LOCUS       NM_005232               3310 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens EPH receptor A1 (EPHA1), mRNA.
ACCESSION   NM_005232
VERSION     NM_005232.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3310)
  AUTHORS   Owens,H.A., Thorburn,L.E., Walsby,E., Moon,O.R., Rizkallah,P.,
            Sherwani,S., Tinsley,C.L., Rogers,L., Cerutti,C., Ridley,A.J.,
            Williams,J., Knauper,V. and Ager,A.
  TITLE     Alzheimer's disease-associated P460L variant of EphA1 dysregulates
            receptor activity and blood-brain barrier function
  JOURNAL   Alzheimers Dement 20 (3), 2016-2033 (2024)
   PUBMED   38184788
  REMARK    GeneRIF: Alzheimer's disease-associated P460L variant of EphA1
            dysregulates receptor activity and blood-brain barrier function.
REFERENCE   2  (bases 1 to 3310)
  AUTHORS   Shin,J.M., Han,M.S., Park,J.H., Lee,S.H., Kim,T.H. and Lee,S.H.
  TITLE     The EphA1 and EphA2 Signaling Modulates the Epithelial Permeability
            in Human Sinonasal Epithelial Cells and the Rhinovirus Infection
            Induces Epithelial Barrier Dysfunction via EphA2 Receptor Signaling
  JOURNAL   Int J Mol Sci 24 (4), 3629 (2023)
   PUBMED   36835041
  REMARK    GeneRIF: The EphA1 and EphA2 Signaling Modulates the Epithelial
            Permeability in Human Sinonasal Epithelial Cells and the Rhinovirus
            Infection Induces Epithelial Barrier Dysfunction via EphA2 Receptor
            Signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3310)
  AUTHORS   LaCombe,R., Cecchini,A., Seibert,M. and Cornelison,D.
  TITLE     EphA1 receptor tyrosine kinase is localized to the nucleus in
            rhabdomyosarcoma from multiple species
  JOURNAL   Biol Open 11 (10) (2022)
   PUBMED   36214254
  REMARK    GeneRIF: EphA1 receptor tyrosine kinase is localized to the nucleus
            in rhabdomyosarcoma from multiple species.
REFERENCE   4  (bases 1 to 3310)
  AUTHORS   Dai,B.Q. and Zhang,X.
  TITLE     SOCS2 affects the proliferation, migration and invasion of
            nasopharyngeal carcinoma cells via regulating EphA1
  JOURNAL   Neoplasma 67 (4), 794-801 (2020)
   PUBMED   32266818
  REMARK    GeneRIF: SOCS2 affects the proliferation, migration and invasion of
            nasopharyngeal carcinoma cells via regulating EphA1.
REFERENCE   5  (bases 1 to 3310)
  AUTHORS   Nagare,R.P., Sneha,S., Sidhanth,C., Roopa,S., Murhekar,K.,
            Shirley,S., Swaminathan,R., Sridevi,V. and Ganesan,T.S.
  TITLE     Expression of cancer stem cell markers CD24, EPHA1 and CD9 and
            their correlation with clinical outcome in epithelial ovarian
            tumours
  JOURNAL   Cancer Biomark 28 (3), 397-408 (2020)
   PUBMED   32224528
  REMARK    GeneRIF: Expression of cancer stem cell markers CD24, EPHA1 and CD9
            and their correlation with clinical outcome in epithelial ovarian
            tumours.
REFERENCE   6  (bases 1 to 3310)
  AUTHORS   Holder,N. and Klein,R.
  TITLE     Eph receptors and ephrins: effectors of morphogenesis
  JOURNAL   Development 126 (10), 2033-2044 (1999)
   PUBMED   10207129
  REMARK    Review article
REFERENCE   7  (bases 1 to 3310)
  AUTHORS   Zhou,R.
  TITLE     The Eph family receptors and ligands
  JOURNAL   Pharmacol Ther 77 (3), 151-181 (1998)
   PUBMED   9576626
  REMARK    Review article
REFERENCE   8  (bases 1 to 3310)
  AUTHORS   Flanagan,J.G. and Vanderhaeghen,P.
  TITLE     The ephrins and Eph receptors in neural development
  JOURNAL   Annu Rev Neurosci 21, 309-345 (1998)
   PUBMED   9530499
  REMARK    Review article
REFERENCE   9  (bases 1 to 3310)
  AUTHORS   Gale,N.W., Holland,S.J., Valenzuela,D.M., Flenniken,A., Pan,L.,
            Ryan,T.E., Henkemeyer,M., Strebhardt,K., Hirai,H., Wilkinson,D.G.,
            Pawson,T., Davis,S. and Yancopoulos,G.D.
  TITLE     Eph receptors and ligands comprise two major specificity subclasses
            and are reciprocally compartmentalized during embryogenesis
  JOURNAL   Neuron 17 (1), 9-19 (1996)
   PUBMED   8755474
REFERENCE   10 (bases 1 to 3310)
  AUTHORS   Hirai,H., Maru,Y., Hagiwara,K., Nishida,J. and Takaku,F.
  TITLE     A novel putative tyrosine kinase receptor encoded by the eph gene
  JOURNAL   Science 238 (4834), 1717-1720 (1987)
   PUBMED   2825356
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC130291.1, EU826605.1,
            CN289901.1 and AI057542.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005232.4.
            
            Summary: This gene belongs to the ephrin receptor subfamily of the
            protein-tyrosine kinase family. EPH and EPH-related receptors have
            been implicated in mediating developmental events, particularly in
            the nervous system. Receptors in the EPH subfamily typically have a
            single kinase domain and an extracellular region containing a
            Cys-rich domain and 2 fibronectin type III repeats. The ephrin
            receptors are divided into 2 groups based on the similarity of
            their extracellular domain sequences and their affinities for
            binding ephrin-A and ephrin-B ligands. This gene is expressed in
            some human cancer cell lines and has been implicated in
            carcinogenesis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290351.1, M18391.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000275815.4/ ENSP00000275815.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-529               BC130291.1         21-549
            530-1042            EU826605.1         479-991
            1043-1887           BC130291.1         1063-1907
            1888-2205           CN289901.1         285-602
            2206-2748           BC130291.1         2226-2768
            2749-3310           AI057542.1         3-564               c
FEATURES             Location/Qualifiers
     source          1..3310
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34-q35"
     gene            1..3310
                     /gene="EPHA1"
                     /gene_synonym="EPH; EPHT; EPHT1"
                     /note="EPH receptor A1"
                     /db_xref="GeneID:2041"
                     /db_xref="HGNC:HGNC:3385"
                     /db_xref="MIM:179610"
     exon            1..133
                     /gene="EPHA1"
                     /gene_synonym="EPH; EPHT; EPHT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..2982
                     /gene="EPHA1"
                     /gene_synonym="EPH; EPHT; EPHT1"
                     /EC_number="2.7.10.1"
                     /note="erythropoietin-producing hepatoma amplified
                     sequence; ephrin type-A receptor 1; tyrosine-protein
                     kinase receptor EPH; oncogene EPH; eph tyrosine kinase 1;
                     hEpha1; erythropoietin-producing hepatoma receptor"
                     /codon_start=1
                     /product="ephrin type-A receptor 1 precursor"
                     /protein_id="NP_005223.4"
                     /db_xref="CCDS:CCDS5884.1"
                     /db_xref="GeneID:2041"
                     /db_xref="HGNC:HGNC:3385"
                     /db_xref="MIM:179610"
                     /translation="MERRWPLGLGLVLLLCAPLPPGARAKEVTLMDTSKAQGELGWLL
                     DPPKDGWSEQQQILNGTPLYMYQDCPMQGRRDTDHWLRSNWIYRGEEASRVHVELQFT
                     VRDCKSFPGGAGPLGCKETFNLLYMESDQDVGIQLRRPLFQKVTTVAADQSFTIRDLV
                     SGSVKLNVERCSLGRLTRRGLYLAFHNPGACVALVSVRVFYQRCPETLNGLAQFPDTL
                     PGPAGLVEVAGTCLPHARASPRPSGAPRMHCSPDGEWLVPVGRCHCEPGYEEGGSGEA
                     CVACPSGSYRMDMDTPHCLTCPQQSTAESEGATICTCESGHYRAPGEGPQVACTGPPS
                     APRNLSFSASGTQLSLRWEPPADTGGRQDVRYSVRCSQCQGTAQDGGPCQPCGVGVHF
                     SPGARGLTTPAVHVNGLEPYANYTFNVEAQNGVSGLGSSGHASTSVSISMGHAESLSG
                     LSLRLVKKEPRQLELTWAGSRPRSPGANLTYELHVLNQDEERYQMVLEPRVLLTELQP
                     DTTYIVRVRMLTPLGPGPFSPDHEFRTSPPVSRGLTGGEIVAVIFGLLLGAALLLGIL
                     VFRSRRAQRQRQQRQRDRATDVDREDKLWLKPYVDLQAYEDPAQGALDFTRELDPAWL
                     MVDTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSH
                     PHILHLEGVVTKRKPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQGIASGMNYL
                     SNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAI
                     AHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLY
                     ELMKNCWAYDRARRPHFQKLQAHLEQLLANPHSLRTIANFDPRMTLRLPSLSGSDGIP
                     YRTVSEWLESIRMKRYILHFHSAGLDTMECVLELTAEDLTQMGITLPGHQKRILCSIQ
                     GFKD"
     exon            134..201
                     /gene="EPHA1"
                     /gene_synonym="EPH; EPHT; EPHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            202..483
                     /gene="EPHA1"
                     /gene_synonym="EPH; EPHT; EPHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            484..886
                     /gene="EPHA1"
                     /gene_synonym="EPH; EPHT; EPHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1042
                     /gene="EPHA1"
                     /gene_synonym="EPH; EPHT; EPHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1387
                     /gene="EPHA1"
                     /gene_synonym="EPH; EPHT; EPHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1515
                     /gene="EPHA1"
                     /gene_synonym="EPH; EPHT; EPHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1666
                     /gene="EPHA1"
                     /gene_synonym="EPH; EPHT; EPHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1763
                     /gene="EPHA1"
                     /gene_synonym="EPH; EPHT; EPHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1822
                     /gene="EPHA1"
                     /gene_synonym="EPH; EPHT; EPHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1948
                     /gene="EPHA1"
                     /gene_synonym="EPH; EPHT; EPHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2134
                     /gene="EPHA1"
                     /gene_synonym="EPH; EPHT; EPHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2196
                     /gene="EPHA1"
                     /gene_synonym="EPH; EPHT; EPHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2403
                     /gene="EPHA1"
                     /gene_synonym="EPH; EPHT; EPHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2553
                     /gene="EPHA1"
                     /gene_synonym="EPH; EPHT; EPHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..2747
                     /gene="EPHA1"
                     /gene_synonym="EPH; EPHT; EPHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2903
                     /gene="EPHA1"
                     /gene_synonym="EPH; EPHT; EPHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..3310
                     /gene="EPHA1"
                     /gene_synonym="EPH; EPHT; EPHT1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3310
                     /gene="EPHA1"
                     /gene_synonym="EPH; EPHT; EPHT1"
                     /note="major polyA site"
ORIGIN      
        1 gcaacctggc gctgccatcc gggccactgt cccaggtccc ggcccggagc tatggagcgg
       61 cgctggcccc tggggctagg gctggtgctg ctgctctgcg ccccgctgcc cccgggggcg
      121 cgcgccaagg aagttactct gatggacaca agcaaggcac agggagagct gggctggctg
      181 ctggatcccc caaaagatgg gtggagtgaa cagcaacaga tactgaatgg gacacccctg
      241 tacatgtacc aggactgccc aatgcaagga cgcagagaca ctgaccactg gcttcgctcc
      301 aattggatct accgcgggga ggaggcttcc cgcgtccacg tggagctgca gttcaccgtg
      361 cgggactgca agagtttccc tgggggagcc gggcctctgg gctgcaagga gaccttcaac
      421 cttctgtaca tggagagtga ccaggatgtg ggcattcagc tccgacggcc cttgttccag
      481 aaggtaacca cggtggctgc agaccagagc ttcaccattc gagaccttgt gtctggctcc
      541 gtgaagctga atgtggagcg ctgctctctg ggccgcctga cccgccgtgg cctctacctc
      601 gctttccaca acccgggtgc ctgtgtggcc ctggtgtctg tccgggtctt ctaccagcgc
      661 tgtcctgaga ccctgaatgg cttggcccaa ttcccagaca ctctgcctgg ccccgctggg
      721 ttggtggaag tggcggggac ctgcttgccc cacgcgcggg ccagccccag gccctcaggt
      781 gcaccccgca tgcactgcag ccctgatggc gagtggctgg tgcctgtagg acggtgccac
      841 tgtgagcctg gctatgagga aggtggcagt ggcgaagcat gtgttgcctg ccctagcggc
      901 tcctaccgga tggacatgga cacaccccat tgtctcacgt gcccccagca gagcactgct
      961 gagtctgagg gggccaccat ctgtacctgt gagagcggcc attacagagc tcccggggag
     1021 ggcccccagg tggcatgcac aggtcccccc tcggcccccc gaaacctgag cttctctgcc
     1081 tcagggactc agctctccct gcgttgggaa cccccagcag atacgggggg acgccaggat
     1141 gtcagataca gtgtgaggtg ttcccagtgt cagggcacag cacaggacgg ggggccctgc
     1201 cagccctgtg gggtgggcgt gcacttctcg ccgggggccc gggggctcac cacacctgca
     1261 gtgcatgtca atggccttga accttatgcc aactacacct ttaatgtgga agcccaaaat
     1321 ggagtgtcag ggctgggcag ctctggccat gccagcacct cagtcagcat cagcatgggg
     1381 catgcagagt cactgtcagg cctgtctctg agactggtga agaaagaacc gaggcaacta
     1441 gagctgacct gggcggggtc ccggccccga agccctgggg cgaacctgac ctatgagctg
     1501 cacgtgctga accaggatga agaacggtac cagatggttc tagaacccag ggtcttgctg
     1561 acagagctgc agcctgacac cacatacatc gtcagagtcc gaatgctgac cccactgggt
     1621 cctggccctt tctcccctga tcatgagttt cggaccagcc caccagtgtc caggggcctg
     1681 actggaggag agattgtagc cgtcatcttt gggctgctgc ttggtgcagc cttgctgctt
     1741 gggattctcg ttttccggtc caggagagcc cagcggcaga ggcagcagag gcagcgtgac
     1801 cgcgccaccg atgtggatcg agaggacaag ctgtggctga agccttatgt ggacctccag
     1861 gcatacgagg accctgcaca gggagccctg gactttaccc gggagcttga tccagcgtgg
     1921 ctgatggtgg acactgtcat aggagaagga gagtttgggg aagtgtatcg agggaccctg
     1981 aggctcccca gccaggactg caagactgtg gccattaaga ccttaaaaga cacatcccca
     2041 ggtggccagt ggtggaactt ccttcgagag gcaactatca tgggccagtt tagccacccg
     2101 catattctgc atctggaagg cgtcgtcaca aagcgaaagc cgatcatgat catcacagaa
     2161 tttatggaga atggagccct ggatgccttc ctgagggagc gggaggacca gctggtccct
     2221 gggcagctag tggccatgct gcagggcata gcatctggca tgaactacct cagtaatcac
     2281 aattatgtcc accgggacct ggctgccaga aacatcttgg tgaatcaaaa cctgtgctgc
     2341 aaggtgtctg actttggcct gactcgcctc ctggatgact ttgatggcac atacgaaacc
     2401 cagggaggaa agatccctat ccgttggaca gcccctgaag ccattgccca tcggatcttc
     2461 accacagcca gcgatgtgtg gagctttggg attgtgatgt gggaggtgct gagctttggg
     2521 gacaagcctt atggggagat gagcaatcag gaggttatga agagcattga ggatgggtac
     2581 cggttgcccc ctcctgtgga ctgccctgcc cctctgtatg agctcatgaa gaactgctgg
     2641 gcatatgacc gtgcccgccg gccacacttc cagaagcttc aggcacatct ggagcaactg
     2701 cttgccaacc cccactccct gcggaccatt gccaactttg accccaggat gactcttcgc
     2761 ctgcccagcc tgagtggctc agatgggatc ccatatcgaa ccgtctctga gtggctcgag
     2821 tccatacgca tgaaacgcta catcctgcac ttccactcgg ctgggctgga caccatggag
     2881 tgtgtgctgg agctgaccgc tgaggacctg acgcagatgg gaatcacact gcccgggcac
     2941 cagaagcgca ttctttgcag tattcaggga ttcaaggact gatccctcct ctcaccccat
     3001 gcccaatcag ggtgcaagga gcaaggacgg ggccaaggtc gctcatggtc actccctgcg
     3061 ccccttccca caacctgcca gactaggcta tcggtgctgc ttctgcccac tttcaggaga
     3121 accctgctct gcaccccaga aaacctcttt gttttaaaag ggaggtgggg gtagaagtaa
     3181 aaggatgatc atgggaggga gctgaggggt taatatatat acatacatac acatatatat
     3241 atttttgtaa ataaacagga actgattttc tgcctccatc ccacccatga gggctgcagg
     3301 cactacaaaa
//
