LOCUS       NM_002354               1547 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens epithelial cell adhesion molecule (EPCAM), mRNA.
ACCESSION   NM_002354
VERSION     NM_002354.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1547)
  AUTHORS   Mule,P., Fernandez-Perez,D., Amato,S., Manganaro,D., Oldani,P.,
            Brandini,S., Diaferia,G., Cuomo,A., Recordati,C., Soriani,C.,
            Dondi,A., Zanotti,M., Rustichelli,S., Bisso,A., Pece,S.,
            Rodighiero,S., Natoli,G., Amati,B., Ferrari,K.J., Chiacchiera,F.
            and Pasini,D.
  TITLE     WNT Oncogenic Transcription Requires MYC Suppression of Lysosomal
            Activity and EPCAM Stabilization in Gastric Tumors
  JOURNAL   Gastroenterology 167 (5), 903-918 (2024)
   PUBMED   38971196
  REMARK    GeneRIF: WNT Oncogenic Transcription Requires MYC Suppression of
            Lysosomal Activity and EPCAM Stabilization in Gastric Tumors.
REFERENCE   2  (bases 1 to 1547)
  AUTHORS   Belmonte,B., Di Lorenzo,G., Mangogna,A., Bortot,B., Bertolazzi,G.,
            Sammataro,S., Merighi,S., Martorana,A., Zito,G., Romano,F.,
            Giorgiutti,A., Bottin,C., Zanconati,F., Romano,A., Ricci,G. and
            Biffi,S.
  TITLE     PARP-1, EpCAM, and FRalpha as potential targets for intraoperative
            detection and delineation of endometriosis: a quantitative tissue
            expression analysis
  JOURNAL   Reprod Biol Endocrinol 22 (1), 92 (2024)
   PUBMED   39085882
  REMARK    GeneRIF: PARP-1, EpCAM, and FRalpha as potential targets for
            intraoperative detection and delineation of endometriosis: a
            quantitative tissue expression analysis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1547)
  AUTHORS   Panda,S.S., Lee,C.C., Geevimaan,K., Chen,K.C., Yang,S.H.,
            Shen,C.N., HuangFu,W.C. and Wu,H.C.
  TITLE     Intracellular domain of epithelial cell adhesion molecule induces
            Wnt receptor transcription to promote colorectal cancer progression
  JOURNAL   J Biomed Sci 31 (1), 72 (2024)
   PUBMED   39010070
  REMARK    GeneRIF: Intracellular domain of epithelial cell adhesion molecule
            induces Wnt receptor transcription to promote colorectal cancer
            progression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1547)
  AUTHORS   Kanahori,M., Shimada,E., Matsumoto,Y., Endo,M., Fujiwara,T.,
            Nabeshima,A., Hirose,T., Kawaguchi,K., Oyama,R., Oda,Y. and
            Nakashima,Y.
  TITLE     Immune evasion in lung metastasis of leiomyosarcoma: upregulation
            of EPCAM inhibits CD8+ T cell infiltration
  JOURNAL   Br J Cancer 130 (7), 1083-1095 (2024)
   PUBMED   38291183
  REMARK    GeneRIF: Immune evasion in lung metastasis of leiomyosarcoma:
            upregulation of EPCAM inhibits CD8[+] T cell infiltration.
REFERENCE   5  (bases 1 to 1547)
  AUTHORS   Hafez,F.S., Shakweer,M.M., Sabry,D., Tawfik,A.M., El-Beah,S.M.,
            Elsheshtawy,N.M., Shash,L.S., Salama,D.E.A. and Gaballah,A.
  TITLE     TLR4, IgA and EpCAM Expression in Colorectal Cancer and Their
            Possible Association with Microbiota as a Pathogenic Factor; An
            Immunohistochemical and Genetic Study
  JOURNAL   Asian Pac J Cancer Prev 25 (2), 627-636 (2024)
   PUBMED   38415550
  REMARK    GeneRIF: TLR4, IgA and EpCAM Expression in Colorectal Cancer and
            Their Possible Association with Microbiota as a Pathogenic Factor;
            An Immunohistochemical and Genetic Study.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1547)
  AUTHORS   Idos,G. and Valle,L.
  TITLE     Lynch Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301390
REFERENCE   7  (bases 1 to 1547)
  AUTHORS   Szala,S., Froehlich,M., Scollon,M., Kasai,Y., Steplewski,Z.,
            Koprowski,H. and Linnenbach,A.J.
  TITLE     Molecular cloning of cDNA for the carcinoma-associated antigen
            GA733-2
  JOURNAL   Proc Natl Acad Sci U S A 87 (9), 3542-3546 (1990)
   PUBMED   2333300
REFERENCE   8  (bases 1 to 1547)
  AUTHORS   Simon,B., Podolsky,D.K., Moldenhauer,G., Isselbacher,K.J.,
            Gattoni-Celli,S. and Brand,S.J.
  TITLE     Epithelial glycoprotein is a member of a family of epithelial cell
            surface antigens homologous to nidogen, a matrix adhesion protein
  JOURNAL   Proc Natl Acad Sci U S A 87 (7), 2755-2759 (1990)
   PUBMED   2108441
REFERENCE   9  (bases 1 to 1547)
  AUTHORS   Perez,M.S. and Walker,L.E.
  TITLE     Isolation and characterization of a cDNA encoding the KS1/4
            epithelial carcinoma marker
  JOURNAL   J Immunol 142 (10), 3662-3667 (1989)
   PUBMED   2469722
REFERENCE   10 (bases 1 to 1547)
  AUTHORS   Strnad,J., Hamilton,A.E., Beavers,L.S., Gamboa,G.C., Apelgren,L.D.,
            Taber,L.D., Sportsman,J.R., Bumol,T.F., Sharp,J.D. and Gadski,R.A.
  TITLE     Molecular cloning and characterization of a human
            adenocarcinoma/epithelial cell surface antigen complementary DNA
  JOURNAL   Cancer Res 49 (2), 314-317 (1989)
   PUBMED   2463074
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP262680.1, BC014785.1,
            DA963872.1 and AW050533.1.
            
            On Aug 31, 2019 this sequence version replaced NM_002354.2.
            
            Summary: This gene encodes a carcinoma-associated antigen and is a
            member of a family that includes at least two type I membrane
            proteins. This antigen is expressed on most normal epithelial cells
            and gastrointestinal carcinomas and functions as a homotypic
            calcium-independent cell adhesion molecule. The antigen is being
            used as a target for immunotherapy treatment of human carcinomas.
            Mutations in this gene result in congenital tufting enteropathy.
            [provided by RefSeq, Dec 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026585.1, M26481.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263735.9/ ENSP00000263735.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BP262680.1         160-172
            14-538              BC014785.1         1-525
            539-539             DA963872.1         539-539
            540-1334            BC014785.1         527-1321
            1335-1547           AW050533.1         22-234              c
FEATURES             Location/Qualifiers
     source          1..1547
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p21"
     gene            1..1547
                     /gene="EPCAM"
                     /gene_synonym="Ber-Ep4; BerEp4; DIAR5; EGP-2; EGP314;
                     EGP40; ESA; HNPCC8; KS1/4; KSA; LYNCH8; M4S1; MIC18; MK-1;
                     MOC-31; TACSTD1; TROP1"
                     /note="epithelial cell adhesion molecule"
                     /db_xref="GeneID:4072"
                     /db_xref="HGNC:HGNC:11529"
                     /db_xref="MIM:185535"
     exon            1..271
                     /gene="EPCAM"
                     /gene_synonym="Ber-Ep4; BerEp4; DIAR5; EGP-2; EGP314;
                     EGP40; ESA; HNPCC8; KS1/4; KSA; LYNCH8; M4S1; MIC18; MK-1;
                     MOC-31; TACSTD1; TROP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1140
                     /gene="EPCAM"
                     /gene_synonym="Ber-Ep4; BerEp4; DIAR5; EGP-2; EGP314;
                     EGP40; ESA; HNPCC8; KS1/4; KSA; LYNCH8; M4S1; MIC18; MK-1;
                     MOC-31; TACSTD1; TROP1"
                     /note="tumor-associated calcium signal transducer 1; human
                     epithelial glycoprotein-2; adenocarcinoma-associated
                     antigen; trophoblast cell surface antigen 1; membrane
                     component, chromosome 4, surface marker (35kD
                     glycoprotein); epithelial glycoprotein 314; cell surface
                     glycoprotein Trop-1; major gastrointestinal
                     tumor-associated protein GA733-2"
                     /codon_start=1
                     /product="epithelial cell adhesion molecule precursor"
                     /protein_id="NP_002345.2"
                     /db_xref="CCDS:CCDS1833.1"
                     /db_xref="GeneID:4072"
                     /db_xref="HGNC:HGNC:11529"
                     /db_xref="MIM:185535"
                     /translation="MAPPQVLAFGLLLAAATATFAAAQEECVCENYKLAVNCFVNNNR
                     QCQCTSVGAQNTVICSKLAAKCLVMKAEMNGSKLGRRAKPEGALQNNDGLYDPDCDES
                     GLFKAKQCNGTSMCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKAREKPYDSK
                     SLRTALQKEITTRYQLDPKFITSILYENNVITIDLVQNSSQKTQNDVDIADVAYYFEK
                     DVKGESLFHSKKMDLTVNGEQLDLDPGQTLIYYVDEKAPEFSMQGLKAGVIAVIVVVV
                     IAVVAGIVVLVISRKKRMAKYEKAEIKEMGEMHRELNA"
     exon            272..379
                     /gene="EPCAM"
                     /gene_synonym="Ber-Ep4; BerEp4; DIAR5; EGP-2; EGP314;
                     EGP40; ESA; HNPCC8; KS1/4; KSA; LYNCH8; M4S1; MIC18; MK-1;
                     MOC-31; TACSTD1; TROP1"
                     /inference="alignment:Splign:2.1.0"
     exon            380..620
                     /gene="EPCAM"
                     /gene_synonym="Ber-Ep4; BerEp4; DIAR5; EGP-2; EGP314;
                     EGP40; ESA; HNPCC8; KS1/4; KSA; LYNCH8; M4S1; MIC18; MK-1;
                     MOC-31; TACSTD1; TROP1"
                     /inference="alignment:Splign:2.1.0"
     exon            621..686
                     /gene="EPCAM"
                     /gene_synonym="Ber-Ep4; BerEp4; DIAR5; EGP-2; EGP314;
                     EGP40; ESA; HNPCC8; KS1/4; KSA; LYNCH8; M4S1; MIC18; MK-1;
                     MOC-31; TACSTD1; TROP1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..750
                     /gene="EPCAM"
                     /gene_synonym="Ber-Ep4; BerEp4; DIAR5; EGP-2; EGP314;
                     EGP40; ESA; HNPCC8; KS1/4; KSA; LYNCH8; M4S1; MIC18; MK-1;
                     MOC-31; TACSTD1; TROP1"
                     /inference="alignment:Splign:2.1.0"
     exon            751..852
                     /gene="EPCAM"
                     /gene_synonym="Ber-Ep4; BerEp4; DIAR5; EGP-2; EGP314;
                     EGP40; ESA; HNPCC8; KS1/4; KSA; LYNCH8; M4S1; MIC18; MK-1;
                     MOC-31; TACSTD1; TROP1"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1053
                     /gene="EPCAM"
                     /gene_synonym="Ber-Ep4; BerEp4; DIAR5; EGP-2; EGP314;
                     EGP40; ESA; HNPCC8; KS1/4; KSA; LYNCH8; M4S1; MIC18; MK-1;
                     MOC-31; TACSTD1; TROP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1098
                     /gene="EPCAM"
                     /gene_synonym="Ber-Ep4; BerEp4; DIAR5; EGP-2; EGP314;
                     EGP40; ESA; HNPCC8; KS1/4; KSA; LYNCH8; M4S1; MIC18; MK-1;
                     MOC-31; TACSTD1; TROP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1547
                     /gene="EPCAM"
                     /gene_synonym="Ber-Ep4; BerEp4; DIAR5; EGP-2; EGP314;
                     EGP40; ESA; HNPCC8; KS1/4; KSA; LYNCH8; M4S1; MIC18; MK-1;
                     MOC-31; TACSTD1; TROP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1422..1427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPCAM"
                     /gene_synonym="Ber-Ep4; BerEp4; DIAR5; EGP-2; EGP314;
                     EGP40; ESA; HNPCC8; KS1/4; KSA; LYNCH8; M4S1; MIC18; MK-1;
                     MOC-31; TACSTD1; TROP1"
                     /note="hexamer: ATTAAA"
     polyA_site      1458
                     /gene="EPCAM"
                     /gene_synonym="Ber-Ep4; BerEp4; DIAR5; EGP-2; EGP314;
                     EGP40; ESA; HNPCC8; KS1/4; KSA; LYNCH8; M4S1; MIC18; MK-1;
                     MOC-31; TACSTD1; TROP1"
     regulatory      1527..1532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPCAM"
                     /gene_synonym="Ber-Ep4; BerEp4; DIAR5; EGP-2; EGP314;
                     EGP40; ESA; HNPCC8; KS1/4; KSA; LYNCH8; M4S1; MIC18; MK-1;
                     MOC-31; TACSTD1; TROP1"
                     /note="hexamer: AATAAA"
     polyA_site      1547
                     /gene="EPCAM"
                     /gene_synonym="Ber-Ep4; BerEp4; DIAR5; EGP-2; EGP314;
                     EGP40; ESA; HNPCC8; KS1/4; KSA; LYNCH8; M4S1; MIC18; MK-1;
                     MOC-31; TACSTD1; TROP1"
                     /note="major polyA site"
ORIGIN      
        1 acagagcgct agtccttcgg cgagcgagca ccttcgacgc ggtccgggga ccccctcgtc
       61 gctgtcctcc cgacgcggac ccgcgtgccc caggcctcgc gctgcccggc cggctcctcg
      121 tgtcccactc ccggcgcacg ccctcccgcg agtcccgggc ccctcccgcg cccctcttct
      181 cggcgcgcgc gcagcatggc gcccccgcag gtcctcgcgt tcgggcttct gcttgccgcg
      241 gcgacggcga cttttgccgc agctcaggaa gaatgtgtct gtgaaaacta caagctggcc
      301 gtaaactgct ttgtgaataa taatcgtcaa tgccagtgta cttcagttgg tgcacaaaat
      361 actgtcattt gctcaaagct ggctgccaaa tgtttggtga tgaaggcaga aatgaatggc
      421 tcaaaacttg ggagaagagc aaaacctgaa ggggccctcc agaacaatga tgggctttat
      481 gatcctgact gcgatgagag cgggctcttt aaggccaagc agtgcaacgg cacctccatg
      541 tgctggtgtg tgaacactgc tggggtcaga agaacagaca aggacactga aataacctgc
      601 tctgagcgag tgagaaccta ctggatcatc attgaactaa aacacaaagc aagagaaaaa
      661 ccttatgata gtaaaagttt gcggactgca cttcagaagg agatcacaac gcgttatcaa
      721 ctggatccaa aatttatcac gagtattttg tatgagaata atgttatcac tattgatctg
      781 gttcaaaatt cttctcaaaa aactcagaat gatgtggaca tagctgatgt ggcttattat
      841 tttgaaaaag atgttaaagg tgaatccttg tttcattcta agaaaatgga cctgacagta
      901 aatggggaac aactggatct ggatcctggt caaactttaa tttattatgt tgatgaaaaa
      961 gcacctgaat tctcaatgca gggtctaaaa gctggtgtta ttgctgttat tgtggttgtg
     1021 gtgatagcag ttgttgctgg aattgttgtg ctggttattt ccagaaagaa gagaatggca
     1081 aagtatgaga aggctgagat aaaggagatg ggtgagatgc atagggaact caatgcataa
     1141 ctatataatt tgaagattat agaagaaggg aaatagcaaa tggacacaaa ttacaaatgt
     1201 gtgtgcgtgg gacgaagaca tctttgaagg tcatgagttt gttagtttaa catcatatat
     1261 ttgtaatagt gaaacctgta ctcaaaatat aagcagcttg aaactggctt taccaatctt
     1321 gaaatttgac cacaagtgtc ttatatatgc agatctaatg taaaatccag aacttggact
     1381 ccatcgttaa aattatttat gtgtaacatt caaatgtgtg cattaaatat gcttccacag
     1441 taaaatctga aaaactgatt tgtgattgaa agctgccttt ctatttactt gagtcttgta
     1501 catacatact tttttatgag ctatgaaata aaacatttta aactgaa
//
