LOCUS       NM_001162495            4081 bp    mRNA    linear   PRI 14-APR-2024
DEFINITION  Homo sapiens exosomal polycystin 1 interacting protein (EPCIP),
            transcript variant 1, mRNA.
ACCESSION   NM_001162495
VERSION     NM_001162495.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4081)
  AUTHORS   Lea,W.A., Winklhofer,T., Zelenchuk,L., Sharma,M.,
            Rossol-Allison,J., Fields,T.A., Reif,G., Calvet,J.P.,
            Bakeberg,J.L., Wallace,D.P. and Ward,C.J.
  TITLE     Polycystin-1 Interacting Protein-1 (CU062) Interacts with the
            Ectodomain of Polycystin-1 (PC1)
  JOURNAL   Cells 12 (17), 2166 (2023)
   PUBMED   37681898
  REMARK    GeneRIF: Polycystin-1 Interacting Protein-1 (CU062) Interacts with
            the Ectodomain of Polycystin-1 (PC1).
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4081)
  AUTHORS   Kang,T.W., Kim,H.J., Ju,H., Kim,J.H., Jeon,Y.J., Lee,H.C.,
            Kim,K.K., Kim,J.W., Lee,S., Kim,J.Y., Kim,S.Y. and Kim,Y.S.
  TITLE     Genome-wide association of serum bilirubin levels in Korean
            population
  JOURNAL   Hum Mol Genet 19 (18), 3672-3678 (2010)
   PUBMED   20639394
REFERENCE   3  (bases 1 to 4081)
  AUTHORS   Denoeud,F., Kapranov,P., Ucla,C., Frankish,A., Castelo,R.,
            Drenkow,J., Lagarde,J., Alioto,T., Manzano,C., Chrast,J., Dike,S.,
            Wyss,C., Henrichsen,C.N., Holroyd,N., Dickson,M.C., Taylor,R.,
            Hance,Z., Foissac,S., Myers,R.M., Rogers,J., Hubbard,T., Harrow,J.,
            Guigo,R., Gingeras,T.R., Antonarakis,S.E. and Reymond,A.
  TITLE     Prominent use of distal 5' transcription start sites and discovery
            of a large number of additional exons in ENCODE regions
  JOURNAL   Genome Res 17 (6), 746-759 (2007)
   PUBMED   17567994
REFERENCE   4  (bases 1 to 4081)
  AUTHORS   Gardiner,K., Slavov,D., Bechtel,L. and Davisson,M.
  TITLE     Annotation of human chromosome 21 for relevance to Down syndrome:
            gene structure and expression analysis
  JOURNAL   Genomics 79 (6), 833-843 (2002)
   PUBMED   12036298
REFERENCE   5  (bases 1 to 4081)
  AUTHORS   Slavov,D., Hattori,M., Sakaki,Y., Rosenthal,A., Shimizu,N.,
            Minoshima,S., Kudoh,J., Yaspo,M.L., Ramser,J., Reinhardt,R.,
            Reimer,C., Clancy,K., Rynditch,A. and Gardiner,K.
  TITLE     Criteria for gene identification and features of genome
            organization: analysis of 6.5 Mb of DNA sequence from human
            chromosome 21
  JOURNAL   Gene 247 (1-2), 215-232 (2000)
   PUBMED   10773462
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ656042.2, BC069779.1, BC069689.1, AP000280.3 and BE466137.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001162495.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069779.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMEA2145774
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000479548.2/ ENSP00000418653.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                DQ656042.2         41-109
            70-315              BC069779.1         1-246
            316-1189            BC069689.1         172-1045
            1190-3634           AP000280.3         26871-29315         c
            3635-4081           BE466137.1         12-458              c
FEATURES             Location/Qualifiers
     source          1..4081
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     gene            1..4081
                     /gene="EPCIP"
                     /gene_synonym="B37; C21orf120; C21orf62; CU062; PRED81"
                     /note="exosomal polycystin 1 interacting protein"
                     /db_xref="GeneID:56245"
                     /db_xref="HGNC:HGNC:1305"
     exon            1..112
                     /gene="EPCIP"
                     /gene_synonym="B37; C21orf120; C21orf62; CU062; PRED81"
                     /inference="alignment:Splign:2.1.0"
     exon            113..193
                     /gene="EPCIP"
                     /gene_synonym="B37; C21orf120; C21orf62; CU062; PRED81"
                     /inference="alignment:Splign:2.1.0"
     exon            194..268
                     /gene="EPCIP"
                     /gene_synonym="B37; C21orf120; C21orf62; CU062; PRED81"
                     /inference="alignment:Splign:2.1.0"
     exon            269..4081
                     /gene="EPCIP"
                     /gene_synonym="B37; C21orf120; C21orf62; CU062; PRED81"
                     /inference="alignment:Splign:2.1.0"
     CDS             333..992
                     /gene="EPCIP"
                     /gene_synonym="B37; C21orf120; C21orf62; CU062; PRED81"
                     /note="uncharacterized protein C21orf62;
                     polycystin-1-interacting protein 1"
                     /codon_start=1
                     /product="exosomal polycystin-1-interacting protein
                     precursor"
                     /protein_id="NP_001155967.2"
                     /db_xref="CCDS:CCDS42919.2"
                     /db_xref="GeneID:56245"
                     /db_xref="HGNC:HGNC:1305"
                     /translation="MAPPSRHCLLLISTLGVFALNCFTKGQKNSTLIFTRENTIRNCS
                     CSADIRDCDYSLANLMCNCKTVLPLAVERTSYNGHLTIWFTDTSALGHLLNFTLVQDL
                     KLSLCSTNTLPTEYLAICGLKRLRINMEAKHPFPEQSLLIHSGGDSDSREKPMWLHKG
                     WQPCMYISFLDMALFNRDSALKSYSIENVTSIANNFPDFSYFRTFPMPSNKSYVVTFI
                     Y"
     regulatory      4061..4066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPCIP"
                     /gene_synonym="B37; C21orf120; C21orf62; CU062; PRED81"
                     /note="hexamer: AATAAA"
     polyA_site      4081
                     /gene="EPCIP"
                     /gene_synonym="B37; C21orf120; C21orf62; CU062; PRED81"
                     /note="major polyA site"
ORIGIN      
        1 attccaccct ggcttgcaga ttaaaccagc tgtcaagcca gggtgaagga tccgtggcca
       61 ggcagaggtc tgtggagtgg agaggcgagg cctcacggtg gaactctcag atgacagcat
      121 gcaggcacca agagagtgga cgcacataca gaagacagcc atgcactgag ctggggacat
      181 gcaacaataa caggccatac aatgaaagtc gctgaagaag aatatgaatt ttgcctgcgg
      241 atttgctaac actcgacaat cctaggaggt gagttccaac aaattggttc aaaaagaggg
      301 gggataaaca cgctggccca tgctgggcaa gcatggcacc accttccagg cactgtcttc
      361 ttctgatcag cactctgggt gtctttgcac ttaactgctt caccaaaggt cagaagaaca
      421 gcacgctcat cttcacaagg gaaaacacca ttcggaactg cagctgttct gcggacatcc
      481 gggattgtga ctacagtttg gccaacctga tgtgcaactg taaaaccgtc ctgccccttg
      541 cagtagagcg aaccagctac aatggccatc tgaccatctg gttcacggac acatctgcgc
      601 tgggccacct gctgaacttc acgctggtcc aagacctgaa gctttccctg tgcagcacca
      661 acactctccc cactgaatac ctggctattt gtggtctgaa gaggctgcgc atcaacatgg
      721 aggccaagca tcccttccca gagcagagct tactcatcca tagcggtggg gacagtgact
      781 ccagagagaa gcccatgtgg ttacacaaag gctggcagcc atgtatgtat atctcattct
      841 tagatatggc tcttttcaac agggactcag ccttaaaatc atatagtatt gaaaacgtta
      901 ccagcattgc caacaacttt cctgactttt cttactttag aaccttccca atgccaagca
      961 acaaaagcta tgttgtcaca tttatttact agcataataa ctgtgtccag ctgcctggaa
     1021 ctttggcaaa tgatgaataa tttgcagaag gaatctggaa ataaggccgt gagataggta
     1081 tccctaccca caactgtgcc tctctccgca ggctccattt gcaacacagc cacacatacc
     1141 aataaccagc tctctgttct gctctgtgcc caactgcgag aacacttttg aaaaacaaaa
     1201 gaaaaagaaa ccaaaaaacc aacttgattc cgtccaggga catgtcttgg gagccagcta
     1261 ggcttggtct ctgcaactag aagcctgcag ggaaatgtcc cgtcagaaat ggagaaagca
     1321 atacacccta gagactgctt agtggagctc ctcctagaag gtgaccccca agaaacatat
     1381 cttctttcaa aatactgcct taattttttt ctgtttcatt ttgtgaaatt gcttggaatt
     1441 cccctaagta gagaataatc aatttcagag gtttggggac tatgagtttt ataaaatggt
     1501 cgggcacagt ggctcacacc tgtaatccca gcactttggg aggccgaggc gggcggatca
     1561 cctgaggtcg ggagttcaag accagcctga ccaacatgga gaaaccccat ctctactaaa
     1621 aatacaaaat tagccgggca tggtggcaca tgcctgtaat cccagctact cggaggctga
     1681 gcaggagaat cgcttgaacc tgggaggcgg aggttgcagt gagccaaaat cgtgccactg
     1741 cactctacac tccagcctgg gtgacagagt cagagatcac accattgcac tccagcctgg
     1801 gcaacaagag cgaaactcca tctcaaaaaa aaaaaaaata ataataataa aatgattagg
     1861 ttctcttaaa ctgatctttt ctaaatacct tgctaagaat agatgcacca agaaataaga
     1921 ggttggagac tgtgtttgtt ggggtggagg taccacaggc atggataggg taagacctta
     1981 ggatcaaatg gggggaccag tgttccagag agagggatgc agcagtgaaa attggaggac
     2041 acaaaacaca tttgcatcta tctcaaaatt ttgcttagag cacagcctaa ctgcaaggaa
     2101 agttcttcac ttctagcctt tcacattctt ttccttttct ttctttgcat ggtctgtctt
     2161 tgcccctgct ataccatttc accaatttct cttctcattt tcatcttctt tctcctactc
     2221 cttttcctct tgctccaaaa atcagaactt agatgaatac cattcaagct atgtttaact
     2281 acattagggg ctagcctggg aatttactca ccacttacaa cattatttct attgttaaaa
     2341 gtgctcaaat tattaacaga taattaacaa aaaaacatct aaggctcaat ccatttggaa
     2401 ggttaagatt gcaaagtgaa ggcattttat atgacacggt taacacaaaa tgattttatg
     2461 tgtgctgata aaaggaacca aagcaacata cttttgaaaa aattaaatgg attcattatt
     2521 gtacaaagaa aattttccct catagagacg caacttgcca ttaaagtgga ctgtaaagaa
     2581 tccatggctt gggaggccga ggcaggcgga tcacctgagg tcgggagttc gagaccagcc
     2641 tgaccaacat ggagaaaccc tgtctctact aaaaatacaa aataagccag gcgtggtggt
     2701 gcatgcctgt aatcccagct actcaggagg ctgaggcagg agagtcactt gaacctggga
     2761 ggcggaggtt gcagtgagcc aagattgcgc cactgcactc cagcctgggc aacaagagca
     2821 aaactccatc tcaaaaaaaa aaaaagaaaa gaaaaaagaa tccactgcaa ttgtgataca
     2881 aatgtctaaa cctggagtgg aatgaatttg aaacattatt gcattcatga taccataatg
     2941 ataagaaata gtccatgact taacaggata tcctggggtt gatgacttta gatcacatac
     3001 atcacttttt tttttttttc acttaacctt aacatagagt aactgaaata atctgcaatt
     3061 tctacatttg cttaattggt gggggattta gccattcagg ctaattagca tgagcccatg
     3121 tcagtgttta aattaggcca aaacaaagac caaagtatga attttaatag aaaaatgtga
     3181 cctcattact gacattgtac tgcagataat gttaaagtga aagaaaaaat aaggaaaagg
     3241 ggaaaaagga ggaaaaagga aagcaagaaa agacaagtga aaagattagt aatatattca
     3301 ttgtcattag ttactgaaaa tataacaaat tgaattttaa taatttttat taataaagta
     3361 taaaattaaa tgatgataga aagtatatgc ctcctataaa tatcttccat ttggtagctt
     3421 ttaatagttt caaagccctt tcacatatgt tttaagtaag tcttttgaga aatacttgtg
     3481 agttaatggg acttaaacca acagaaaagg aaagctaatt tagttataaa tcaagcctga
     3541 ggtttcagat ttctggacta aaaatatggt tcagtttgtg ctgctgtggg atgaagaatg
     3601 ggcagagaaa atccacagtg caggcatggg gattaatggc atttggcact tagctgcagg
     3661 gtttggggga caacagggag tggtgggatg gtggttaagt aagggtgcat gccccacctg
     3721 aagctctaca gtggctcagc tccaactgag tgttgccatg ggaaaatctg atggggccag
     3781 atctgatcct tcagagaatg aggaattcca ggttgttatg tgaattctca caatttgtaa
     3841 atgtcggctt gccattcagc ttttttgttt gtttgtttta aataatatca tgtgggtcaa
     3901 acaaactatg ttaatggtag ccatctggcc tggggctagt agcttattgc ctctggccag
     3961 tggtgtgcta acaaaagttt aaccagcagc tctccaacaa aaaagggagg tgggctgctc
     4021 tgcctatgca gtagccatgc ttttattcct ttactttgtt aataaacttg ctttcacttt
     4081 a
//
