LOCUS       NM_001080448           16254 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens EPH receptor A6 (EPHA6), transcript variant 1, mRNA.
ACCESSION   NM_001080448 XM_114973
VERSION     NM_001080448.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 16254)
  AUTHORS   Salokas,K., Liu,X., Ohman,T., Chowdhury,I., Gawriyski,L.,
            Keskitalo,S. and Varjosalo,M.
  TITLE     Physical and functional interactome atlas of human receptor
            tyrosine kinases
  JOURNAL   EMBO Rep 23 (6), e54041 (2022)
   PUBMED   35384245
REFERENCE   2  (bases 1 to 16254)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 16254)
  AUTHORS   Raja,E., Morikawa,M., Nishida,J., Tanabe,R., Takahashi,K.,
            Seeherman,H.J., Saito,N., Todo,T. and Miyazono,K.
  TITLE     Tyrosine kinase Eph receptor A6 sensitizes glioma-initiating cells
            towards bone morphogenetic protein-induced apoptosis
  JOURNAL   Cancer Sci 110 (11), 3486-3496 (2019)
   PUBMED   31483918
  REMARK    GeneRIF: our data imply that EPHA6 expression is beneficial for
            glioblastoma multiforme inhibition, particularly in combination
            with activation of BMP-2 signaling.These results suggest that EPHA6
            expression or protein levels could be used as biomarkers for
            identification of subsets of glioblastoma multiforme patients who
            might benefit from BMP treatment.
REFERENCE   4  (bases 1 to 16254)
  AUTHORS   Kim,M., Yoo,H.J., Kim,M., Kim,J., Baek,S.H., Song,M. and Lee,J.H.
  TITLE     EPHA6 rs4857055 C > T polymorphism associates with hypertension
            through triglyceride and LDL particle size in the Korean population
  JOURNAL   Lipids Health Dis 16 (1), 230 (2017)
   PUBMED   29208002
  REMARK    GeneRIF: The EPHA6 rs4857055 C > T SNP is a novel candidate gene
            for hypertension in the Korean population.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 16254)
  AUTHORS   Apellaniz-Ruiz,M., Tejero,H., Inglada-Perez,L., Sanchez-Barroso,L.,
            Gutierrez-Gutierrez,G., Calvo,I., Castelo,B., Redondo,A.,
            Garcia-Donas,J., Romero-Laorden,N., Sereno,M., Merino,M.,
            Curras-Freixes,M., Montero-Conde,C., Mancikova,V.,
            Avall-Lundqvist,E., Green,H., Al-Shahrour,F., Cascon,A., Robledo,M.
            and Rodriguez-Antona,C.
  TITLE     Targeted Sequencing Reveals Low-Frequency Variants in EPHA Genes as
            Markers of Paclitaxel-Induced Peripheral Neuropathy
  JOURNAL   Clin Cancer Res 23 (5), 1227-1235 (2017)
   PUBMED   27582484
  REMARK    GeneRIF: Gene-based analysis identified EPHA6 as the gene most
            significantly associated with paclitaxel-induced neuropathy...This
            first study sequencing EPHA genes revealed that low-frequency
            variants in EPHA6, EPHA5, and EPHA8 contribute to the
            susceptibility to paclitaxel-induced neuropathy
REFERENCE   6  (bases 1 to 16254)
  AUTHORS   Hafner,C., Schmitz,G., Meyer,S., Bataille,F., Hau,P., Langmann,T.,
            Dietmaier,W., Landthaler,M. and Vogt,T.
  TITLE     Differential gene expression of Eph receptors and ephrins in benign
            human tissues and cancers
  JOURNAL   Clin Chem 50 (3), 490-499 (2004)
   PUBMED   14726470
REFERENCE   7  (bases 1 to 16254)
  AUTHORS   Nakamoto,T., Kain,K.H. and Ginsberg,M.H.
  TITLE     Neurobiology: New connections between integrins and axon guidance
  JOURNAL   Curr Biol 14 (3), R121-R123 (2004)
   PUBMED   14986683
  REMARK    Review article
REFERENCE   8  (bases 1 to 16254)
  AUTHORS   Prevost,N., Woulfe,D., Tanaka,T. and Brass,L.F.
  TITLE     Interactions between Eph kinases and ephrins provide a mechanism to
            support platelet aggregation once cell-to-cell contact has occurred
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9219-9224 (2002)
   PUBMED   12084815
REFERENCE   9  (bases 1 to 16254)
  AUTHORS   Xu,Q., Mellitzer,G. and Wilkinson,D.G.
  TITLE     Roles of Eph receptors and ephrins in segmental patterning
  JOURNAL   Philos Trans R Soc Lond B Biol Sci 355 (1399), 993-1002 (2000)
   PUBMED   11128993
  REMARK    Review article
REFERENCE   10 (bases 1 to 16254)
  AUTHORS   Wilkinson,D.G.
  TITLE     Eph receptors and ephrins: regulators of guidance and assembly
  JOURNAL   Int Rev Cytol 196, 177-244 (2000)
   PUBMED   10730216
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA385338.1, AC119745.2, AC107482.2, AC117470.8, AC130510.3,
            AC117439.5, AC135369.2, AC110491.5 and BM676895.1.
            
            On Sep 25, 2018 this sequence version replaced NM_001080448.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2155371,
                              SAMN03465402 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389672.10/ ENSP00000374323.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-551               DA385338.1         14-564
            552-1144            AC119745.2         59977-60569         c
            1145-1300           AC107482.2         43752-43907         c
            1301-1636           AC107482.2         25884-26219         c
            1637-1761           AC117470.8         82460-82584
            1762-1924           AC117470.8         125878-126040
            1925-2033           AC117470.8         152662-152770
            2034-2104           AC117470.8         156604-156674
            2105-2230           AC117470.8         161244-161369
            2231-2416           AC130510.3         21042-21227
            2417-2542           AC117439.5         151656-151781       c
            2543-2604           AC117439.5         133539-133600       c
            2605-2814           AC117439.5         106311-106520       c
            2815-2964           AC117439.5         23983-24132         c
            2965-3158           AC117439.5         8275-8468           c
            3159-3308           AC135369.2         9566-9715           c
            3309-11859          AC135369.2         1-8551              c
            11860-15635         AC110491.5         184191-187966       c
            15636-16254         BM676895.1         17-635              c
FEATURES             Location/Qualifiers
     source          1..16254
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q11.2"
     gene            1..16254
                     /gene="EPHA6"
                     /gene_synonym="EHK-2; EHK2; EK12; EPA6; HEK12; PRO57066"
                     /note="EPH receptor A6"
                     /db_xref="GeneID:285220"
                     /db_xref="HGNC:HGNC:19296"
                     /db_xref="MIM:600066"
     exon            1..415
                     /gene="EPHA6"
                     /gene_synonym="EHK-2; EHK2; EK12; EPA6; HEK12; PRO57066"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..3423
                     /gene="EPHA6"
                     /gene_synonym="EHK-2; EHK2; EK12; EPA6; HEK12; PRO57066"
                     /EC_number="2.7.10.1"
                     /note="isoform a is encoded by transcript variant 1;
                     ephrin type-A receptor 6; ephrin receptor EphA6; EPH
                     homology kinase 2; EPH-like kinase 12"
                     /codon_start=1
                     /product="ephrin type-A receptor 6 isoform a"
                     /protein_id="NP_001073917.2"
                     /db_xref="CCDS:CCDS46876.1"
                     /db_xref="GeneID:285220"
                     /db_xref="HGNC:HGNC:19296"
                     /db_xref="MIM:600066"
                     /translation="MQFPSPPAARSSPAPQAASSSEAAAPATGQPGPSCPVPGTSRRG
                     RPGTPPAGRVEEEEEEEEEDVDKDPHPTQNTCLRCRHFSLRERKREPRRTMGGCEVRE
                     FLLQFGFFLPLLTAWPGDCSHVSNNQVVLLDTTTVLGELGWKTYPLNGWDAITEMDEH
                     NRPIHTYQVCNVMEPNQNNWLRTNWISRDAAQKIYVEMKFTLRDCNSIPWVLGTCKET
                     FNLFYMESDESHGIKFKPNQYTKIDTIAADESFTQMDLGDRILKLNTEIREVGPIERK
                     GFYLAFQDIGACIALVSVRVFYKKCPFTVRNLAMFPDTIPRVDSSSLVEVRGSCVKSA
                     EERDTPKLYCGADGDWLVPLGRCICSTGYEEIEGSCHACRPGFYKAFAGNTKCSKCPP
                     HSLTYMEATSVCQCEKGYFRAEKDPPSMACTRPPSAPRNVVFNINETALILEWSPPSD
                     TGGRKDLTYSVICKKCGLDTSQCEDCGGGLRFIPRHTGLINNSVIVLDFVSHVNYTFE
                     IEAMNGVSELSFSPKPFTAITVTTDQDAPSLIGVVRKDWASQNSIALSWQAPAFSNGA
                     ILDYEIKYYEKEHEQLTYSSTRSKAPSVIITGLKPATKYVFHIRVRTATGYSGYSQKF
                     EFETGDETSDMAAEQGQILVIATAAVGGFTLLVILTLFFLITGRCQWYIKAKMKSEEK
                     RRNHLQNGHLRFPGIKTYIDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVC
                     SGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSF
                     PAIGVEAFCPSFLRAGFLNSIQAPHPVPGGGSLPPRIPAGRPVMIVVEYMENGSLDSF
                     LRKHDGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLS
                     RVLEDDPEAAYTTTGGKIPIRWTAPEAIAYRKFSSASDAWSYGIVMWEVMSYGERPYW
                     EMSNQDVILSIEEGYRLPAPMGCPASLHQLMLHCWQKERNHRPKFTDIVSFLDKLIRN
                     PSALHTLVEDILVMPESPGEVPEYPLFVTVGDWLDSIKMGQYKNNFVAAGFTTFDLIS
                     RMSIDDIRRIGVILIGHQRRIVSSIQTLRLHMMHIQEKGFHV"
     exon            416..480
                     /gene="EPHA6"
                     /gene_synonym="EHK-2; EHK2; EK12; EPA6; HEK12; PRO57066"
                     /inference="alignment:Splign:2.1.0"
     exon            481..1144
                     /gene="EPHA6"
                     /gene_synonym="EHK-2; EHK2; EK12; EPA6; HEK12; PRO57066"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1300
                     /gene="EPHA6"
                     /gene_synonym="EHK-2; EHK2; EK12; EPA6; HEK12; PRO57066"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1636
                     /gene="EPHA6"
                     /gene_synonym="EHK-2; EHK2; EK12; EPA6; HEK12; PRO57066"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1761
                     /gene="EPHA6"
                     /gene_synonym="EHK-2; EHK2; EK12; EPA6; HEK12; PRO57066"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1924
                     /gene="EPHA6"
                     /gene_synonym="EHK-2; EHK2; EK12; EPA6; HEK12; PRO57066"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2033
                     /gene="EPHA6"
                     /gene_synonym="EHK-2; EHK2; EK12; EPA6; HEK12; PRO57066"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2104
                     /gene="EPHA6"
                     /gene_synonym="EHK-2; EHK2; EK12; EPA6; HEK12; PRO57066"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2230
                     /gene="EPHA6"
                     /gene_synonym="EHK-2; EHK2; EK12; EPA6; HEK12; PRO57066"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2416
                     /gene="EPHA6"
                     /gene_synonym="EHK-2; EHK2; EK12; EPA6; HEK12; PRO57066"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2542
                     /gene="EPHA6"
                     /gene_synonym="EHK-2; EHK2; EK12; EPA6; HEK12; PRO57066"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2604
                     /gene="EPHA6"
                     /gene_synonym="EHK-2; EHK2; EK12; EPA6; HEK12; PRO57066"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2814
                     /gene="EPHA6"
                     /gene_synonym="EHK-2; EHK2; EK12; EPA6; HEK12; PRO57066"
                     /inference="alignment:Splign:2.1.0"
     exon            2815..2964
                     /gene="EPHA6"
                     /gene_synonym="EHK-2; EHK2; EK12; EPA6; HEK12; PRO57066"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3158
                     /gene="EPHA6"
                     /gene_synonym="EHK-2; EHK2; EK12; EPA6; HEK12; PRO57066"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..3308
                     /gene="EPHA6"
                     /gene_synonym="EHK-2; EHK2; EK12; EPA6; HEK12; PRO57066"
                     /inference="alignment:Splign:2.1.0"
     exon            3309..16254
                     /gene="EPHA6"
                     /gene_synonym="EHK-2; EHK2; EK12; EPA6; HEK12; PRO57066"
                     /inference="alignment:Splign:2.1.0"
     regulatory      16227..16232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPHA6"
                     /gene_synonym="EHK-2; EHK2; EK12; EPA6; HEK12; PRO57066"
                     /note="hexamer: AATAAA"
     polyA_site      16254
                     /gene="EPHA6"
                     /gene_synonym="EHK-2; EHK2; EK12; EPA6; HEK12; PRO57066"
                     /note="major polyA site"
ORIGIN      
        1 agtcctcgcg caagcgggac actgtggtgg atgcaattcc cctcgcctcc agccgcgagg
       61 agctccccgg cgccgcaggc agcgtcctcc tccgaagcag ctgcacctgc aactgggcag
      121 cctggaccct cgtgccctgt tcccgggacc tcgcgcaggg ggcgccccgg gacaccccct
      181 gcgggccggg tggaggagga agaggaggag gaggaagaag acgtggacaa ggacccccat
      241 cctacccaga acacctgcct gcgctgccgc cacttctctt taagggagag gaaaagagag
      301 cctaggagaa ccatgggggg ctgcgaagtc cgggaatttc ttttgcaatt tggtttcttc
      361 ttgcctctgc tgacagcgtg gccaggcgac tgcagtcacg tctccaacaa ccaagttgtg
      421 ttgcttgata caacaactgt actgggagag ctaggatgga aaacatatcc attaaatggg
      481 tgggatgcca tcactgaaat ggatgaacat aataggccca ttcacacata ccaggtatgt
      541 aatgtaatgg aaccaaacca aaacaactgg cttcgtacaa actggatctc ccgtgatgca
      601 gctcagaaaa tttatgtgga aatgaaattc acactaaggg attgtaacag catcccatgg
      661 gtcttgggga cttgcaaaga aacatttaat ctgttttata tggaatcaga tgagtcccac
      721 ggaattaaat tcaagccaaa ccagtataca aagatcgaca caattgctgc tgatgagagt
      781 tttacccaga tggatttggg tgatcgcatc ctcaaactca acactgaaat tcgtgaggtg
      841 gggcctatag aaaggaaagg attttatctg gcttttcaag acattggggc gtgcattgcc
      901 ctggtttcag tccgtgtttt ctacaagaaa tgccccttca ctgttcgtaa cttggccatg
      961 tttcctgata ccattccaag ggttgattcc tcctctttgg ttgaagtacg gggttcttgt
     1021 gtgaagagtg ctgaagagcg tgacactcct aaactgtatt gtggagctga tggagattgg
     1081 ctggttcctc ttggaaggtg catctgcagt acaggatatg aagaaattga gggttcttgc
     1141 catgcttgca gaccaggatt ctataaagct tttgctggga acacaaaatg ttctaaatgt
     1201 cctccacaca gtttaacata catggaagca acttctgtct gtcagtgtga aaagggttat
     1261 ttccgagctg aaaaagaccc accttctatg gcatgtacca ggccaccttc agctcctagg
     1321 aatgtggttt ttaacatcaa tgaaacagcc cttattttgg aatggagccc accaagtgac
     1381 acaggaggga gaaaagatct cacatacagt gtaatctgta agaaatgtgg cttagacacc
     1441 agccagtgtg aggactgtgg tggaggactc cgcttcatcc caagacatac aggcctgatc
     1501 aacaattccg tgatagtact tgactttgtg tctcacgtga attacacctt tgaaatagaa
     1561 gcaatgaatg gagtttctga gttgagtttt tctcccaagc cattcacagc tattacagtg
     1621 accacggatc aagatgcacc ttccctgata ggtgtggtaa ggaaggactg ggcatcccaa
     1681 aatagcattg ccctatcatg gcaagcacct gctttttcca atggagccat tctggactac
     1741 gagatcaagt actatgagaa agaacatgag cagctgacct actcttccac aaggtccaaa
     1801 gcccccagtg tcatcatcac aggtcttaag ccagccacca aatatgtatt tcacatccga
     1861 gtgagaactg cgacaggata cagtggctac agtcagaaat ttgaatttga aacaggagat
     1921 gaaacttctg acatggcagc agaacaagga cagattctcg tgatagccac cgccgctgtt
     1981 ggcggattca ctctcctcgt catcctcact ttattcttct tgatcactgg gagatgtcag
     2041 tggtacataa aagccaagat gaagtcagaa gagaagagaa gaaaccactt acagaatggg
     2101 catttgcgct tcccgggaat taaaacttac attgatccag atacatatga agacccatcc
     2161 ctagcagtcc atgaatttgc aaaggagatt gatccctcaa gaattcgtat tgagagagtc
     2221 attggggcag gtgaatttgg agaagtctgt agtgggcgtt tgaagacacc agggaaaaga
     2281 gagatcccag ttgccattaa aactttgaaa ggtggccaca tggatcggca aagaagagat
     2341 tttctaagag aagctagtat catgggccag tttgaccatc caaacatcat tcgcctagaa
     2401 ggggttgtca ccaaaagatc cttcccggcc attggggtgg aggcgttttg ccccagcttc
     2461 ctgagggcag ggtttttaaa tagcatccag gccccgcatc cagtgccagg gggaggatct
     2521 ttgcccccca ggattcctgc tggcagacca gtaatgattg tggtggaata tatggagaat
     2581 ggatccctag actccttttt gcggaagcat gatggccact tcacagtcat ccagttggtc
     2641 ggaatgctcc gaggcattgc atcaggcatg aagtatcttt ctgatatggg ttatgttcat
     2701 cgagacctag cggctcggaa tatactggtc aatagcaact tagtatgcaa agtttctgat
     2761 tttggtctct ccagagtgct ggaagatgat ccagaagctg cttatacaac aactggtgga
     2821 aaaatcccca taaggtggac agccccagaa gccatcgcct acagaaaatt ctcctcagca
     2881 agcgatgcat ggagctatgg cattgtcatg tgggaggtca tgtcctatgg agagagacct
     2941 tattgggaaa tgtctaacca agatgtcatt ctgtccattg aagaagggta cagacttcca
     3001 gctcccatgg gctgtccagc atctctacac cagctgatgc tccactgctg gcagaaggag
     3061 agaaatcaca gaccaaaatt tactgacatt gtcagcttcc ttgacaaact gatccgaaat
     3121 cccagtgccc ttcacaccct ggtggaggac atccttgtaa tgccagagtc ccctggtgaa
     3181 gttccggaat atcctttgtt tgtcacagtt ggtgactggc tagattctat aaagatgggg
     3241 caatacaaga ataacttcgt ggcagcaggg tttacaacat ttgacctgat ttcaagaatg
     3301 agcattgatg acattagaag aattggagtc atacttattg gacaccagag acgaatagtc
     3361 agcagcatac agactttacg tttacacatg atgcacatac aggagaaggg atttcatgta
     3421 tgaaagtacc acaagcacct gtgttttgtg cctcagcatt tctaaaatga acgatatcct
     3481 ctctactact ctctcttctg attctccaaa catcacttca caaactgcag tcttctgttc
     3541 agactatagg cacacacctt atgtttatgc ttccaaccag gattttaaaa tcatgctaca
     3601 taaatccgtt ctgaataacc tgcaactaaa accctggccc actgcagatt attgctacgc
     3661 aatggtaaat aactcagcat ggatgtgtaa ttttgtataa gccgtatatg ggaagtgttc
     3721 acggacttaa cctaaaaaaa tttatccagg tggggcttcc ttagtgatgt atgtagagtg
     3781 tgatggtaga tgagaaagaa ctagttgacc tttctttcat gttttgtgat caagtagctt
     3841 ccaaactgac agaaatgttt catttttaga taattatatt cagctctatt ggttgtatta
     3901 ttactttatt ttttaatact ttaactgttg gtgcctgata ttgttagaat tatttgcaga
     3961 aatgaccagt gatatcatgt aatgaatttt tgtgaggtat gactatggtg agaagggggt
     4021 tattagggag ggagaaaaaa atactgtgtt tataaatctt ctgaggctgg gtttgtcaat
     4081 tttttaaaaa ttaactttat aatgtcatac atatttcata gtaggtggta gtttaaaggc
     4141 ttttcacctc taattttatt tatttattta tttattttta ctaaccgtag tatatttctc
     4201 tactacctta tgaagaccgc tcctggaaag accaagggtg acttcattga tctaatggct
     4261 ttcatagaga aaagcttggg ataaatccat gactatttcc tttgtgcatt gtcacaagtt
     4321 tgcaaaagca attatcaaag cactgagaaa attggtcatt ctcagtagaa ttgctttgaa
     4381 taaaatacgt tagattatac ccttagattt aatgtaaaat tattaattta atttaaacag
     4441 aactttatga tagatacatg gtggcccaag aaaataaaca gacttagctg atcatttggt
     4501 attggcacat tttgcaagtt gaagcgttct tatgttttct ttgcaaaaat agttacatga
     4561 acatgctgag ctcttttcga aaccttctaa gaaataagta tgaatactcc aaagagcata
     4621 taaacagatc ttacacatga gcatagtgtg tcaacctggg tccaacgtac agttacataa
     4681 aaatgagaac acagctgtgt tgtcataatc ttctgagagg cttaaaaaac aaaggtaaat
     4741 atatatttta agtgatttaa gctgagttgg cttatcaaaa ttgtgctata tcttatgaac
     4801 aaattaaatt ataaaatcag ctgctccctg taaaactaaa aaaatgacga ctgttttagg
     4861 tgaaagagta agtaaaatgt gttgagagaa aaaaacagag taggttgtct aaagatgctg
     4921 atttaataaa ttagcttttg ttggatctca gtgataatgg tgccctacct accctaattc
     4981 tcaaattcct atctaaattc attttttgtc atagtagtgg tttttttttt ttaaataaag
     5041 gaccctgttt ttgttttttg tttttgtttt tgttgttcgt ttgtttgttt ttgagacgga
     5101 ggcgttttgc tcttgttgcc caggctggag tgcaatggtg agatcttggc tcacggcaac
     5161 ctctgcctcc cgggttcaag cgattctcct gcctcagcca cccgagtagc tgggattaca
     5221 ggcgcctgcc accactcccg gctaattttt gtatttttag tagagacggg gtttcaccat
     5281 gttggccagg ctgctcgaac tcctgacctc agatgatctg cccgcctcag cctctcaaag
     5341 tgctgagatt acaggcgtga gccaccgcgc ctggccattt ttttcttata tttagatttt
     5401 gttgatcgtc ccattatact agacccttct acatattttc ttttgctgac ttgtctcctg
     5461 atttttccct accacagctt aatccttctc atttcaaaac aaatgtgtaa agcaaagcta
     5521 gaaggaagag tctttagatg tttcttaaaa tatacaaaaa aaggtagggg gtgatgggaa
     5581 aatcatcact tttcaagtaa gtgtgccaga tatagctagc cacattttcc agccatcaac
     5641 ctgcatggtt gtgcatcact catagactat ctgcagtttg cttgatacat ttacacaaat
     5701 ctggatacac ttagaagaaa tataaaattt ccatatttac ctatcttcaa atatatatta
     5761 aataagaaca gatataaaac agattaaatt tattaatcat atatttattt ttataataca
     5821 aaaaaggtat ttaggaaaat aaggaataga ataatatggt cttccacagg actctgtcgg
     5881 caccatctgt gtaccttgaa ataaattcta ttaagttatt taaatttcta tgggatgagc
     5941 attcagtgat tacaagatta aagttgccta ttaagaattc tttcttttaa aatgtctgat
     6001 gatcctattc tacatctggt taatttgtac ttattttttc tttctctaac atcttttgat
     6061 agtatcataa aactactttt tgctttgtct ctcatcccat gtctccttca aaattccttt
     6121 taaattataa ttttattttt cagaatggta agcatgataa tcttaaatgt aactttgaac
     6181 ttcattatgg ttatggcaac attgaaacat gtgtgcaaga ttaaacagaa acattaaaat
     6241 ataaggattt actataagga tttactgcct accaatcatg gaccccatga tcccaggaat
     6301 attacaatat tcaggaatat aaacagttaa aatgccaaat tcatctgaaa attttacatg
     6361 aaacattttg agacttacta gtgtaaattt taggtaatta aatctgttta atatgcaaag
     6421 cataaaactt aattataaaa agaaaataag taacttccat aaatcacaag tcttcaggaa
     6481 taatctttga tacctaaaat atgcatatag actcacatac ctactttatt ttaaatgtct
     6541 tgatctatgc tactgagggg gtgttttgga ttttaaaacc agacagttaa aaaatcattt
     6601 tcattttatt tctagatggt caattttgtc tatggtgaac tcattatctc atagtagaag
     6661 gcatatttgg aaaaaatgtg aaaacaatgt acaatcaagg agagagataa agtatttaaa
     6721 tcattttaaa aagcaatcaa attgcaaaat tttggtggtt taacacgaat caagaattat
     6781 agcacttttg caatgagtta taactggtga taaatgttct acattccata tcaaaataag
     6841 acatcttatt tcactctgca ttggtcttta aaatctatca aagtataacc tgaataaaac
     6901 tgccttccag caacagcttt aaaacctatc tcagcccatg aatggaaaac aaatccaaat
     6961 ccgatccttg aaaagcaaag gctctaaaga agctcttcag aagagacggt aaagaatgaa
     7021 ttcttttact tatcacccaa ccacatttct taaaaatgtg ttttggtgtc ttttcctacc
     7081 aaatttctgc tctacaaggc agtcagttaa atctctcatt tcataatttt cactgtgcta
     7141 gttctttctt ttctcctctt ttaataaatt ttctaaaact ttctcagccc tgtttttaat
     7201 tcccccatcc tctctcttta ttcctttctc agcttctatc acgccacaca ttatctcaat
     7261 cagcataaaa aaggtagcac aacaaatcta aaaagattgt atagactttt ttagaagagg
     7321 cttggggcag ggggatgttg caaaagctat aatattttgg gttctatcac ataattgaga
     7381 acatttgtac tcacagagga tatgggttct ggcttttcct taacttgaaa tcaagttttt
     7441 ggaaagtaat tttgaaatgg atgatgatga tcctttttaa ttgctttaac taaggaagtt
     7501 tattattaat attttaaaaa ttagtatttt aagatcaata tctgttatta taaactcaca
     7561 gttggtgtcc atgtctctat atatcaaaga gatttgaagc atatgtatca cttcttttag
     7621 tatgagcatc ttaacttttc caatctcaaa ttctgtgaag tagaagagac tcatattact
     7681 ttacattcaa tcaacaaata ttttaatatt ttttaatatg aagactccaa aaggtagagg
     7741 agtacactgg gttaaatgga tggtattctt ccaccagaat ataagatact taagtcacct
     7801 aacttttggt ttttataagc aacattttca acaatttttc aatctttata atgttccaca
     7861 aagacagtat agattttatc tagttcagct taacaaatat ctatggaata tctcctatat
     7921 gcacaaaatt ttactacaaa gatacgtttg gctgtgctgt cattgctttc aagtaactct
     7981 cattattaaa atttagagct ttatttgcta tgtttgctat ggttgccatg tcaccggggg
     8041 atagcacttt ccatagaata taaagaaata aataggatct tcgtccagtg tgaattggat
     8101 ttgcaattct aattcaaatg gaaagaaata ttttggacct caaattctca tagtattctt
     8161 ccgaaacact ccataacccc tctggcggag gggaagcata cttcctgggt tctctaaaac
     8221 agtttctctc attaacagtt gatcctcttc aggagtcaca gatttttatt gtctgatagc
     8281 atagctatca gttcgtatat ggattcacta cctcaaaggt gcctcctgtt agaaaacatt
     8341 agcttttttt caagagcaat tctggagtaa tctcttgttc aagcttattc acttgttcta
     8401 gtaaacataa taataggtat gaactgcaat ggtggcataa aatcctttta aattccatcc
     8461 atttaacagg ggaaatagat gattactcct gactataaca tattactaag tgaaatgata
     8521 gaaacatctt atattgtgta aaagtaaaca ctccatctat ttcttactgt taaaaaaaaa
     8581 gtactgatga gatgtagcaa agatttctca ggataaaaat taactttttt tgttataagt
     8641 ggatgtggca taatgtacat gtattcttgg aaaaaaatta aaagatccag aaaaagatac
     8701 aggtcatcaa aatgtagttt taacaaatca tctttttctg agtaataaat tagcttcaaa
     8761 ttaacaatga gtttgtataa aatgtataaa aaataacatt tatatctttt tttttttttt
     8821 tttttttgag atggagtttc cctcttgttg cccaggctgg agtgcaatgg tgcaatcttg
     8881 gctcaccaca acctccgcct cccaggttca agcaattctc ctgcctcagc ctcccgagta
     8941 gctaggatta caggcatgcg ccaccacgcc cagctaattt tgtattttta gtagagacgg
     9001 gatttctcca tgttggttag gctggtctcg aactcccgac ctcaggtgat ctgcccgcct
     9061 cagcctccca aagtgctggg attacaggcg tgagccactg tgcccagtga gaagatttat
     9121 agcttaatgg aaagacttgg attctttgct cttaattcaa aagagttttt gttttattag
     9181 catttacttt ttgagatttt acaatatatt tggaacttct ttaggtagcc agtggcaatc
     9241 caaaattaca ttttaaaatg aaaaaaagag aaaacttttc aattactaag gcaggcaaag
     9301 cactaggaaa tgaataaact ttacctttta aaaaggaatc tgtcaactgc aaagtttgta
     9361 tatctcagtg acatcaagtg atttttgcac tgtcccattg aaagcaaagt ttcctttatt
     9421 tatttattta ttcatttatt tttgagacgg agtctcgctc tgtcgcctag gctggagtgc
     9481 agtggcgaga tctcggctca ctgctaactc cgcctcccgg gttcacgcca ttctcctgcc
     9541 tcagtctcca gagtagctgg aactacaggc gtccgtcacc acgcccggct aattttttgt
     9601 atttttagta gagacggagt ttcaccgtgt tagccaggat ggtctcgatc tcctgacctg
     9661 gtgatccaac cgcctcggcc tcccaaagtg gtgggattac aggcgtgagc caccgcgccc
     9721 ggccacaaag ttttctttta aacaaaacat ggaaaagttc ttgcttgaac tttcacactg
     9781 attaatcaaa gtaacaaatc tctacatcat taagagaact tttgatttgt ttcattatag
     9841 agaaagtctc aaagaattcc attaccctta gacacaacta attcattcct cagaataaca
     9901 aaggtattaa agaaaaatca cttgacagat gaggaggaaa agtagctctt aaatgttaaa
     9961 taaagatgtg gcttctatat ttaattaaaa aataaggtat aaattaacaa cacaatcttc
    10021 tcaggagttg taaactagaa aagtatcaga attagtgaaa atcttccctt aagtaaaact
    10081 gttcttactt gtattttctg cattatttgt gacctctggc catttttaat ttgtcataat
    10141 aaactcattt ctggttagat aataagttat aatctcaaca aatcagaaca actgagatac
    10201 aagtatagat agggtgctct acaaaataat aaaaggagga caactctaat tcaggattcc
    10261 tatttagtta gtaacagggt ctccatctca ttatccctcg ctgaagtgag aactatcttt
    10321 atcccaaaat aatacattat tatagaaaaa attccaagga tataagaatc atttttcata
    10381 tattccattc aatttgtata tttaggtatt agtaactgag gatagatatc tttgtttcat
    10441 gagttcaata tgagcttaca tgagaagcaa attgatgtga acatttctct acaagttttt
    10501 ccacatttgt agctcatcct tagaacagtc ttaatttggc tctgttctat aaagactcaa
    10561 tatcatttaa tttttcaaaa tcatgatagg gagaagaatg ctaatttgta aagataggca
    10621 aacactacac ttttaagatt tttaccgtaa gtaaaatgtc ctcttccact gcttttataa
    10681 ttaaaaatct ctttcctacc tttagtaatt tgtaggatga actgtatgca tttagataga
    10741 aattgctttt gttaaattta catttaaaca catcttcatt cacttagaga agccataata
    10801 taattcttca tattagttta tttttcaaag tagtaacttt tgctatcttt agaattctca
    10861 tctacccagt aatataatta ttaaagtcat gaggaagttt ttctttgact gtgcatgctt
    10921 tatttattac catattgttt ttgtcttcag aataagtctg ctcaaaattg tagcctttag
    10981 aagctctata acaaaaatca atggccaata acttgctaac aaacttgtaa ctgaacaagc
    11041 tatttttttc tgtcaatgtg attgatatgc tcattgttaa atttaacttg tttaaatatc
    11101 cattggtata ttatcaagag ctattactgc aataacctca aagtatcttt aagacaatgc
    11161 tgaatatcat acatagttaa taaacaatga ttggagcttt tcaaaattgc tgctctgcat
    11221 ggaaagtaag gtttaatgtg tataaatgtt tgtcattgaa gtttggaatt tattttaatg
    11281 tactctttct tcccatgcta gatatgtctt caaagaaaaa tgtattaata tattcatact
    11341 atgcaaaaat atcattttat tcttaccaaa aaaatgtagc tttgataaaa ttttatggtt
    11401 tttaggcctc ttagagtaaa aaaaatcaaa atgtgaaatg ggagcatttt ggggagcgag
    11461 caggacacaa tatctgagca gtgttaacaa atatgaacat gagtaacatt tgatgtaaag
    11521 attatggtgt gtgcttgatt ttggatacat tattattcat tttgttagtc acattccacc
    11581 ttggattgtg acattgaaaa acattgaata tatacaggat ataaatatct ttgggatatt
    11641 ttacataatc atacttattt ttaattttgt gtacagtgaa aactttgaca gtttaatttt
    11701 gaattttgaa ggaataattt ttaacagtct ttgtttctta aaatgttaat tatggtatac
    11761 gtgctatagt aacctcattt tttaaaaaaa tcagaggcaa agcaagaatg cagaacatgg
    11821 caacagacta agttccacta aaattaagga aaacactaaa aggtaataca gtacaaagag
    11881 gagtttgttt taaaattgtt acttacctca ttttaaaaac tgttagaaaa gagtgaataa
    11941 aaagtatgtc acagtactct tactggtaat tttgaaacta aagtgcattt caaggatggg
    12001 aatctctaat ataaatgagt acactaatag ttgttaaaat atgtattgat acatacaatt
    12061 agaaagaaat gtcatcaaaa tatcaaaaat aggaaaaagt tcattttaaa aatgttttgt
    12121 aatggaacaa gtcatcaaaa ttcttaacat ttccatatta ttaatccttt gttttccaag
    12181 acatatataa tcaaagaatt tgccaaaaaa ttcaaataat aatacattga atattggact
    12241 gccatagcac tttaaacata ttaataaatt atcccatgga taataaagag atttttttcc
    12301 agccatcatt aaatataaaa atagtatata taaagatgca taaaaaagga acttacttga
    12361 taccgtcttt tagcatcaat ttatcttgtt aagcagttat attaatttta cacatactct
    12421 taaatgctta aaaacatagt acttacatat taattttatg tgatataata tgttttgatc
    12481 tctaaatgct tacattcttt caagaagatt gccttctctt tccagttgtt ttaagtattt
    12541 taaaaaagag ccattgtatt ttttatattt ccattcagtc tcattatgct tgaaagtttc
    12601 caactctcaa ataagttgaa accaagtgtc atagcacagt ggctagaagt tattcttttt
    12661 gaagttattc ttcttttatt taatattagt ctgatatccc ctaaaatttg ctagagaaag
    12721 caaactcttc tcatgaatgg aaatacaaaa tgaaaattct ccactggatg ttataaattc
    12781 aaaaaaagaa catatatttt ttatagttac ttctcactac ttactgctta ttcagtttgt
    12841 aaaatcttac caagtaggat acttcaaaca agagtgaaaa gctactccat ttacgtgtaa
    12901 tctgcttatt ttcttcagag tttccaaaaa cctttgagaa aacaaaataa tcgttttccc
    12961 taccttacaa ccttgatcac tctaccatta aatgcaataa taaggtatct ataatataac
    13021 aatcaaaaat atcagtcaaa gcttagtgtt tacctcttta aactatataa caaatataac
    13081 cgtagcaaca acaaattaaa ggagatcatg tctccttact ggtccaaaat tgtataattc
    13141 ctaaattttc atatatatac atatactgac atacctttaa aatatattta tctgtaagtc
    13201 cattcactcc attcaactgt ttattgaaca ctaccatgta ccattgtcct gttcgaagca
    13261 ctgaggatac atggtgacca agacaagcaa agtccctgtc tcatggaatt gaccttctag
    13321 tgataaagac acacaatgaa gaaatagtga tgtgctgtgc ttataattaa aaatgttaca
    13381 tagcatgact gtggctcctt taagcggtag aggaaatctt cccccaagga catgccattt
    13441 aaactgatat ctgaaaagca tgaaggaagc atccatgaga agatatgggg gaagagcatt
    13501 acaagcagag ggaaaattta atgaatgaaa ttacaagcag agggggatag ttaatgaatg
    13561 aaaatttgga gtgttggaga gtagagaaca gtgttcttgg tacactgaaa tgaggcaaaa
    13621 agaggagaag gtatacgcat gaggctactg gagtaattcc agcaaaaacg tggtggattc
    13681 actacttcaa gatttggaag gcatcagtat atatatgcta tttaaagttt ggaaatcacc
    13741 taggaaaagc ctgtggaggt aggcctagga ttgcactata tgctattcca atgtttaata
    13801 ggcagataat tagaattaaa cagaagaaat ggagtataaa gtaagctaga gaaaaaggaa
    13861 atgcagttgc tcatctggat taaatgcttt taagaagtca agattagaac aaagacatgt
    13921 ccatgggaat tagcaacatg gaagttgttg ttgttgatga ccttcacaag gtcatcaact
    13981 atgaaaatag tggagtcaac tatcaactat gaaatagtgg agtcaaatcc caactgacat
    14041 ggattaaggc gagatgtaaa ggaaggaggt gaaatcacta tctataaaca actctctcaa
    14101 aaagctttga tgtaaaggga gcaagagaaa taggataata gctggagaaa ggaagtcaag
    14161 gaattgtctt gttttttaag gatgctacag catatttatc tactaatgaa aatgacttgg
    14221 cagacagggg aaaactgatt atgcaagaga gatgataatt gtaacaaagg ccttgagaga
    14281 tagaggggtt gcgatttaaa gcataagtag ggaggttaat ttttgatagg tgccggaata
    14341 tagaactcca atgaaaggaa ggcagaatgt gtaatgtgca aataggttgg tatatttgtg
    14401 gtagaaaggg aaggatgtca ctacgtaagt ttttttttaa ttttaccaag aatgagataa
    14461 aagccaatat gcaggatggg aaggacgtat aggttggaag agacatatgt aagtagttgg
    14521 atagtaggaa agtgaatata tatttgatga aatattttaa aggcatcttt actaaatatt
    14581 tttgagacat cttattggaa gacccgaaac tttgaattct gtggtttcca aggactctgg
    14641 taagagtcct ttccataatg tagagattga gaacttctca atgccataaa tactgttttc
    14701 cttattttca tctattacag attaaaaggc agaaacattt tgtagctaat ctgttataat
    14761 gcaaagccta tcaaacttaa aattagctta atcctgaaag atgtatattg cataatcaac
    14821 ctgtcacttt tttcaaacac gatttgggag ggtattgagg tcccatgtaa attttaaaat
    14881 aaaagacaaa caggaactaa tcttttagta aaaattattt tgttttcata taggaaaaca
    14941 atgccttctg tcatttacgg aaaacacatg ggcaatatgg ttggttgttc attgtgcccc
    15001 tctatcctat aggaagaatg tgatctttta attgtgcttg gtgctttgtt tctggagata
    15061 tatatatata tattatatat atgtatatat accatatgta tatatacata tgtatgtgtg
    15121 tatgtgtgta tatatatctc tctaggttgt atgtaattca atatgttgga atttaaagat
    15181 gcattattat ttggatttga tgtgaaatta gattgtgaat aatggagatt gctctccatt
    15241 ttttgctgtt ctagcatagc caaaaatata aagatataga tgtacatata catatgtatt
    15301 tgattaaaca ctttaaattt taaatggccg catcaaattt taaatggtag atgatatcaa
    15361 caattgcagt gcactcaaaa tgttataaaa tctttgtagc acaaatcctg aagtatatgc
    15421 aaactaaata gcatatttat ataaaatacc tagataacat gtctaggttg agatatttaa
    15481 tccctcatag agctatattt gactaataaa aaacgacagc taaaaataat ttccctccct
    15541 ataagtacaa atatgatttt taaagcatca ttgtaacttg tcatgaagct atttattatt
    15601 aattaaggat ttaactctgt acccatctgc tcttacaaaa ggggaaaaag atttatctat
    15661 gagaataggg aagtatagca ctgttttatg tttttctctt tagtattctg tcaccattta
    15721 aagcttcaat atatgccttc cactcaggtt cctgacacag cctacattct cttttctggt
    15781 tataatcaca atatggtaga gctataaaca aggtaaaaag gtgttaacaa ttgaactgca
    15841 atcctaccta ttatctactt tactatagca gtgaagtagt ccagacttat ttgaaggtgg
    15901 tactattttt atcttacaaa aatctactat aatattaata actttccatg taaattttca
    15961 tgtgctggca tgcttacaag ttaatagtgt tatagaatgc tcagctctca atatgagggg
    16021 ttgtttgtgg tgaattgcat aacatatgtc atctatttgc tgaaagaata tgctgtttag
    16081 caaactacct gctgagcaac ataataagat ttttgtacaa ggtacaaatt actaattatt
    16141 gtattttatt tttctatgat ttcctaagag gcattatcag ggtcttacag atggagtaag
    16201 cctgtttatt aaaatatcta ttggcaaata aaagttacag ctttggtggt tgaa
//
