LOCUS       NM_005233               5712 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens EPH receptor A3 (EPHA3), transcript variant 1, mRNA.
ACCESSION   NM_005233
VERSION     NM_005233.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5712)
  AUTHORS   Talia,M., Cirillo,F., Spinelli,A., Zicarelli,A., Scordamaglia,D.,
            Muglia,L., De Rosis,S., Rigiracciolo,D.C., Filippelli,G.,
            Perrotta,I.D., Davoli,M., De Rosa,R., Macirella,R., Brunelli,E.,
            Miglietta,A.M., Nardo,B., Tosoni,D., Pece,S., De Francesco,E.M.,
            Belfiore,A., Maggiolini,M. and Lappano,R.
  TITLE     The Ephrin tyrosine kinase a3 (EphA3) is a novel mediator of
            RAGE-prompted motility of breast cancer cells
  JOURNAL   J Exp Clin Cancer Res 42 (1), 164 (2023)
   PUBMED   37434266
  REMARK    GeneRIF: The Ephrin tyrosine kinase a3 (EphA3) is a novel mediator
            of RAGE-prompted motility of breast cancer cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5712)
  AUTHORS   Salokas,K., Liu,X., Ohman,T., Chowdhury,I., Gawriyski,L.,
            Keskitalo,S. and Varjosalo,M.
  TITLE     Physical and functional interactome atlas of human receptor
            tyrosine kinases
  JOURNAL   EMBO Rep 23 (6), e54041 (2022)
   PUBMED   35384245
REFERENCE   3  (bases 1 to 5712)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5712)
  AUTHORS   Kim,S.H., Kang,B.C., Seong,D., Lee,W.H., An,J.H., Je,H.U.,
            Cha,H.J., Chang,H.W., Kim,S.Y., Kim,S.W. and Han,M.W.
  TITLE     EPHA3 Contributes to Epigenetic Suppression of PTEN in
            Radioresistant Head and Neck Cancer
  JOURNAL   Biomolecules 11 (4), 599 (2021)
   PUBMED   33919657
  REMARK    GeneRIF: EPHA3 Contributes to Epigenetic Suppression of PTEN in
            Radioresistant Head and Neck Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5712)
  AUTHORS   Wang,L., Tang,S., Yu,Y., Lv,Y., Wang,A., Yan,X., Li,N., Sha,C.,
            Sun,K. and Li,Y.
  TITLE     Intranasal Delivery of Temozolomide-Conjugated Gold Nanoparticles
            Functionalized with Anti-EphA3 for Glioblastoma Targeting
  JOURNAL   Mol Pharm 18 (3), 915-927 (2021)
   PUBMED   33417456
  REMARK    GeneRIF: Intranasal Delivery of Temozolomide-Conjugated Gold
            Nanoparticles Functionalized with Anti-EphA3 for Glioblastoma
            Targeting.
REFERENCE   6  (bases 1 to 5712)
  AUTHORS   Cerretti,D.P., Vanden Bos,T., Nelson,N., Kozlosky,C.J., Reddy,P.,
            Maraskovsky,E., Park,L.S., Lyman,S.D., Copeland,N.G., Gilbert,D.J.
            et al.
  TITLE     Isolation of LERK-5: a ligand of the eph-related receptor tyrosine
            kinases
  JOURNAL   Mol Immunol 32 (16), 1197-1205 (1995)
   PUBMED   8559144
REFERENCE   7  (bases 1 to 5712)
  AUTHORS   Beckmann,M.P., Cerretti,D.P., Baum,P., Vanden Bos,T., James,L.,
            Farrah,T., Kozlosky,C., Hollingsworth,T., Shilling,H.,
            Maraskovsky,E. et al.
  TITLE     Molecular characterization of a family of ligands for eph-related
            tyrosine kinase receptors
  JOURNAL   EMBO J 13 (16), 3757-3762 (1994)
   PUBMED   8070404
REFERENCE   8  (bases 1 to 5712)
  AUTHORS   Wicks,I.P., Lapsys,N.M., Baker,E., Campbell,L.J., Boyd,A.W. and
            Sutherland,G.R.
  TITLE     Localization of a human receptor tyrosine kinase (ETK1) to
            chromosome region 3p11.2
  JOURNAL   Genomics 19 (1), 38-41 (1994)
   PUBMED   8188238
REFERENCE   9  (bases 1 to 5712)
  AUTHORS   Wicks,I.P., Wilkinson,D., Salvaris,E. and Boyd,A.W.
  TITLE     Molecular cloning of HEK, the gene encoding a receptor tyrosine
            kinase expressed by human lymphoid tumor cell lines
  JOURNAL   Proc Natl Acad Sci U S A 89 (5), 1611-1615 (1992)
   PUBMED   1311845
REFERENCE   10 (bases 1 to 5712)
  AUTHORS   Boyd,A.W., Ward,L.D., Wicks,I.P., Simpson,R.J., Salvaris,E.,
            Wilks,A., Welch,K., Loudovaris,M., Rockman,S. and Busmanis,I.
  TITLE     Isolation and characterization of a novel receptor-type protein
            tyrosine kinase (hek) from a human pre-B cell line
  JOURNAL   J Biol Chem 267 (5), 3262-3267 (1992)
   PUBMED   1737782
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF213459.1 and BC063282.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005233.5.
            
            Summary: This gene belongs to the ephrin receptor subfamily of the
            protein-tyrosine kinase family. EPH and EPH-related receptors have
            been implicated in mediating developmental events, particularly in
            the nervous system. Receptors in the EPH subfamily typically have a
            single kinase domain and an extracellular region containing a
            Cys-rich domain and 2 fibronectin type III repeats. The ephrin
            receptors are divided into 2 groups based on the similarity of
            their extracellular domain sequences and their affinities for
            binding ephrin-A and ephrin-B ligands. This gene encodes a protein
            that binds ephrin-A ligands. Two alternatively spliced transcript
            variants have been described for this gene. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063282.1, SRR1660805.169028.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336596.7/ ENSP00000337451.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5095              AF213459.1         98-5192
            5096-5695           BC063282.1         5097-5696
            5696-5712           AF213459.1         5755-5771
FEATURES             Location/Qualifiers
     source          1..5712
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p11.1"
     gene            1..5712
                     /gene="EPHA3"
                     /gene_synonym="EK4; ETK; ETK1; HEK; HEK4; TYRO4"
                     /note="EPH receptor A3"
                     /db_xref="GeneID:2042"
                     /db_xref="HGNC:HGNC:3387"
                     /db_xref="MIM:179611"
     exon            1..216
                     /gene="EPHA3"
                     /gene_synonym="EK4; ETK; ETK1; HEK; HEK4; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..3080
                     /gene="EPHA3"
                     /gene_synonym="EK4; ETK; ETK1; HEK; HEK4; TYRO4"
                     /EC_number="2.7.10.1"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; TYRO4 protein tyrosine kinase; eph-like
                     tyrosine kinase 1; testicular tissue protein Li 64; human
                     embryo kinase 1; ephrin type-A receptor 3; EPH-like kinase
                     4; tyrosine-protein kinase receptor ETK1"
                     /codon_start=1
                     /product="ephrin type-A receptor 3 isoform a precursor"
                     /protein_id="NP_005224.2"
                     /db_xref="CCDS:CCDS2922.1"
                     /db_xref="GeneID:2042"
                     /db_xref="HGNC:HGNC:3387"
                     /db_xref="MIM:179611"
                     /translation="MDCQLSILLLLSCSVLDSFGELIPQPSNEVNLLDSKTIQGELGW
                     ISYPSHGWEEISGVDEHYTPIRTYQVCNVMDHSQNNWLRTNWVPRNSAQKIYVELKFT
                     LRDCNSIPLVLGTCKETFNLYYMESDDDHGVKFREHQFTKIDTIAADESFTQMDLGDR
                     ILKLNTEIREVGPVNKKGFYLAFQDVGACVALVSVRVYFKKCPFTVKNLAMFPDTVPM
                     DSQSLVEVRGSCVNNSKEEDPPRMYCSTEGEWLVPIGKCSCNAGYEERGFMCQACRPG
                     FYKALDGNMKCAKCPPHSSTQEDGSMNCRCENNYFRADKDPPSMACTRPPSSPRNVIS
                     NINETSVILDWSWPLDTGGRKDVTFNIICKKCGWNIKQCEPCSPNVRFLPRQFGLTNT
                     TVTVTDLLAHTNYTFEIDAVNGVSELSSPPRQFAAVSITTNQAAPSPVLTIKKDRTSR
                     NSISLSWQEPEHPNGIILDYEVKYYEKQEQETSYTILRARGTNVTISSLKPDTIYVFQ
                     IRARTAAGYGTNSRKFEFETSPDSFSISGESSQVVMIAISAAVAIILLTVVIYVLIGR
                     FCGYKSKHGADEKRLHFGNGHLKLPGLRTYVDPHTYEDPTQAVHEFAKELDATNISID
                     KVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNI
                     IRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDM
                     GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAY
                     RKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQL
                     MLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDITTFR
                     TTGDWLNGVWTAHCKEIFTGVEYSSCDTIAKISTDDMKKVGVTVVGPQKKIISSIKAL
                     ETQSKNGPVPV"
     exon            217..281
                     /gene="EPHA3"
                     /gene_synonym="EK4; ETK; ETK1; HEK; HEK4; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            282..942
                     /gene="EPHA3"
                     /gene_synonym="EK4; ETK; ETK1; HEK; HEK4; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1098
                     /gene="EPHA3"
                     /gene_synonym="EK4; ETK; ETK1; HEK; HEK4; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1434
                     /gene="EPHA3"
                     /gene_synonym="EK4; ETK; ETK1; HEK; HEK4; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1559
                     /gene="EPHA3"
                     /gene_synonym="EK4; ETK; ETK1; HEK; HEK4; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1722
                     /gene="EPHA3"
                     /gene_synonym="EK4; ETK; ETK1; HEK; HEK4; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1825
                     /gene="EPHA3"
                     /gene_synonym="EK4; ETK; ETK1; HEK; HEK4; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1890
                     /gene="EPHA3"
                     /gene_synonym="EK4; ETK; ETK1; HEK; HEK4; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2016
                     /gene="EPHA3"
                     /gene_synonym="EK4; ETK; ETK1; HEK; HEK4; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2202
                     /gene="EPHA3"
                     /gene_synonym="EK4; ETK; ETK1; HEK; HEK4; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2264
                     /gene="EPHA3"
                     /gene_synonym="EK4; ETK; ETK1; HEK; HEK4; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2474
                     /gene="EPHA3"
                     /gene_synonym="EK4; ETK; ETK1; HEK; HEK4; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2624
                     /gene="EPHA3"
                     /gene_synonym="EK4; ETK; ETK1; HEK; HEK4; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2818
                     /gene="EPHA3"
                     /gene_synonym="EK4; ETK; ETK1; HEK; HEK4; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            2819..2974
                     /gene="EPHA3"
                     /gene_synonym="EK4; ETK; ETK1; HEK; HEK4; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..5712
                     /gene="EPHA3"
                     /gene_synonym="EK4; ETK; ETK1; HEK; HEK4; TYRO4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5686..5691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPHA3"
                     /gene_synonym="EK4; ETK; ETK1; HEK; HEK4; TYRO4"
                     /note="hexamer: AATGAA"
     polyA_site      5712
                     /gene="EPHA3"
                     /gene_synonym="EK4; ETK; ETK1; HEK; HEK4; TYRO4"
                     /note="major polyA site"
ORIGIN      
        1 agtgtcaaac ttgacatcag cctgcgagcg gagcatggta acttctccag caatcagagc
       61 gctccccctc acatcagtgg catgcttcat ggagatatgc tcctctcact gccctctgca
      121 ccagcaacat ggattgtcag ctctccatcc tcctccttct cagctgctct gttctcgaca
      181 gcttcgggga actgattccg cagccttcca atgaagtcaa tctactggat tcaaaaacaa
      241 ttcaagggga gctgggctgg atctcttatc catcacatgg gtgggaagag atcagtggtg
      301 tggatgaaca ttacacaccc atcaggactt accaggtgtg caatgtcatg gaccacagtc
      361 aaaacaattg gctgagaaca aactgggtcc ccaggaactc agctcagaag atttatgtgg
      421 agctcaagtt cactctacga gactgcaata gcattccatt ggttttagga acttgcaagg
      481 agacattcaa cctgtactac atggagtctg atgatgatca tggggtgaaa tttcgagagc
      541 atcagtttac aaagattgac accattgcag ctgatgaaag tttcactcaa atggatcttg
      601 gggaccgtat tctgaagctc aacactgaga ttagagaagt aggtcctgtc aacaagaagg
      661 gattttattt ggcatttcaa gatgttggtg cttgtgttgc cttggtgtct gtgagagtat
      721 acttcaaaaa gtgcccattt acagtgaaga atctggctat gtttccagac acggtaccca
      781 tggactccca gtccctggtg gaggttagag ggtcttgtgt caacaattct aaggaggaag
      841 atcctccaag gatgtactgc agtacagaag gcgaatggct tgtacccatt ggcaagtgtt
      901 cctgcaatgc tggctatgaa gaaagaggtt ttatgtgcca agcttgtcga ccaggtttct
      961 acaaggcatt ggatggtaat atgaagtgtg ctaagtgccc gcctcacagt tctactcagg
     1021 aagatggttc aatgaactgc aggtgtgaga ataattactt ccgggcagac aaagaccctc
     1081 catccatggc ttgtacccga cctccatctt caccaagaaa tgttatctct aatataaacg
     1141 agacctcagt tatcctggac tggagttggc ccctggacac aggaggccgg aaagatgtta
     1201 ccttcaacat catatgtaaa aaatgtgggt ggaatataaa acagtgtgag ccatgcagcc
     1261 caaatgtccg cttcctccct cgacagtttg gactcaccaa caccacggtg acagtgacag
     1321 accttctggc acatactaac tacacctttg agattgatgc cgttaatggg gtgtcagagc
     1381 tgagctcccc accaagacag tttgctgcgg tcagcatcac aactaatcag gctgctccat
     1441 cacctgtcct gacgattaag aaagatcgga cctccagaaa tagcatctct ttgtcctggc
     1501 aagaacctga acatcctaat gggatcatat tggactacga ggtcaaatac tatgaaaagc
     1561 aggaacaaga aacaagttat accattctga gggcaagagg cacaaatgtt accatcagta
     1621 gcctcaagcc tgacactata tacgtattcc aaatccgagc ccgaacagcc gctggatatg
     1681 ggacgaacag ccgcaagttt gagtttgaaa ctagtccaga ctctttctcc atctctggtg
     1741 aaagtagcca agtggtcatg atcgccattt cagcggcagt agcaattatt ctcctcactg
     1801 ttgtcatcta tgttttgatt gggaggttct gtggctataa gtcaaaacat ggggcagatg
     1861 aaaaaagact tcattttggc aatgggcatt taaaacttcc aggtctcagg acttatgttg
     1921 acccacatac atatgaagac cctacccaag ctgttcatga gtttgccaag gaattggatg
     1981 ccaccaacat atccattgat aaagttgttg gagcaggtga atttggagag gtgtgcagtg
     2041 gtcgcttaaa acttccttca aaaaaagaga tttcagtggc cattaagacc ctgaaagttg
     2101 gctacacaga aaagcagagg agagacttcc tgggagaagc aagcattatg ggacagtttg
     2161 accaccccaa tatcattcga ctggaaggag ttgttaccaa aagtaagcca gttatgattg
     2221 tcacagaata catggagaat ggttccttgg atagtttcct acgtaaacac gatgcccagt
     2281 ttactgtcat tcagctagtg gggatgcttc gagggatagc atctggcatg aagtacctgt
     2341 cagacatggg ctatgttcac cgagacctcg ctgctcggaa catcttgatc aacagtaact
     2401 tggtgtgtaa ggtttctgat ttcggacttt cgcgtgtcct ggaggatgac ccagaagctg
     2461 cttatacaac aagaggaggg aagatcccaa tcaggtggac atcaccagaa gctatagcct
     2521 accgcaagtt cacgtcagcc agcgatgtat ggagttatgg gattgttctc tgggaggtga
     2581 tgtcttatgg agagagacca tactgggaga tgtccaatca ggatgtaatt aaagctgtag
     2641 atgagggcta tcgactgcca ccccccatgg actgcccagc tgccttgtat cagctgatgc
     2701 tggactgctg gcagaaagac aggaacaaca gacccaagtt tgagcagatt gttagtattc
     2761 tggacaagct tatccggaat cccggcagcc tgaagatcat caccagtgca gccgcaaggc
     2821 catcaaacct tcttctggac caaagcaatg tggatatcac taccttccgc acaacaggtg
     2881 actggcttaa tggtgtctgg acagcacact gcaaggaaat cttcacgggt gtggagtaca
     2941 gttcttgtga cacaatagcc aagatttcca cagatgacat gaaaaaggtt ggtgtcaccg
     3001 tggttgggcc acagaagaag atcatcagta gcattaaagc tctagaaacg caatcaaaga
     3061 atggcccagt tcccgtgtaa agcacgggac ggaagtgctt ctggacggaa gtggtggctg
     3121 tggaaggcgt agcatcatcc tgcagacaga caataattct ggagatactg gtggaagttc
     3181 caagtccaat aagacactca aatatgagta caaatgcctt aaaatggaat tgaaaaactc
     3241 tttattttcc cctatcattt attggatggg tgggtggggt atttttttgt aattgctttt
     3301 ttaaatatta gttaatggat taaatttaat tcttcagcgt aaaatggtga agaactagca
     3361 tatagccatt gatcataaac tgactatcat aaaatcaaaa caagtgaaat aacaaaatgg
     3421 acatggtggc tttgtttagg tagagccaca aaagaaaaga cttgtaatat ttttatatac
     3481 agaggaaatc tgtaacaggt attttgtttc ttttaaagca agcaacacag aggaatttat
     3541 acctcaaact atctggccat atttactacc ttatcactgc attattctct tttatctgtt
     3601 taaagcatat agagatgaag tttgtagttg ttttaagtac tacacatttt taaattgtta
     3661 gcttccttaa gtatatcatg taaagaaatg tcttaatttt tgaaaaaagt acatatttat
     3721 tttcttttga attgttttta ttgttttcta tttatgcctt gatgatttaa tatggatttg
     3781 ttacagccaa gtgccaaatg ctctctcaaa ttgtcagcaa tttaactaga cacagataat
     3841 aatgggtttc tttcagattt tttgaaccat ccacttacat atatttttaa aaaatgaaat
     3901 ccttttcctg ttcatacact aaccaaatct ctcaaatctg ttatcccaat cattgttgcc
     3961 tctccgttta ttataaactg tatgctcaca acttagtgta atataccagc ttgtatgcaa
     4021 tggattttca accagataac atacctttcc tgctctggtg cttagagact atcaactccc
     4081 tcctttagtg aaggagccgt gttagagctt ccgagaatag ctccactgga gagaagtgga
     4141 atcctatata gaatgctgca ctaattgaca acacagccta taggccaatg catgagtaaa
     4201 aaaaaaaaca attactggct cactggcttt gaaaagtcac ttactattgt tgctgaaact
     4261 tgctgagctg tttatagaga atgatgataa cagaactttt cctctgtatc actggtgttt
     4321 aggtgaatta attaaacatt gtgatcatta gtaccaggta ttattatctt taagagtctt
     4381 ccacttcaat gcacatggtg cagttttggt gtgtaactta gaaggattga acttctttga
     4441 atttactgga cataacattt tcagaatagt tggtcatcta gcaaccgcct caaaatgtgt
     4501 aagcaggaga gaaatttctc atcacaggga tttagactta ctattacata aaggctaact
     4561 atgagcttgc tcattaattt tgaaaagatg tacctggtgg atatctagct agtaatatat
     4621 tctgaagcaa cattttagct ctattgatac tctttctaat gctgatatga tcttgagtat
     4681 aagaaatgca tatgtcacta gaatggataa aataatgctg caaacttaat gttcttatgc
     4741 aaaatggaac gctaatgaaa cacagcttac aatcgcaaat caaaactcac aagtgctcat
     4801 ctgttgtaga tttagtgtaa taagacttag attgtgctcc ttcggatatg attgtttctc
     4861 aaatcttggc aatattcctt agtcaaatca ggctactaga attctgtatt ggatatataa
     4921 gagcatgaaa tttttaaaaa tacacttgtg attataaaat taatcacaaa tttcacttat
     4981 acctgctatc agcagctaga aaacattttt tttttaaatc aagtattttg tgtttggaat
     5041 gttagaatga gatctgaatg tggtttcaat ctaatttttt cccagactac tattttcttt
     5101 tttaggtact attctgagca tactcaacaa aacccatgca tttcataaac taatagaagt
     5161 tgaggattgt tgaatctatt tcacttattt tggctgtggt ttccatctga aagtagaggt
     5221 tgtatacacc atatactgtt cttcatttta ttaatatttt tctccttgac ctctcataaa
     5281 tttactttac acaattctta ccctgtacat atgtaaacat aagtgtacga ttcttaacca
     5341 tggagtagag gtactagaat gcttacggcc atctctttgt acaggaactg cattgacttt
     5401 cagtaaacat aaagccacaa ctcctacatg atgttatgta ccatatgatc tgttttgtat
     5461 cttaaatttg atttacatat attatttatt tctggtaact cactcagttt atgctgtgct
     5521 aaatatcaat caagccatgt ataaatgtga tatgattggc aatatgtgtt tactttaaac
     5581 ttgtcttttc aaaatattac tcagtttatg ttgtacaatg tagatggcct cttactaatg
     5641 taaaatgatt tgtagtggaa acatttatat ttttataata aacataatga aaatattttt
     5701 tacagattgg aa
//
