LOCUS       NM_001281766            8345 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens EPH receptor A5 (EPHA5), transcript variant 4, mRNA.
ACCESSION   NM_001281766 XM_005265651
VERSION     NM_001281766.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8345)
  AUTHORS   Han,X., Liu,T., Zhai,J., Liu,C., Wang,W., Nie,C., Wang,Q., Zhu,X.,
            Zhou,H. and Tian,W.
  TITLE     Association between EPHA5 methylation status in peripheral blood
            leukocytes and the risk and prognosis of gastric cancer
  JOURNAL   PeerJ 10, e13774 (2022)
   PUBMED   36164608
  REMARK    GeneRIF: Association between EPHA5 methylation status in peripheral
            blood leukocytes and the risk and prognosis of gastric cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8345)
  AUTHORS   Salokas,K., Liu,X., Ohman,T., Chowdhury,I., Gawriyski,L.,
            Keskitalo,S. and Varjosalo,M.
  TITLE     Physical and functional interactome atlas of human receptor
            tyrosine kinases
  JOURNAL   EMBO Rep 23 (6), e54041 (2022)
   PUBMED   35384245
REFERENCE   3  (bases 1 to 8345)
  AUTHORS   Liu,C., He,Y., Feng,X., Li,J. and Wang,J.
  TITLE     Expression of EPHA5 in lung adenocarcinoma is associated with lymph
            node metastasis and EGFR mutation
  JOURNAL   APMIS 130 (6), 338-345 (2022)
   PUBMED   35332588
  REMARK    GeneRIF: Expression of EPHA5 in lung adenocarcinoma is associated
            with lymph node metastasis and EGFR mutation.
REFERENCE   4  (bases 1 to 8345)
  AUTHORS   Abouhashem,N., Harb,O., Elwan,A., Zaitoun,M. and Saraya,Y.
  TITLE     Immunohistochemical evaluation of forkhead box A1 and EphA5 markers
            in serous ovarian carcinomas, and their impact on the clinical
            outcome of patients
  JOURNAL   Pol J Pathol 73 (2), 120-133 (2022)
   PUBMED   36345952
  REMARK    GeneRIF: Immunohistochemical evaluation of forkhead box A1 and
            EphA5 markers in serous ovarian carcinomas, and their impact on the
            clinical outcome of patients.
REFERENCE   5  (bases 1 to 8345)
  AUTHORS   Caras,I.W.
  TITLE     A link between axon guidance and axon fasciculation suggested by
            studies of the tyrosine kinase receptor EphA5/REK7 and its ligand
            ephrin-A5/AL-1
  JOURNAL   Cell Tissue Res 290 (2), 261-264 (1997)
   PUBMED   9321687
  REMARK    Review article
REFERENCE   6  (bases 1 to 8345)
  AUTHORS   Zhou,R.
  TITLE     Regulation of topographic projection by the Eph family receptor Bsk
            (EphA5) and its ligands
  JOURNAL   Cell Tissue Res 290 (2), 251-259 (1997)
   PUBMED   9321686
  REMARK    Review article
REFERENCE   7  (bases 1 to 8345)
  AUTHORS   Miescher,G.C., Taylor,V., Olivieri,G., Mindermann,T., Schrock,E.
            and Steck,A.J.
  TITLE     Extensive splice variation and localization of the EHK-1 receptor
            tyrosine kinase in adult human brain and glial tumors
  JOURNAL   Brain Res Mol Brain Res 46 (1-2), 17-24 (1997)
   PUBMED   9191074
REFERENCE   8  (bases 1 to 8345)
  AUTHORS   Gale,N.W., Holland,S.J., Valenzuela,D.M., Flenniken,A., Pan,L.,
            Ryan,T.E., Henkemeyer,M., Strebhardt,K., Hirai,H., Wilkinson,D.G.,
            Pawson,T., Davis,S. and Yancopoulos,G.D.
  TITLE     Eph receptors and ligands comprise two major specificity subclasses
            and are reciprocally compartmentalized during embryogenesis
  JOURNAL   Neuron 17 (1), 9-19 (1996)
   PUBMED   8755474
REFERENCE   9  (bases 1 to 8345)
  AUTHORS   Fox,G.M., Holst,P.L., Chute,H.T., Lindberg,R.A., Janssen,A.M.,
            Basu,R. and Welcher,A.A.
  TITLE     cDNA cloning and tissue distribution of five human EPH-like
            receptor protein-tyrosine kinases
  JOURNAL   Oncogene 10 (5), 897-905 (1995)
   PUBMED   7898931
REFERENCE   10 (bases 1 to 8345)
  AUTHORS   Spritz,R.A., Strunk,K.M., Lee,S.T., Lu-Kuo,J.M., Ward,D.C., Le
            Paslier,D., Altherr,M.R., Dorman,T.E. and Moir,D.T.
  TITLE     A YAC contig spanning a cluster of human type III receptor protein
            tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12
  JOURNAL   Genomics 22 (2), 431-436 (1994)
   PUBMED   7528718
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104137.5, BC143427.1,
            AC018683.4 and BX537946.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001281766.2.
            
            Summary: This gene belongs to the ephrin receptor subfamily of the
            protein-tyrosine kinase family. EPH and EPH-related receptors have
            been implicated in mediating developmental events, particularly in
            the nervous system. Receptors in the EPH subfamily typically have a
            single kinase domain and an extracellular region containing a
            Cys-rich domain and 2 fibronectin type III repeats. The ephrin
            receptors are divided into 2 groups based on the similarity of
            their extracellular domain sequences and their affinities for
            binding ephrin-A and ephrin-B ligands. Alternatively spliced
            transcript variants encoding different isoforms have been
            described. [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (4) lacks an alternate in-frame
            exon in the coding region compared to variant 3. The resulting
            protein (isoform d) is shorter but has the same N- and C-termini
            compared to isoform c.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.3437563.1,
                                           SRR14038194.3333595.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000613740.5/ ENSP00000478537.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-727               AC104137.5         82818-83544         c
            728-3874            BC143427.1         1-3147
            3875-7613           AC018683.4         95771-99509
            7614-8345           BX537946.1         6805-7536
FEATURES             Location/Qualifiers
     source          1..8345
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.1-q13.2"
     gene            1..8345
                     /gene="EPHA5"
                     /gene_synonym="CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4"
                     /note="EPH receptor A5"
                     /db_xref="GeneID:2044"
                     /db_xref="HGNC:HGNC:3389"
                     /db_xref="MIM:600004"
     exon            1..928
                     /gene="EPHA5"
                     /gene_synonym="CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     CDS             748..3798
                     /gene="EPHA5"
                     /gene_synonym="CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4"
                     /EC_number="2.7.10.1"
                     /note="isoform d is encoded by transcript variant 4;
                     ephrin type-A receptor 5; receptor protein-tyrosine kinase
                     HEK7; tyrosine-protein kinase receptor EHK-1; EPH-like
                     kinase 7; EPH homology kinase 1; brain-specific kinase;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="ephrin type-A receptor 5 isoform d"
                     /protein_id="NP_001268695.1"
                     /db_xref="CCDS:CCDS75131.1"
                     /db_xref="GeneID:2044"
                     /db_xref="HGNC:HGNC:3389"
                     /db_xref="MIM:600004"
                     /translation="MRGSGPRGAGRRRPPSGGGDTPITPASLAGCYSAPRRAPLWTCL
                     LLCAALRTLLASPSNEVNLLDSRTVMGDLGWIAFPKNGWEEIGEVDENYAPIHTYQVC
                     KVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFESDD
                     QNGRNIKENQYIKIDTIAADESFTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVG
                     ACIALVSVRVYYKKCPSVVRHLAVFPDTITGADSSQLLEVSGSCVNHSVTDEPPKMHC
                     SAEGEWLVPIGKCMCKAGYEEKNGTCQVCRPGFFKASPHIQSCGKCPPHSYTHEEAST
                     SCVCEKDYFRRESDPPTMACTRPPSAPRNAISNVNETSVFLEWIPPADTGGRKDVSYY
                     IACKKCNSHAGVCEECGGHVRYLPRQSGLKNTSVMMVDLLAHTNYTFEIEAVNGVSDL
                     SPGARQYVSVNVTTNQAAPSPVTNVKKGKIAKNSISLSWQEPDRPNGIILEYEIKYFE
                     KDQETSYTIIKSKETTITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFETTPVSVAA
                     SSDQSQIPVIAVSVTVGVILLAVVIGVLLSGRRCGYSKAKQDPEEEKMHFHNGHIKLP
                     GVRTYIDPHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELP
                     VAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSL
                     DTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDF
                     GLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGER
                     PYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKL
                     IRNPSSLKTLVNASCRVSNLLAEHSPLGSGAYRSVGEWLEAIKMGRYTEIFMENGYSS
                     MDAVAQVTLEDLRRLGVTLVGHQKKIMNSLQEMKVQLVNGMVPL"
     exon            929..993
                     /gene="EPHA5"
                     /gene_synonym="CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1657
                     /gene="EPHA5"
                     /gene_synonym="CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1813
                     /gene="EPHA5"
                     /gene_synonym="CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..2149
                     /gene="EPHA5"
                     /gene_synonym="CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2274
                     /gene="EPHA5"
                     /gene_synonym="CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2434
                     /gene="EPHA5"
                     /gene_synonym="CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2540
                     /gene="EPHA5"
                     /gene_synonym="CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2608
                     /gene="EPHA5"
                     /gene_synonym="CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2734
                     /gene="EPHA5"
                     /gene_synonym="CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..2920
                     /gene="EPHA5"
                     /gene_synonym="CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..2982
                     /gene="EPHA5"
                     /gene_synonym="CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            2983..3192
                     /gene="EPHA5"
                     /gene_synonym="CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            3193..3342
                     /gene="EPHA5"
                     /gene_synonym="CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            3343..3536
                     /gene="EPHA5"
                     /gene_synonym="CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            3537..3692
                     /gene="EPHA5"
                     /gene_synonym="CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            3693..8345
                     /gene="EPHA5"
                     /gene_synonym="CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8325..8330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPHA5"
                     /gene_synonym="CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4"
                     /note="hexamer: AATAAA"
     polyA_site      8345
                     /gene="EPHA5"
                     /gene_synonym="CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4"
                     /note="major polyA site"
ORIGIN      
        1 acagcaggag cgcgccttgg cggtgcagtt tcaacctcga cttcgcagcc gcgcacacac
       61 cgcctgctcc ccgagcagcg ggaaccgcag cagctcctgg gccgccgcag cgcagctccg
      121 cgctcctacc ggccggcagc cgtcagtccc tcccctcttc agcactcagc ccgcagctat
      181 ttccttctgc cagtctcttt gaactctgga tctttgcttt tgctcgctgc tctcctgttt
      241 ttcattctcc acattttctc aagtcctctt tctttatcct tagccaccct gcttttttcc
      301 tcctttttta aaaaatcgga gatttcgtct taaaatgatt tgccttcctt accttcgtcc
      361 atttcaacac tgaaggctgc aaagaacctt cacctttccc ctagtggtat ttaaaaattc
      421 tcaatccgta aaaagtcttt ttgaaaggca aaggaacagg acccaggacc ctctcgacac
      481 ccttgatccg agtccagatc tgcactagca accagaacta atatttcatt taaccccacc
      541 aaagggggag gcgagaggag ccagaagcaa acttcagctg tctcagccgg atccgtggtt
      601 cctacatttg gaggagccgc gtgccagaag gcgtaggacc ccaagggggg acaaggagga
      661 ctcccgagtc tcccttcgcc gctctgcgag gccgaagcgg tggactgagc cgctcgggac
      721 agcggcaccg gaggaggctc ggagaagatg cggggctcgg ggccccgggg tgcgggacgc
      781 cggcggcccc caagcggcgg cggcgacacc cccatcaccc cagcgtccct ggccggctgc
      841 tactctgcac ctcgacgggc tcccctctgg acgtgccttc tcctgtgcgc cgcactccgg
      901 accctcctgg ccagccccag caacgaagtg aatttattgg attcacgcac tgtcatgggg
      961 gacctgggat ggattgcttt tccaaaaaat gggtgggaag agattggtga agtggatgaa
     1021 aattatgccc ctatccacac ataccaagta tgcaaagtga tggaacagaa tcagaataac
     1081 tggcttttga ccagttggat ctccaatgaa ggtgcttcca gaatcttcat agaactcaaa
     1141 tttaccctgc gggactgcaa cagccttcct ggaggactgg ggacctgtaa ggaaaccttt
     1201 aatatgtatt actttgagtc agatgatcag aatgggagaa acatcaagga aaaccaatac
     1261 atcaaaattg ataccattgc tgccgatgaa agctttacag aacttgatct tggtgaccgt
     1321 gttatgaaac tgaatacaga ggtcagagat gtaggacctc taagcaaaaa gggattttat
     1381 cttgcttttc aagatgttgg tgcttgcatt gctctggttt ctgtgcgtgt atactataaa
     1441 aaatgccctt ctgtggtacg acacttggct gtcttccctg acaccatcac tggagctgat
     1501 tcttcccaat tgctcgaagt gtcaggctcc tgtgtcaacc attctgtgac cgatgaacct
     1561 cccaaaatgc actgcagcgc cgaaggggag tggctggtgc ccatcgggaa atgcatgtgc
     1621 aaggcaggat atgaagagaa aaatggcacc tgtcaagtgt gcagacctgg gttcttcaaa
     1681 gcctcacctc acatccagag ctgcggcaaa tgtccacctc acagttatac ccatgaggaa
     1741 gcttcaacct cttgtgtctg tgaaaaggat tatttcagga gagagtctga tccacccaca
     1801 atggcatgca caagaccccc ctctgctcct cggaatgcca tctcaaatgt taatgaaact
     1861 agtgtctttc tggaatggat tccgcctgct gacactggtg gaaggaaaga cgtgtcatat
     1921 tatattgcat gcaagaagtg caactcccat gcaggtgtgt gtgaggagtg tggcggtcat
     1981 gtcaggtacc ttccccggca aagcggcctg aaaaacacct ctgtcatgat ggtggatcta
     2041 ctcgctcaca caaactatac ctttgagatt gaggcagtga atggagtgtc cgacttgagc
     2101 ccaggagccc ggcagtatgt gtctgtaaat gtaaccacaa atcaagcagc tccatctcca
     2161 gtcaccaatg tgaaaaaagg gaaaattgca aaaaacagca tctctttgtc ttggcaagaa
     2221 ccagatcgtc ccaatggaat catcctagag tatgaaatca agtattttga aaaggaccaa
     2281 gagaccagct acacgattat caaatctaaa gagacaacta ttactgcaga gggcttgaaa
     2341 ccagcttcag tttatgtctt ccaaattcga gcacgtacag cagcaggcta tggtgtcttc
     2401 agtcgaagat ttgagtttga aaccacccca gtgtcagttg cagcatccag cgatcaaagc
     2461 cagattcctg taattgctgt gtctgtgaca gtgggagtca ttttgttggc agtggttatc
     2521 ggcgtcctcc tcagtggaag gcggtgtggc tacagcaaag caaaacaaga tccagaagag
     2581 gaaaagatgc attttcataa tgggcacatt aaactgccag gagtaagaac ttacattgat
     2641 ccacatacct atgaggatcc caatcaagct gtccacgaat ttgctaagga gatagaagca
     2701 tcatgtatca ccattgagag agttattgga gcaggtgaat ttggtgaagt ttgtagtgga
     2761 cgtttgaaac taccaggaaa aagagaatta cctgtggcta tcaaaaccct taaagtaggc
     2821 tatactgaaa agcaacgcag agatttccta ggtgaagcaa gtatcatggg acagtttgat
     2881 catcctaaca tcatccattt agaaggtgtg gtgaccaaaa gtaaaccagt gatgatcgtg
     2941 acagagtata tggagaatgg ctctttagat acatttttga agaaaaacga tgggcagttc
     3001 actgtgattc agcttgttgg catgctgaga ggtatctctg caggaatgaa gtacctttct
     3061 gacatgggct atgtgcatag agatcttgct gccagaaaca tcttaatcaa cagtaacctt
     3121 gtgtgcaaag tgtctgactt tggactttcc cgggtactgg aagatgatcc cgaggcagcc
     3181 tacaccacaa ggggaggaaa aattccaatc agatggactg ccccagaagc aatagctttc
     3241 cgaaagttta cttctgccag tgatgtctgg agttatggaa tagtaatgtg ggaagttgtg
     3301 tcttatggag agagacccta ctgggagatg accaatcaag atgtgattaa agcggtagag
     3361 gaaggctatc gtctgccaag ccccatggat tgtcctgctg ctctctatca gttaatgctg
     3421 gattgctggc agaaagagcg aaatagcagg cccaagtttg atgaaatagt caacatgttg
     3481 gacaagctga tacgtaaccc aagtagtctg aagacgctgg ttaatgcatc ctgcagagta
     3541 tctaatttat tggcagaaca tagcccacta ggatctgggg cctacagatc agtaggtgaa
     3601 tggctagagg caatcaagat gggccggtat acagagattt tcatggaaaa tggatacagt
     3661 tcaatggacg ctgtggctca ggtgaccttg gaggatttga gacggcttgg agtgactctt
     3721 gtcggtcacc agaagaagat catgaacagc cttcaagaaa tgaaggtgca gctggtaaac
     3781 ggaatggtgc cattgtaact tcatgtaaat gtcgcttctt caagtgaatg attctgcact
     3841 ttgtaaacag cactgagatt tattttaaca aaaaaagggg gaaaagggaa aacagtgatt
     3901 tctaaacctt agaaaacatt tgcctcagcc acagaatttg taatcatggt tttactgaag
     3961 tatccagttc ttagtcctta gtcttcattt ttcatgaagc aaacatatct tgcattaaaa
     4021 gggacatgaa gttagacatc atcttaagtt acaacaacag aatccttccc actacttcta
     4081 caaaattttg tacatgaaat atataattat atagcacttt tatagactga attaaggcaa
     4141 cccctttcaa aacttccagg gatctacttg aaaggaaatg ttttatagcc atttgtgagc
     4201 taacaaaagc tacagtttac tgaagtttac ttcaagtctt aattgtctac aaaagtgtat
     4261 tgaagagcaa tatgattaga ttatttctta atagatatct tcttttgtaa ttttaaaatg
     4321 ctgttacaca gcgttaagtt atagaaacta gtgtgtaaac atgttgcttg atcaagaaaa
     4381 agtacaatac agggtgtata tttatttttt gtgttataaa gtttactttt agttgctctt
     4441 ctagagatta ttaggtaata aatgtgtata tactgtataa tttgcaatat acccaggaac
     4501 tgatttaaga tggaattgtg tgtgtgtttg cttgcacatg tgtgtgttac cattctgctt
     4561 gcatttctaa tagtgtttca attttagcaa catataggag caagtgttcc agaatgtaat
     4621 atgaatagga gaaataggga agcagtaaaa caaaatttaa cacaagcttg tgtctctttt
     4681 cctctcatgt gtccaaaagc taatctcttt attcactaaa aggaaatgtg tataagacta
     4741 aatccccttt ggctttttaa aaacattttg tgatatcagt gacaatgcag ttcttctagc
     4801 cattaatctt gtacccctgt aagaaatttc acctttctga gtcctgaaaa gtatcttgtc
     4861 aagcaaagtt gacaccgaag ggcacatttt cagcaggatg tagaaggatt taactgtgca
     4921 ggcttctgtt aatgttgtta aatccaggca catagcacga agcatcaccc ttaagtgtta
     4981 atccgttgta accattccca ttttgactca gttctagaaa ttttgactct aaggcagcaa
     5041 tggaattatg acaaatatat atatatacac atacacacac acaaatatat atatatgctt
     5101 atttcccttc agaattttat ttcaataatt gataagtttt atttttaatg gatgtttatt
     5161 catttgttaa tttcagtttg tattcagtta catggctttg agtttatttt attgaaccaa
     5221 tccaaggtat tatgtaatta ggcttattaa ggaatataac atatcttcta tgtatgctct
     5281 atataccaca catgatgaag acttatattt gtgatacaaa ttatgcagtg tattagaaat
     5341 tgtccaaaac tgagctcctg agataaccaa catttttgta ttattacact ttataaaaat
     5401 tatggaatgt catgtgatta gtcaaaatca gagcatttaa ataaaataca gcctactcat
     5461 gattatcaat gttaatagta cagtagatca gagaagcctg gattaatgaa atttatcaga
     5521 aatatagcca cgttatatta atggtattct tttttccaag cacttgtttt atttgaatat
     5581 tagcacatat aagaataaac ttttgggaaa taactacttc ctattctgcc caccctttac
     5641 ttaagcagta aagtacctct tttctaaaga accaggaaac atcaaaataa ccacaacaaa
     5701 aatctaaaca gttttcaaat aatacattca gttctcataa taataagggc tatataccat
     5761 gggtccacac aaactgtgct gcaaacatat aatctattag tttagtaaaa tttccagaga
     5821 tgtgaattta atattttctt gataaaatca taaaaaagca tcaccattat taaagatgca
     5881 tttgttcatt tcaataaaca gaaattaatg aaacaaatta cttttgtaca aaataaatga
     5941 tgattatgtg gcactttatt gaattttata gaaatattcc aatctaagtg ataaagtaac
     6001 aactgagaaa cttcagaatg aaagccttat tgattcaaaa ggaaaattac catatgcttt
     6061 agggctgatg aacttgccac aattgcttag acataacaaa gatattttct acattgtttt
     6121 ccaactttat atgctgaaag ataattagga ggtccgggtg gagtgtatct aaatgactag
     6181 aactttaagt tgcaatatag attttctctt tttaacaaag gaagaatata aattaatttg
     6241 gatcaaattt atttgccttc tttgcaatct tggtgatcat tttggaaagt aaattgaaag
     6301 gaaagttaaa tagccacata gttttctttt gcatctcaat ttggttgaga atttctaagg
     6361 aaggttaata tgactttaga atgaataaag agactgtcaa acaacaagta ctctccctaa
     6421 aaaagaggaa agaatgcctt cctaaaatat ttgtttccta ttgtatatgt caccaattgg
     6481 aaaatgccaa tctcatctgc aagtgtgaga aatggaacaa ggagaggagc caactctagt
     6541 aaaatgtagt gaggccataa tccaaggcaa agtttaacaa atcttgattg tgtaatttct
     6601 tattctgttg attcattttg tcacccacca gactaccaaa aataaagcac agacatgaca
     6661 attttagtat atacaacaga tttggcaaat aatacataat cttattgtaa ttgccagtag
     6721 caatatctta aggggcatga gtctttcaca gtattggact ttgaaaaatt ggtacaggga
     6781 gtaattttca acagactgat acttgaagtc actcaattac tactttgacc tatcataatt
     6841 tgtttctaat cttgtcattt gctcatatat actattaata taaccagttg ctcttttcat
     6901 aatgtactat ttctatgtaa agatgtaaag attttgattt tcctatgttt taaaattgta
     6961 atgtgcatga tcttttattt cttgtgtttc aattaccaag tcagtattct aaggttgtaa
     7021 gattactgta aaaattatat tccaatattt tatctaaact taagtgtggc cagcattatt
     7081 ggtttcagag ttgcctaaac aacacagaat atccttaatt cagtttgtaa aagagttttg
     7141 accagtgtaa aaaagtgaag acacagtttc atgtttcaag tttaaaatgg aaagttaata
     7201 tcatttgagc acttatgtgt tttcatgtct tctacttaat ctgtatgtga aagtaaaata
     7261 tttttaacac cattatttat gccatgtaaa gtgggttctc agaagcacaa gcacagatat
     7321 ttaccttctg aagacatttt tggctataaa agtgcattgg atggcaaaca ctatttgagt
     7381 caggtgttag aaatttatta gatgtattat attacatagt agaataaggt ccctttctca
     7441 ttttgttttt cctaaaaata agaaaaaaaa gaagtgtgat agtaaactgt ctttgctaat
     7501 gtcctgccag atgtttaact tcaaattaag caaaaagtag gtacaatatg atgatgatcc
     7561 tgatgatgat gatgatgatg atgatgaaga ataaatggaa tcaaaatgct agctttattt
     7621 gacattaata agtaaaataa gtcatcattt tttcaactct gtagcacagc tgtttacatt
     7681 gaataatttt ctctattgtg ctgttaatta tatagtaatg tatcaaaata gaaataggaa
     7741 ctttcttttc atttcttatt catttatgaa gaaatctttt cacacataaa tgattgaatg
     7801 ttcttgttca gaatgaccac ataatcattg cttagaagaa gataccaatt cttttaaaag
     7861 aaaaaaagtc tgtttataat aatcagaatc aaatgttgtt tgtttcttct aaacgttaat
     7921 ggagaaaatt gaaggtggta aaatgtcatg tttattcagg ctgggaactg tattcacagt
     7981 agaagtttca gtggtcaaca tatctatgac tctttaggct gctgtagttt tacagtcaat
     8041 tatttaaaag tgagtagtta catttataag agcctgagaa tacttagact cagtcatttg
     8101 ttagtatttt taccaaaatc tcttagtttc agacatgtca gaagcagcta tatagcatat
     8161 cttattctat gatatacatc aggctatctc aagttcctgt ctcacagtta attcaaagaa
     8221 ggattaggat ttctgtattt tttctcattt gaatctttat gtgcatttgg tttgtgtaca
     8281 tgctttttgt agtgtaagat atgaaatttt atattttttc agaaaataaa aaccctttga
     8341 ataca
//
