgt cccacagcac tgcaccagct
     3061 catgctggac tgctgggtgc gggaccggaa cctcaggccc aaattctccc agattgtcaa
     3121 taccctggac aagctcatcc gcaatgctgc cagcctcaag gtcattgcca gcgctcagtc
     3181 tggcatgtca cagcccctcc tggaccgcac ggtcccagat tacacaacct tcacgacagt
     3241 tggtgattgg ctggatgcca tcaagatggg gcggtacaag gagagcttcg tcagtgcggg
     3301 gtttgcatct tttgacctgg tggcccagat gacggcagaa gacctgctcc gtattggggt
     3361 caccctggcc ggccaccaga agaagatcct gagcagtatc caggacatgc ggctgcagat
     3421 gaaccagacg ctgcctgtgc aggtctgaca ccggctccca cggggaccct gaggaccgtg
     3481 cagggatgcc aagcagccgg ctggactttc ggactcttgg acttttggat gcctggcctt
     3541 aggctgtggc ccagaagctg gaagtttggg aaaggcccaa gctgggactt ctccaggcct
     3601 gtgttccctc cccaggaagt gcgccccaaa cctcttcata ttgaagatgg attaggagag
     3661 ggggtgatga cccctcccca agcccctcag ggcccagacc ttcctgctct ccagcagggg
     3721 atccccacaa cctcacactt gtctgttctt cagtgctgga ggtcctggca gggtcaggct
     3781 ggggtaagcc ggggttccac agggcccagc cctggcaggg gtctggcccc ccaggtaggc
     3841 ggagagcagt ccctccctca ggaactggag gaggggactc caggaatggg gaaatgtgac
     3901 accaccatcc tgaagccagc ttgcacctcc agtttgcaca gggatttgtt ctgggggctg
     3961 agggccctgt ccccaccccc gcccttggtg ctgtcataaa agggcaggca ggggcaggct
     4021 gaggagttgc cctttgcccc ccagagactg actctcagag ccagagatgg gatgtgtgag
     4081 tgtgtgtgtg tgtgtgtgtg tgtgcgcgcg cgcgcgcgtg tgtgtgtgca cgcactggcc
     4141 tgcacagaga gcatgggtga gcgtgtaaaa gcttggccct gtgccctaca atggggccag
     4201 ctgggccgac agcagaataa aggcaataag atga
//
