LOCUS       NM_001363748            6391 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens EPH receptor A4 (EPHA4), transcript variant 4, mRNA.
ACCESSION   NM_001363748 XM_005246374
VERSION     NM_001363748.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6391)
  AUTHORS   Verma,M., Chopra,M. and Kumar,H.
  TITLE     Unraveling the Potential of EphA4: A Breakthrough Target and Beacon
            of Hope for Neurological Diseases
  JOURNAL   Cell Mol Neurobiol 43 (7), 3375-3391 (2023)
   PUBMED   37477786
  REMARK    GeneRIF: Unraveling the Potential of EphA4: A Breakthrough Target
            and Beacon of Hope for Neurological Diseases.
            Review article
REFERENCE   2  (bases 1 to 6391)
  AUTHORS   Kina,S., Kawabata-Iwakawa,R., Miyamoto,S., Kato,T., Kina-Tanada,M.
            and Arasaki,A.
  TITLE     EphA4 signaling is involved in the phenotype of well-differentiated
            oral squamous cell arcinoma with decreased tumor immunity
  JOURNAL   Eur J Pharmacol 945, 175611 (2023)
   PUBMED   36804938
  REMARK    GeneRIF: EphA4 signaling is involved in the phenotype of
            well-differentiated oral squamous cell arcinoma with decreased
            tumor immunity.
REFERENCE   3  (bases 1 to 6391)
  AUTHORS   Ganguly,D., Thomas,J.A., Ali,A. and Kumar,R.
  TITLE     Mechanistic and therapeutic implications of EphA-4 receptor
            tyrosine kinase in the pathogenesis of Alzheimer's disease
  JOURNAL   Eur J Neurosci 56 (9), 5532-5546 (2022)
   PUBMED   34989046
  REMARK    GeneRIF: Mechanistic and therapeutic implications of EphA-4
            receptor tyrosine kinase in the pathogenesis of Alzheimer's
            disease.
            Review article
REFERENCE   4  (bases 1 to 6391)
  AUTHORS   Liu,C., Han,S., Zheng,J., Wang,H., Li,S. and Li,J.
  TITLE     EphA4 regulates white matter remyelination after ischemic stroke
            through Ephexin-1/RhoA/ROCK signaling pathway
  JOURNAL   Glia 70 (10), 1971-1991 (2022)
   PUBMED   35762396
  REMARK    GeneRIF: EphA4 regulates white matter remyelination after ischemic
            stroke through Ephexin-1/RhoA/ROCK signaling pathway.
REFERENCE   5  (bases 1 to 6391)
  AUTHORS   Salokas,K., Liu,X., Ohman,T., Chowdhury,I., Gawriyski,L.,
            Keskitalo,S. and Varjosalo,M.
  TITLE     Physical and functional interactome atlas of human receptor
            tyrosine kinases
  JOURNAL   EMBO Rep 23 (6), e54041 (2022)
   PUBMED   35384245
REFERENCE   6  (bases 1 to 6391)
  AUTHORS   Karidis,N.P., Giaginis,C., Tsourouflis,G., Alexandrou,P.,
            Delladetsima,I. and Theocharis,S.
  TITLE     Eph-A2 and Eph-A4 expression in human benign and malignant thyroid
            lesions: an immunohistochemical study
  JOURNAL   Med Sci Monit 17 (9), BR257-BR265 (2011)
   PUBMED   21873938
  REMARK    GeneRIF: The present data suggest that Eph-A2, but not Eph-A4,
            overexpression may be associated with the malignant transformation
            of thyroid neoplasia.
REFERENCE   7  (bases 1 to 6391)
  AUTHORS   Aasheim,H.C., Terstappen,L.W. and Logtenberg,T.
  TITLE     Regulated expression of the Eph-related receptor tyrosine kinase
            Hek11 in early human B lymphopoiesis
  JOURNAL   Blood 90 (9), 3613-3622 (1997)
   PUBMED   9345045
REFERENCE   8  (bases 1 to 6391)
  AUTHORS   Gale,N.W., Holland,S.J., Valenzuela,D.M., Flenniken,A., Pan,L.,
            Ryan,T.E., Henkemeyer,M., Strebhardt,K., Hirai,H., Wilkinson,D.G.,
            Pawson,T., Davis,S. and Yancopoulos,G.D.
  TITLE     Eph receptors and ligands comprise two major specificity subclasses
            and are reciprocally compartmentalized during embryogenesis
  JOURNAL   Neuron 17 (1), 9-19 (1996)
   PUBMED   8755474
REFERENCE   9  (bases 1 to 6391)
  AUTHORS   Ellis,C., Kasmi,F., Ganju,P., Walls,E., Panayotou,G. and Reith,A.D.
  TITLE     A juxtamembrane autophosphorylation site in the Eph family receptor
            tyrosine kinase, Sek, mediates high affinity interaction with
            p59fyn
  JOURNAL   Oncogene 12 (8), 1727-1736 (1996)
   PUBMED   8622893
REFERENCE   10 (bases 1 to 6391)
  AUTHORS   Fox,G.M., Holst,P.L., Chute,H.T., Lindberg,R.A., Janssen,A.M.,
            Basu,R. and Welcher,A.A.
  TITLE     cDNA cloning and tissue distribution of five human EPH-like
            receptor protein-tyrosine kinases
  JOURNAL   Oncogene 10 (5), 897-905 (1995)
   PUBMED   7898931
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079834.8 and AC010899.8.
            
            On May 31, 2019 this sequence version replaced NM_001363748.1.
            
            Summary: This gene belongs to the ephrin receptor subfamily of the
            protein-tyrosine kinase family. EPH and EPH-related receptors have
            been implicated in mediating developmental events, particularly in
            the nervous system. Receptors in the EPH subfamily typically have a
            single kinase domain and an extracellular region containing a
            Cys-rich domain and 2 fibronectin type III repeats. The ephrin
            receptors are divided into 2 groups based on the similarity of
            their extracellular domain sequences and their affinities for
            binding ephrin-A and ephrin-B ligands. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (4) differs in the 5' UTR and 3'
            coding sequence compared to variant (1). The resulting isoform (c)
            has a shorter and distinct C-terminus compared to isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.224421.1,
                                           SRR1803613.57869.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate :: PMID: 21873938
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AC079834.8         53014-53160         c
            148-215             AC079834.8         49574-49641         c
            216-879             AC079834.8         44587-45250         c
            880-1035            AC010899.8         190115-190270       c
            1036-1374           AC010899.8         171450-171788       c
            1375-1499           AC010899.8         146964-147088       c
            1500-1659           AC010899.8         145711-145870       c
            1660-1771           AC010899.8         144645-144756       c
            1772-1830           AC010899.8         135221-135279       c
            1831-1944           AC010899.8         132591-132704       c
            1945-2130           AC010899.8         131927-132112       c
            2131-2192           AC010899.8         126159-126220       c
            2193-2402           AC010899.8         125497-125706       c
            2403-2552           AC010899.8         123240-123389       c
            2553-2746           AC010899.8         119056-119249       c
            2747-2931           AC010899.8         115533-115717       c
            2932-3865           AC010899.8         114307-115240       c
            3866-6391           AC010899.8         107125-109650       c
FEATURES             Location/Qualifiers
     source          1..6391
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q36.1"
     gene            1..6391
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /note="EPH receptor A4"
                     /db_xref="GeneID:2043"
                     /db_xref="HGNC:HGNC:3388"
                     /db_xref="MIM:602188"
     exon            1..147
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..2906
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /EC_number="2.7.10.1"
                     /note="isoform c precursor is encoded by transcript
                     variant 4; receptor protein-tyrosine kinase HEK8; ephrin
                     type-A receptor 4; tyrosine-protein kinase receptor SEK;
                     TYRO1 protein tyrosine kinase; EPH-like kinase 8;
                     tyrosine-protein kinase TYRO1"
                     /codon_start=1
                     /product="ephrin type-A receptor 4 isoform c precursor"
                     /protein_id="NP_001350677.1"
                     /db_xref="CCDS:CCDS86924.1"
                     /db_xref="GeneID:2043"
                     /db_xref="HGNC:HGNC:3388"
                     /db_xref="MIM:602188"
                     /translation="MAGIFYFALFSCLFGICDAVTGSRVYPANEVTLLDSRSVQGELG
                     WIASPLEGGWEEVSIMDEKNTPIRTYQVCNVMEPSQNNWLRTDWITREGAQRVYIEIK
                     FTLRDCNSLPGVMGTCKETFNLYYYESDNDKERFIRENQFVKIDTIAADESFTQVDIG
                     DRIMKLNTEIRDVGPLSKKGFYLAFQDVGACIALVSVRVFYKKCPLTVRNLAQFPDTI
                     TGADTSSLVEVRGSCVNNSEEKDVPKMYCGADGEWLVPIGNCLCNAGHEERSGECQAC
                     KIGYYKALSTDATCAKCPPHSYSVWEGATSCTCDRGFFRADNDAASMPCTRPPSAPLN
                     LISNVNETSVNLEWSSPQNTGGRQDISYNVVCKKCGAGDPSKCRPCGSGVHYTPQQNG
                     LKTTKVSITDLLAHTNYTFEIWAVNGVSKYNPNPDQSVSVTVTTNQAAPSSIALVQAK
                     EVTRYSVALAWLEPDRPNGVILEYEVKYYEKDQNERSYRIVRTAARNTDIKGLNPLTS
                     YVFHVRARTAAGYGDFSEPLEVTTNTVPSRIIGDGANSTVLLVSVSGSVVLVVILIAA
                     FVISRRRSKYSKAKQEADEEKHLNQGVRTYVDPFTYEDPNQAVREFAKEIDASCIKIE
                     KVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNI
                     IHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDM
                     SYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAY
                     RKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQL
                     MLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGTESSRPNTALLDPSSPEFSAVV
                     SVGDWLQAIKMDRYKDNFTAAGYTTLEAVVHVNQE"
     exon            148..215
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            216..879
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1035
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1374
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1499
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1659
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1771
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1830
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1944
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2130
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2192
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2402
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2552
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2746
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..2931
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..3865
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3866..6391
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4380..4385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /note="hexamer: AATATA"
     polyA_site      4403
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
     regulatory      6361..6366
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /note="hexamer: AATAAA"
     polyA_site      6391
                     /gene="EPHA4"
                     /gene_synonym="EK8; HEK8; SEK; TYRO1"
                     /note="major polyA site"
ORIGIN      
        1 aagcatttat tccactggga tagaagcggc aggagcagcg ttggcaccgg cgaaccatgg
       61 ctgggatttt ctatttcgcc ctattttcgt gtctcttcgg gatttgcgac gctgtcacag
      121 gttccagggt ataccccgcg aatgaagtta ccttattgga ttccagatct gttcagggag
      181 aacttgggtg gatagcaagc cctctggaag gagggtggga ggaagtgagt atcatggatg
      241 aaaaaaatac accaatccga acctaccaag tgtgcaatgt gatggaaccc agccagaata
      301 actggctacg aactgattgg atcacccgag aaggggctca gagggtgtat attgagatta
      361 aattcacctt gagggactgc aatagtcttc cgggcgtcat ggggacttgc aaggagacgt
      421 ttaacctgta ctactatgaa tcagacaacg acaaagagcg tttcatcaga gagaaccagt
      481 ttgtcaaaat tgacaccatt gctgctgatg agagcttcac ccaagtggac attggtgaca
      541 gaatcatgaa gctgaacacc gagatccggg atgtagggcc attaagcaaa aaggggtttt
      601 acctggcttt tcaggatgtg ggggcctgca tcgccctggt atcagtccgt gtgttctata
      661 aaaagtgtcc actcacagtc cgcaatctgg cccagtttcc tgacaccatc acaggggctg
      721 atacgtcttc cctggtggaa gttcgaggct cctgtgtcaa caactcagaa gagaaagatg
      781 tgccaaaaat gtactgtggg gcagatggtg aatggctggt acccattggc aactgcctat
      841 gcaacgctgg gcatgaggag cggagcggag aatgccaagc ttgcaaaatt ggatattaca
      901 aggctctctc cacggatgcc acctgtgcca agtgcccacc ccacagctac tctgtctggg
      961 aaggagccac ctcgtgcacc tgtgaccgag gctttttcag agctgacaac gatgctgcct
     1021 ctatgccctg cacccgtcca ccatctgctc ccctgaactt gatttcaaat gtcaacgaga
     1081 catctgtgaa cttggaatgg agtagccctc agaatacagg tggccgccag gacatttcct
     1141 ataatgtggt atgcaagaaa tgtggagctg gtgaccccag caagtgccga ccctgtggaa
     1201 gtggggtcca ctacacccca cagcagaatg gcttgaagac caccaaagtc tccatcactg
     1261 acctcctagc tcataccaat tacacctttg aaatctgggc tgtgaatgga gtgtccaaat
     1321 ataaccctaa cccagaccaa tcagtttctg tcactgtgac caccaaccaa gcagcaccat
     1381 catccattgc tttggtccag gctaaagaag tcacaagata cagtgtggca ctggcttggc
     1441 tggaaccaga tcggcccaat ggggtaatcc tggaatatga agtcaagtat tatgagaagg
     1501 atcagaatga gcgaagctat cgtatagttc ggacagctgc caggaacaca gatatcaaag
     1561 gcctgaaccc tctcacttcc tatgttttcc acgtgcgagc caggacagca gctggctatg
     1621 gagacttcag tgagcccttg gaggttacaa ccaacacagt gccttcccgg atcattggag
     1681 atggggctaa ctccacagtc cttctggtct ctgtctcggg cagtgtggtg ctggtggtaa
     1741 ttctcattgc agcttttgtc atcagccgga gacggagtaa atacagtaaa gccaaacaag
     1801 aagcggatga agagaaacat ttgaatcaag gtgtaagaac atatgtggac ccctttacgt
     1861 acgaagatcc caaccaagca gtgcgagagt ttgccaaaga aattgacgca tcctgcatta
     1921 agattgaaaa agttatagga gttggtgaat ttggtgaggt atgcagtggg cgtctcaaag
     1981 tgcctggcaa gagagagatc tgtgtggcta tcaagactct gaaagctggt tatacagaca
     2041 aacagaggag agacttcctg agtgaggcca gcatcatggg acagtttgac catccgaaca
     2101 tcattcactt ggaaggcgtg gtcactaaat gtaaaccagt aatgatcata acagagtaca
     2161 tggagaatgg ctccttggat gcattcctca ggaaaaatga tggcagattt acagtcattc
     2221 agctggtggg catgcttcgt ggcattgggt ctgggatgaa gtatttatct gatatgagct
     2281 atgtgcatcg tgatctggcc gcacggaaca tcctggtgaa cagcaacttg gtctgcaaag
     2341 tgtctgattt tggcatgtcc cgagtgcttg aggatgatcc ggaagcagct tacaccacca
     2401 ggggtggcaa gattcctatc cggtggactg cgccagaagc aattgcctat cgtaaattca
     2461 catcagcaag tgatgtatgg agctatggaa tcgttatgtg ggaagtgatg tcgtacgggg
     2521 agaggcccta ttgggatatg tccaatcaag atgtgattaa agccattgag gaaggctatc
     2581 ggttaccccc tccaatggac tgccccattg cgctccacca gctgatgcta gactgctggc
     2641 agaaggagag gagcgacagg cctaaatttg ggcagattgt caacatgttg gacaaactca
     2701 tccgcaaccc caacagcttg aagaggacag ggacggagag ctccagacct aacactgcct
     2761 tgttggatcc aagctcccct gaattctctg ctgtggtatc agtgggcgat tggctccagg
     2821 ccattaaaat ggaccggtat aaggataact tcacagctgc tggttatacc acactagagg
     2881 ctgtggtgca cgtgaaccag gagtaagtac tcaacgatgt aacacgaaag gggacctggc
     2941 aagaattggt atcacagcca tcacgcacca gaataagatt ttgagcagtg tccaggcaat
     3001 gcgaacccaa atgcagcaga tgcacggcag aatggttccc gtctgagcca gtactgaata
     3061 aactcaaaac tcttgaaatt agtttacctc atccatgcac tttaattgaa gaactgcact
     3121 ttttttactt cgtcttcgcc ctctgaaatt aaagaaatga aaaaaaaaaa caatatctgc
     3181 agcgttgctt ggtgcacaga ttgctgaaac tgtggggctt acagaaatga ctgccggtca
     3241 tttgaatgag acctggaaca aatcgtttct cagaagtact tttctgttca tcaccagtct
     3301 gtaaaataca tgtacctata gaaatagaac actgcctctg agttttgatg ctgtatttgc
     3361 tgccagacac tgagcttctg agacatccct gattctctct ccatttggaa ttacaaccat
     3421 tgtattttgt ttgtggcata aattacagtc atctgtcttt cactggaatg aagaccatgc
     3481 ctaggaacat tttttaagga ctcagctgtg gcttttaggg cttggttcat accatggggg
     3541 aaaaaaaagt cctaggagaa agcgacgtgg ctcattagtg ttgcctcttc agtgctcaag
     3601 ccgcctggtg gattcctatg acacaggggg cctggaaaga aagggaaagt ggatttaaaa
     3661 tatatatata cgtaacccaa gccccataac ccctaactgg acaaatgagg tctgtttctt
     3721 tgggcctgag gctgtgccat ataaagtctt attttgggac tttacaaact tgtcctaact
     3781 atcttgtgga tagtgggctg tgacaatctg gaatagagaa cgttcacact tcgctccttt
     3841 aaagaagcga ccccagatct gcaagggagt agattctgct atcttggcct cacagccctt
     3901 cctgttgatt acaaagcccg tggaagaaaa cagaacacac cctcctcagt tccgtctaaa
     3961 tgtgtttctt ctgcttcaat tacaccagtt ctggggcaaa gacactgatg aaacaacacc
     4021 catacctgaa aagaataaat gtgtgacttt caaatcccct ttcgcagtga aagaaacagc
     4081 aaacacttaa gattcagcat ctgttctcca gttgcactga ggaatgcact gtctcgcagc
     4141 accagctctg cagagccctt gccccagact ctttgcggtt ttatttatat gtatttccat
     4201 atttcattcc tgtgtgtcac tgctgcattg gtgtggcagc aagtgaccaa atgctacagg
     4261 tcttactatg gacaccaggt caggtgcaac cacacaaaac aaagccagtt ccatgagctg
     4321 cctatgatat gcattgcgga agtaacattt tacccagggt gtgccattgc agtgatataa
     4381 atatattttt ttcttagact aaatatgagc tgactatctc ttttgatgtg tgtacatagg
     4441 tgtgagtgtg tctgtatgcg tgcctgtctg tgtgcgggtg tgtgtatgtg cgtagcctca
     4501 tgcttaggac tacccatgaa tgttgtggaa tgctacacct ggagagttct ggttttccac
     4561 cagtttcaag atgaagaact acatgataca gtggacctgg agaccatccc cttggaaaga
     4621 caacccagag atgttcagca tcctgtatct acacgcatcc tgtatctaca cgtgtatttt
     4681 gtagctgtca cactaacctt aataagaatt ctacagcttt ggacagaggc attttcacct
     4741 taatggtgaa gtaatttaaa atataaatcc attcaggtga caacccatca tcaaaattac
     4801 aaattttctg attgaactca tctgaatcat cagttccttg atggagagag agaaggagat
     4861 ggaatgtgtc tggtaacccc aaatggagta caagtagcct ttgttttcct gcataaatgg
     4921 acttgttgaa tgcgaacgaa tatatgcaat tcatatactt ttggagatga acgtagatat
     4981 gtgtgtcagc tttgagatgg tgtgtcctgg attaatactt tgtctcccaa tatcacagaa
     5041 aaatacatgc cagtgactct tgaggttaag gtagttggga tgaaatggcc tcaggcaatt
     5101 tcacattccc taattacctg gaaagttcta cagtaattaa tatgcagcta actcctgttg
     5161 ccctcacaag agcatcagcc ttctagaatc ggagctccgg agtgtgaaga ttcagtattg
     5221 atatgatatg tataccaaac tccagccaac ttactgccat ttttcataat ctgagtggct
     5281 gccttgctta tcctaagctg tggttgcaga aaccgtggcc atttatataa gctataacat
     5341 caaatcaggg aaaaatgagg aaaaaaaata gattctgaac catttattgt tgaataagta
     5401 gagaaaatca tcaataaata tttattacat tctgacaggg tgtgtggcat tgtgttctat
     5461 gccagagtga caaagttgat tcaccccttt ttggggacct taatatattt tttaagggat
     5521 gtgcctatgc attgatgcct gaaaaatatg tataaagaaa tgaggttgac tcttctgagc
     5581 agttcatctt ttccagaggt aagggtagga ggccaacttc agggtctggg tctgagcccg
     5641 tgggcaagcc ctggccgagt gagctccaat gctaactcat gtgccgatct ctagagcagt
     5701 gggaaactac cccgctgcac caaatcaagt agcttcacct tgtgtatgca ggccccaagt
     5761 tattttttag caatcttacg agtgaaatgt tctggtgggt tgaaaaacgt tcttatttta
     5821 aagaaaggtt gtgctcgcta cactgctggt gtgtgcattc tgagacctct tgtattcaat
     5881 ctgtgaagga tatgtgtatt aatccgtaca cccgtatagc ctcaatattt gtctgaagac
     5941 acttaaattc tgacccataa aggaaagttc tagaagcaat attttcactt atttaacatt
     6001 ctccaaacaa catcaagcat tgatacacac tgaagagtgc gtttattttt tgtatcactc
     6061 taagtatgtt ggaatatgca aggactgtgg ttcaaattag aatgtataag gcatattata
     6121 atttagttca tactgaataa gaaattaaca gaacattgtt cggttcacac gttccaaact
     6181 ttgagtgatt tctggagtta gacatagatt ttctattttg ttttaatttg tcaaggtatt
     6241 tttcttccct tcatgaactt taggtacaca taacttatgt catttattta tggtctttta
     6301 tacctagttt gtaaaattgt aaaatagcaa actaaatgca aagagtttgc atttgaaaat
     6361 aataaagtag ttgccgtata caaccctgca a
//
