LOCUS       NM_004440               6621 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens EPH receptor A7 (EPHA7), transcript variant 1, mRNA.
ACCESSION   NM_004440
VERSION     NM_004440.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6621)
  AUTHORS   Wang,L., Zhao,Q.F., Yang,B.B., Liang,H.J., Zhang,X.E., Zhang,X.Y.,
            Yang,W.J., Guo,Z.Y., Xu,X., Tian,F. and Wu,Q.H.
  TITLE     STAT3-EphA7 axis contributes to the progression of esophageal
            squamous cell carcinoma
  JOURNAL   Acta Oncol 62 (12), 1757-1766 (2023)
   PUBMED   37738252
  REMARK    GeneRIF: STAT3-EphA7 axis contributes to the progression of
            esophageal squamous cell carcinoma.
REFERENCE   2  (bases 1 to 6621)
  AUTHORS   Zhang,W., Cao,H., Yang,J., Zhao,J., Liang,Z., Kang,X. and Wang,R.
  TITLE     The identification and validation of EphA7 hypermethylation, a
            novel biomarker, in cervical cancer
  JOURNAL   BMC Cancer 22 (1), 636 (2022)
   PUBMED   35681118
  REMARK    GeneRIF: The identification and validation of EphA7
            hypermethylation, a novel biomarker, in cervical cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6621)
  AUTHORS   Salokas,K., Liu,X., Ohman,T., Chowdhury,I., Gawriyski,L.,
            Keskitalo,S. and Varjosalo,M.
  TITLE     Physical and functional interactome atlas of human receptor
            tyrosine kinases
  JOURNAL   EMBO Rep 23 (6), e54041 (2022)
   PUBMED   35384245
REFERENCE   4  (bases 1 to 6621)
  AUTHORS   Levy,J., Schell,B., Nasser,H., Rachid,M., Ruaud,L., Couque,N.,
            Callier,P., Faivre,L., Marle,N., Engwerda,A., van
            Ravenswaaij-Arts,C.M.A., Plutino,M., Karmous-Benailly,H.,
            Benech,C., Redon,S., Boute,O., Boudry Labis,E., Rama,M., Kuentz,P.,
            Assoumani,J., Maldergem,L.V., Dupont,C., Verloes,A. and Tabet,A.C.
  TITLE     EPHA7 haploinsufficiency is associated with a neurodevelopmental
            disorder
  JOURNAL   Clin Genet 100 (4), 396-404 (2021)
   PUBMED   34176129
  REMARK    GeneRIF: EPHA7 haploinsufficiency is associated with a
            neurodevelopmental disorder.
REFERENCE   5  (bases 1 to 6621)
  AUTHORS   Chakraborty,S. and Varma,A.K.
  TITLE     Crystal structure of clinically reported mutations Gly656Arg,
            Gly656Glu and Asp751His identified in the kinase domain of EphA7
  JOURNAL   Biochem Biophys Res Commun 568, 62-67 (2021)
   PUBMED   34186436
  REMARK    GeneRIF: Crystal structure of clinically reported mutations
            Gly656Arg, Gly656Glu and Asp751His identified in the kinase domain
            of EphA7.
REFERENCE   6  (bases 1 to 6621)
  AUTHORS   Zhou,R.
  TITLE     The Eph family receptors and ligands
  JOURNAL   Pharmacol Ther 77 (3), 151-181 (1998)
   PUBMED   9576626
  REMARK    Review article
REFERENCE   7  (bases 1 to 6621)
  AUTHORS   Flanagan,J.G. and Vanderhaeghen,P.
  TITLE     The ephrins and Eph receptors in neural development
  JOURNAL   Annu Rev Neurosci 21, 309-345 (1998)
   PUBMED   9530499
  REMARK    Review article
REFERENCE   8  (bases 1 to 6621)
  AUTHORS   Ciossek,T. and Ullrich,A.
  TITLE     Identification of Elf-1 and B61 as high affinity ligands for the
            receptor tyrosine kinase MDK1
  JOURNAL   Oncogene 14 (1), 35-43 (1997)
   PUBMED   9010230
REFERENCE   9  (bases 1 to 6621)
  AUTHORS   Gale,N.W., Holland,S.J., Valenzuela,D.M., Flenniken,A., Pan,L.,
            Ryan,T.E., Henkemeyer,M., Strebhardt,K., Hirai,H., Wilkinson,D.G.,
            Pawson,T., Davis,S. and Yancopoulos,G.D.
  TITLE     Eph receptors and ligands comprise two major specificity subclasses
            and are reciprocally compartmentalized during embryogenesis
  JOURNAL   Neuron 17 (1), 9-19 (1996)
   PUBMED   8755474
REFERENCE   10 (bases 1 to 6621)
  AUTHORS   Fox,G.M., Holst,P.L., Chute,H.T., Lindberg,R.A., Janssen,A.M.,
            Basu,R. and Welcher,A.A.
  TITLE     cDNA cloning and tissue distribution of five human EPH-like
            receptor protein-tyrosine kinases
  JOURNAL   Oncogene 10 (5), 897-905 (1995)
   PUBMED   7898931
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA503795.1, AB209269.1,
            AL591036.8, L36642.1, BC126125.1 and AL354857.13.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004440.3.
            
            Summary: This gene belongs to the ephrin receptor subfamily of the
            protein-tyrosine kinase family. EPH and EPH-related receptors have
            been implicated in mediating developmental events, particularly in
            the nervous system. Receptors in the EPH subfamily typically have a
            single kinase domain and an extracellular region containing a
            Cys-rich domain and 2 fibronectin type III repeats. The ephrin
            receptors are divided into 2 groups based on the similarity of
            their extracellular domain sequences and their affinities for
            binding ephrin-A and ephrin-B ligands. Increased expression of this
            gene is associated with multiple forms of carcinoma. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Dec 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.203281.1,
                                           SRR1660803.257326.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369303.9/ ENSP00000358309.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-528               DA503795.1         24-551
            529-1198            AB209269.1         539-1208
            1199-1199           AL591036.8         31528-31528         c
            1200-1836           AB209269.1         1210-1846
            1837-2293           L36642.1           1804-2260
            2294-3328           BC126125.1         2191-3225
            3329-6621           AL354857.13        110508-113800       c
FEATURES             Location/Qualifiers
     source          1..6621
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q16.1"
     gene            1..6621
                     /gene="EPHA7"
                     /gene_synonym="EHK-3; EHK3; EK11; HEK11"
                     /note="EPH receptor A7"
                     /db_xref="GeneID:2045"
                     /db_xref="HGNC:HGNC:3390"
                     /db_xref="MIM:602190"
     exon            1..315
                     /gene="EPHA7"
                     /gene_synonym="EHK-3; EHK3; EK11; HEK11"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..3215
                     /gene="EPHA7"
                     /gene_synonym="EHK-3; EHK3; EK11; HEK11"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; ephrin type-A receptor 7; tyrosine-protein
                     kinase receptor EHK-3; Eph homology kinase-3; receptor
                     protein-tyrosine kinase HEK11; EPH-like kinase 11; EPH
                     homology kinase 3"
                     /codon_start=1
                     /product="ephrin type-A receptor 7 isoform 1 precursor"
                     /protein_id="NP_004431.1"
                     /db_xref="CCDS:CCDS5031.1"
                     /db_xref="GeneID:2045"
                     /db_xref="HGNC:HGNC:3390"
                     /db_xref="MIM:602190"
                     /translation="MVFQTRYPSWIILCYIWLLRFAHTGEAQAAKEVLLLDSKAQQTE
                     LEWISSPPNGWEEISGLDENYTPIRTYQVCQVMEPNQNNWLRTNWISKGNAQRIFVEL
                     KFTLRDCNSLPGVLGTCKETFNLYYYETDYDTGRNIRENLYVKIDTIAADESFTQGDL
                     GERKMKLNTEVREIGPLSKKGFYLAFQDVGACIALVSVKVYYKKCWSIIENLAIFPDT
                     VTGSEFSSLVEVRGTCVSSAEEEAENAPRMHCSAEGEWLVPIGKCICKAGYQQKGDTC
                     EPCGRGFYKSSSQDLQCSRCPTHSFSDKEGSSRCECEDGYYRAPSDPPYVACTRPPSA
                     PQNLIFNINQTTVSLEWSPPADNGGRNDVTYRILCKRCSWEQGECVPCGSNIGYMPQQ
                     TGLEDNYVTVMDLLAHANYTFEVEAVNGVSDLSRSQRLFAAVSITTGQAAPSQVSGVM
                     KERVLQRSVELSWQEPEHPNGVITEYEIKYYEKDQRERTYSTVKTKSTSASINNLKPG
                     TVYVFQIRAFTAAGYGNYSPRLDVATLEEATGKMFEATAVSSEQNPVIIIAVVAVAGT
                     IILVFMVFGFIIGRRHCGYSKADQEGDEELYFHFKFPGTKTYIDPETYEDPNRAVHQF
                     AKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCE
                     ASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLR
                     GIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKI
                     PVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLP
                     APMDCPAGLHQLMLDCWQKERAERPKFEQIVGILDKMIRNPNSLKTPLGTCSRPISPL
                     LDQNTPDFTTFCSVGEWLQAIKMERYKDNFTAAGYNSLESVARMTIEDVMSLGITLVG
                     HQKKIMSSIQTMRAQMLHLHGTGIQV"
     exon            316..380
                     /gene="EPHA7"
                     /gene_synonym="EHK-3; EHK3; EK11; HEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            381..1050
                     /gene="EPHA7"
                     /gene_synonym="EHK-3; EHK3; EK11; HEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1206
                     /gene="EPHA7"
                     /gene_synonym="EHK-3; EHK3; EK11; HEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1542
                     /gene="EPHA7"
                     /gene_synonym="EHK-3; EHK3; EK11; HEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1667
                     /gene="EPHA7"
                     /gene_synonym="EHK-3; EHK3; EK11; HEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1851
                     /gene="EPHA7"
                     /gene_synonym="EHK-3; EHK3; EK11; HEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1960
                     /gene="EPHA7"
                     /gene_synonym="EHK-3; EHK3; EK11; HEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2016
                     /gene="EPHA7"
                     /gene_synonym="EHK-3; EHK3; EK11; HEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2142
                     /gene="EPHA7"
                     /gene_synonym="EHK-3; EHK3; EK11; HEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2328
                     /gene="EPHA7"
                     /gene_synonym="EHK-3; EHK3; EK11; HEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2390
                     /gene="EPHA7"
                     /gene_synonym="EHK-3; EHK3; EK11; HEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2600
                     /gene="EPHA7"
                     /gene_synonym="EHK-3; EHK3; EK11; HEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2750
                     /gene="EPHA7"
                     /gene_synonym="EHK-3; EHK3; EK11; HEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..2944
                     /gene="EPHA7"
                     /gene_synonym="EHK-3; EHK3; EK11; HEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            2945..3100
                     /gene="EPHA7"
                     /gene_synonym="EHK-3; EHK3; EK11; HEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            3101..6621
                     /gene="EPHA7"
                     /gene_synonym="EHK-3; EHK3; EK11; HEK11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5200..5205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPHA7"
                     /gene_synonym="EHK-3; EHK3; EK11; HEK11"
                     /note="hexamer: AATATA"
     polyA_site      5220
                     /gene="EPHA7"
                     /gene_synonym="EHK-3; EHK3; EK11; HEK11"
                     /note="major polyA site"
     regulatory      6593..6598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPHA7"
                     /gene_synonym="EHK-3; EHK3; EK11; HEK11"
                     /note="hexamer: AACAAG"
     polyA_site      6621
                     /gene="EPHA7"
                     /gene_synonym="EHK-3; EHK3; EK11; HEK11"
                     /note="major polyA site"
ORIGIN      
        1 ggtctgcagt cggagacttg caggcagcaa acacggtgcg agcgaacagg agtggggggg
       61 aaattaaaaa aagctaaacg tggagcagcc gatcggggac cgagaagggg aatcgatgca
      121 aggagcacaa taaaacaaaa gctacttcgg aacaaacagc atttaaaaat ccacgactca
      181 agataactga aacctaaaat aaaacctgct catgcaccat ggtttttcaa actcggtacc
      241 cttcatggat tattttatgc tacatctggc tgctccgctt tgcacacaca ggggaggcgc
      301 aggctgcgaa ggaagtacta ctgctggatt ctaaagcaca acaaacagag ttggagtgga
      361 tttcctctcc acccaatggg tgggaagaaa ttagtggttt ggatgagaac tataccccga
      421 tacgaacata ccaggtgtgc caagtcatgg agcccaacca aaacaactgg ctgcggacta
      481 actggatttc caaaggcaat gcacaaagga tttttgtaga attgaaattc accctgaggg
      541 attgtaacag tcttcctgga gtactgggaa cttgcaagga aacatttaat ttgtactatt
      601 atgaaacaga ctatgacact ggcaggaata taagagaaaa cctctatgta aaaatagaca
      661 ccattgctgc agatgaaagt tttacccaag gtgaccttgg tgaaagaaag atgaagctta
      721 acactgaggt gagagagatt ggacctttgt ccaaaaaggg attctatctt gcctttcagg
      781 atgtaggggc ttgcatagct ttggtttctg tcaaagtgta ctacaagaag tgctggtcca
      841 ttattgagaa cttagctatc tttccagata cagtgactgg ttcagaattt tcctctttag
      901 tcgaggttcg agggacatgt gtcagcagtg cagaggaaga agcggaaaac gcccccagga
      961 tgcactgcag tgcagaagga gaatggttag tgcccattgg aaaatgtatc tgcaaagcag
     1021 gctaccagca aaaaggagac acttgtgaac cctgtggccg tgggttctac aagtcttcct
     1081 ctcaagatct tcagtgctct cgttgtccaa ctcacagttt ttctgataaa gaaggctcct
     1141 ccagatgtga atgtgaagat gggtattaca gggctccatc tgacccacca tacgttgcgt
     1201 gcacaaggcc tccatctgca ccacagaacc tcattttcaa catcaaccaa accacagtaa
     1261 gtttggaatg gagtcctcct gcagacaatg ggggaagaaa cgatgtgacc tacagaatat
     1321 tgtgtaagcg gtgcagttgg gagcagggcg aatgtgttcc ctgtgggagt aacattggat
     1381 acatgcccca gcagactgga ttagaggata actatgtcac tgtcatggac ctgctagccc
     1441 acgctaatta tacttttgaa gttgaagctg taaatggagt ttctgactta agccgatccc
     1501 agaggctctt tgctgctgtc agtatcacca ctggtcaagc agctccctcg caagtgagtg
     1561 gagtaatgaa ggagagagta ctgcagcgga gtgtcgagct ttcctggcag gaaccagagc
     1621 atcccaatgg agtcatcaca gaatatgaaa tcaagtatta cgagaaagat caaagggaac
     1681 ggacctactc aacagtaaaa accaagtcta cttcagcctc cattaataat ctgaaaccag
     1741 gaacagtgta tgttttccag attcgggctt ttactgctgc tggttatgga aattacagtc
     1801 ccagacttga tgttgctaca ctagaggaag ctacaggtaa aatgtttgaa gctacagctg
     1861 tctccagtga acagaatcct gttattatca ttgctgtggt tgctgtagct gggaccatca
     1921 ttttggtgtt catggtcttt ggcttcatca ttgggagaag gcactgtggt tatagcaaag
     1981 ctgaccaaga aggcgatgaa gagctttact ttcattttaa atttccaggc accaaaacct
     2041 acattgaccc tgaaacctat gaggacccaa atagagctgt ccatcaattc gccaaggagc
     2101 tagatgcctc ctgtattaaa attgagcgtg tgattggtgc aggagaattc ggtgaagtct
     2161 gcagtggccg tttgaaactt ccagggaaaa gagatgttgc agtagccata aaaaccctga
     2221 aagttggtta cacagaaaaa caaaggagag actttttgtg tgaagcaagc atcatggggc
     2281 agtttgacca cccgaatgtt gtccatttgg aaggggttgt tacaagaggg aaaccagtca
     2341 tgatagtaat agagttcatg gaaaatggag ccctagatgc atttctcagg aaacatgatg
     2401 ggcaatttac agtcattcag ttagtaggaa tgctgagagg aattgctgct ggaatgagat
     2461 atttggctga tatgggatat gttcacaggg accttgcagc tcgcaatatt cttgtcaaca
     2521 gcaatctcgt ttgtaaagtg tcagattttg gcctgtcccg agttatagag gatgatccag
     2581 aagctgtcta tacaactact ggtggaaaaa ttccagtaag gtggacagca cccgaagcca
     2641 tccagtaccg gaaattcaca tcagccagtg atgtatggag ctatggaata gtcatgtggg
     2701 aagttatgtc ttatggagaa agaccttatt gggacatgtc aaatcaagat gttataaaag
     2761 caatagaaga aggttatcgt ttaccagcac ccatggactg cccagctggc cttcaccagc
     2821 taatgttgga ttgttggcaa aaggagcgtg ctgaaaggcc aaaatttgaa cagatagttg
     2881 gaattctaga caaaatgatt cgaaacccaa atagtctgaa aactcccctg ggaacttgta
     2941 gtaggccaat aagccctctt ctggatcaaa acactcctga tttcactacc ttttgttcag
     3001 ttggagaatg gctacaagct attaagatgg aaagatataa agataatttc acggcagctg
     3061 gctacaattc ccttgaatca gtagccagga tgactattga ggatgtgatg agtttaggga
     3121 tcacactggt tggtcatcaa aagaaaatca tgagcagcat tcagactatg agagcacaaa
     3181 tgctacattt acatggaact ggcattcaag tgtgatatgc atttctccct tttaagggag
     3241 attacagact gcaagagaac agtactggcc ttcagtatat gcatagaatg ctgctagaag
     3301 acaagtgatg tcctgggtcc ttccaacagt gaagagaaga tttaagaagc acctatagac
     3361 ttgaactcct aagtgccacc agaatatata aaaagggaat ttaggatcca ccatcggtgg
     3421 ccaggaaaat agcagtgaca ataaacaaag tactacctga aaaacatcca aacaccttga
     3481 gctctctaac ctcctttttg tcttatagac tttttaaaat gtacataaag aatttaagaa
     3541 agaatatatt tgtcaaataa aatcatgatc ttattgttaa aattaatgaa atattttcct
     3601 taaatatgtg atttcagact attccttttt aaaatcattt gtgtttattc ttcataagga
     3661 ctttgtttta gaaagctgtt tatagctttg gaccttttta gtgttaaatc tgtaacatta
     3721 ctacactggg tacctttgaa agaatctcaa atttcaaaag aaatagcatg attgaagata
     3781 catctctgtt agaacattgg tatccttttt gtgccatttt attctgttta atcagtgctg
     3841 ttttgatatt gtttgctaat tggcaggtag tcaagaaaat gcaagttgcc aagagctctg
     3901 atatttttta aaaagaattt ttttgtaaag atcagacaac acactatctt ttcaatgaaa
     3961 aaagcaataa tgatccatac atactataag gcacttttaa cagattgttt atagagtgat
     4021 tttactagaa agaatttaat aaactcgaag tttaggttta tgagtatata aacaaatgag
     4081 gcacttcatc tgaagaatgt tggtgaaggc aagtctctga aagcagaact atccagtgtt
     4141 atctaaaaat taatctgagc acatcaagat tttttcattc tcgtgacatt aggaaattta
     4201 ggataaatag ttgacatata ttttatatcc tcttctgttg aatgcagtcc aaacatgaaa
     4261 ggaaataatt gttttatatt ataactctga agcatgataa aggggcagtt cacaattttc
     4321 accatttaaa cacaaatttg ctgcacagaa tatcaccatt gcagttcaaa acaaaacaaa
     4381 acaaaaagtc ttttgtttgt gaacactgat gcaagaaact tgttaaatga aaggactctt
     4441 taccctagaa ggaagaggtg aaggatctgg cttgttttta aagctttatt tattaaacca
     4501 tattatttga ttactgtgtt agaatttcat aagcaataat taaatgtgtc tttatagata
     4561 ttgcaggaat gtatacatat tgtgattaat gctttcaaaa cttatgaaaa tcatgaacta
     4621 ccccagaatt gaactgttgt acttccaaag agaattgggc tgtttataat gattttaata
     4681 gagaaagatc ccagggatcg gtcataattg gtcttgtttg ataatgtggg catccacaaa
     4741 caaacaaaca aataacagaa acaaaatctg taaatgttcc tttgtaaaac ttgtaaattt
     4801 tatttatact gtcttgtttt gtacacacat ttctctgtag tgggctctga atacattgaa
     4861 aatgcactat atttttctat tttacttgca gagcatcaca aaagaacagg tattttcagt
     4921 gctacataat gtgttttccc acatttagga ccaaagacgg ctatagaaaa actcaaatgg
     4981 attgcttccc aaacccctcc ccaccctttt tttttggttt taaatcactg tacagtgtta
     5041 tttgatattt taatttattt tttgattgac tagaaaaatc attttaattt cactaaaatg
     5101 ttttttgtcc ctaaggaaaa gtaatctgta aaaataattt taattagcat aatacagtca
     5161 cctagacact tccatttgta atctttgtaa tagactgtaa atatattttt ggaactataa
     5221 cacaatgtgc ttgagggtta tttttcagtg tctgcagtgt gtacaagtgt ttatactaag
     5281 tccagcactt tacaattcta atcagtagca ttggcctttg tgagaatgag tgaaagagtt
     5341 tgagtgagtg ttcttaattc cttttggatt ctagactcac taataatgaa gttcttttct
     5401 tgttcatagc ttaaggtgct tattttttct attaaaatta aattaacaaa agccattcta
     5461 gaaatagaag acatagtatg gtacatgcaa acggtgtctt tcctgctttt ttctagcact
     5521 agatttatag ttgagtagtc tttcttgagt agaagggcag aataaaagtt tttttgagtt
     5581 tttttcaaaa ataaattttt ccttcagcaa tatacctcat ctgccttaaa ttttttacag
     5641 ctctttacag ggaaagggga gaagggatgg gaaagacaca cagcacaata ggaagtgtat
     5701 gattacatca ctatctcgtt tgtaagtttc ttttcctaat caacattatg atttcgaaat
     5761 acatgtatgt gaaacaaata ttaagagaaa aagaattaac attgtaatgc tgattgtaat
     5821 actctcttcc agaaagagat gagatggtat aacgataaga atgtacaact tgcaccttga
     5881 aatctttttt tttaaataaa ttagtgctca ggggaggaaa agtagagaaa gtgaacgtca
     5941 aaaatagaat tccaaaatta taaaaatgca aaaggaaatg gcctccttgc tttaatagag
     6001 ccaccttttt tagaacactg tcctcacact tgacctgtgt tttgcattca gtactgaaat
     6061 aaaagtaact tgttctacat ttgaatctaa cattttctca gcaattgatc tggtccttgt
     6121 ttactagaac tggtggttta tgcttgtcag agcactatta gttgaatcat attgtatact
     6181 tatgtaatct acattagcta gtactgttta ggactatatt ttaattgctc ttcttatccg
     6241 tgtttttaag acaattaaaa tggtgtgatt cacctctctt ttttatttag gtaatgctga
     6301 tattctccct tttgtttctt gagtagccta gaactatgct actcactgat gtgcatgttc
     6361 aaataaatta ctgatgtgta tttttttgct atatgtggag aaatcatggg gaactcgggg
     6421 cgagatgtgc ttttcgttgg ttgaatttgt ccctccttgc ctaagaaata ctacaggggt
     6481 catcctttta taaggacaaa ctgcttttga acagtgtctt caatgtatca agcacaaata
     6541 actctttctt caacatgaat cataagtctc tttttaccag cttaaaataa taaacaagtc
     6601 tattagacaa tgtaaagaaa a
//
