LOCUS       NM_015630               3883 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens enhancer of polycomb homolog 2 (EPC2), mRNA.
ACCESSION   NM_015630
VERSION     NM_015630.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3883)
  AUTHORS   Jacquet,K., Fradet-Turcotte,A., Avvakumov,N., Lambert,J.P.,
            Roques,C., Pandita,R.K., Paquet,E., Herst,P., Gingras,A.C.,
            Pandita,T.K., Legube,G., Doyon,Y., Durocher,D. and Cote,J.
  TITLE     The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1
            through Direct H4K20me Binding and H2AK15 Acetylation
  JOURNAL   Mol Cell 62 (3), 409-421 (2016)
   PUBMED   27153538
REFERENCE   2  (bases 1 to 3883)
  AUTHORS   Huang,X., Spencer,G.J., Lynch,J.T., Ciceri,F., Somerville,T.D. and
            Somervaille,T.C.
  TITLE     Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential
            of MLL leukemia stem cells
  JOURNAL   Leukemia 28 (5), 1081-1091 (2014)
   PUBMED   24166297
  REMARK    GeneRIF: EPC1 and EPC2 are components of a complex that directly or
            indirectly serves to prevent MYC accumulation and AML cell
            apoptosis, thus sustaining oncogenic potential
REFERENCE   3  (bases 1 to 3883)
  AUTHORS   Kim,S., Swaminathan,S., Shen,L., Risacher,S.L., Nho,K., Foroud,T.,
            Shaw,L.M., Trojanowski,J.Q., Potkin,S.G., Huentelman,M.J.,
            Craig,D.W., DeChairo,B.M., Aisen,P.S., Petersen,R.C., Weiner,M.W.
            and Saykin,A.J.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     Genome-wide association study of CSF biomarkers Abeta1-42, t-tau,
            and p-tau181p in the ADNI cohort
  JOURNAL   Neurology 76 (1), 69-79 (2011)
   PUBMED   21123754
REFERENCE   4  (bases 1 to 3883)
  AUTHORS   Melzer,D., Perry,J.R., Hernandez,D., Corsi,A.M., Stevens,K.,
            Rafferty,I., Lauretani,F., Murray,A., Gibbs,J.R., Paolisso,G.,
            Rafiq,S., Simon-Sanchez,J., Lango,H., Scholz,S., Weedon,M.N.,
            Arepalli,S., Rice,N., Washecka,N., Hurst,A., Britton,A., Henley,W.,
            van de Leemput,J., Li,R., Newman,A.B., Tranah,G., Harris,T.,
            Panicker,V., Dayan,C., Bennett,A., McCarthy,M.I., Ruokonen,A.,
            Jarvelin,M.R., Guralnik,J., Bandinelli,S., Frayling,T.M.,
            Singleton,A. and Ferrucci,L.
  TITLE     A genome-wide association study identifies protein quantitative
            trait loci (pQTLs)
  JOURNAL   PLoS Genet 4 (5), e1000072 (2008)
   PUBMED   18464913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3883)
  AUTHORS   Jarjanazi,H., Kiefer,J., Savas,S., Briollais,L., Tuzmen,S.,
            Pabalan,N., Ibrahim-Zada,I., Mousses,S. and Ozcelik,H.
  TITLE     Discovery of genetic profiles impacting response to chemotherapy:
            application to gemcitabine
  JOURNAL   Hum Mutat 29 (4), 461-467 (2008)
   PUBMED   18330920
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 3883)
  AUTHORS   Cai,Y., Jin,J., Florens,L., Swanson,S.K., Kusch,T., Li,B.,
            Workman,J.L., Washburn,M.P., Conaway,R.C. and Conaway,J.W.
  TITLE     The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60
            histone acetyltransferase and SRCAP complexes
  JOURNAL   J Biol Chem 280 (14), 13665-13670 (2005)
   PUBMED   15647280
REFERENCE   7  (bases 1 to 3883)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC017080.8, AK125789.1 and AC016763.8.
            
            On Nov 23, 2018 this sequence version replaced NM_015630.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF286904.1, SRR1803616.9717.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258484.11/ ENSP00000258484.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               AC017080.8         73268-73507         c
            241-3399            AK125789.1         70-3228
            3400-3881           AK125789.1         3230-3711
            3882-3883           AC016763.8         73772-73773         c
FEATURES             Location/Qualifiers
     source          1..3883
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q23.1"
     gene            1..3883
                     /gene="EPC2"
                     /gene_synonym="EPC-LIKE"
                     /note="enhancer of polycomb homolog 2"
                     /db_xref="GeneID:26122"
                     /db_xref="HGNC:HGNC:24543"
                     /db_xref="MIM:611000"
     exon            1..420
                     /gene="EPC2"
                     /gene_synonym="EPC-LIKE"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..2691
                     /gene="EPC2"
                     /gene_synonym="EPC-LIKE"
                     /codon_start=1
                     /product="enhancer of polycomb homolog 2"
                     /protein_id="NP_056445.3"
                     /db_xref="CCDS:CCDS46422.1"
                     /db_xref="GeneID:26122"
                     /db_xref="HGNC:HGNC:24543"
                     /db_xref="MIM:611000"
                     /translation="MSKLSFRARALDAAKPLPIYRGKDMPDLNDCVSINRAVPQMPTG
                     MEKEEESEHHLQRAISAQQVFREKKESMVIPVPEAESNVNYYNRLYKGEFKQPKQFIH
                     IQPFNLDNEQPDYDMDSEDETLLNRLNRKMEIKPLQFEIMIDRLEKASSNQLVTLQEA
                     KLLLNEDDYLIKAVYDYWVRKRKNCRGPSLIPQIKQEKRDGSTNNDPYVAFRRRTEKM
                     QTRKNRKNDEASYEKMLKLRREFSRAITILEMIKRREKTKRELLHLTLEVVEKRYHLG
                     DYGGEILNEVKISRSEKELYATPATLHNGNHHKVQECKTKHPHHLSLKEEASDVVRQK
                     KKYPKKPKAEALITSQQPTPETLPVINKSDIKQYDFHSSDEDEFPQVLSPVSEPEEEN
                     DPDGPCAFRRRAGCQYYAPRLDQANHSCENSELADLDKLRYRHCLTTLTVPRRCIGFA
                     RRRIGRGGRVIMDRISTEHDPVLKQIDPEMLNSFSSSSQTIDFSSNFSRTNASSKHCE
                     NRLSLSEILSNIRSCRLQCFQPRLLNLQDSDSEECTSRKPGQTVNNKRVSAASVALLN
                     TSKNGISVTGGITEEQFQTHQQQLVQMQRQQLAQLQQKQQSQHSSQQTHPKAQGSSTS
                     DCMSKTLDSASAHFAASAVVSAPVPSRSEVAKEQNTGHNNINGVVQPSGTSKTLYSTN
                     MALSSSPGISAVQLVRTVGHTTTNHLIPALCTSSPQTLPMNNSCLTNAVHLNNVSVVS
                     PVNVHINTRTSAPSPTALKLATVAASMDRVPKVTPSSAISSIARENHEPERLGLNGIA
                     ETTVAMEVT"
     exon            421..580
                     /gene="EPC2"
                     /gene_synonym="EPC-LIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            581..726
                     /gene="EPC2"
                     /gene_synonym="EPC-LIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            727..933
                     /gene="EPC2"
                     /gene_synonym="EPC-LIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1082
                     /gene="EPC2"
                     /gene_synonym="EPC-LIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1215
                     /gene="EPC2"
                     /gene_synonym="EPC-LIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1407
                     /gene="EPC2"
                     /gene_synonym="EPC-LIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1497
                     /gene="EPC2"
                     /gene_synonym="EPC-LIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1643
                     /gene="EPC2"
                     /gene_synonym="EPC-LIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1987
                     /gene="EPC2"
                     /gene_synonym="EPC-LIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2124
                     /gene="EPC2"
                     /gene_synonym="EPC-LIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2284
                     /gene="EPC2"
                     /gene_synonym="EPC-LIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2618
                     /gene="EPC2"
                     /gene_synonym="EPC-LIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            2619..3883
                     /gene="EPC2"
                     /gene_synonym="EPC-LIKE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3074..3079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPC2"
                     /gene_synonym="EPC-LIKE"
                     /note="hexamer: AATAAA"
     polyA_site      3099
                     /gene="EPC2"
                     /gene_synonym="EPC-LIKE"
     regulatory      3859..3864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPC2"
                     /gene_synonym="EPC-LIKE"
                     /note="hexamer: AATAAA"
     polyA_site      3883
                     /gene="EPC2"
                     /gene_synonym="EPC-LIKE"
                     /note="major polyA site"
ORIGIN      
        1 ggtaatgtcc gccatgttgg ccatggcgca gggagcggat cgggcgggcg agcggcggat
       61 ctagtgtgtg gaggcggccg cgggcgcggg gggctgtttt cgggcggggt gggcgcccat
      121 gctgtggccg ggggcagtga ggaggaggag gagcgggccg gccgcgctgc actgaggaag
      181 gaggtggagg aggcggcggg agtcctcccc ccctccccgc ccgccccgcc gccgccgccc
      241 gggctgttcc tgtaaggcgg ggagacaatg agtaaactct ccttccgagc gcgggcgctg
      301 gacgccgcca agccgctgcc tatctaccgc ggcaaggaca tgcctgatct caacgactgc
      361 gtctccatca accgggccgt gccccagatg cccaccggga tggagaagga ggaggaatcg
      421 gaacatcatt tacagcgagc aatttcagca cagcaagtgt ttagagaaaa aaaagagagt
      481 atggtcattc ctgttcctga ggcagagagc aacgtcaact attacaatcg cttgtacaaa
      541 ggagagttta aacagccaaa acagttcatt catattcagc cttttaatct agacaacgag
      601 caaccagatt atgatatgga ttcagaagat gagactttat taaatagact taacagaaag
      661 atggaaatta agcctttgca atttgaaatt atgattgaca gacttgaaaa agccagttct
      721 aatcagcttg taacacttca agaagcaaaa ctgctgctaa acgaagatga ttaccttatt
      781 aaagctgtat atgactactg ggtgagaaaa cgtaaaaact gcagggggcc atccctcatt
      841 cctcagataa aacaagagaa aagagatggc tctaccaaca atgaccctta tgttgccttt
      901 cggagaagaa cagagaaaat gcaaactcga aagaatcgta agaatgatga agcctcttat
      961 gaaaagatgt tgaaactgag acgagaattt agtagagcca taacaatttt ggaaatgatt
     1021 aagagaagag agaaaacaaa acgagaatta ttgcacttaa ccttagaagt tgtggagaaa
     1081 agataccatt tgggagacta tggtggtgaa atccttaatg aagtaaaaat cagtagatca
     1141 gaaaaagagt tatatgccac tccagcaact cttcataatg gaaatcatca caaagttcaa
     1201 gaatgtaaaa ctaagcaccc tcatcatttg tctttgaaag aagaggcttc tgatgtggtt
     1261 cgtcaaaaga agaagtaccc aaagaagcct aaagcagagg ctttgataac atctcagcaa
     1321 cccactcctg agacattgcc tgtgatcaat aagagtgaca ttaagcaata tgattttcac
     1381 agctcagatg aagatgaatt tccacaggta ttgtccccag tatcagaacc ggaagaagaa
     1441 aatgatcctg atggtccctg tgctttcaga aggcgggcag gatgccagta ttatgctcct
     1501 cgtttggacc aagctaacca ttcatgtgaa aattcagaat tggcagattt ggataagttg
     1561 aggtataggc attgccttac aacacttaca gtcccaagaa gatgtatagg atttgcaagg
     1621 aggcgaattg gcagaggtgg aagggtcata atggaccgaa tatccacaga acatgaccca
     1681 gtcctgaaac agatagaccc tgaaatgctg aatagttttt caagctcttc ccaaactata
     1741 gacttttctt ctaatttctc tcggaccaat gcttccagta aacattgtga aaatagactg
     1801 tctctttctg aaatattaag caatatcaga tcatgtcgac tacagtgttt ccagccaagg
     1861 ctactaaatt tacaggacag tgatagtgaa gaatgtacct caagaaaacc agggcagact
     1921 gtgaacaata aaagagtttc tgcagcatct gtagctttat tgaacaccag caagaatggc
     1981 atatcagtaa cagggggtat cacagaagag cagtttcaga cacatcagca gcagttagtt
     2041 cagatgcaaa ggcagcaact tgcccagctt cagcagaaac agcaatctca gcattcctcg
     2101 caacagacac atccaaaagc acagggctca agcacctctg actgtatgtc taaaacactt
     2161 gactcagcca gcgcccactt tgctgcatct gcagtggtca gtgcacctgt tccaagtcgc
     2221 agtgaggtag ccaaggaaca gaacactggc cacaacaaca taaacggtgt tgtccagcct
     2281 tcaggaacct ctaaaacatt atactccacc aatatggctt tatcatccag cccagggatt
     2341 tcagctgtac agcttgtaag gacagttggc cacaccacta caaaccactt aatcccagca
     2401 ttgtgcacaa gcagtcctca gacacttccc atgaacaatt cctgcctgac aaatgcagtg
     2461 cacctcaata atgtcagtgt tgtttctcca gtcaatgtgc atatcaatac acggacttca
     2521 gcaccatcgc caacagcctt aaaacttgcc acagttgctg ccagtatgga cagagtgcca
     2581 aaggttactc ccagcagtgc catcagcagc atagcaagag agaaccacga accagaaaga
     2641 ttgggcttaa atggaatagc agagacaaca gtagctatgg aagtgacata acctaaaaca
     2701 cgtggctctg acctgtgctg atggtgtgca gtcattcata ttccagctga atgcaaaagg
     2761 caacactctg tggatcacag agtgtaacaa tggacctaaa tggactatag tatattggat
     2821 gttaaatcca tatatgatgt atattttgta aaattgggaa aatcactacc ttgtaaaata
     2881 gtttatttgt atcatcaata ttatttctgt tacttgaata gtagatattc atcatcatgc
     2941 ttttgcactt gaatttgcaa ctgaatggat tttaaaaaat aattctttaa tgggatcatg
     3001 agcatgaaat gggatcctgc atcacttgtt ttaactattt attttgccat gtttacattt
     3061 tgtatcttgt aaaaataaat ccaactttgt gtctaaaaag ttaaagattc atagctagga
     3121 aatgaaattc ttgtaatttt tttctaaagg aactgtaaag ttttcacttg gttcattttg
     3181 tttcacaatt tgactagatg gactttttgg taaatacttt agtggcattt cactgtcaaa
     3241 tatgaagttc aaggcaaaat agtattttct attactgtgc aggggaaagg gatggatcga
     3301 tacatgcaaa tttaatgtag taactcactt ttccatatat tttgaatgta tatttctatt
     3361 tatgatacca atttataaaa aataattaca cagaaaaaat ggaataggaa aaattatgca
     3421 tctagcacat ttaaactgtg caaatatgaa aatttttcga ggattacatt ttatctgaag
     3481 gctgcatatt ttaactggct ttaaaactgt aacacatcac ataaaagata ctttaccagg
     3541 tatgtattgc attatatcat tgcaataatt attggaagtc tagatatcga gccatcccag
     3601 gtgttgggcg gggggagggt tgtggcaaga ttgtcttttc aattttggag agttttcctg
     3661 tggctacaag gcaagtaacg ggttggaaaa agtctgactg taagcgttgg acaccttcat
     3721 agtgtagtgt tttagtgact ttttttatac ggttcttgta aattagatac gtgtagtggt
     3781 gtttcagaat gtttgtttat gcactagttc agacaacttt ccctgttact tgttcttgat
     3841 aagtgaaaac tgcagggaaa taaaaaatac atatcaaaac atg
//
