LOCUS       NM_020909               6556 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens erythrocyte membrane protein band 4.1 like 5
            (EPB41L5), transcript variant 1, mRNA.
ACCESSION   NM_020909
VERSION     NM_020909.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6556)
  AUTHORS   Jeong,J.H., Park,S.H., Kim,H., Nam,H.Y., Kim,S.H., Jeong,M.,
            Kong,M.J., Son,J., Jeong,J.E., Song,J.H., Kim,S.W. and Choi,K.C.
  TITLE     ZBTB7A suppresses glioblastoma tumorigenesis through the
            transcriptional repression of EPB41L5
  JOURNAL   Exp Mol Med 55 (1), 43-54 (2023)
   PUBMED   36596853
  REMARK    GeneRIF: ZBTB7A suppresses glioblastoma tumorigenesis through the
            transcriptional repression of EPB41L5.
REFERENCE   2  (bases 1 to 6556)
  AUTHORS   Bao,S., Ji,Z., Shi,M. and Liu,X.
  TITLE     EPB41L5 promotes EMT through the ERK/p38 MAPK signaling pathway in
            esophageal squamous cell carcinoma
  JOURNAL   Pathol Res Pract 228, 153682 (2021)
   PUBMED   34784520
  REMARK    GeneRIF: EPB41L5 promotes EMT through the ERK/p38 MAPK signaling
            pathway in esophageal squamous cell carcinoma.
REFERENCE   3  (bases 1 to 6556)
  AUTHORS   Maier,J.I., Rogg,M., Helmstadter,M., Sammarco,A., Schilling,O.,
            Sabass,B., Miner,J.H., Dengjel,J., Walz,G., Werner,M., Huber,T.B.
            and Schell,C.
  TITLE     EPB41L5 controls podocyte extracellular matrix assembly by
            adhesome-dependent force transmission
  JOURNAL   Cell Rep 34 (12), 108883 (2021)
   PUBMED   33761352
  REMARK    GeneRIF: EPB41L5 controls podocyte extracellular matrix assembly by
            adhesome-dependent force transmission.
REFERENCE   4  (bases 1 to 6556)
  AUTHORS   Saller,J., Seydafkan,S., Shahid,M., Gadara,M., Cives,M.,
            Eschrich,S.A., Boulware,D., Strosberg,J.R., Aejaz,N. and Coppola,D.
  TITLE     EPB41L5 is Associated With the Metastatic Potential of Low-grade
            Pancreatic Neuroendocrine Tumors
  JOURNAL   Cancer Genomics Proteomics 16 (5), 309-318 (2019)
   PUBMED   31467225
  REMARK    GeneRIF: These results support further investigation into whether
            EPB41L5 is a biomarker of PNETs with high risk for metastases
REFERENCE   5  (bases 1 to 6556)
  AUTHORS   Jeong,M.H., Park,S.Y., Lee,S.H., Seo,J., Yoo,J.Y., Park,S.H.,
            Kim,M.J., Lee,S., Jang,S., Choi,H.K., Lee,J.E., Shin,S.J.,
            Choi,K.C., Cheong,J.H. and Yoon,H.G.
  TITLE     EPB41L5 Mediates TGFbeta-Induced Metastasis of Gastric Cancer
  JOURNAL   Clin Cancer Res 25 (12), 3617-3629 (2019)
   PUBMED   30814110
  REMARK    GeneRIF: Increased expression of Erythrocyte membrane protein band
            4.1-like 5 ( EPB41L5) in gastric cancer associated with poor
            prognosis and low survival rate.  In experimental models, EPB41L5
            mediated TGF induces metastasis.
REFERENCE   6  (bases 1 to 6556)
  AUTHORS   Handa,H., Hashimoto,A., Hashimoto,S. and Sabe,H.
  TITLE     Arf6 and its ZEB1-EPB41L5 mesenchymal axis are required for both
            mesenchymal- and amoeboid-type invasion of cancer cells
  JOURNAL   Small GTPases 9 (5), 420-426 (2018)
   PUBMED   27754741
  REMARK    GeneRIF: Arf6 appears to be necessary for both RhoA- and
            Rac1-driven cancer invasion
REFERENCE   7  (bases 1 to 6556)
  AUTHORS   Schell,C., Rogg,M., Suhm,M., Helmstadter,M., Sellung,D.,
            Yasuda-Yamahara,M., Kretz,O., Kuttner,V., Suleiman,H.,
            Kollipara,L., Zahedi,R.P., Sickmann,A., Eimer,S., Shaw,A.S.,
            Kramer-Zucker,A., Hirano-Kobayashi,M., Abe,T., Aizawa,S.,
            Grahammer,F., Hartleben,B., Dengjel,J. and Huber,T.B.
  TITLE     The FERM protein EPB41L5 regulates actomyosin contractility and
            focal adhesion formation to maintain the kidney filtration barrier
  JOURNAL   Proc Natl Acad Sci U S A 114 (23), E4621-E4630 (2017)
   PUBMED   28536193
  REMARK    GeneRIF: A diminution of EPB41L5-dependent signaling programs
            appears to be a common theme of podocyte disease, and therefore
            offers unexpected interventional therapeutic strategies to prevent
            podocyte loss and kidney disease progression.
REFERENCE   8  (bases 1 to 6556)
  AUTHORS   Otsuka,Y., Sato,H., Oikawa,T., Onodera,Y., Nam,J.M., Hashimoto,A.,
            Fukunaga,K., Hatanaka,K.C., Hatanaka,Y., Matsuno,Y., Fukuda,S. and
            Sabe,H.
  TITLE     High expression of EPB41L5, an integral component of the
            Arf6-driven mesenchymal program, correlates with poor prognosis of
            squamous cell carcinoma of the tongue
  JOURNAL   Cell Commun Signal 14 (1), 28 (2016)
   PUBMED   27871329
  REMARK    GeneRIF: The Squamous cell carcinoma of the tongue cell line SCC-9,
            which overexpress Arf6 and AMAP1, also expressed EPB41L5 at high
            levels to promote invasiveness, whereas the weakly invasive SCC-25
            cells did not express EPB41L5 at notable levels.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 6556)
  AUTHORS   Chang,R.M., Pei,L., Fang,F., Xu,J.F., Yang,H., Zuo,C.H., Zhou,J.H.,
            Luo,G.Q. and Yang,L.Y.
  TITLE     YMO1 suppresses invasion and metastasis by inhibiting RhoC
            signaling and predicts favorable prognosis in hepatocellular
            carcinoma
  JOURNAL   Oncotarget 7 (34), 55585-55600 (2016)
   PUBMED   27487132
  REMARK    GeneRIF: YMO1 suppresses tumor invasion and metastasis by
            inhibiting RhoC activity.
REFERENCE   10 (bases 1 to 6556)
  AUTHORS   Gosens,I., Sessa,A., den Hollander,A.I., Letteboer,S.J.,
            Belloni,V., Arends,M.L., Le Bivic,A., Cremers,F.P., Broccoli,V. and
            Roepman,R.
  TITLE     FERM protein EPB41L5 is a novel member of the mammalian CRB-MPP5
            polarity complex
  JOURNAL   Exp Cell Res 313 (19), 3959-3970 (2007)
   PUBMED   17920587
  REMARK    GeneRIF: the importance of a conserved Crumbs-MPP5-EPB41L5 polarity
            complex in mammals for separation of the apical and basolateral
            domains through specialized cell-cell junctions
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016691.10 and BC054508.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020909.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054508.1, SRR1660803.139976.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263713.10/ ENSP00000263713.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC016691.10        56412-56427
            17-6556             BC054508.1         1-6540
FEATURES             Location/Qualifiers
     source          1..6556
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.2"
     gene            1..6556
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /note="erythrocyte membrane protein band 4.1 like 5"
                     /db_xref="GeneID:57669"
                     /db_xref="HGNC:HGNC:19819"
                     /db_xref="MIM:611730"
     exon            1..134
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /inference="alignment:Splign:2.1.0"
     exon            135..322
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..2344
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /note="isoform 1 is encoded by transcript variant 1; yurt
                     homolog"
                     /codon_start=1
                     /product="band 4.1-like protein 5 isoform 1"
                     /protein_id="NP_065960.2"
                     /db_xref="CCDS:CCDS2130.1"
                     /db_xref="GeneID:57669"
                     /db_xref="HGNC:HGNC:19819"
                     /db_xref="MIM:611730"
                     /translation="MLSFFRRTLGRRSMRKHAEKERLREAQRAATHIPAAGDSKSIIT
                     CRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQVAHWLDGTK
                     SIKKQVKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLDCPFDTAV
                     QLAAYNLQAELGDYDLAEHSPELVSEFRFVPIQTEEMELAIFEKWKEYRGQTPAQAET
                     NYLNKAKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGDTKIGLFFWPKITRLDF
                     KKNKLTLVVVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVEHHAFFRLRGPVQKSSH
                     RSGFIRLGSRFRYSGKTEYQTTKTNKARRSTSFERRPSKRYSRRTLQMKACATKPEEL
                     SVHNNVSTQSNGSQQAWGMRSALPVSPSISSAPVPVEIENLPQSPGTDQHDRKCIPLN
                     IDLLNSPDLLEATIGDVIGASDTMETSQALNDVNVATRLPGLGEPEVEYETLKDTSEK
                     LKQLEMENSPLLSPRSNIDVNINSQEEVVKLTEKCLNNVIESPGLNVMRVPPDFKSNI
                     LKAQVEAVHKVTKEDSLLSHKNANVQDAATNSAVLNENNVPLPKESLETLMLITPADS
                     GSVLKEATDELDALLASLTENLIDHTVAPQVSSTSMITPRWIVPQSGAMSNGLAGCEM
                     LLTGKEGHGNKDGISLISPPAPFLVDAVTSSGPILAEEAVLKQKCLLTTEL"
     exon            323..427
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /inference="alignment:Splign:2.1.0"
     exon            428..470
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /inference="alignment:Splign:2.1.0"
     exon            471..549
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /inference="alignment:Splign:2.1.0"
     exon            550..594
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /inference="alignment:Splign:2.1.0"
     exon            595..647
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /inference="alignment:Splign:2.1.0"
     exon            648..768
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /inference="alignment:Splign:2.1.0"
     exon            769..856
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /inference="alignment:Splign:2.1.0"
     exon            857..945
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1015
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1185
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1292
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1320
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1363
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1479
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1643
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1741
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1870
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..1935
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2029
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2104
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2146
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2277
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..6556
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6534..6539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /note="hexamer: AATAAA"
     polyA_site      6556
                     /gene="EPB41L5"
                     /gene_synonym="BE37; LULU; LULU1; YMO1; YRT"
                     /note="major polyA site"
ORIGIN      
        1 gtcctccggg gattagagcc ggtgggctcg ttgtgggcgc catttctcgg cgtctaccga
       61 ggagccgccc ctttctcagc cttgctcggc tcttccccgc tctggtcgcc ggggctgcgc
      121 cgtccccagc tcagtgacaa aaatgctgag tttcttccgt agaacactag ggcgtcggtc
      181 tatgcgtaaa catgcagaga aggaacgact ccgagaagca caacgcgccg ccacacatat
      241 tcctgcagct ggagattcta agtccatcat cacgtgtcgg gtgtcccttc tggatggtac
      301 tgatgttagt gtggacttgc caaaaaaagc caaaggacaa gagttgtttg atcagattat
      361 gtaccacctg gacctgattg aaagcgacta ttttggtctg agatttatgg attcagcaca
      421 agtagcacat tggttggatg gtacaaaaag catcaaaaag caagtaaaaa ttggttcacc
      481 ctattgtctg catcttcgag ttaagtttta ttcctcagaa ccaaataacc ttcgtgagga
      541 gctaacccgg tatttatttg ttcttcagtt aaaacaagat attctcagtg gaaaattaga
      601 ctgtcccttt gatacagcag tgcaattggc agcttataat ctgcaagctg aacttggtga
      661 ctatgatctt gctgagcata gtcctgaact tgtctcagag ttcagattcg tgcctattca
      721 gactgaagag atggaactgg ctatttttga gaaatggaag gaatacagag gtcaaacacc
      781 agcacaggct gaaaccaatt atctgaataa agccaaatgg ctagaaatgt atggggttga
      841 tatgcatgtg gtcaaggcta gagatgggaa tgactatagt ttgggactaa caccaacagg
      901 agtccttgtt tttgaaggag ataccaaaat tggcttattt ttttggccga agataaccag
      961 attggatttt aagaagaata aattaacctt ggtggttgta gaagatgatg atcagggcaa
     1021 agaacaggaa catacatttg tctttagact ggatcatcca aaagcatgca aacatttatg
     1081 gaaatgtgct gtggagcatc atgctttctt ccgccttcga ggccccgtcc aaaagagttc
     1141 tcatcgatca ggatttattc gactaggatc acgatttaga tatagtggga aaacagagta
     1201 tcagaccaca aaaaccaata aagcaagaag atcaacatcc tttgaaagaa ggcccagcaa
     1261 acgatattct agacgaactc tacaaatgaa agcatgtgct acaaaacctg aagaacttag
     1321 tgttcacaat aatgtttcga cccaaagtaa tggctcccaa caggcttggg ggatgagatc
     1381 tgctctgcct gtgagtcctt ccatttcctc tgctcctgtg ccagtggaga tagagaatct
     1441 tccacagagt cctggaacag accagcatga caggaaatgc attcctctga atattgattt
     1501 gctgaatagc ccagacttat tggaagcaac gattggtgat gtaattgggg catctgacac
     1561 tatggaaaca tcccaagcac tgaatgacgt taatgtagcc accaggcttc cgggattagg
     1621 ggaacctgaa gttgaatatg agacattaaa agacacctca gagaagctca aacagcttga
     1681 gatggagaac agtcctttgc tgtcccctcg atccaacatc gatgttaaca taaacagcca
     1741 ggaggaagtg gtgaagttga ctgagaaatg ccttaataat gtcattgaga gcccaggatt
     1801 gaatgtcatg agagttcctc ctgacttcaa gagtaacatt ttgaaggctc aagtagaagc
     1861 agtgcataag gttacaaaag aagatagctt attaagtcat aaaaatgcca atgttcagga
     1921 tgctgccaca aacagtgctg tgttaaatga gaataatgtg cccctcccca aagagtctct
     1981 tgagactctg atgcttatca cacctgccga cagtggttct gttctaaagg aagctacaga
     2041 tgaattggat gccttgcttg catctctaac tgagaatcta attgatcaca cagttgcacc
     2101 tcaggtgtct tccacatcca tgatcacacc ccggtggatt gttccgcaga gtggtgccat
     2161 gtctaatgga cttgcgggat gtgaaatgct tttgacaggg aaggagggac atggtaataa
     2221 agatggaatc tcactgatct ctcccccagc gccattcttg gtagatgctg tgaccagctc
     2281 tggtcccatt ttggcagaag aagctgtcct gaagcagaag tgtttactga ccactgagct
     2341 ctgagggcct gtagctggaa tacgcatctc tccagcattc cgtcctggga tccgtttcag
     2401 ctagaatatg ttggattcag gagcttgtcc attatttgta ggtaaaaaaa gctgcacgta
     2461 gatttgactt caactccgta aaaaagacag ctgtattttc cgtccaactg gaattgttga
     2521 atcacactgc atagctgccc aaaagagagt gtttggtctt gaactttcta tacttttata
     2581 aatgttacaa attcccgaaa gaagggaatt tctttttctg gggtttcctt caaactcttg
     2641 gctccaccta gcggttctat ttgttcataa caacttcata acaagcctgc ctctggtagt
     2701 caacagcctt ttgaaagcta tttccatcta gtatcagggt gagagcatcc ttgatctggc
     2761 tgcctgttag agaaattgca cttttcctga cttacctaga aatcaagaat ttaggaaatt
     2821 aatgtggaca ctataaaggc agacttaggg ccaacttttt ttttttttta caattattac
     2881 aacactaaag agaagtttag aatatagaga gtttttaaat gtctcccatt cttttgattt
     2941 cttactgtac tggctatctt aatatttcaa gtttacatca agataaaccc tgagaagaac
     3001 tacggagaaa tcaaataaaa tcctgtcata tttttttcac cctgcctttc cacaggaagc
     3061 actcacaggc accacacacg tatcatgtaa cttatcagtg gggtgggtta ctgttgaaga
     3121 gaccctgggg catttacctc aggcatctgc actcctccga gcccggtgga gaatgcaggc
     3181 tgctgtagtc tcaggtaatg aaggcacagc acagcagtac tccacattgt ttcctatttg
     3241 gacatagact tcatttcctt tcagtataag ctgaataaat ttagagcttt caaactggaa
     3301 aaaaaaatga aacaaaacaa atacaccaag accaaaatag gcaataggaa caggggtgaa
     3361 gggatgttgt ttcttaaata cctaccatgt atgaagctat acacagcata taccgaaaga
     3421 acctgcattg cactaggaat tctgtgttag tttaaaagag atctctaaaa cttccccatc
     3481 cctttgggcc tgtacaaaga aattctggat gttaaaataa tatatactca tcacagaaaa
     3541 ataaagtata gcaatgtcca tctgtaattc taatacccag aaataacgct atttagcttt
     3601 ataattttcg aatgaacaag gtaaacctcg gttgccatgg ggaagaagga tgatgtggaa
     3661 accatattgg taaagttgtt aatccctcgt tatggagaac tgatcttaag ctatacctcc
     3721 tggaatttgc tttctagttt tctgtcctgc aatatgtata taattaagca ctaatttgta
     3781 ctgcttagca taaaagaaca tccagtctta gatccttaaa acttcatgga ttggactttc
     3841 ctgggctcct tataacataa tcgtgtgtcc aggcaaacgc acactagtgt ctgactggaa
     3901 agctcaggaa ttttaatctt gcactgtttc ccagggagct gtagtgattg gaacccacgt
     3961 ttgcacaaaa catttttgca gaaggaaagt caacacttct tgctggctgc ctccccttag
     4021 ccattatgct aaaaacagct tctgagtttc actggtgggg ctcttgccag ttcttaatta
     4081 taggacatat tttctcaaag ctgaaggtga cacctagaac caggggcttg acccaggaca
     4141 tgatggaatg agcatcaaat tttcagtgtc ttggcaaccg tagatgtcct acagggttac
     4201 cgttgtgctg ctcaccacag agcagctgag gcattatgcc ttggaagacc taaatctccc
     4261 atccagttca ggaggtgaca acatccttat tttaaacttc ctaaaattag gaattaggta
     4321 gttggacata gtctgtgacc tttatgtcgt tggatacctg tattcttgac agttagaata
     4381 ttggtaggga ctttgttaaa attcacttga atttcaagct cagaggaaac tttgtctcat
     4441 gccctgacat gaagtggcaa acacggaagt tcatacttga atgctgaatt ggccccgaca
     4501 gattaaatgc gtgttgggga ttggtttcct gtcatagctg ctgctgctgc catgcgcaga
     4561 gctgctgtaa cagctcttcc tgttctgctc ccctgagaac agtgtggtgg ggagaggcag
     4621 ggctgaggtg gtctacgaat gtggcaggta gggaagggga gatgtctgtc tcttgagaag
     4681 agagaggcat gtgtgccggc atccttgatg ggttcaaaga gaaaggttgg agatgatagt
     4741 gggtgagaag caggctggtg agactgggct gaggttggag aaggggcagc cgggggcact
     4801 gctgagggtt tgccgtgcac gcctcggacg gagcacggtg gggtggcggg gagcagatag
     4861 tgctgcctcc ctgcgggcag acaggagagg aacctcaact cagtccattt catagccctg
     4921 ataggggaag tgggagttga caggatggtt taaaataaga cgtgaaggtt tcagttacct
     4981 gctctagact ttgcctgaga acttgtaaat taatcagtga gacctaattt gtgacatgtc
     5041 agtagcatca tcttttgaca cacaggaggt catggtcatt tcattcctac tcttcaggag
     5101 acactgctga acagaggaat gattctgttc cttgtgtgct tacttcctta acatttatac
     5161 attgttttaa gaaaaaactt ttaaaaatat ttcttatagt ctcctaacat ttgtctctag
     5221 cctttgcctt tgtacaatca cagatatcct atggagattt aaggatgaaa gccctgagtt
     5281 gttcttgggt tcttggatct ggactacttg ttatcttatg cttctcactt ctggctaaaa
     5341 cttgcacctc ttcttctctt agctaagccc caaaatgaag atttccttca gaagtcttgt
     5401 tagcagaatt atttatcagt cacagagaga aaaatctgct atttttctaa gtaagagtct
     5461 cgagaagcag agtttttgtc ttgtcattga gaggagtcag cagtcttgtt ctgtaaagga
     5521 ccagagatgg taaatactgt cccactcagc tctgctggcg cagtacagca gcagcagccc
     5581 cagcacagct gtgttcctgc ggagtcccct ttacaaagcc gctgacccct gatgtgaaac
     5641 tttgtagagc agcagagtgg ctgcgtgaaa cgggaggctg gcaggtcctc agataggttc
     5701 tgcagtgtta cctgtcactt ggaggcagcc aacacttctg gacattgcat ccttattcac
     5761 acatgtggca gctgaacgag gtgctgttgt gggtgtctca gctctgaggg tctttgtgag
     5821 ctcccactgt tgtgggtgtc tcagctctga gggtctttgt gagctcccac tgttgtgggt
     5881 gtctcagctc tgagggtctt tgtgagttcc caccaacttt taattattca tgcccttgac
     5941 catgtggttg cttggagacc tggggtcttc tgcagactga agaagacaca tttctagatt
     6001 atttgtcctt tttatcctct caaaaattta aacactgtac ctcttcagtg gtcagaagaa
     6061 agttggaaac ttttcctaca tattaggcgt tagtatgagg acatttgttt gaattataga
     6121 aatttgccct gagctgaact gggttgtgtt aacacattgg tagagctatg attccttccc
     6181 agttctaaga gatacgatct gtaagtccct atgtcaccac attgcttgag atgatcattc
     6241 agttacttgt caggatttct cctcttcaga gagatttttt tttatagcac agattccttt
     6301 gcccctttta tctccttatc tggatatgat aagtggttat gagggtctca ctaactattt
     6361 tgtgtttacc ttttatatgt gtaaaacttt gcagtagcat ttaaagtgta atttattttt
     6421 ctatcaagtg cactattcat ttagtgtgtt ccagttttat atgacttgta ttagaaacac
     6481 tgcactgagt tgtttgtaca ctgaaatgag aactctagat gtaactctat tcaaataaac
     6541 cttcgtgaga cattca
//
