LOCUS       NM_017449              11035 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens EPH receptor B2 (EPHB2), transcript variant 1, mRNA.
ACCESSION   NM_017449
VERSION     NM_017449.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11035)
  AUTHORS   David,E.T., Yousuf,M.S., Mei,H.R., Jain,A., Krishnagiri,S.,
            Elahi,H., Venkatesan,R., Srikanth,K.D., Dussor,G., Dalva,M.B. and
            Price,T.J.
  TITLE     ephrin-B2 promotes nociceptive plasticity and hyperalgesic priming
            through EphB2-MNK-eIF4E signaling in both mice and humans
  JOURNAL   Pharmacol Res 206, 107284 (2024)
   PUBMED   38925462
  REMARK    GeneRIF: ephrin-B2 promotes nociceptive plasticity and hyperalgesic
            priming through EphB2-MNK-eIF4E signaling in both mice and humans.
REFERENCE   2  (bases 1 to 11035)
  AUTHORS   Overman,R.C., Debreczeni,J.E., Truman,C.M., McAlister,M.S. and
            Attwood,T.K.
  TITLE     Completing the structural family portrait of the human EphB
            tyrosine kinase domains
  JOURNAL   Protein Sci 23 (5), 627-638 (2014)
   PUBMED   24677421
  REMARK    GeneRIF: Comparative crystalisation analysis of the human EphB
            family kinases has yielded new crystal forms of the human EphB2 and
            EphB4 catalytic domains.
REFERENCE   3  (bases 1 to 11035)
  AUTHORS   Badzioch,M., Eeles,R., Leblanc,G., Foulkes,W.D., Giles,G.,
            Edwards,S., Goldgar,D., Hopper,J.L., Bishop,D.T., Moller,P.,
            Heimdal,K., Easton,D. and Simard,J.
  TITLE     Suggestive evidence for a site specific prostate cancer gene on
            chromosome 1p36. The CRC/BPG UK Familial Prostate Cancer Study
            Coordinators and Collaborators. The EU Biomed Collaborators
  JOURNAL   J Med Genet 37 (12), 947-949 (2000)
   PUBMED   11186936
REFERENCE   4  (bases 1 to 11035)
  AUTHORS   Gibbs,M., Stanford,J.L., McIndoe,R.A., Jarvik,G.P., Kolb,S.,
            Goode,E.L., Chakrabarti,L., Schuster,E.F., Buckley,V.A.,
            Miller,E.L., Brandzel,S., Li,S., Hood,L. and Ostrander,E.A.
  TITLE     Evidence for a rare prostate cancer-susceptibility locus at
            chromosome 1p36
  JOURNAL   Am J Hum Genet 64 (3), 776-787 (1999)
   PUBMED   10053012
REFERENCE   5  (bases 1 to 11035)
  AUTHORS   Tang,X.X., Pleasure,D.E., Brodeur,G.M. and Ikegaki,N.
  TITLE     A variant transcript encoding an isoform of the human protein
            tyrosine kinase EPHB2 is generated by alternative splicing and
            alternative use of polyadenylation signals
  JOURNAL   Oncogene 17 (4), 521-526 (1998)
   PUBMED   9696046
REFERENCE   6  (bases 1 to 11035)
  AUTHORS   Saito,T., Seki,N., Matsuda,Y., Kitahara,M., Murata,M., Kanda,N.,
            Nomura,N., Yamamoto,T. and Hori,T.A.
  TITLE     Identification of the human ERK gene as a putative receptor
            tyrosine kinase and its chromosomal localization to 1p36.1: a
            comparative mapping of human, mouse, and rat chromosomes
  JOURNAL   Genomics 26 (2), 382-384 (1995)
   PUBMED   7601466
REFERENCE   7  (bases 1 to 11035)
  AUTHORS   Fox,G.M., Holst,P.L., Chute,H.T., Lindberg,R.A., Janssen,A.M.,
            Basu,R. and Welcher,A.A.
  TITLE     cDNA cloning and tissue distribution of five human EPH-like
            receptor protein-tyrosine kinases
  JOURNAL   Oncogene 10 (5), 897-905 (1995)
   PUBMED   7898931
REFERENCE   8  (bases 1 to 11035)
  AUTHORS   Kiyokawa,E., Takai,S., Tanaka,M., Iwase,T., Suzuki,M., Xiang,Y.Y.,
            Naito,Y., Yamada,K., Sugimura,H. and Kino,I.
  TITLE     Overexpression of ERK, an EPH family receptor protein tyrosine
            kinase, in various human tumors
  JOURNAL   Cancer Res 54 (14), 3645-3650 (1994)
   PUBMED   8033077
REFERENCE   9  (bases 1 to 11035)
  AUTHORS   Iwase,T., Tanaka,M., Suzuki,M., Naito,Y., Sugimura,H. and Kino,I.
  TITLE     Identification of protein-tyrosine kinase genes preferentially
            expressed in embryo stomach and gastric cancer
  JOURNAL   Biochem Biophys Res Commun 194 (2), 698-705 (1993)
   PUBMED   7688222
REFERENCE   10 (bases 1 to 11035)
  AUTHORS   Chan,J. and Watt,V.M.
  TITLE     eek and erk, new members of the eph subclass of receptor
            protein-tyrosine kinases
  JOURNAL   Oncogene 6 (6), 1057-1061 (1991)
   PUBMED   1648701
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL158086.32, AL512444.20 and
            AL035704.9.
            
            On May 19, 2020 this sequence version replaced NM_017449.4.
            
            Summary: This gene encodes a member of the Eph receptor family of
            receptor tyrosine kinase transmembrane glycoproteins. These
            receptors are composed of an N-terminal glycosylated ligand-binding
            domain, a transmembrane region and an intracellular kinase domain.
            They bind ligands called ephrins and are involved in diverse
            cellular processes including motility, division, and
            differentiation. A distinguishing characteristic of Eph-ephrin
            signaling is that both receptors and ligands are competent to
            transduce a signaling cascade, resulting in bidirectional
            signaling. This protein belongs to a subgroup of the Eph receptors
            called EphB. Proteins of this subgroup are distinguished from other
            members of the family by sequence homology and preferential binding
            affinity for membrane-bound ephrin-B ligands. Allelic variants are
            associated with prostate and brain cancer susceptibility.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, May 2015].
            
            Transcript Variant: This variant (1) uses an alternate in-frame
            splice site compared to variant 2. It encodes isoform 1, which is
            shorter than isoform 2.
            
            CCDS Note: The coding region has been updated to represent an
            alternative 3' splice pattern, resulting in a shorter and distinct
            C-terminus that is better supported by available transcript and
            homology data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB210018.1, SRR11853558.414.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374630.8/ ENSP00000363761.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               AL158086.32        83556-83760
            206-270             AL512444.20        25897-25961
            271-955             AL512444.20        28868-29552
            956-1111            AL512444.20        107513-107668
            1112-1447           AL512444.20        109353-109688
            1448-1572           AL035704.9         2246-2370
            1573-1735           AL035704.9         12771-12933
            1736-1844           AL035704.9         15359-15467
            1845-1909           AL035704.9         16301-16365
            1910-2032           AL035704.9         25874-25996
            2033-2280           AL035704.9         26597-26844
            2281-2496           AL035704.9         27840-28055
            2497-2646           AL035704.9         28909-29058
            2647-2840           AL035704.9         30269-30462
            2841-2996           AL035704.9         32331-32486
            2997-11035          AL035704.9         33349-41387
FEATURES             Location/Qualifiers
     source          1..11035
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..11035
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
                     /note="EPH receptor B2"
                     /db_xref="GeneID:2048"
                     /db_xref="HGNC:HGNC:3393"
                     /db_xref="MIM:600997"
     exon            1..205
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..3105
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; elk-related tyrosine kinase; ephrin type-B
                     receptor 2; protein-tyrosine kinase HEK5; eph tyrosine
                     kinase 3; EPH-like kinase 5; tyrosine-protein kinase
                     TYRO5; renal carcinoma antigen NY-REN-47; tyrosine-protein
                     kinase receptor EPH-3; developmentally-regulated
                     Eph-related tyrosine kinase"
                     /codon_start=1
                     /product="ephrin type-B receptor 2 isoform 1 precursor"
                     /protein_id="NP_059145.2"
                     /db_xref="CCDS:CCDS229.2"
                     /db_xref="GeneID:2048"
                     /db_xref="HGNC:HGNC:3393"
                     /db_xref="MIM:600997"
                     /translation="MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWE
                     EVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPS
                     VPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKIN
                     TEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTS
                     LVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGT
                     FKANQGDEACTHCPINSRTTSEGATNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISS
                     VNETSLMLEWTPPRDSGGREDLVYNIICKSCGSGRGACTRCGDNVQYAPRQLGLTEPR
                     IYISDLLAHTQYTFEIQAVNGVTDQSPFSPQFASVNITTNQAAPSAVSIMHQVSRTVD
                     SITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQV
                     RARTVAGYGRYSGKMYFQTMTEAEYQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCN
                     RRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVKIE
                     QVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNV
                     IHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADM
                     NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAI
                     QYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALH
                     QLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSGINLPLLDRTIPDYTS
                     FNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQ
                     VMRAQMNQIQSVEV"
     exon            206..270
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            271..955
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1111
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1447
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1572
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1735
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1844
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1909
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2032
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2280
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2496
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2646
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..2840
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..2996
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..11035
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4100..4105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
                     /note="hexamer: AATGAA"
     polyA_site      4126
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
                     /note="major polyA site"
     regulatory      4186..4191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
                     /note="hexamer: AATACA"
     polyA_site      4214
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
                     /note="major polyA site"
     regulatory      4841..4846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
                     /note="hexamer: AATAAA"
     polyA_site      4860
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
                     /note="major polyA site"
     regulatory      11012..11017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
                     /note="hexamer: AATAAA"
     polyA_site      11035
                     /gene="EPHB2"
                     /gene_synonym="BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5;
                     PCBC; Tyro5"
ORIGIN      
        1 attctgctgg ctgcgcggtg gcggcggctg tgtgtgcgcc gcgccttgcc gccccccctg
       61 gccccccgag cccggggcgc gcgctcccgc ccgggccgtc cgggccccgc ggcgccgcgg
      121 cccgaggccc cgggaagcgc agccatggct ctgcggaggc tgggggccgc gctgctgctg
      181 ctgccgctgc tcgccgccgt ggaagaaacg ctaatggact ccactacagc gactgctgag
      241 ctgggctgga tggtgcatcc tccatcaggg tgggaagagg tgagtggcta cgatgagaac
      301 atgaacacga tccgcacgta ccaggtgtgc aacgtgtttg agtcaagcca gaacaactgg
      361 ctacggacca agtttatccg gcgccgtggc gcccaccgca tccacgtgga gatgaagttt
      421 tcggtgcgtg actgcagcag catccccagc gtgcctggct cctgcaagga gaccttcaac
      481 ctctattact atgaggctga ctttgactcg gccaccaaga ccttccccaa ctggatggag
      541 aatccatggg tgaaggtgga taccattgca gccgacgaga gcttctccca ggtggacctg
      601 ggtggccgcg tcatgaaaat caacaccgag gtgcggagct tcggacctgt gtcccgcagc
      661 ggcttctacc tggccttcca ggactatggc ggctgcatgt ccctcatcgc cgtgcgtgtc
      721 ttctaccgca agtgcccccg catcatccag aatggcgcca tcttccagga aaccctgtcg
      781 ggggctgaga gcacatcgct ggtggctgcc cggggcagct gcatcgccaa tgcggaagag
      841 gtggatgtac ccatcaagct ctactgtaac ggggacggcg agtggctggt gcccatcggg
      901 cgctgcatgt gcaaagcagg cttcgaggcc gttgagaatg gcaccgtctg ccgaggttgt
      961 ccatctggga ctttcaaggc caaccaaggg gatgaggcct gtacccactg tcccatcaac
     1021 agccggacca cttctgaagg ggccaccaac tgtgtctgcc gcaatggcta ctacagagca
     1081 gacctggacc ccctggacat gccctgcaca accatcccct ccgcgcccca ggctgtgatt
     1141 tccagtgtca atgagacctc cctcatgctg gagtggaccc ctccccgcga ctccggaggc
     1201 cgagaggacc tcgtctacaa catcatctgc aagagctgtg gctcgggccg gggtgcctgc
     1261 acccgctgcg gggacaatgt acagtacgca ccacgccagc taggcctgac cgagccacgc
     1321 atttacatca gtgacctgct ggcccacacc cagtacacct tcgagatcca ggctgtgaac
     1381 ggcgttactg accagagccc cttctcgcct cagttcgcct ctgtgaacat caccaccaac
     1441 caggcagctc catcggcagt gtccatcatg catcaggtga gccgcaccgt ggacagcatt
     1501 accctgtcgt ggtcccagcc ggaccagccc aatggcgtga tcctggacta tgagctgcag
     1561 tactatgaga aggagctcag tgagtacaac gccacagcca taaaaagccc caccaacacg
     1621 gtcaccgtgc agggcctcaa agccggcgcc atctatgtct tccaggtgcg ggcacgcacc
     1681 gtggcaggtt acgggcgcta cagcggcaag atgtacttcc agaccatgac agaagccgag
     1741 taccagacaa gcatccagga gaagttgcca ctcatcatcg gctcctcggc cgctggcctg
     1801 gtcttcctca ttgctgtggt tgtcatcgcc atcgtgtgta acagacgggg gtttgagcgt
     1861 gctgactcgg agtacacgga caagctgcaa cactacacca gtggccacat gaccccaggc
     1921 atgaagatct acatcgatcc tttcacctac gaggacccca acgaggcagt gcgggagttt
     1981 gccaaggaaa ttgacatctc ctgtgtcaaa attgagcagg tgatcggagc aggggagttt
     2041 ggcgaggtct gcagtggcca cctgaagctg ccaggcaaga gagagatctt tgtggccatc
     2101 aagacgctca agtcgggcta cacggagaag cagcgccggg acttcctgag cgaagcctcc
     2161 atcatgggcc agttcgacca tcccaacgtc atccacctgg agggtgtcgt gaccaagagc
     2221 acacctgtga tgatcatcac cgagttcatg gagaatggct ccctggactc ctttctccgg
     2281 caaaacgatg ggcagttcac agtcatccag ctggtgggca tgcttcgggg catcgcagct
     2341 ggcatgaagt acctggcaga catgaactat gttcaccgtg acctggctgc ccgcaacatc
     2401 ctcgtcaaca gcaacctggt ctgcaaggtg tcggactttg ggctctcacg ctttctagag
     2461 gacgatacct cagaccccac ctacaccagt gccctgggcg gaaagatccc catccgctgg
     2521 acagccccgg aagccatcca gtaccggaag ttcacctcgg ccagtgatgt gtggagctac
     2581 ggcattgtca tgtgggaggt gatgtcctat ggggagcggc cctactggga catgaccaac
     2641 caggatgtaa tcaatgccat tgagcaggac tatcggctgc caccgcccat ggactgcccg
     2701 agcgccctgc accaactcat gctggactgt tggcagaagg accgcaacca ccggcccaag
     2761 ttcggccaaa ttgtcaacac gctagacaag atgatccgca atcccaacag cctcaaagcc
     2821 atggcgcccc tctcctctgg catcaacctg ccgctgctgg accgcacgat ccccgactac
     2881 accagcttta acacggtgga cgagtggctg gaggccatca agatggggca gtacaaggag
     2941 agcttcgcca atgccggctt cacctccttt gacgtcgtgt ctcagatgat gatggaggac
     3001 attctccggg ttggggtcac tttggctggc caccagaaaa aaatcctgaa cagtatccag
     3061 gtgatgcggg cgcagatgaa ccagattcag tctgtggagg tttgacattc acctgcctcg
     3121 gctcacctct tcctccaagc cccgccccct ctgccccacg tgccggccct cctggtgctc
     3181 tatccactgc agggccagcc actcgccagg aggccacggg ccacgggaag aaccaagcgg
     3241 tgccagccac gagacgtcac caagaaaaca tgcaactcaa acgacggaaa aaaaaaggga
     3301 atgggaaaaa agaaaacaga tcctgggagg gggcgggaaa tacaaggaat attttttaaa
     3361 gaggattctc ataaggaaag caatgactgt tcttgcgggg gataaaaaag ggcttgggag
     3421 attcatgcga tgtgtccaat cggagacaaa agcagtttct ctccaactcc ctctgggaag
     3481 gtgacctggc cagagccaag aaacactttc agaaaaacaa atgtgaaggg gagagacagg
     3541 ggccgccctt ggctcctgtc cctgctgctc ctctaggcct cactcaacaa ccaagcgcct
     3601 ggaggacggg acagatggac agacagccac cctgagaacc cctctgggaa aatctattcc
     3661 tgccaccact gggcaaacag aagaattttt ctgtctttgg agagtatttt agaaactcca
     3721 atgaaagaca ctgtttctcc tgttggctca cagggctgaa aggggctttt gtcctcctgg
     3781 gtcagggaga acgcggggac cccagaaagg tcagccttcc tgaggatggg caacccccag
     3841 gtctgcagct ccaggtacat atcacgcgca cagcctggca gcctggccct cctggtgccc
     3901 actcccgcca gcccctgcct cgaggactga tactgcagtg actgccgtca gctccgactg
     3961 ccgctgagaa gggttgatcc tgcatctggg tttgtttaca gcaattcctg gactcggggg
     4021 tattttggtc acagggtggt tttggtttag ggggtttgtt tgttgggttg ttttttgttt
     4081 tttggttttt tttaatgaca atgaagtgac actttgacat ttcctacctt ttgaggactt
     4141 gatccttctc caggaagaag gtgctttctg cttactgact taggcaatac accaagggcg
     4201 agattttata tgcacatttc tggatttttt tatacggttt tcattgacac tcttccctcc
     4261 tcccacctgc caccaggcct caccaaagcc cactgccatg gggccatctg ggccattcag
     4321 agactggagt gagatttggg tgtggagggg gaggcgccaa ggtggaggag cttcccactc
     4381 caggactgtt gatgaaaggg acagattgag gaggaagtgg gctctgaggc tgcagggctg
     4441 gaagtccttg cccacttccc actctcctgc cccaatctat ctagtacttc ccaggcaaat
     4501 aggccccttt gaggctcctg agtgccctca gatggtcaaa acccagtttt ccctctggga
     4561 gcctaaacca ggctgcatcg gaggccagga cccggatcat tcactgtgat accctgccct
     4621 ccagagggtg cgctcagaga cacgggcaag catgcctctt cccttccctg gagagaaagt
     4681 gtgtgatttc tctcccacct ccttcccccc accagacctt tgctgggcct aaaggtcttg
     4741 gccatgggga cgccctcagt ctagggatct ggccacagac tccctcctgt gaaccaacac
     4801 agacacccaa gcagagcaat cagttagtga attgaatgga aataaacgct ttagttataa
     4861 tatgacccct gttctctgta agttccaagg gagaccttgg tacccttggg atgcacgtga
     4921 cccaggtgct aagggttgct cttctaagca gcccttcctc cctcaggctt ccagaaagcc
     4981 cagggcagag aaaacacatg gagaacgaca gctccacgtg gcctttctgg ccctggcttg
     5041 tcaaaagcac aggcaacaaa ggaagtgagt tggaagtggc tcagaactca gccttcgatg
     5101 ccctgggaat cagggtgagc ccctgcaggt acataagtag cagagaattg acgagagtgc
     5161 actcggaaga gggtctgagt gtcaggtgag ctgtcatagt gggaacgtga gggtcttaga
     5221 gtgctcatgt acccccaggc acagccaact ctggttttct ctgtgcaaat gagctcttgc
     5281 tcacattaaa atcagaattg tccacgtggc aggaggaggc agggagatgg atgtgccatg
     5341 gatatcgggt ctggctgagg aaggggagcc aaggagacta cctctcggga cctttcccag
     5401 atccgaggag atggccagtg agaaagattc gggccacagg cagccagcta gaagcgccac
     5461 ggtcagagtg aacatccagc acagcacagc ccatcgtctg tcactcacct gttccgggag
     5521 cctgagctgc aaagggaagg aagggattag agagaagtgt gggcccccca tggggacagc
     5581 agggcaagcc acagggaaag cattggcagg tttcccacaa actggccggc agtggcccac
     5641 tggccttcac tttgtgcccc aaaggtgccc tgcgcgggtg gcagctgtct cggcacacaa
     5701 ggtcaccttc tggtgggagc tgccctgatg ctctttagat tagttctgtc tccccagccc
     5761 accccccaac tgttctgggg ccccacatgg ggctggcagt cggtgcttcc cgtcagatgg
     5821 cttcctgtcc taagccgctg agctggtgac cactagccag catgtctgcc cctccaccct
     5881 ccagggccga ggtcctcagt ggccatggcc ccctgcaaac ctgcttccca gagcacaggt
     5941 gctaccagac ctctgtgtct ccacttcagg gtaacaaaca gatgtcactg tgactgtccc
     6001 aggggtacag gcgctgctca catctcttcc acccccaccc acccacccca cccgctaccg
     6061 gggcagtcgc cccgccccaa cctcttgctt gctgctcagc ggggagtggc aggccatgtt
     6121 gccaagcgcc ttccacttac accacccgct cacccaggca cacagctctg agccacccgc
     6181 tgcctggtta ctaatccttt cctggctcaa cctccccaag tgccagcccc cgcctgccca
     6241 gcagtgttag gggagtttcc ggctgctctg cacacagttg gtactgcagg aaagaaagct
     6301 gccttgtaaa cacaggccag ggcaccgtgg aaatggggac cagctgctct gggagggtgc
     6361 agctagcaga gctgtgcagc gccaggctgg gtaggagaga gccatgctac ccacccgcac
     6421 ccctactgct acgaagcccc cagaatgggt cattgttggt gctcagcagt cctctccctc
     6481 ggggatgata tccaaaatat caactgcgaa gactcgggca gaccaatcag aatagatgat
     6541 ggcctgagtg ctggaccaga ggcctcagag cagggacccg ggtggcgggg cagtaggaga
     6601 cacttaaggg actcagggct atggctgttt actaaccagc agtgcctctt actcagatgg
     6661 catcagctga actttcccca tcatttctag ttggtcccca ccctgccacc atctaggggc
     6721 ttctctgcca ccaccttgtg agcagttgct agcctcacac tcctctccca tcaggggctc
     6781 atctccaaaa ggctgggagc tcccgccctg cccagttaat cctcctgcct cactgaagca
     6841 caggaaggac ccaggcccca gaccatcacc caccccaggg ctgggccctg ggccactcct
     6901 ggctcactcc agggcccctg ttgtttgaag atggtaccaa aggctggaag actcttgcta
     6961 gggaagataa cgtaaatgca ttcaaaagac agggtaccac atgatgctag ggaaagtgcg
     7021 tcatgaccgc agggtagcag cctgctcctg tcactaggga tgtgaatctg gggagacact
     7081 tcccctcact gagccatctg taaaatgaga gcattggact gggtgaggca ggctgtgcaa
     7141 aacacttata caccttagtc ccatgaggaa ggagtattcc ccctgcatat tttgggggga
     7201 aactgaggct cagggggatg aagtactttg ctcagggtaa cacagccagg aaggagcaga
     7261 gcaaggccat gagctttgga tttttctgtt tccaatgtct cctctaccgt gctcaattag
     7321 atgatgagaa acagttggtg tctgatgctg gccaataaga gaaaagaaag ctcaagtggg
     7381 ctggggctgt cagggagggc ttcatggaga ggctgtcttg aaaatgacag aggtcaaaag
     7441 aaaggtcact ccaagacgca gctgccagaa tggtccaaca cagtgaggag ttgtgtctgg
     7501 atgggccagt ggaacggggg aagtgaaggt tgatataagt ggaggttgag gcagtttagg
     7561 cgtgatgtac agtccagcca cagcaggttc ttgagcagga gggtagcata gtgagcatca
     7621 ggttctagga agaagcacca gttcagccat cagatggggc aggatgcctc ccagctactc
     7681 ctctccccga gaaggaattg cccccggagc ggccctcatt tattccagga gaagccaggc
     7741 cctgctgctt cagtttccat cctcactgac gcagataatc caaagagtca cttcagctgc
     7801 ttggaacagc agggttgggt cttgtgctac ctgattctta atttggctga tgtctacccc
     7861 atttcctcca ggcttctcta gaggtggcag gggtggggtg gggagaaagc tgccagacac
     7921 caaaggagct gagcctggcg ggggcgggcg tgcgggtggg catgagaaat tgctcaggaa
     7981 acccatccct gccctggtca ccctagtcct ggagagatca cccagacatg ttggaatgag
     8041 tctggggtcc tgtcttttcc aataatgtgt tatcctgggg aaacccagag ggaagttgag
     8101 ggagccccac tgtgctgtgt gatgctacat acgcatgcga atacaccacc gggtggcctt
     8161 gacccagcct tctgcaaaat ggcttctgcc atcaaactta aggtggagaa tggtcttgca
     8221 gctgccagtt tttccttcag agaaactaag gtcagagtgt tggctgcaga aaaggacttg
     8281 gcctttgtca cataacagga aagagagtca actccgggca caccccctcg gaggctaatc
     8341 tcaggaggtt ggaaccacag ggattgcaat aatcgctgaa tacttaccat atgccaggtg
     8401 ccaaagcatt atcctctcca ctttatgagt gaggaaactg attcccagag gtgattccca
     8461 gaagattcca accaggccat ctgtctgtag tccttccttc ccacctcctg ggatttctca
     8521 aaatgtttgc catcgcccac ctgtatcaga atctcctggg ctatttattg tttaacttgc
     8581 agactcctgg gcgccacccc aaccccctaa atcagaatcc ctggggttgg gcccaagagt
     8641 ctccattttt tgacaagctc ctccaggaga ttcctccaga catggaaatc ctcacttgac
     8701 tcttccccca taacaaactg ccctgatgtc tgcagagaga gggtctgctg tagacaggga
     8761 ttaagaaaaa gcaggacatt ttcagatagg atgcccaaac ccagacgcag attaggaccc
     8821 atgaagtagg gggtagagct gaccctcagg aatgtgccca gacagagcta agctttcagg
     8881 aaaattagaa agaccctcag acccagagtc tgtctgagtt tagcttcgca gcatgaaggc
     8941 tgccttgaga aagctgatat aacaagaagc agcagaaatt taatactttg gaggggccca
     9001 gcaacccact cagggccacc ctgggagacc ccacagaccc caaggctatg gtccagacct
     9061 gttcactcaa cacctggcca ggcggggcct ccagctggac ctagagctac agatgcccca
     9121 ccaccactac caagcccggc tacccagacc aagacacggc ttttcctgga ggagagagag
     9181 agcaaaggcc ctgtctctac ccaagaccta acggcccctg ttgaaggaga gggagcagga
     9241 gagggaggag ggaggaggtc acagccagga ccacatacac tcttgggggc cctgctgaga
     9301 ctgcaagagt catgaattct aacgttccac aggtgaaaga ttccaagatt ctaggattgc
     9361 aaaaccccat cattctaaga ttccaatgga atgattccat gtttctaaga ttccatcaca
     9421 ctatgattct atgctgctaa ttcttgaaat ttcgagtctc attgttcgtt gctgttcccc
     9481 agacctgtgg gccctagcat ttttttaaaa gcacaaaaaa aaaagagcaa gaaagagaga
     9541 aagagatggg gagggagaca gctgaaaaca gatactaaga aaagctccat cccttggatc
     9601 tgagttacag atgcaccttg gcaagggcca aagaccctcc ttttgagtgg ggtgcagaac
     9661 gtctttccct ggtagagtgg cagaattgca tgcatcaggc cttcctgggg gtaaaagggg
     9721 ctggctgttc caggctacag ctgagtaaag ccccacacag gccacagtgc ccactggctg
     9781 gtggacctag gaaccaagca gggccccact ggctcagtct ggggagggac tcatctgggg
     9841 tggaatttcc ctccctgcag caaggaagct gcagggccag gaatttgcct tgggagaccc
     9901 ccactgagga atatttccga agcagaaccc cttcctattc agagccagag tcttaacact
     9961 ggacaaccac agggtgttgc tgcaaactcc agagccaggt gccttccctc tgacatttgg
    10021 gacatagctt ccatggccac acagccttcg cccccttcca agacccccct tgacctttct
    10081 aatcttagtc actgccttcc agagctggga ggccacacgg cagaggtgcc tgtgaatcac
    10141 tccgtcatca gcctggccgc tttcccctct gtggagaggg actctgatgg gcagggggca
    10201 ccaagttgag cctctgaggc tggcccagca taggccaggc agggacattc actcacaacc
    10261 agcctttttg gactctagag aagagtaatt accacttggt catgcccagc ccccaaatca
    10321 taatcatagc tgctatttct tgagtgccag caatgtgcca ggcaccgtgc ccaacttttt
    10381 atacacaatg tcttgcctaa tcctcacacc tctgtgagac aggtacaatt attactccca
    10441 ttccacagac tagcaaactc agagacgtga catggtggct ctcccaggtc acacagccag
    10501 taagtggcct ctgaccccag taccccccac ttaatcacca tgctatgctg ctaccagtgg
    10561 tacacactca gcccctctcc actgtcagat cctttgccag tcaaatccca gatccccggg
    10621 ggggcactgt ggcaccctct ttgagcgtgg cctccctgga gctgctgtca gagccatggg
    10681 ctgtgggagt gagtgtgcac actccttctc ctgaagtgtc tgccccagcc tgagctatgc
    10741 agaccggagc tctcaaccag ggtatggggc tgtctggcag ggtttcccag aaccctgttt
    10801 cctgtggtca taaatatggg ttttcctgac aatgttggga ggtcagggac tgatacagct
    10861 ggggttccaa ccgccgtggg tcagacctgg ctcctccgga ccccactgct gtgaccaagg
    10921 aaatctcacc agctgtgtcc aagatcaacc ctgaccctgt tactccaatg cctttgtagg
    10981 agtattttta gcagaaccgt ttttttccca aaataaatgt gaattgtaaa aatta
//
