LOCUS       NP_001155967             219 aa            linear   PRI 14-APR-2024
DEFINITION  exosomal polycystin-1-interacting protein precursor [Homo sapiens].
ACCESSION   NP_001155967
VERSION     NP_001155967.2
DBSOURCE    REFSEQ: accession NM_001162495.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 219)
  AUTHORS   Lea,W.A., Winklhofer,T., Zelenchuk,L., Sharma,M.,
            Rossol-Allison,J., Fields,T.A., Reif,G., Calvet,J.P.,
            Bakeberg,J.L., Wallace,D.P. and Ward,C.J.
  TITLE     Polycystin-1 Interacting Protein-1 (CU062) Interacts with the
            Ectodomain of Polycystin-1 (PC1)
  JOURNAL   Cells 12 (17), 2166 (2023)
   PUBMED   37681898
  REMARK    GeneRIF: Polycystin-1 Interacting Protein-1 (CU062) Interacts with
            the Ectodomain of Polycystin-1 (PC1).
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 219)
  AUTHORS   Kang,T.W., Kim,H.J., Ju,H., Kim,J.H., Jeon,Y.J., Lee,H.C.,
            Kim,K.K., Kim,J.W., Lee,S., Kim,J.Y., Kim,S.Y. and Kim,Y.S.
  TITLE     Genome-wide association of serum bilirubin levels in Korean
            population
  JOURNAL   Hum Mol Genet 19 (18), 3672-3678 (2010)
   PUBMED   20639394
REFERENCE   3  (residues 1 to 219)
  AUTHORS   Denoeud,F., Kapranov,P., Ucla,C., Frankish,A., Castelo,R.,
            Drenkow,J., Lagarde,J., Alioto,T., Manzano,C., Chrast,J., Dike,S.,
            Wyss,C., Henrichsen,C.N., Holroyd,N., Dickson,M.C., Taylor,R.,
            Hance,Z., Foissac,S., Myers,R.M., Rogers,J., Hubbard,T., Harrow,J.,
            Guigo,R., Gingeras,T.R., Antonarakis,S.E. and Reymond,A.
  TITLE     Prominent use of distal 5' transcription start sites and discovery
            of a large number of additional exons in ENCODE regions
  JOURNAL   Genome Res 17 (6), 746-759 (2007)
   PUBMED   17567994
REFERENCE   4  (residues 1 to 219)
  AUTHORS   Gardiner,K., Slavov,D., Bechtel,L. and Davisson,M.
  TITLE     Annotation of human chromosome 21 for relevance to Down syndrome:
            gene structure and expression analysis
  JOURNAL   Genomics 79 (6), 833-843 (2002)
   PUBMED   12036298
REFERENCE   5  (residues 1 to 219)
  AUTHORS   Slavov,D., Hattori,M., Sakaki,Y., Rosenthal,A., Shimizu,N.,
            Minoshima,S., Kudoh,J., Yaspo,M.L., Ramser,J., Reinhardt,R.,
            Reimer,C., Clancy,K., Rynditch,A. and Gardiner,K.
  TITLE     Criteria for gene identification and features of genome
            organization: analysis of 6.5 Mb of DNA sequence from human
            chromosome 21
  JOURNAL   Gene 247 (1-2), 215-232 (2000)
   PUBMED   10773462
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ656042.2, BC069779.1, BC069689.1, AP000280.3 and BE466137.1.
            
            On Jul 30, 2009 this sequence version replaced NP_001155967.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069779.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMEA2145774
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000479548.2/ ENSP00000418653.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..219
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     Protein         1..219
                     /product="exosomal polycystin-1-interacting protein
                     precursor"
                     /note="uncharacterized protein C21orf62;
                     polycystin-1-interacting protein 1"
                     /calculated_mol_wt=22079
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2790
     Region          2..219
                     /region_name="DUF4571"
                     /note="Domain of unknown function (DUF4571); pfam15137"
                     /db_xref="CDD:464523"
     CDS             1..219
                     /gene="EPCIP"
                     /gene_synonym="B37; C21orf120; C21orf62; CU062; PRED81"
                     /coded_by="NM_001162495.3:333..992"
                     /db_xref="CCDS:CCDS42919.2"
                     /db_xref="GeneID:56245"
                     /db_xref="HGNC:HGNC:1305"
ORIGIN      
        1 mappsrhcll listlgvfal ncftkgqkns tliftrenti rncscsadir dcdyslanlm
       61 cncktvlpla vertsynghl tiwftdtsal ghllnftlvq dlklslcstn tlpteylaic
      121 glkrlrinme akhpfpeqsl lihsggdsds rekpmwlhkg wqpcmyisfl dmalfnrdsa
      181 lksysienvt siannfpdfs yfrtfpmpsn ksyvvtfiy
//
