LOCUS       NM_001099439            5477 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens EPH receptor A10 (EPHA10), transcript variant 3, mRNA.
ACCESSION   NM_001099439
VERSION     NM_001099439.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5477)
  AUTHORS   Huang,S., Ma,L., Liu,X., He,C., Li,J., Hu,Z., Jiang,L., Liu,Y.,
            Liu,X., Feng,Y. and Cai,X.
  TITLE     A non-coding variant in 5' untranslated region drove up-regulation
            of pseudo-kinase EPHA10 and caused non-syndromic hearing loss in
            humans
  JOURNAL   Hum Mol Genet 32 (5), 720-731 (2023)
   PUBMED   36048850
  REMARK    GeneRIF: A non-coding variant in 5' untranslated region drove
            up-regulation of pseudo-kinase EPHA10 and caused non-syndromic
            hearing loss in humans.
REFERENCE   2  (bases 1 to 5477)
  AUTHORS   Zhao,W., Liu,L., Li,X. and Xu,S.
  TITLE     EphA10 drives tumor progression and immune evasion by regulating
            the MAPK/ERK cascade in lung adenocarcinoma
  JOURNAL   Int Immunopharmacol 110, 109031 (2022)
   PUBMED   35839564
  REMARK    GeneRIF: EphA10 drives tumor progression and immune evasion by
            regulating the MAPK/ERK cascade in lung adenocarcinoma.
REFERENCE   3  (bases 1 to 5477)
  AUTHORS   Peng,J. and Zhang,D.
  TITLE     Coexpression of EphA10 and Gli3 promotes breast cancer cell
            proliferation, invasion and migration
  JOURNAL   J Investig Med 69 (6), 1215-1221 (2021)
   PUBMED   33990369
  REMARK    GeneRIF: Coexpression of EphA10 and Gli3 promotes breast cancer
            cell proliferation, invasion and migration.
REFERENCE   4  (bases 1 to 5477)
  AUTHORS   Chen,Y.L., Yen,Y.C., Jang,C.W., Wang,S.H., Huang,H.T., Chen,C.H.,
            Hsiao,J.R., Chang,J.Y. and Chen,Y.W.
  TITLE     Ephrin A4-ephrin receptor A10 signaling promotes cell migration and
            spheroid formation by upregulating NANOG expression in oral
            squamous cell carcinoma cells
  JOURNAL   Sci Rep 11 (1), 644 (2021)
   PUBMED   33436772
  REMARK    GeneRIF: Ephrin A4-ephrin receptor A10 signaling promotes cell
            migration and spheroid formation by upregulating NANOG expression
            in oral squamous cell carcinoma cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5477)
  AUTHORS   Shrestha,S., Byrne,D.P., Harris,J.A., Kannan,N. and Eyers,P.A.
  TITLE     Cataloguing the dead: breathing new life into pseudokinase research
  JOURNAL   FEBS J 287 (19), 4150-4169 (2020)
   PUBMED   32053275
  REMARK    GeneRIF: Cataloguing the dead: breathing new life into pseudokinase
            research.
            Review article
REFERENCE   6  (bases 1 to 5477)
  AUTHORS   Cheng,C.Y., Schache,M., Ikram,M.K., Young,T.L., Guggenheim,J.A.,
            Vitart,V., MacGregor,S., Verhoeven,V.J., Barathi,V.A., Liao,J.,
            Hysi,P.G., Bailey-Wilson,J.E., St Pourcain,B., Kemp,J.P.,
            McMahon,G., Timpson,N.J., Evans,D.M., Montgomery,G.W., Mishra,A.,
            Wang,Y.X., Wang,J.J., Rochtchina,E., Polasek,O., Wright,A.F.,
            Amin,N., van Leeuwen,E.M., Wilson,J.F., Pennell,C.E., van
            Duijn,C.M., de Jong,P.T., Vingerling,J.R., Zhou,X., Chen,P., Li,R.,
            Tay,W.T., Zheng,Y., Chew,M., Burdon,K.P., Craig,J.E., Iyengar,S.K.,
            Igo,R.P. Jr., Lass,J.H. Jr., Chew,E.Y., Haller,T., Mihailov,E.,
            Metspalu,A., Wedenoja,J., Simpson,C.L., Wojciechowski,R., Hohn,R.,
            Mirshahi,A., Zeller,T., Pfeiffer,N., Lackner,K.J., Bettecken,T.,
            Meitinger,T., Oexle,K., Pirastu,M., Portas,L., Nag,A.,
            Williams,K.M., Yonova-Doing,E., Klein,R., Klein,B.E.,
            Hosseini,S.M., Paterson,A.D., Makela,K.M., Lehtimaki,T.,
            Kahonen,M., Raitakari,O., Yoshimura,N., Matsuda,F., Chen,L.J.,
            Pang,C.P., Yip,S.P., Yap,M.K., Meguro,A., Mizuki,N., Inoko,H.,
            Foster,P.J., Zhao,J.H., Vithana,E., Tai,E.S., Fan,Q., Xu,L.,
            Campbell,H., Fleck,B., Rudan,I., Aung,T., Hofman,A.,
            Uitterlinden,A.G., Bencic,G., Khor,C.C., Forward,H., Parssinen,O.,
            Mitchell,P., Rivadeneira,F., Hewitt,A.W., Williams,C., Oostra,B.A.,
            Teo,Y.Y., Hammond,C.J., Stambolian,D., Mackey,D.A., Klaver,C.C.,
            Wong,T.Y., Saw,S.M. and Baird,P.N.
  CONSRTM   Consortium for Refractive Error and Myopia; Fuchs' Genetics
            Multi-Center Study Group; Wellcome Trust Case Control Consortium 2;
            Diabetes Control and Complications Trial/Epidemiology of Diabetes
            Interventions, and Complications Research Group
  TITLE     Nine loci for ocular axial length identified through genome-wide
            association studies, including shared loci with refractive error
  JOURNAL   Am J Hum Genet 93 (2), 264-277 (2013)
   PUBMED   24144296
REFERENCE   7  (bases 1 to 5477)
  AUTHORS   Tao,S., Wang,Z., Feng,J., Hsu,F.C., Jin,G., Kim,S.T., Zhang,Z.,
            Gronberg,H., Zheng,L.S., Isaacs,W.B., Xu,J. and Sun,J.
  TITLE     A genome-wide search for loci interacting with known prostate
            cancer risk-associated genetic variants
  JOURNAL   Carcinogenesis 33 (3), 598-603 (2012)
   PUBMED   22219177
REFERENCE   8  (bases 1 to 5477)
  AUTHORS   Fox,B.P. and Kandpal,R.P.
  TITLE     A paradigm shift in EPH receptor interaction: biological relevance
            of EPHB6 interaction with EPHA2 and EPHB2 in breast carcinoma cell
            lines
  JOURNAL   Cancer Genomics Proteomics 8 (4), 185-193 (2011)
   PUBMED   21737611
  REMARK    GeneRIF: EPHA10 does not interact with EPHB6 in breast neoplasms
REFERENCE   9  (bases 1 to 5477)
  AUTHORS   Alonso-C,L.M., Trinidad,E.M., de Garcillan,B., Ballesteros,M.,
            Castellanos,M., Cotillo,I., Munoz,J.J. and Zapata,A.G.
  TITLE     Expression profile of Eph receptors and ephrin ligands in healthy
            human B lymphocytes and chronic lymphocytic leukemia B-cells
  JOURNAL   Leuk Res 33 (3), 395-406 (2009)
   PUBMED   18819711
  REMARK    GeneRIF: CLL B-cells showed a more heterogeneous Eph/EFN profile,
            specially EFNA4, EphB6 and EphA10.
REFERENCE   10 (bases 1 to 5477)
  AUTHORS   Aasheim,H.C., Patzke,S., Hjorthaug,H.S. and Finne,E.F.
  TITLE     Characterization of a novel Eph receptor tyrosine kinase, EphA10,
            expressed in testis
  JOURNAL   Biochim Biophys Acta 1723 (1-3), 1-7 (2005)
   PUBMED   15777695
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ872185.1, BC041360.1, AC104336.2 and BC039363.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001099439.1.
            
            Summary: Ephrin receptors, the largest subfamily of receptor
            tyrosine kinases (RTKs), and their ephrin ligands are important
            mediators of cell-cell communication regulating cell attachment,
            shape, and mobility in neuronal and epithelial cells (Aasheim et
            al., 2005 [PubMed 15777695]). See MIM 179610 for additional
            background on Eph receptors and ephrins.[supplied by OMIM, Mar
            2008].
            
            Transcript Variant: This variant (3) represents the longer
            transcript and encodes the longer isoform (3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373048.9/ ENSP00000362139.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1426              AJ872185.1         33-1458
            1427-1939           BC041360.1         47-559
            1940-3286           AJ872185.1         1972-3318
            3287-3592           AC104336.2         38509-38814         c
            3593-5477           BC039363.1         5-1889
FEATURES             Location/Qualifiers
     source          1..5477
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..5477
                     /gene="EPHA10"
                     /gene_synonym="DFNA88"
                     /note="EPH receptor A10"
                     /db_xref="GeneID:284656"
                     /db_xref="HGNC:HGNC:19987"
                     /db_xref="MIM:611123"
     exon            1..160
                     /gene="EPHA10"
                     /gene_synonym="DFNA88"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..3081
                     /gene="EPHA10"
                     /gene_synonym="DFNA88"
                     /EC_number="2.7.10.1"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; EphA10s protein; Ephrin type-A receptor 10"
                     /codon_start=1
                     /product="ephrin type-A receptor 10 isoform 3 precursor"
                     /protein_id="NP_001092909.1"
                     /db_xref="CCDS:CCDS41305.1"
                     /db_xref="GeneID:284656"
                     /db_xref="HGNC:HGNC:19987"
                     /db_xref="MIM:611123"
                     /translation="METCAGPHPLRLFLCRMQLCLALLLGPWRPGTAEEVILLDSKAS
                     QAELGWTALPSNGWEEISGVDEHDRPIRTYQVCNVLEPNQDNWLQTGWISRGRGQRIF
                     VELQFTLRDCSSIPGAAGTCKETFNVYYLETEADLGRGRPRLGGSRPRKIDTIAADES
                     FTQGDLGERKMKLNTEVREIGPLSRRGFHLAFQDVGACVALVSVRVYYKQCRATVRGL
                     ATFPATAAESAFSTLVEVAGTCVAHSEGEPGSPPRMHCGADGEWLVPVGRCSCSAGFQ
                     ERGDFCEACPPGFYKVSPRRPLCSPCPEHSRALENASTFCVCQDSYARSPTDPPSASC
                     TRPPSAPRDLQYSLSRSPLVLRLRWLPPADSGGRSDVTYSLLCLRCGREGPAGACEPC
                     GPRVAFLPRQAGLRERAATLLHLRPGARYTVRVAALNGVSGPAAAAGTTYAQVTVSTG
                     PGAPWEEDEIRRDRVEPQSVSLSWREPIPAGAPGANDTEYEIRYYEKGQSEQTYSMVK
                     TGAPTVTVTNLKPATRYVFQIRAASPGPSWEAQSFNPSIEVQTLGEAASGSRDQSPAI
                     VVTVVTISALLVLGSVMSVLAIWRRPCSYGKGGGDAHDEEELYFHFKVPTRRTFLDPQ
                     SCGDLLQAVHLFAKELDAKSVTLERSLGGGRFGELCCGCLQLPGRQELLVAVHMLRDS
                     ASDSQRLGFLAEALTLGQFDHSHIVRLEGVVTRGSTLMIVTEYMSHGALDGFLRRHEG
                     QLVAGQLMGLLPGLASAMKYLSEMGYVHRGLAARHVLVSSDLVCKISGFGRGPRDRSE
                     AVYTTMSGRSPALWAAPETLQFGHFSSASDVWSFGIIMWEVMAFGERPYWDMSGQDVI
                     KAVEDGFRLPPPRNCPNLLHRLMLDCWQKDPGERPRFSQIHSILSKMVQDPEPPKCAL
                     TTCPRPPTPLADRAFSTFPSFGSVGAWLEALDLCRYKDSFAAAGYGSLEAVAEMTAQD
                     LVSLGISLAEHREALLSGISALQARVLQLQGQGVQV"
     exon            161..225
                     /gene="EPHA10"
                     /gene_synonym="DFNA88"
                     /inference="alignment:Splign:2.1.0"
     exon            226..904
                     /gene="EPHA10"
                     /gene_synonym="DFNA88"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1060
                     /gene="EPHA10"
                     /gene_synonym="DFNA88"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1411
                     /gene="EPHA10"
                     /gene_synonym="DFNA88"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1545
                     /gene="EPHA10"
                     /gene_synonym="DFNA88"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1717
                     /gene="EPHA10"
                     /gene_synonym="DFNA88"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1826
                     /gene="EPHA10"
                     /gene_synonym="DFNA88"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1888
                     /gene="EPHA10"
                     /gene_synonym="DFNA88"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2014
                     /gene="EPHA10"
                     /gene_synonym="DFNA88"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2200
                     /gene="EPHA10"
                     /gene_synonym="DFNA88"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2262
                     /gene="EPHA10"
                     /gene_synonym="DFNA88"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2466
                     /gene="EPHA10"
                     /gene_synonym="DFNA88"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2616
                     /gene="EPHA10"
                     /gene_synonym="DFNA88"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2810
                     /gene="EPHA10"
                     /gene_synonym="DFNA88"
                     /inference="alignment:Splign:2.1.0"
     exon            2811..2966
                     /gene="EPHA10"
                     /gene_synonym="DFNA88"
                     /inference="alignment:Splign:2.1.0"
     exon            2967..5477
                     /gene="EPHA10"
                     /gene_synonym="DFNA88"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5459..5464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPHA10"
                     /gene_synonym="DFNA88"
                     /note="hexamer: AATAAA"
     polyA_site      5477
                     /gene="EPHA10"
                     /gene_synonym="DFNA88"
                     /note="major polyA site"
ORIGIN      
        1 gctaggctgg cgcggcttga gccgccgccg gactgacagc tcggtctgcg gaccatggag
       61 acctgcgccg gtccacaccc gctgcgcctc ttcctctgcc ggatgcagct ctgtctcgcg
      121 ctgcttttgg gaccctggcg gcctgggacc gccgaggaag ttatcctcct ggattccaaa
      181 gcctcccagg ccgagctggg ctggactgca ctgccaagta atgggtggga ggagatcagc
      241 ggcgtggatg aacacgaccg tcccatccgc acgtaccaag tgtgcaatgt gctggagccc
      301 aaccaggaca actggctgca gactggctgg ataagccgtg gccgcgggca gcgcatcttc
      361 gtggaactgc agttcacact ccgtgactgc agcagcatcc ctggcgccgc gggtacctgc
      421 aaggagacct tcaacgtcta ctacctggaa actgaggccg acctgggccg tgggcgtccc
      481 cgcctaggcg gcagccggcc ccgcaaaatc gacacgatcg cggcggacga gagcttcacg
      541 cagggcgacc tgggtgagcg caagatgaag ctgaacacag aggtgcgcga gatcggaccg
      601 ctcagccggc ggggtttcca cctggccttt caggacgtgg gcgcatgcgt ggcgcttgtc
      661 tcggtgcgcg tctactacaa gcagtgccgc gccaccgtgc ggggcctggc cacgttccca
      721 gccaccgcag ccgagagcgc cttctccaca ctggtggaag tggccggaac gtgcgtggcg
      781 cactcggaag gggagcctgg cagcccccca cgcatgcact gcggcgccga cggcgagtgg
      841 ctggtgcctg tgggccgctg cagctgcagc gcgggattcc aggagcgtgg tgacttctgc
      901 gaagcctgtc ccccagggtt ttacaaggtg tccccgcggc ggcccctctg ctcaccgtgc
      961 ccagagcaca gccgggccct ggaaaacgcc tccaccttct gcgtgtgcca ggacagctat
     1021 gcgcgctcac ccaccgaccc gccctcggct tcctgcaccc ggccgccgtc ggcgccgcgg
     1081 gacctgcagt acagcctgag ccgctcgccg ctggtgctgc gactgcgctg gctgccgccg
     1141 gccgactcgg gaggccgctc ggacgtcacc tactcgctgc tgtgcctgcg ctgcggccgc
     1201 gagggcccgg cgggcgcctg cgagccgtgc gggccgcgcg tggccttcct accgcgccag
     1261 gcagggctgc gggagcgagc cgccacgctg ctgcacctgc ggcccggcgc gcgctacacc
     1321 gtgcgcgtgg ccgcgctcaa cggcgtctcg ggcccggcgg ccgccgcggg aaccacctac
     1381 gcgcaggtca ccgtctccac cgggcccggg gcgccctggg aggaggatga gatccgcagg
     1441 gaccgagtgg aaccccagag cgtgtccctg tcgtggcggg agcccatccc tgccggagcc
     1501 cctggggcca atgacacgga gtacgagatc cgatactacg agaagggtca gagtgagcag
     1561 acttactcca tggtgaagac aggggcgccc acagtcaccg tcaccaacct gaagccggct
     1621 acccgctacg tctttcagat ccgggccgct tccccggggc catcctggga ggcccagagt
     1681 tttaacccca gcattgaagt acagaccctg ggggaggctg cctcagggtc cagggaccag
     1741 agccccgcca ttgtcgtcac cgtagtgacc atctcggccc tcctcgtcct gggctccgtg
     1801 atgagtgtgc tggccatttg gaggaggccc tgcagctatg gcaaaggagg aggggatgcc
     1861 catgatgaag aggagctgta tttccacttc aaagtcccaa cacgtcgcac attcctggac
     1921 ccccagagct gtggggacct gctgcaggct gtgcatctgt tcgccaagga actggatgcg
     1981 aaaagcgtca cgctggagag gagccttgga ggagggcggt ttggggagct gtgctgtggc
     2041 tgcttgcagc tccccggtcg ccaggagctg ctcgtagccg tgcatatgct gagggacagc
     2101 gcctccgact cacagaggct cggcttcctg gccgaggccc tcacgctggg ccagtttgac
     2161 catagccaca tcgtgcggct ggagggcgtt gttacccgag gaagcacctt gatgattgtc
     2221 accgagtaca tgagccatgg ggccctggac ggcttcctca ggcggcacga ggggcagctg
     2281 gtggctgggc aactgatggg gttgctgcct gggctggcat cagccatgaa gtatctgtca
     2341 gagatgggct acgttcaccg gggcctggca gctcgccatg tgctggtcag cagcgacctt
     2401 gtctgcaaga tctctggctt cgggcggggc ccccgggacc gatcagaggc tgtctacacc
     2461 actatgagtg gccggagccc agcgctatgg gccgctcccg agacacttca gtttggccac
     2521 ttcagctctg ccagtgacgt gtggagcttc ggcatcatca tgtgggaggt gatggccttt
     2581 ggggagcggc cttactggga catgtctggc caagacgtga tcaaggctgt ggaggatggc
     2641 ttccggctgc caccccccag gaactgtcct aaccttctgc accgactaat gctcgactgc
     2701 tggcagaagg acccaggtga gcggcccagg ttctcccaga tccacagcat cctgagcaag
     2761 atggtgcagg acccagagcc ccccaagtgt gccctgacta cctgtcccag gcctcccacc
     2821 ccactagcgg accgtgcctt ctccaccttc ccctcctttg gctctgtggg cgcgtggctg
     2881 gaggccctgg acctgtgccg ctacaaggac agcttcgcgg ctgctggcta tgggagcctg
     2941 gaggccgtgg ccgagatgac tgcccaggac ctggtgagcc taggcatctc tttggctgaa
     3001 catcgagagg ccctcctcag cgggatcagc gccctgcagg cacgagtgct ccagctgcag
     3061 ggccaggggg tgcaggtgtg agtggacccc attcttccaa ggcaggactc cggtgggggt
     3121 ccagtccccc agccctgccc aaggaccgtg gcaagctgcg ctccagcagt gtgggaggga
     3181 gcgctctctt cctctgcttg ggcccagatc tggtggggcc acagcttccc cgctttcact
     3241 gcctgcccct cccattttca cgagtctgaa cgccttggct aactcagtgc ccctgaaaag
     3301 aggttcaaat ccctagggag gacccctgag ataacagcag gaggaaattc ggggtctcag
     3361 agaaaagctg gggcagggat gggagggaag acagtgggtt gagattgccc tggctcatgc
     3421 cctactgcca tttgtaccca ctgggggctg gggcctaccc cgtggggtgt tcccttttcc
     3481 cacagaccca ttgaccagtc agacagcgtg ggtcctgggg gggtcttctt ctacctggca
     3541 gtgactgcag ctgcctggtg gctcaggcgt cgggggctgg gccagaggtg catccacctc
     3601 agctccctgt gccttggcag gggctgactg gacactggcc aaggctcagg caggcaaaga
     3661 tggtgctgag ctcaggggct gatacccaag agccctagac tcaggatctg gtttctgtgt
     3721 ccccctgcct tgggctgaca gttcagggtg aggccaaaag tcctggccag gccgggccat
     3781 gagaggccct ggtgctccct ggggccccat gaggccctcg tgtgcattcc ttttatgaac
     3841 ttagtggcca ggacatctgg gaaaagcata aagggccatg ttatctcccc agggacccaa
     3901 gagcttttct ctccagccat ggggagggtg aagaggagac tcagagatgg gtcctctctc
     3961 tcaaacaggc tggtctaacc cccagtgtac agatggggga aactgaggcc aagtgaggag
     4021 tcaggagcag agctgaggtc agaacccaat ccaggggtaa ggctggctct ggggagagag
     4081 tccttggtcc tgccctatgg caccaccact tccctgtaca gcccttgggg actctagagg
     4141 cgactcccct ccagccagct ccgtgccttg ggcactaccc agccttccat ggagcccctc
     4201 cctgctctga ctttgaagag ccctggcaga agtggttgtg ctgagcccac cgtggagttc
     4261 cttatccaca agggcccccg ggaatggtgg ggcccagtat gccagagctt tcgtagggtg
     4321 gcaggaaggc agctggatct cagcagggcc acagggactg agtttgttta ggccgcccgt
     4381 gacacttgtc tgctctgctt ggctgtgtgt tggtggggtg ggatggggcg ggaaagagga
     4441 gacaagaggt aaagatgaaa aagacacaca gcctgccctt ggggggctca gactagacca
     4501 ggagaagagc tcaggtacca agaagtaatt ccagggcacc atccacagtg cccagggccc
     4561 cccaggagcc ctctgggtca gtgggtaggt gggctggagg gggagatagc cactctctta
     4621 atgtgtgaag ttgagatgta agttgaacag ggccttgcag gtgggaaagg gaaggttctt
     4681 tccttggggt gggtggagtt ttcggcaggc aagatggcag gcctcggaca aaaggagtcc
     4741 atgcagagag gctagcatga gaaagagccc agaggcggga aggtgcagtg cctctttgca
     4801 gagcacccag aggtggggga cagtgactca cagaggtgcc tttggcctta ccctgccagc
     4861 agcagctccc ctgctcttgg aatctccccc cagccccctg cctccctgtc tcctgagcac
     4921 ctgccccagc tcagtgactc tgggggtact ggggagacca agatgttgct accaccttag
     4981 tcagggttgg gggagccccc ggccaggtgc cctccaggat ccgccttccc cacccctcct
     5041 gggaagcctg gaccagcatc ccttcttggg tggatggagc ctcgtcctca tctccagcta
     5101 catcagtcat tctctgcagg gcaaaatctc ctccccctac cccagctgtt tctgcagaag
     5161 ggcccctggc tgtgttggca ggacttcggt gtccagggta gatctcccct ccactgagga
     5221 gtgaggtccc agaatcctgt tgggtcccag gcctcagccc tgcacagatg tgatgtgggg
     5281 cgatggctct ctgggaaccc tctacagatc tatttttata tggaacttgt tcactggaca
     5341 gaggtggcct gcaagccccc attaccctgg tctgagctca ccctgggagg gagggggcca
     5401 gtcggagggg gttccttctg gagatgtttt tatatttctt gggttctcta tgcaggataa
     5461 taaaaacttg tctgtga
//
