LOCUS       NM_004431               3946 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens EPH receptor A2 (EPHA2), transcript variant 1, mRNA.
ACCESSION   NM_004431
VERSION     NM_004431.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3946)
  AUTHORS   de Aguiar,A.C.F., Ferreira,N.C.F.L., Borba,M.A.C.S.M.,
            Filho,D.L.F., Leitao,G.M., Mattos,L.A., Filho,J.L.L. and
            Martins,D.B.G.
  TITLE     TYRO3 and EPHA2 Expression Are Dysregulated in Breast Cancer
  JOURNAL   Cell Biochem Funct 42 (7), e4128 (2024)
   PUBMED   39327735
  REMARK    GeneRIF: TYRO3 and EPHA2 Expression Are Dysregulated in Breast
            Cancer.
REFERENCE   2  (bases 1 to 3946)
  AUTHORS   Harris,E.D., Sharpe,J.C., Strozen,T., Abdi,S., Kliewer,M.,
            Sanchez,M.G., Hogan,N.S., MacDonald-Dickinson,V., Vizeacoumar,F.J.
            and Toosi,B.M.
  TITLE     The EphA2 Receptor Regulates Invasiveness and Drug Sensitivity in
            Canine and Human Osteosarcoma Cells
  JOURNAL   Cells 13 (14), 1201 (2024)
   PUBMED   39056783
  REMARK    GeneRIF: The EphA2 Receptor Regulates Invasiveness and Drug
            Sensitivity in Canine and Human Osteosarcoma Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3946)
  AUTHORS   Wirth,D., Ozdemir,E., Wimley,W.C., Pasquale,E.B. and Hristova,K.
  TITLE     Transmembrane helix interactions regulate oligomerization of the
            receptor tyrosine kinase EphA2
  JOURNAL   J Biol Chem 300 (7), 107441 (2024)
   PUBMED   38838777
  REMARK    GeneRIF: Transmembrane helix interactions regulate oligomerization
            of the receptor tyrosine kinase EphA2.
REFERENCE   4  (bases 1 to 3946)
  AUTHORS   Bai,J., Chen,Y., Sun,Y., Wang,X., Wang,Y., Guo,S., Shang,Z. and
            Shao,Z.
  TITLE     EphA2 promotes the transcription of KLF4 to facilitate stemness in
            oral squamous cell carcinoma
  JOURNAL   Cell Mol Life Sci 81 (1), 278 (2024)
   PUBMED   38916835
  REMARK    GeneRIF: EphA2 promotes the transcription of KLF4 to facilitate
            stemness in oral squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3946)
  AUTHORS   Sulman,E.P., Tang,X.X., Allen,C., Biegel,J.A., Pleasure,D.E.,
            Brodeur,G.M. and Ikegaki,N.
  TITLE     ECK, a human EPH-related gene, maps to 1p36.1, a common region of
            alteration in human cancers
  JOURNAL   Genomics 40 (2), 371-374 (1997)
   PUBMED   9119409
REFERENCE   6  (bases 1 to 3946)
  AUTHORS   Pandey,A., Duan,H. and Dixit,V.M.
  TITLE     Characterization of a novel Src-like adapter protein that
            associates with the Eck receptor tyrosine kinase
  JOURNAL   J Biol Chem 270 (33), 19201-19204 (1995)
   PUBMED   7543898
REFERENCE   7  (bases 1 to 3946)
  AUTHORS   Pandey,A., Shao,H., Marks,R.M., Polverini,P.J. and Dixit,V.M.
  TITLE     Role of B61, the ligand for the Eck receptor tyrosine kinase, in
            TNF-alpha-induced angiogenesis
  JOURNAL   Science 268 (5210), 567-569 (1995)
   PUBMED   7536959
REFERENCE   8  (bases 1 to 3946)
  AUTHORS   Pandey,A., Lazar,D.F., Saltiel,A.R. and Dixit,V.M.
  TITLE     Activation of the Eck receptor protein tyrosine kinase stimulates
            phosphatidylinositol 3-kinase activity
  JOURNAL   J Biol Chem 269 (48), 30154-30157 (1994)
   PUBMED   7982920
REFERENCE   9  (bases 1 to 3946)
  AUTHORS   Davis,S., Gale,N.W., Aldrich,T.H., Maisonpierre,P.C., Lhotak,V.,
            Pawson,T., Goldfarb,M. and Yancopoulos,G.D.
  TITLE     Ligands for EPH-related receptor tyrosine kinases that require
            membrane attachment or clustering for activity
  JOURNAL   Science 266 (5186), 816-819 (1994)
   PUBMED   7973638
REFERENCE   10 (bases 1 to 3946)
  AUTHORS   Lindberg,R.A. and Hunter,T.
  TITLE     cDNA cloning and characterization of eck, an epithelial cell
            receptor protein-tyrosine kinase in the eph/elk family of protein
            kinases
  JOURNAL   Mol Cell Biol 10 (12), 6316-6324 (1990)
   PUBMED   2174105
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY005615.1, BC037166.2,
            AL451042.10 and AI302504.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004431.4.
            
            Summary: This gene belongs to the ephrin receptor subfamily of the
            protein-tyrosine kinase family. EPH and EPH-related receptors have
            been implicated in mediating developmental events, particularly in
            the nervous system. Receptors in the EPH subfamily typically have a
            single kinase domain and an extracellular region containing a
            Cys-rich domain and 2 fibronectin type III repeats. The ephrin
            receptors are divided into 2 groups based on the similarity of
            their extracellular domain sequences and their affinities for
            binding ephrin-A and ephrin-B ligands. This gene encodes a protein
            that binds ephrin-A ligands. Mutations in this gene are the cause
            of certain genetically-related cataract disorders.[provided by
            RefSeq, May 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037166.2, M59371.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358432.8/ ENSP00000351209.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                HY005615.1         42-60
            20-3364             BC037166.2         1-3345
            3365-3666           AL451042.10        14852-15153         c
            3667-3946           AI302504.1         7-286               c
FEATURES             Location/Qualifiers
     source          1..3946
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..3946
                     /gene="EPHA2"
                     /gene_synonym="ARCC2; CTPA; CTPP1; CTRCT6; ECK"
                     /note="EPH receptor A2"
                     /db_xref="GeneID:1969"
                     /db_xref="HGNC:HGNC:3386"
                     /db_xref="MIM:176946"
     exon            1..222
                     /gene="EPHA2"
                     /gene_synonym="ARCC2; CTPA; CTPP1; CTRCT6; ECK"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..3068
                     /gene="EPHA2"
                     /gene_synonym="ARCC2; CTPA; CTPP1; CTRCT6; ECK"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; ephrin type-A receptor 2; epithelial cell
                     receptor protein tyrosine kinase; tyrosine-protein kinase
                     receptor ECK"
                     /codon_start=1
                     /product="ephrin type-A receptor 2 isoform 1 precursor"
                     /protein_id="NP_004422.2"
                     /db_xref="CCDS:CCDS169.1"
                     /db_xref="GeneID:1969"
                     /db_xref="HGNC:HGNC:3386"
                     /db_xref="MIM:176946"
                     /translation="MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWL
                     THPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTV
                     RDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARH
                     VKLNVEERSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGS
                     DAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQAC
                     SPGFFKFEASESPCLECPEHTLPSPEGATSCECEEGFFRAPQDPASMPCTRPPSAPHY
                     LTAVGMGAKVELRWTPPQDSGGREDIVYSVTCEQCWPESGECGPCEASVRYSEPPHGL
                     TRTSVTVSDLEPHMNYTFTVEARNGVSGLVTSRSFRTASVSINQTEPPKVRLEGRSTT
                     SLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSYNVRRTEGFSVTLDDLAPDTTYLVQVQ
                     ALTQEGQGAGSKVHEFQTLSPEGSGNLAVIGGVAVGVVLLLVLAGVGFFIHRRRKNQR
                     ARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEF
                     GEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVI
                     SKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDL
                     AARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSAS
                     DVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQ
                     ERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSGSEGVPFRTVSEWLE
                     SIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAYSLLGLKDQVNTV
                     GIPI"
     exon            223..290
                     /gene="EPHA2"
                     /gene_synonym="ARCC2; CTPA; CTPP1; CTRCT6; ECK"
                     /inference="alignment:Splign:2.1.0"
     exon            291..960
                     /gene="EPHA2"
                     /gene_synonym="ARCC2; CTPA; CTPP1; CTRCT6; ECK"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1116
                     /gene="EPHA2"
                     /gene_synonym="ARCC2; CTPA; CTPP1; CTRCT6; ECK"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1449
                     /gene="EPHA2"
                     /gene_synonym="ARCC2; CTPA; CTPP1; CTRCT6; ECK"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1565
                     /gene="EPHA2"
                     /gene_synonym="ARCC2; CTPA; CTPP1; CTRCT6; ECK"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1719
                     /gene="EPHA2"
                     /gene_synonym="ARCC2; CTPA; CTPP1; CTRCT6; ECK"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1819
                     /gene="EPHA2"
                     /gene_synonym="ARCC2; CTPA; CTPP1; CTRCT6; ECK"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1875
                     /gene="EPHA2"
                     /gene_synonym="ARCC2; CTPA; CTPP1; CTRCT6; ECK"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2001
                     /gene="EPHA2"
                     /gene_synonym="ARCC2; CTPA; CTPP1; CTRCT6; ECK"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2190
                     /gene="EPHA2"
                     /gene_synonym="ARCC2; CTPA; CTPP1; CTRCT6; ECK"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2252
                     /gene="EPHA2"
                     /gene_synonym="ARCC2; CTPA; CTPP1; CTRCT6; ECK"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2462
                     /gene="EPHA2"
                     /gene_synonym="ARCC2; CTPA; CTPP1; CTRCT6; ECK"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2612
                     /gene="EPHA2"
                     /gene_synonym="ARCC2; CTPA; CTPP1; CTRCT6; ECK"
                     /inference="alignment:Splign:2.1.0"
     exon            2613..2806
                     /gene="EPHA2"
                     /gene_synonym="ARCC2; CTPA; CTPP1; CTRCT6; ECK"
                     /inference="alignment:Splign:2.1.0"
     exon            2807..2962
                     /gene="EPHA2"
                     /gene_synonym="ARCC2; CTPA; CTPP1; CTRCT6; ECK"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3946
                     /gene="EPHA2"
                     /gene_synonym="ARCC2; CTPA; CTPP1; CTRCT6; ECK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3920..3925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPHA2"
                     /gene_synonym="ARCC2; CTPA; CTPP1; CTRCT6; ECK"
                     /note="hexamer: AATAAA"
     polyA_site      3946
                     /gene="EPHA2"
                     /gene_synonym="ARCC2; CTPA; CTPP1; CTRCT6; ECK"
                     /note="major polyA site"
ORIGIN      
        1 attaaggact cggggcagga ggggcagaag ttgcgcgcag gccggcgggc gggagcggac
       61 accgaggccg gcgtgcaggc gtgcgggtgt gcgggagccg ggctcggggg gatcggaccg
      121 agagcgagaa gcgcggcatg gagctccagg cagcccgcgc ctgcttcgcc ctgctgtggg
      181 gctgtgcgct ggccgcggcc gcggcggcgc agggcaagga agtggtactg ctggactttg
      241 ctgcagctgg aggggagctc ggctggctca cacacccgta tggcaaaggg tgggacctga
      301 tgcagaacat catgaatgac atgccgatct acatgtactc cgtgtgcaac gtgatgtctg
      361 gcgaccagga caactggctc cgcaccaact gggtgtaccg aggagaggct gagcgtatct
      421 tcattgagct caagtttact gtacgtgact gcaacagctt ccctggtggc gccagctcct
      481 gcaaggagac tttcaacctc tactatgccg agtcggacct ggactacggc accaacttcc
      541 agaagcgcct gttcaccaag attgacacca ttgcgcccga tgagatcacc gtcagcagcg
      601 acttcgaggc acgccacgtg aagctgaacg tggaggagcg ctccgtgggg ccgctcaccc
      661 gcaaaggctt ctacctggcc ttccaggata tcggtgcctg tgtggcgctg ctctccgtcc
      721 gtgtctacta caagaagtgc cccgagctgc tgcagggcct ggcccacttc cctgagacca
      781 tcgccggctc tgatgcacct tccctggcca ctgtggccgg cacctgtgtg gaccatgccg
      841 tggtgccacc ggggggtgaa gagccccgta tgcactgtgc agtggatggc gagtggctgg
      901 tgcccattgg gcagtgcctg tgccaggcag gctacgagaa ggtggaggat gcctgccagg
      961 cctgctcgcc tggatttttt aagtttgagg catctgagag cccctgcttg gagtgccctg
     1021 agcacacgct gccatcccct gagggtgcca cctcctgcga gtgtgaggaa ggcttcttcc
     1081 gggcacctca ggacccagcg tcgatgcctt gcacacgacc cccctccgcc ccacactacc
     1141 tcacagccgt gggcatgggt gccaaggtgg agctgcgctg gacgccccct caggacagcg
     1201 ggggccgcga ggacattgtc tacagcgtca cctgcgaaca gtgctggccc gagtctgggg
     1261 aatgcgggcc gtgtgaggcc agtgtgcgct actcggagcc tcctcacgga ctgacccgca
     1321 ccagtgtgac agtgagcgac ctggagcccc acatgaacta caccttcacc gtggaggccc
     1381 gcaatggcgt ctcaggcctg gtaaccagcc gcagcttccg tactgccagt gtcagcatca
     1441 accagacaga gccccccaag gtgaggctgg agggccgcag caccacctcg cttagcgtct
     1501 cctggagcat ccccccgccg cagcagagcc gagtgtggaa gtacgaggtc acttaccgca
     1561 agaagggaga ctccaacagc tacaatgtgc gccgcaccga gggtttctcc gtgaccctgg
     1621 acgacctggc cccagacacc acctacctgg tccaggtgca ggcactgacg caggagggcc
     1681 agggggccgg cagcaaggtg cacgaattcc agacgctgtc cccggaggga tctggcaact
     1741 tggcggtgat tggcggcgtg gctgtcggtg tggtcctgct tctggtgctg gcaggagttg
     1801 gcttctttat ccaccgcagg aggaagaacc agcgtgcccg ccagtccccg gaggacgttt
     1861 acttctccaa gtcagaacaa ctgaagcccc tgaagacata cgtggacccc cacacatatg
     1921 aggaccccaa ccaggctgtg ttgaagttca ctaccgagat ccatccatcc tgtgtcactc
     1981 ggcagaaggt gatcggagca ggagagtttg gggaggtgta caagggcatg ctgaagacat
     2041 cctcggggaa gaaggaggtg ccggtggcca tcaagacgct gaaagccggc tacacagaga
     2101 agcagcgagt ggacttcctc ggcgaggccg gcatcatggg ccagttcagc caccacaaca
     2161 tcatccgcct agagggcgtc atctccaaat acaagcccat gatgatcatc actgagtaca
     2221 tggagaatgg ggccctggac aagttccttc gggagaagga tggcgagttc agcgtgctgc
     2281 agctggtggg catgctgcgg ggcatcgcag ctggcatgaa gtacctggcc aacatgaact
     2341 atgtgcaccg tgacctggct gcccgcaaca tcctcgtcaa cagcaacctg gtctgcaagg
     2401 tgtctgactt tggcctgtcc cgcgtgctgg aggacgaccc cgaggccacc tacaccacca
     2461 gtggcggcaa gatccccatc cgctggaccg ccccggaggc catttcctac cggaagttca
     2521 cctctgccag cgacgtgtgg agctttggca ttgtcatgtg ggaggtgatg acctatggcg
     2581 agcggcccta ctgggagttg tccaaccacg aggtgatgaa agccatcaat gatggcttcc
     2641 ggctccccac acccatggac tgcccctccg ccatctacca gctcatgatg cagtgctggc
     2701 agcaggagcg tgcccgccgc cccaagttcg ctgacatcgt cagcatcctg gacaagctca
     2761 ttcgtgcccc tgactccctc aagaccctgg ctgactttga cccccgcgtg tctatccggc
     2821 tccccagcac gagcggctcg gagggggtgc ccttccgcac ggtgtccgag tggctggagt
     2881 ccatcaagat gcagcagtat acggagcact tcatggcggc cggctacact gccatcgaga
     2941 aggtggtgca gatgaccaac gacgacatca agaggattgg ggtgcggctg cccggccacc
     3001 agaagcgcat cgcctacagc ctgctgggac tcaaggacca ggtgaacact gtggggatcc
     3061 ccatctgagc ctcgacaggg cctggagccc catcggccaa gaatacttga agaaacagag
     3121 tggcctccct gctgtgccat gctgggccac tggggacttt atttatttct agttctttcc
     3181 tccccctgca acttccgctg aggggtctcg gatgacaccc tggcctgaac tgaggagatg
     3241 accagggatg ctgggctggg ccctctttcc ctgcgagacg cacacagctg agcacttagc
     3301 aggcaccgcc acgtcccagc atccctggag caggagcccc gccacagcct tcggacagac
     3361 atatgggata ttcccaagcc gaccttccct ccgccttctc ccacatgagg ccatctcagg
     3421 agatggaggg cttggcccag cgccaagtaa acagggtacc tcaagcccca tttcctcaca
     3481 ctaagagggc agactgtgaa cttgactggg tgagacccaa agcggtccct gtccctctag
     3541 tgccttcttt agaccctcgg gccccatcct catccctgac tggccaaacc cttgctttcc
     3601 tgggcctttg caagatgctt ggttgtgttg aggtttttaa atatatattt tgtactttgt
     3661 ggagagaatg tgtgtgtgtg gcagggggcc ccgccagggc tggggacaga gggtgtcaaa
     3721 cattcgtgag ctggggactc agggaccggt gctgcaggag tgtcctgccc atgccccagt
     3781 cggccccatc tctcatcctt ttggataagt ttctattctg tcagtgttaa agattttgtt
     3841 ttgttggaca tttttttcga atcttaattt attatttttt ttatatttat tgttagaaaa
     3901 tgacttattt ctgctctgga ataaagttgc agatgattca aaccga
//
