LOCUS       NM_001272004            3997 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens enhancer of polycomb homolog 1 (EPC1), transcript
            variant 2, mRNA.
ACCESSION   NM_001272004
VERSION     NM_001272004.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3997)
  AUTHORS   Dai,Y., Chen,W., Huang,J., Zheng,L., Lin,Q., Cui,T. and Huang,C.
  TITLE     Multiomics Integrative Analysis Identifying EPC1 as a Prognostic
            Biomarker in Head and Neck Squamous Cell Carcinoma
  JOURNAL   Biomed Res Int 2022, 1074412 (2022)
   PUBMED   36158885
  REMARK    GeneRIF: Multiomics Integrative Analysis Identifying EPC1 as a
            Prognostic Biomarker in Head and Neck Squamous Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3997)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3997)
  AUTHORS   Zhang,H., Devoucoux,M., Song,X., Li,L., Ayaz,G., Cheng,H.,
            Tempel,W., Dong,C., Loppnau,P., Cote,J. and Min,J.
  TITLE     Structural Basis for EPC1-Mediated Recruitment of MBTD1 into the
            NuA4/TIP60 Acetyltransferase Complex
  JOURNAL   Cell Rep 30 (12), 3996-4002 (2020)
   PUBMED   32209463
  REMARK    GeneRIF: Structural Basis for EPC1-Mediated Recruitment of MBTD1
            into the NuA4/TIP60 Acetyltransferase Complex.
REFERENCE   4  (bases 1 to 3997)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3997)
  AUTHORS   Dong,Y., Isono,K.I., Ohbo,K., Endo,T.A., Ohara,O., Maekawa,M.,
            Toyama,Y., Ito,C., Toshimori,K., Helin,K., Ogonuki,N., Inoue,K.,
            Ogura,A., Yamagata,K., Kitabayashi,I. and Koseki,H.
  TITLE     EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis
            in Mice
  JOURNAL   Mol Cell Biol 37 (19), e00082-17 (2017)
   PUBMED   28694333
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3997)
  AUTHORS   Attwooll,C., Oddi,S., Cartwright,P., Prosperini,E., Agger,K.,
            Steensgaard,P., Wagener,C., Sardet,C., Moroni,M.C. and Helin,K.
  TITLE     A novel repressive E2F6 complex containing the polycomb group
            protein, EPC1, that interacts with EZH2 in a proliferation-specific
            manner
  JOURNAL   J Biol Chem 280 (2), 1199-1208 (2005)
   PUBMED   15536069
REFERENCE   7  (bases 1 to 3997)
  AUTHORS   Doyon,Y. and Cote,J.
  TITLE     The highly conserved and multifunctional NuA4 HAT complex
  JOURNAL   Curr Opin Genet Dev 14 (2), 147-154 (2004)
   PUBMED   15196461
  REMARK    Review article
REFERENCE   8  (bases 1 to 3997)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
REFERENCE   9  (bases 1 to 3997)
  AUTHORS   Shimono,Y., Murakami,H., Hasegawa,Y. and Takahashi,M.
  TITLE     RET finger protein is a transcriptional repressor and interacts
            with enhancer of polycomb that has dual transcriptional functions
  JOURNAL   J Biol Chem 275 (50), 39411-39419 (2000)
   PUBMED   10976108
REFERENCE   10 (bases 1 to 3997)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL391839.9, BC036529.1,
            AK309822.1, AF286905.1, BU195035.1 and AW021213.1.
            
            On May 20, 2020 this sequence version replaced NM_001272004.2.
            
            Summary: This gene encodes a member of the polycomb group (PcG)
            family. The encoded protein is a component of the NuA4 histone
            acetyltransferase complex and can act as both a transcriptional
            activator and repressor. The encoded protein has been linked to
            apoptosis, DNA repair, skeletal muscle differentiation, gene
            silencing, and adult T-cell leukemia/lymphoma. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Dec
            2012].
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            coding region compared to variant 1. The encoded isoform (b) is
            shorter than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.1678435.1, BC036529.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319778.11/ ENSP00000318559.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AL391839.9         53357-53385         c
            30-159              BC036529.1         91-220
            160-1987            AK309822.1         89-1916
            1988-2521           BC036529.1         2049-2582
            2522-3303           AF286905.1         2252-3033
            3304-3304           BC036529.1         3365-3365
            3305-3677           BU195035.1         285-657
            3678-3993           BC036529.1         3735-4050
            3994-3997           AW021213.1         304-307
FEATURES             Location/Qualifiers
     source          1..3997
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p11.22"
     gene            1..3997
                     /gene="EPC1"
                     /gene_synonym="Epl1"
                     /note="enhancer of polycomb homolog 1"
                     /db_xref="GeneID:80314"
                     /db_xref="HGNC:HGNC:19876"
                     /db_xref="MIM:610999"
     exon            1..396
                     /gene="EPC1"
                     /gene_synonym="Epl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..2685
                     /gene="EPC1"
                     /gene_synonym="Epl1"
                     /note="isoform b is encoded by transcript variant 2"
                     /codon_start=1
                     /product="enhancer of polycomb homolog 1 isoform b"
                     /protein_id="NP_001258933.1"
                     /db_xref="CCDS:CCDS60511.1"
                     /db_xref="GeneID:80314"
                     /db_xref="HGNC:HGNC:19876"
                     /db_xref="MIM:610999"
                     /translation="MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTG
                     MEKEEESEHHLQRAISAQQVYGEKRDNMVIPVPEAESNIAYYESIYPGEFKMPKQLIH
                     IQPFSLDAEQPDYDLDSEDEVFVNKLKKKMDICPLQFEEMIDRLEKGSGQQPVSLQEA
                     KLLLKEDDELIREVYEYWIKKRKNCRGPSLIPSVKQEKRDGSSTNDPYVAFRRRTEKM
                     QTRKNRKNDEASYEKMLKLRRDLSRAVTILEMIKRREKSKRELLHLTLEIMEKRYNLG
                     DYNGEIMSEVMAQRQPMKPTYAIPIIPITNSSQFKHQEAMDVKEFKVNKQDKADLIRP
                     KRKYEKKPKVLPSSAAATPQQTSPAALPVFNAKDLNQYDFPSSDEEPLSQVLSGSSEA
                     EEDNDPDGPFAFRRKAGCQYYAPHLDQTGNWPWTSPKDGGLGDVRYRYCLTTLTVPQR
                     CIGFARRRVGRGGRVLLDRAHSDYDSVFHHLDLEMLSSPQHSPVNQFANTSETNTSDK
                     SFSKDLSQILVNIKSCRWRHFRPRTPSLHDSDNDELSCRKLYRSINRTGTAQPGTQTC
                     STSTQSKSSSGSAHFAFTAEQYQQHQQQLALMQKQQLAQIQQQQANSNSSTNTSQGFV
                     SKTLDSASAQFAASALVTSEQLMGFKMKDDVVLGIGVNGVLPASGVYKGLHLSSTTPT
                     ALVHTSPSTAGSALLQPSNITQTSSSHSALSHQVTAANSATTQVLIGNNIRLTVPSSV
                     ATVNSIAPINARHIPRTLSAVPSSALKLAAAANCQVSKVPSSSSVDSVPRENHESEKP
                     ALNNIADNTVAMEVT"
     exon            397..556
                     /gene="EPC1"
                     /gene_synonym="Epl1"
                     /inference="alignment:Splign:2.1.0"
     exon            557..702
                     /gene="EPC1"
                     /gene_synonym="Epl1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..909
                     /gene="EPC1"
                     /gene_synonym="Epl1"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1058
                     /gene="EPC1"
                     /gene_synonym="Epl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1218
                     /gene="EPC1"
                     /gene_synonym="Epl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1395
                     /gene="EPC1"
                     /gene_synonym="Epl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1485
                     /gene="EPC1"
                     /gene_synonym="Epl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1634
                     /gene="EPC1"
                     /gene_synonym="Epl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1987
                     /gene="EPC1"
                     /gene_synonym="Epl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2106
                     /gene="EPC1"
                     /gene_synonym="Epl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2248
                     /gene="EPC1"
                     /gene_synonym="Epl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2612
                     /gene="EPC1"
                     /gene_synonym="Epl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2613..3997
                     /gene="EPC1"
                     /gene_synonym="Epl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3964..3969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPC1"
                     /gene_synonym="Epl1"
                     /note="hexamer: AATAAA"
     regulatory      3978..3983
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPC1"
                     /gene_synonym="Epl1"
                     /note="hexamer: ATTACA"
     polyA_site      3993
                     /gene="EPC1"
                     /gene_synonym="Epl1"
                     /note="major polyA site"
     polyA_site      3997
                     /gene="EPC1"
                     /gene_synonym="Epl1"
                     /note="major polyA site"
ORIGIN      
        1 acagtggagt tttaatgtcc gccatgttgg ccatggcgta ttgaagagag cgagcgagag
       61 aggagcggag cggcacagcc tcccaccctc ccggctggtg ttagtgcccg gacggcgggc
      121 tctgcgctcc gcccctcaag tccccggcag cggttggcga gtggggaccg aacccccggt
      181 tctccatgat cccgctggcc ggggccgttt ccccagagcg gagaggtatc tgctgcgcct
      241 gagatgagta aactgtcgtt tcgggcgcgg gcgctagacg cctcgaagcc gctgccggtt
      301 ttccgctgtg aggatctgcc cgacctgcac gaatacgcct cgataaacag ggccgtgccg
      361 cagatgccca ccggaatgga gaaggaagag gagtcggaac atcatcttca gcgggctatt
      421 tcagcacagc aggtgtatgg cgagaagagg gataatatgg ttataccggt cccagaggca
      481 gaaagtaata ttgcttacta tgagtctata tatcctgggg aatttaagat gccaaagcag
      541 ctcattcaca tacagccttt tagtttggat gctgaacagc ctgattatga tttggattct
      601 gaagatgaag tatttgtgaa taaactgaaa aagaaaatgg acatctgccc attgcaattt
      661 gaggagatga ttgaccgcct agaaaaaggc agtggtcagc agccagtcag tctgcaggaa
      721 gccaaactac tgctaaaaga agatgatgaa ctaattagag aagtttatga atattggatt
      781 aaaaagagaa aaaactgtcg agggccatct cttattccat cagtaaaaca agagaagcga
      841 gatggttcca gcacaaatga tccttatgtg gcttttagaa ggcgtactga aaaaatgcag
      901 actcgaaaaa atcgcaaaaa tgatgaagcc tcttacgaaa aaatgcttaa gctgcgacga
      961 gatctaagtc gagctgttac tattctagag atgataaaaa gaagagaaaa aagtaaaaga
     1021 gagctattgc acttaacact ggaaattatg gaaaagaggt ataatttggg cgactacaat
     1081 ggagagatca tgtctgaggt tatggcacag agacagccaa tgaaacctac ttatgccatc
     1141 cccatcatcc ctattactaa tagcagtcaa tttaaacacc aggaagcaat ggatgtgaag
     1201 gagttcaaag ttaataagca agataaagcc gatcttatcc gaccgaaacg gaaatatgaa
     1261 aagaagccca aagtcttacc atcgtctgcc gctgctactc cccaacagac gagtcctgct
     1321 gcactgccag tcttcaatgc taaagatctg aatcagtatg actttcccag ctcagacgaa
     1381 gaacctctct cccaggtttt gtctggctct tcggaagctg aggaagacaa tgatcctgat
     1441 ggtccttttg ctttccgtag gaaagcaggc tgtcagtact atgctcctca cttagaccaa
     1501 actggcaact ggccttggac tagtcctaaa gatggaggat taggggatgt gcgatataga
     1561 tactgcttaa ctactctcac cgtaccccaa aggtgtattg gatttgcacg aagacgggtt
     1621 gggcgcggtg gaagggtctt actggacaga gctcattcag actatgacag tgtgtttcac
     1681 catctggatt tggaaatgct ttcctcacca caacattctc cagtcaatca gtttgccaat
     1741 acctcagaaa caaatacctc ggacaaatct ttctctaaag acctcagtca gatactagtc
     1801 aatatcaaat catgtagatg gcggcatttt aggcctcgga caccatccct acatgacagt
     1861 gacaatgatg aactctcctg tagaaaatta tataggagta taaaccgaac aggaacagca
     1921 caacctggga cccagacatg cagtacctct acgcaaagta aaagtagcag tggttcagca
     1981 cactttgcat ttacagccga acaataccag caacatcaac agcaactggc actcatgcag
     2041 aaacagcagc ttgcacaaat tcagcaacag caagcaaata gtaattcctc caccaacaca
     2101 tcacagggtt ttgtttctaa gactttggat tctgctagtg cacagtttgc tgcttctgct
     2161 ttggtgacat cagaacaact gatgggattc aagatgaagg atgatgtggt gcttggaatc
     2221 ggggtgaatg gcgtccttcc agcctcagga gtatacaagg gcttacacct cagtagtact
     2281 acaccaacag cacttgtaca tacaagtcca tcaacggcag gttcagcttt gttacagcct
     2341 tcaaatatta cacagacttc aagttcccac agtgcactga gtcatcaagt aactgctgcc
     2401 aattctgcaa caactcaggt tctgattggg aacaacattc gattaactgt accttcatca
     2461 gttgccactg taaactctat tgccccaata aatgcacgac atatacctag gactttaagt
     2521 gctgttccat catctgcctt aaagctggcc gctgcagcaa actgtcaagt ttccaaggtc
     2581 ccatcttcat cctctgtaga ttcagttcca agggaaaatc atgaatcaga aaagccagca
     2641 ctgaacaaca tagcagacaa cacagtagcg atggaggtga cgtagcttcc tccgagtgga
     2701 actgcagcct ggggacttga ttaggtgcta tgcatcagta gcattttgaa tgcaagggat
     2761 gatggaaagc agcacatgcg tttctgtggc agctgtgggg acttgacagc aatgctcatc
     2821 tctcatgctt caatttttct tttcttactg ttaataggaa aaaaatcaac atctgtaaat
     2881 taagaataca gcaattatct gtacagtact gcatatttgt aatacccttg tatatatgtt
     2941 acttgaatac agaaatgttc atttgtgatg ctttgcactt gggggtgggg ggtgggaggg
     3001 aaatcaattg caacaaagag tgtgagatgt gagattgtat agagatgaag tgtcatcaca
     3061 tcatgtgcat ggtgcggaac ctgctgtttt atctatttat tgtgccgtgt ttacagtttt
     3121 ttgtacactg taccttcatt ggttcctgtg ctgtagtaaa tgtgttaggt agctgtggac
     3181 tccttggtat tttgtaaatg gtataacata acttggttcc cctctgggtc cttgagtttt
     3241 ctgtgtatca tgtgaaaaaa aatggtgaca tacatacaga attttacaaa aaaaaaaaaa
     3301 aaaaaaaagg catcagtttt tttaaaaatg gggaatgtac tattaaatgg ggatcttcct
     3361 ggtctactat cattaggaca agtaacaagc taaaaatgaa gtctcttgaa tctttccatc
     3421 cccaacttgc ccacaaagct gtgggtggtt tctggtactt aaagcactaa tattatgttg
     3481 ctgctctgcg aacagcccag tagtcccatt tccttccaca ccaaaaagtg ttaaatcaag
     3541 tatgcaaatg gagtccttac aactggagtt tatgttgtct tgcccttttt ttagcacaaa
     3601 aaaaattgta cttttttatt gtcgaattgt ttaaaagact tcattcttta cttgttctta
     3661 cgaaaaggat ataagggaga agaatgcagt aattgctgta cgtgtatcat cattccagtt
     3721 tctaaaaaca gccagccagc ttttttcctt ttaagattct ccagaaggct gcaaggccag
     3781 aaccacaaat atcgggtgcc ttcctttgga aatatttgac ctctcttctg tgaagagaat
     3841 ggtacttaac agactactac tagtgctttg tcagtaccga agtctgaatg cccagtccaa
     3901 tggcatacat tatccttaag gtttttaatc ccacctggaa aaattgtgat agaattctca
     3961 caaaataaac ccagggcatt acatgttgac aaactaa
//
