LOCUS       NM_004438               6362 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens EPH receptor A4 (EPHA4), transcript variant 2, mRNA.
ACCESSION   NM_004438 XM_379155
VERSION     NM_004438.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6362)
  AUTHORS   Verma,M., Chopra,M. and Kumar,H.
  TITLE     Unraveling the Potential of EphA4: A Breakthrough Target and Beacon
            of Hope for Neurological Diseases
  JOURNAL   Cell Mol Neurobiol 43 (7), 3375-3391 (2023)
   PUBMED   37477786
  REMARK    GeneRIF: Unraveling the Potential of EphA4: A Breakthrough Target
            and Beacon of Hope for Neurological Diseases.
            Review article
REFERENCE   2  (bases 1 to 6362)
  AUTHORS   Kina,S., Kawabata-Iwakawa,R., Miyamoto,S., Kato,T., Kina-Tanada,M.
            and Arasaki,A.
  TITLE     EphA4 signaling is involved in the phenotype of well-differentiated
            oral squamous cell arcinoma with decreased tumor immunity
  JOURNAL   Eur J Pharmacol 945, 175611 (2023)
   PUBMED   36804938
  REMARK    GeneRIF: EphA4 signaling is involved in the phenotype of
            well-differentiated oral squamous cell arcinoma with decreased
            tumor immunity.
REFERENCE   3  (bases 1 to 6362)
  AUTHORS   Ganguly,D., Thomas,J.A., Ali,A. and Kumar,R.
  TITLE     Mechanistic and therapeutic implications of EphA-4 receptor
            tyrosine kinase in the pathogenesis of Alzheimer's disease
  JOURNAL   Eur J Neurosci 56 (9), 5532-5546 (2022)
   PUBMED   34989046
  REMARK    GeneRIF: Mechanistic and therapeutic implications of EphA-4
            receptor tyrosine kinase in the pathogenesis of Alzheimer's
            disease.
            Review article
REFERENCE   4  (bases 1 to 6362)
  AUTHORS   Liu,C., Han,S., Zheng,J., Wang,H., Li,S. and Li,J.
  TITLE     EphA4 regulates white matter remyelination after ischemic stroke
            through Ephexin-1/RhoA/ROCK signaling pathway
  JOURNAL   Glia 70 (10), 1971-1991 (2022)
   PUBMED   35762396
  REMARK    GeneRIF: EphA4 regulates white matter remyelination after ischemic
            stroke through Ephexin-1/RhoA/ROCK signaling pathway.
REFERENCE   5  (bases 1 to 6362)
  AUTHORS   Salokas,K., Liu,X., Ohman,T., Chowdhury,I., Gawriyski,L.,
            Keskitalo,S. and Varjosalo,M.
  TITLE     Physical and functional interactome atlas of human receptor
            tyrosine kinases
  JOURNAL   EMBO Rep 23 (6), e54041 (2022)
   PUBMED   35384245
REFERENCE   6  (bases 1 to 6362)
  AUTHORS   Karidis,N.P., Giaginis,C., Tsourouflis,G., Alexandrou,P.,
            Delladetsima,I. and Theocharis,S.
  TITLE     Eph-A2 and Eph-A4 expression in human benign and malignant thyroid
            lesions: an immunohistochemical study
  JOURNAL   Med Sci Monit 17 (9), BR257-BR265 (2011)
   PUBMED   21873938
  REMARK    GeneRIF: The present data suggest that Eph-A2, but not Eph-A4,
            overexpression may be associated with the malignant transformation
            of thyroid neoplasia.
REFERENCE   7  (bases 1 to 6362)
  AUTHORS   Aasheim,H.C., Terstappen,L.W. and Logtenberg,T.
  TITLE     Regulated expression of the Eph-related receptor tyrosine kinase
            Hek11 in early human B lymphopoiesis
  JOURNAL   Blood 90 (9), 3613-3622 (1997)
   PUBMED   9345045
REFERENCE   8  (bases 1 to 6362)
  AUTHORS   Gale,N.W., Holland,S.J., Valenzuela,D.M., Flenniken,A., Pan,L.,
            Ryan,T.E., Henkemeyer,M., Strebhardt,K., Hirai,H., Wilkinson,D.G.,
            Pawson,T., Davis,S. and Yancopoulos,G.D.
  TITLE     Eph receptors and ligands comprise two major specificity subclasses
            and are reciprocally compartmentalized during embryogenesis
  JOURNAL   Neuron 17 (1), 9-19 (1996)
   PUBMED   8755474
REFERENCE   9  (bases 1 to 6362)
  AUTHORS   Ellis,C., Kasmi,F., Ganju,P., Walls,E., Panayotou,G. and Reith,A.D.
  TITLE     A juxtamembrane autophosphorylation site in the Eph family receptor
            tyrosine kinase, Sek, mediates high affinity interaction with
            p59fyn
  JOURNAL   Oncogene 12 (8), 1727-1736 (1996)
   PUBMED   8622893
REFERENCE   10 (bases 1 to 6362)
  AUTHORS   Fox,G.M., Holst,P.L., Chute,H.T., Lindberg,R.A., Janssen,A.M.,
            Basu,R. and Welcher,A.A.
  TITLE     cDNA cloning and tissue distribution of five human EPH-like
            receptor protein-tyrosine kinases
  JOURNAL   Oncogene 10 (5), 897-905 (1995)
   PUBMED   7898931
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA451606.1, BC105000.1,
            AC010899.8 and BM676153.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004438.4.
            
            Summary: This gene belongs to the ephrin receptor subfamily of the
            protein-tyrosine kinase family. EPH and EPH-related receptors have
            been implicated in mediating developmental events, particularly in
            the nervous system. Receptors in the EPH subfamily typically have a
            single kinase domain and an extracellular region containing a
            Cys-rich domain and 2 fibronectin type III repeats. The ephrin
            receptors are divided into 2 groups based on the similarity of
            their extracellular domain sequences and their affinities for
            binding ephrin-A and ephrin-B ligands. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.89906.1,
                                           SRR1803614.85638.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281821.7/ ENSP00000281821.2
            NMD candidate          :: PMID: 21873938
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DA451606.1         55-74
            21-3117             BC105000.1         1-3097
            3118-3836           AC010899.8         114307-115025       c
            3837-6354           AC010899.8         107133-109650       c
            6355-6362           BM676153.1         17-24               c
FEATURES             Location/Qualifiers
     source          1..6362
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q36.1"
     gene            1..6362
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /note="EPH receptor A4"
                     /db_xref="GeneID:2043"
                     /db_xref="HGNC:HGNC:3388"
                     /db_xref="MIM:602188"
     exon            1..147
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..3017
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /EC_number="2.7.10.1"
                     /note="isoform a precursor is encoded by transcript
                     variant 2; receptor protein-tyrosine kinase HEK8; ephrin
                     type-A receptor 4; tyrosine-protein kinase receptor SEK;
                     TYRO1 protein tyrosine kinase; EPH-like kinase 8;
                     tyrosine-protein kinase TYRO1"
                     /codon_start=1
                     /product="ephrin type-A receptor 4 isoform a precursor"
                     /protein_id="NP_004429.1"
                     /db_xref="CCDS:CCDS2447.1"
                     /db_xref="GeneID:2043"
                     /db_xref="HGNC:HGNC:3388"
                     /db_xref="MIM:602188"
                     /translation="MAGIFYFALFSCLFGICDAVTGSRVYPANEVTLLDSRSVQGELG
                     WIASPLEGGWEEVSIMDEKNTPIRTYQVCNVMEPSQNNWLRTDWITREGAQRVYIEIK
                     FTLRDCNSLPGVMGTCKETFNLYYYESDNDKERFIRENQFVKIDTIAADESFTQVDIG
                     DRIMKLNTEIRDVGPLSKKGFYLAFQDVGACIALVSVRVFYKKCPLTVRNLAQFPDTI
                     TGADTSSLVEVRGSCVNNSEEKDVPKMYCGADGEWLVPIGNCLCNAGHEERSGECQAC
                     KIGYYKALSTDATCAKCPPHSYSVWEGATSCTCDRGFFRADNDAASMPCTRPPSAPLN
                     LISNVNETSVNLEWSSPQNTGGRQDISYNVVCKKCGAGDPSKCRPCGSGVHYTPQQNG
                     LKTTKVSITDLLAHTNYTFEIWAVNGVSKYNPNPDQSVSVTVTTNQAAPSSIALVQAK
                     EVTRYSVALAWLEPDRPNGVILEYEVKYYEKDQNERSYRIVRTAARNTDIKGLNPLTS
                     YVFHVRARTAAGYGDFSEPLEVTTNTVPSRIIGDGANSTVLLVSVSGSVVLVVILIAA
                     FVISRRRSKYSKAKQEADEEKHLNQGVRTYVDPFTYEDPNQAVREFAKEIDASCIKIE
                     KVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNI
                     IHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDM
                     SYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAY
                     RKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQL
                     MLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGTESSRPNTALLDPSSPEFSAVV
                     SVGDWLQAIKMDRYKDNFTAAGYTTLEAVVHVNQEDLARIGITAITHQNKILSSVQAM
                     RTQMQQMHGRMVPV"
     exon            148..215
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            216..879
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1035
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1374
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1499
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1659
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1771
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1830
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1944
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2130
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2192
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2402
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2552
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2746
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..2902
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2903..3836
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3837..6362
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4351..4356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /note="hexamer: AATATA"
     polyA_site      4374
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
     regulatory      6332..6337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /note="hexamer: AATAAA"
     polyA_site      6362
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /note="major polyA site"
ORIGIN      
        1 aagcatttat tccactggga tagaagcggc aggagcagcg ttggcaccgg cgaaccatgg
       61 ctgggatttt ctatttcgcc ctattttcgt gtctcttcgg gatttgcgac gctgtcacag
      121 gttccagggt ataccccgcg aatgaagtta ccttattgga ttccagatct gttcagggag
      181 aacttgggtg gatagcaagc cctctggaag gagggtggga ggaagtgagt atcatggatg
      241 aaaaaaatac accaatccga acctaccaag tgtgcaatgt gatggaaccc agccagaata
      301 actggctacg aactgattgg atcacccgag aaggggctca gagggtgtat attgagatta
      361 aattcacctt gagggactgc aatagtcttc cgggcgtcat ggggacttgc aaggagacgt
      421 ttaacctgta ctactatgaa tcagacaacg acaaagagcg tttcatcaga gagaaccagt
      481 ttgtcaaaat tgacaccatt gctgctgatg agagcttcac ccaagtggac attggtgaca
      541 gaatcatgaa gctgaacacc gagatccggg atgtagggcc attaagcaaa aaggggtttt
      601 acctggcttt tcaggatgtg ggggcctgca tcgccctggt atcagtccgt gtgttctata
      661 aaaagtgtcc actcacagtc cgcaatctgg cccagtttcc tgacaccatc acaggggctg
      721 atacgtcttc cctggtggaa gttcgaggct cctgtgtcaa caactcagaa gagaaagatg
      781 tgccaaaaat gtactgtggg gcagatggtg aatggctggt acccattggc aactgcctat
      841 gcaacgctgg gcatgaggag cggagcggag aatgccaagc ttgcaaaatt ggatattaca
      901 aggctctctc cacggatgcc acctgtgcca agtgcccacc ccacagctac tctgtctggg
      961 aaggagccac ctcgtgcacc tgtgaccgag gctttttcag agctgacaac gatgctgcct
     1021 ctatgccctg cacccgtcca ccatctgctc ccctgaactt gatttcaaat gtcaacgaga
     1081 catctgtgaa cttggaatgg agtagccctc agaatacagg tggccgccag gacatttcct
     1141 ataatgtggt atgcaagaaa tgtggagctg gtgaccccag caagtgccga ccctgtggaa
     1201 gtggggtcca ctacacccca cagcagaatg gcttgaagac caccaaagtc tccatcactg
     1261 acctcctagc tcataccaat tacacctttg aaatctgggc tgtgaatgga gtgtccaaat
     1321 ataaccctaa cccagaccaa tcagtttctg tcactgtgac caccaaccaa gcagcaccat
     1381 catccattgc tttggtccag gctaaagaag tcacaagata cagtgtggca ctggcttggc
     1441 tggaaccaga tcggcccaat ggggtaatcc tggaatatga agtcaagtat tatgagaagg
     1501 atcagaatga gcgaagctat cgtatagttc ggacagctgc caggaacaca gatatcaaag
     1561 gcctgaaccc tctcacttcc tatgttttcc acgtgcgagc caggacagca gctggctatg
     1621 gagacttcag tgagcccttg gaggttacaa ccaacacagt gccttcccgg atcattggag
     1681 atggggctaa ctccacagtc cttctggtct ctgtctcggg cagtgtggtg ctggtggtaa
     1741 ttctcattgc agcttttgtc atcagccgga gacggagtaa atacagtaaa gccaaacaag
     1801 aagcggatga agagaaacat ttgaatcaag gtgtaagaac atatgtggac ccctttacgt
     1861 acgaagatcc caaccaagca gtgcgagagt ttgccaaaga aattgacgca tcctgcatta
     1921 agattgaaaa agttatagga gttggtgaat ttggtgaggt atgcagtggg cgtctcaaag
     1981 tgcctggcaa gagagagatc tgtgtggcta tcaagactct gaaagctggt tatacagaca
     2041 aacagaggag agacttcctg agtgaggcca gcatcatggg acagtttgac catccgaaca
     2101 tcattcactt ggaaggcgtg gtcactaaat gtaaaccagt aatgatcata acagagtaca
     2161 tggagaatgg ctccttggat gcattcctca ggaaaaatga tggcagattt acagtcattc
     2221 agctggtggg catgcttcgt ggcattgggt ctgggatgaa gtatttatct gatatgagct
     2281 atgtgcatcg tgatctggcc gcacggaaca tcctggtgaa cagcaacttg gtctgcaaag
     2341 tgtctgattt tggcatgtcc cgagtgcttg aggatgatcc ggaagcagct tacaccacca
     2401 ggggtggcaa gattcctatc cggtggactg cgccagaagc aattgcctat cgtaaattca
     2461 catcagcaag tgatgtatgg agctatggaa tcgttatgtg ggaagtgatg tcgtacgggg
     2521 agaggcccta ttgggatatg tccaatcaag atgtgattaa agccattgag gaaggctatc
     2581 ggttaccccc tccaatggac tgccccattg cgctccacca gctgatgcta gactgctggc
     2641 agaaggagag gagcgacagg cctaaatttg ggcagattgt caacatgttg gacaaactca
     2701 tccgcaaccc caacagcttg aagaggacag ggacggagag ctccagacct aacactgcct
     2761 tgttggatcc aagctcccct gaattctctg ctgtggtatc agtgggcgat tggctccagg
     2821 ccattaaaat ggaccggtat aaggataact tcacagctgc tggttatacc acactagagg
     2881 ctgtggtgca cgtgaaccag gaggacctgg caagaattgg tatcacagcc atcacgcacc
     2941 agaataagat tttgagcagt gtccaggcaa tgcgaaccca aatgcagcag atgcacggca
     3001 gaatggttcc cgtctgagcc agtactgaat aaactcaaaa ctcttgaaat tagtttacct
     3061 catccatgca ctttaattga agaactgcac tttttttact tcgtcttcgc cctctgaaat
     3121 taaagaaatg aaaaaaaaaa acaatatctg cagcgttgct tggtgcacag attgctgaaa
     3181 ctgtggggct tacagaaatg actgccggtc atttgaatga gacctggaac aaatcgtttc
     3241 tcagaagtac ttttctgttc atcaccagtc tgtaaaatac atgtacctat agaaatagaa
     3301 cactgcctct gagttttgat gctgtatttg ctgccagaca ctgagcttct gagacatccc
     3361 tgattctctc tccatttgga attacaacca ttgtattttg tttgtggcat aaattacagt
     3421 catctgtctt tcactggaat gaagaccatg cctaggaaca ttttttaagg actcagctgt
     3481 ggcttttagg gcttggttca taccatgggg gaaaaaaaag tcctaggaga aagcgacgtg
     3541 gctcattagt gttgcctctt cagtgctcaa gccgcctggt ggattcctat gacacagggg
     3601 gcctggaaag aaagggaaag tggatttaaa atatatatat acgtaaccca agccccataa
     3661 cccctaactg gacaaatgag gtctgtttct ttgggcctga ggctgtgcca tataaagtct
     3721 tattttggga ctttacaaac ttgtcctaac tatcttgtgg atagtgggct gtgacaatct
     3781 ggaatagaga acgttcacac ttcgctcctt taaagaagcg accccagatc tgcaagggag
     3841 tagattctgc tatcttggcc tcacagccct tcctgttgat tacaaagccc gtggaagaaa
     3901 acagaacaca ccctcctcag ttccgtctaa atgtgtttct tctgcttcaa ttacaccagt
     3961 tctggggcaa agacactgat gaaacaacac ccatacctga aaagaataaa tgtgtgactt
     4021 tcaaatcccc tttcgcagtg aaagaaacag caaacactta agattcagca tctgttctcc
     4081 agttgcactg aggaatgcac tgtctcgcag caccagctct gcagagccct tgccccagac
     4141 tctttgcggt tttatttata tgtatttcca tatttcattc ctgtgtgtca ctgctgcatt
     4201 ggtgtggcag caagtgacca aatgctacag gtcttactat ggacaccagg tcaggtgcaa
     4261 ccacacaaaa caaagccagt tccatgagct gcctatgata tgcattgcgg aagtaacatt
     4321 ttacccaggg tgtgccattg cagtgatata aatatatttt tttcttagac taaatatgag
     4381 ctgactatct cttttgatgt gtgtacatag gtgtgagtgt gtctgtatgc gtgcctgtct
     4441 gtgtgcgggt gtgtgtatgt gcgtagcctc atgcttagga ctacccatga atgttgtgga
     4501 atgctacacc tggagagttc tggttttcca ccagtttcaa gatgaagaac tacatgatac
     4561 agtggacctg gagaccatcc ccttggaaag acaacccaga gatgttcagc atcctgtatc
     4621 tacacgcatc ctgtatctac acgtgtattt tgtagctgtc acactaacct taataagaat
     4681 tctacagctt tggacagagg cattttcacc ttaatggtga agtaatttaa aatataaatc
     4741 cattcaggtg acaacccatc atcaaaatta caaattttct gattgaactc atctgaatca
     4801 tcagttcctt gatggagaga gagaaggaga tggaatgtgt ctggtaaccc caaatggagt
     4861 acaagtagcc tttgttttcc tgcataaatg gacttgttga atgcgaacga atatatgcaa
     4921 ttcatatact tttggagatg aacgtagata tgtgtgtcag ctttgagatg gtgtgtcctg
     4981 gattaatact ttgtctccca atatcacaga aaaatacatg ccagtgactc ttgaggttaa
     5041 ggtagttggg atgaaatggc ctcaggcaat ttcacattcc ctaattacct ggaaagttct
     5101 acagtaatta atatgcagct aactcctgtt gccctcacaa gagcatcagc cttctagaat
     5161 cggagctccg gagtgtgaag attcagtatt gatatgatat gtataccaaa ctccagccaa
     5221 cttactgcca tttttcataa tctgagtggc tgccttgctt atcctaagct gtggttgcag
     5281 aaaccgtggc catttatata agctataaca tcaaatcagg gaaaaatgag gaaaaaaaat
     5341 agattctgaa ccatttattg ttgaataagt agagaaaatc atcaataaat atttattaca
     5401 ttctgacagg gtgtgtggca ttgtgttcta tgccagagtg acaaagttga ttcacccctt
     5461 tttggggacc ttaatatatt ttttaaggga tgtgcctatg cattgatgcc tgaaaaatat
     5521 gtataaagaa atgaggttga ctcttctgag cagttcatct tttccagagg taagggtagg
     5581 aggccaactt cagggtctgg gtctgagccc gtgggcaagc cctggccgag tgagctccaa
     5641 tgctaactca tgtgccgatc tctagagcag tgggaaacta ccccgctgca ccaaatcaag
     5701 tagcttcacc ttgtgtatgc aggccccaag ttatttttta gcaatcttac gagtgaaatg
     5761 ttctggtggg ttgaaaaacg ttcttatttt aaagaaaggt tgtgctcgct acactgctgg
     5821 tgtgtgcatt ctgagacctc ttgtattcaa tctgtgaagg atatgtgtat taatccgtac
     5881 acccgtatag cctcaatatt tgtctgaaga cacttaaatt ctgacccata aaggaaagtt
     5941 ctagaagcaa tattttcact tatttaacat tctccaaaca acatcaagca ttgatacaca
     6001 ctgaagagtg cgtttatttt ttgtatcact ctaagtatgt tggaatatgc aaggactgtg
     6061 gttcaaatta gaatgtataa ggcatattat aatttagttc atactgaata agaaattaac
     6121 agaacattgt tcggttcaca cgttccaaac tttgagtgat ttctggagtt agacatagat
     6181 tttctatttt gttttaattt gtcaaggtat ttttcttccc ttcatgaact ttaggtacac
     6241 ataacttatg tcatttattt atggtctttt atacctagtt tgtaaaattg taaaatagca
     6301 aactaaatgc aaagagtttg catttgaaaa taataaagta gttgccgtat acaaccctgc
     6361 aa
//
