LOCUS       NM_019114               5896 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens erythrocyte membrane protein band 4.1 like 4B
            (EPB41L4B), transcript variant 2, mRNA.
ACCESSION   NM_019114
VERSION     NM_019114.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5896)
  AUTHORS   Yin,X., Li,G., Fan,D., Ge,Z., Yang,T., Shang,Y., Ma,T., Yuan,B.,
            Huang,W., Teng,X. and Yu,H.
  TITLE     Ehm2 transcript variant 1 inhibits breast cancer progression and
            increases E-cadherin stability
  JOURNAL   Carcinogenesis 43 (12), 1110-1120 (2022)
   PUBMED   36422008
  REMARK    GeneRIF: Ehm2 transcript variant 1 inhibits breast cancer
            progression and increases E-cadherin stability.
REFERENCE   2  (bases 1 to 5896)
  AUTHORS   Li,S., Ma,J., Si,Y., Cheng,S., Hu,M., Zhi,X., Li,B., Yu,H. and
            Jiang,W.G.
  TITLE     Differential expression and functions of Ehm2 transcript variants
            in lung adenocarcinoma
  JOURNAL   Int J Oncol 54 (5), 1747-1758 (2019)
   PUBMED   30816447
  REMARK    GeneRIF: Data show that the two Ehm2 variants appear to be
            differentially expressed in lung adenocarcinoma. Ehm2/1 may
            function as a putative tumor suppressor in the disease progression
            of lung adenocarcinoma, while Ehm2/2 may have an opposite function.
REFERENCE   3  (bases 1 to 5896)
  AUTHORS   Walker,S.J., Selfors,L.M., Margolis,B.L. and Brugge,J.S.
  TITLE     CRB3 and the FERM protein EPB41L4B regulate proliferation of
            mammary epithelial cells through the release of amphiregulin
  JOURNAL   PLoS One 13 (11), e0207470 (2018)
   PUBMED   30440051
  REMARK    GeneRIF: We found that CRB3-induced proliferation is epidermal
            growth factor (EGF)-independent and occurs through a mechanism that
            involves secretion of the EGF-family ligand, amphiregulin
            (AREG)..We identified the FBD-containing protein, EPB41L4B, as an
            essential mediator of CRB3-driven proliferation and observed that
            the CRB3-dependent changes in endocytic trafficking were also
            dependent on EPB41L4B
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5896)
  AUTHORS   Loie,E., Charrier,L.E., Sollier,K., Masson,J.Y. and Laprise,P.
  TITLE     CRB3A Controls the Morphology and Cohesion of Cancer Cells through
            Ehm2/p114RhoGEF-Dependent Signaling
  JOURNAL   Mol Cell Biol 35 (19), 3423-3435 (2015)
   PUBMED   26217016
  REMARK    GeneRIF: CRB3A recruits p114RhoGEF and its activator Ehm2 to the
            cell periphery using both functional motifs of its cytoplasmic tail
            and increases RhoA activation levels.
REFERENCE   5  (bases 1 to 5896)
  AUTHORS   Bosanquet,D.C., Ye,L., Harding,K.G. and Jiang,W.G.
  TITLE     Expressed in high metastatic cells (Ehm2) is a positive regulator
            of keratinocyte adhesion and motility: The implication for wound
            healing
  JOURNAL   J Dermatol Sci 71 (2), 115-121 (2013)
   PUBMED   23664528
  REMARK    GeneRIF: Ehm2 may be an important player in the wound healing
            process; Ehm2 knockdown downregulates the expression of NWasp,
            through which it may have its effect on cellular migration
REFERENCE   6  (bases 1 to 5896)
  AUTHORS   Nakajima,H. and Tanoue,T.
  TITLE     Lulu2 regulates the circumferential actomyosin tensile system in
            epithelial cells through p114RhoGEF
  JOURNAL   J Cell Biol 195 (2), 245-261 (2011)
   PUBMED   22006950
REFERENCE   7  (bases 1 to 5896)
  AUTHORS   Chauhan,S., Kunz,S., Davis,K., Roberts,J., Martin,G.,
            Demetriou,M.C., Sroka,T.C., Cress,A.E. and Miesfeld,R.L.
  TITLE     Androgen control of cell proliferation and cytoskeletal
            reorganization in human fibrosarcoma cells: role of RhoB signaling
  JOURNAL   J Biol Chem 279 (2), 937-944 (2004)
   PUBMED   14576147
REFERENCE   8  (bases 1 to 5896)
  AUTHORS   Chauhan,S., Pandey,R., Way,J.F., Sroka,T.C., Demetriou,M.C.,
            Kunz,S., Cress,A.E., Mount,D.W. and Miesfeld,R.L.
  TITLE     Androgen regulation of the human FERM domain encoding gene EHM2 in
            a cell model of steroid-induced differentiation
  JOURNAL   Biochem Biophys Res Commun 310 (2), 421-432 (2003)
   PUBMED   14521927
REFERENCE   9  (bases 1 to 5896)
  AUTHORS   Shimizu,K., Nagamachi,Y., Tani,M., Kimura,K., Shiroishi,T.,
            Wakana,S. and Yokota,J.
  TITLE     Molecular cloning of a novel NF2/ERM/4.1 superfamily gene, ehm2,
            that is expressed in high-metastatic K1735 murine melanoma cells
  JOURNAL   Genomics 65 (2), 113-120 (2000)
   PUBMED   10783258
REFERENCE   10 (bases 1 to 5896)
  AUTHORS   Chadwick,B.P., Leyne,M., Gill,S., Liebert,C.B., Mull,J., Mezey,E.,
            Robbins,C.M., Pinkett,H.W., Makalowska,I., Maayan,C.,
            Blumenfeld,A., Axelrod,F.B., Brownstein,M., Gusella,J.F. and
            Slaugenhaupt,S.A.
  TITLE     Cloning, mapping, and expression of a novel brain-specific
            transcript in the familial dysautonomia candidate region on
            chromosome 9q31
  JOURNAL   Mamm Genome 11 (1), 81-83 (2000)
   PUBMED   10603000
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL359963.29 and AL358815.12.
            
            On Jul 21, 2020 this sequence version replaced NM_019114.4.
            
            Transcript Variant: This variant (2) represents the longer
            transcript and encodes the longer isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF153416.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374566.8/ ENSP00000363694.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-919               AL359963.29        36594-37512         c
            920-1024            AL358815.12        187137-187241       c
            1025-1067           AL358815.12        175711-175753       c
            1068-1146           AL358815.12        174793-174871       c
            1147-1191           AL358815.12        172300-172344       c
            1192-1244           AL358815.12        170370-170422       c
            1245-1365           AL358815.12        165497-165617       c
            1366-1453           AL358815.12        163713-163800       c
            1454-1542           AL358815.12        163456-163544       c
            1543-1612           AL358815.12        163094-163163       c
            1613-1782           AL358815.12        162831-163000       c
            1783-1892           AL358815.12        160761-160870       c
            1893-1923           AL358815.12        158801-158831       c
            1924-1957           AL358815.12        155076-155109       c
            1958-2022           AL358815.12        150938-151002       c
            2023-2246           AL358815.12        124242-124465       c
            2247-2365           AL358815.12        121020-121138       c
            2366-2491           AL358815.12        115244-115369       c
            2492-2559           AL358815.12        110983-111050       c
            2560-2658           AL358815.12        107556-107654       c
            2659-2836           AL358815.12        101540-101717       c
            2837-2914           AL358815.12        99598-99675         c
            2915-3031           AL358815.12        92809-92925         c
            3032-3100           AL358815.12        90049-90117         c
            3101-3246           AL358815.12        83871-84016         c
            3247-5896           AL358815.12        79294-81943         c
FEATURES             Location/Qualifiers
     source          1..5896
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.3"
     gene            1..5896
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /note="erythrocyte membrane protein band 4.1 like 4B"
                     /db_xref="GeneID:54566"
                     /db_xref="HGNC:HGNC:19818"
                     /db_xref="MIM:610340"
     exon            1..919
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     CDS             614..3316
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /note="isoform 2 is encoded by transcript variant 2; band
                     4.1-like protein 4B; FERM-containing protein CG1"
                     /codon_start=1
                     /product="band 4.1-like protein 4B isoform 2"
                     /protein_id="NP_061987.3"
                     /db_xref="CCDS:CCDS43859.1"
                     /db_xref="GeneID:54566"
                     /db_xref="HGNC:HGNC:19818"
                     /db_xref="MIM:610340"
                     /translation="MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAA
                     ASSSALPAAPGGSVFPAGGGPLLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLP
                     KHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPIKKQMKIGPAYALHF
                     RVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAALCLQAELGECEL
                     PEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDM
                     HVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQG
                     REQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGR
                     TEYQATHGSRLRRTSTFERKPSKRYPSRRHSTFKASNPVIAAQLCSKTNPEVHNYQPQ
                     YHPNIHPSQPRWHPHSPNVSYPLPSPVLSSSDRLPFGIEENGGTPFLTAASGRHHHQH
                     QHQHQHQHHSNYSLSLTLENKEGPLRSPNSSSKSLTKLSPGTPALFSEAAAHLKKLEL
                     ETVKAAGPWPPLHININKAEEKKVSEKTLQTPLLPSPVADHVKCNILKAQLENASRVN
                     IQGGKEESPFVNINKKSSLQDASVRSPIPIRVETAQPAVEKPEIKPPRVRKLTRQYSF
                     DEDDLPPDLAEAVGVTTSTTTNTTTAATQVSVPLPSPKVQNVSSPHKSEGKGLLSPGA
                     KSPSDRGGAFTLEPGDLLMDFTEATPLAEPASNPHCAHSRCSPPLSLPMKEETTGVCM
                     YPPIKTRLIKTFPVDTMNPFPDTFTTGPQFTADFRDSKLQCCPGPTSPLIPAATLRPL
                     TETVSTVQTIYTTRKPVSLAASAETLRQELEREKMMKRLLMTEL"
     exon            920..1024
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1067
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1146
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1191
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1244
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1365
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1453
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1542
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1612
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1782
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1892
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..1923
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..1957
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2022
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2246
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2365
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2491
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2559
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2658
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2836
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2837..2914
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..3031
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3100
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     exon            3101..3246
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     exon            3247..5896
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3928..3933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /note="hexamer: AATAAA"
     polyA_site      3956
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
     regulatory      5869..5874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /note="hexamer: AGTAAA"
     polyA_site      5896
                     /gene="EPB41L4B"
                     /gene_synonym="CG1; EHM2; LULU2"
                     /note="major polyA site"
ORIGIN      
        1 agggcgtgct gcagtcccgg cggcagcggc ggcggcggcg gcggcggcgg ctggaggtgc
       61 agcctcccag gtgggaggcg ggggctgcgg gcgcaggaaa aggcgccttg ggagcgggcg
      121 ctcggcgggg cctcctcggg ccccgggcgc ggcgcggcga gtgggagcga gcgcgccagg
      181 accacgcagg cgccctgctc cggctggccc tcggccggcg cgcggcgcgg gagcagcccg
      241 cagcccgcct cccgcgcccc cggcagcccc ctggcagccc gcagccgccc gtccggagca
      301 gcccctcggc agcccgcgca ggccgccggc ccgggagagc gcgcggcggc ggcggcggcg
      361 ggacggcccc gagcgcgccc tcccgcctgc ggccactcgc agccggcgct ggccgggccg
      421 gcgcgccccg caggcggcta gagcgcggcc tcggcctcgg cgcgggcttg ccccgggccg
      481 tagcccgcga gaggcggcgc gggcggccga gggcactgac ggcgtcgcgg gacgctcccg
      541 ggcggcggcg cagcggcagc ggcagcggca gcggcagcgc agggggcgga ggcagggggc
      601 gcccccagcc aggatgctgc ggttcctgcg ccggaccttt ggccgccgct ccatgcagcg
      661 ctacgcgcgg ggcgcggcgg ggcgcggggc cgccgggctg ggggacgagc gcgatggggg
      721 gccacggggg ggcccggccg ccgccgcctc ctcctcggcg ctgcccgccg cgcccggggg
      781 cagcgtgttc ccggcgggcg gcgggcccct gctcaccggc ggcgcggccg tgcacatctc
      841 cgccgccggc gccgccaagg ccaccctcta ctgccgcgtc ttcctgctcg acgggaccga
      901 agtgagcgtg gacctgccga aacatgccaa aggccaggat ttgtttgatc agattgtgta
      961 ccacttggac cttgtggaaa cagattactt tggcctccag ttcctcgact ctgcccaggt
     1021 tgcgcactgg ctggatcatg ccaaacccat aaaaaagcag atgaaaattg gacctgctta
     1081 tgctttacac tttcgagtta aatactattc ttcagaacca aacaaccttc gtgaggagtt
     1141 tacaaggtac ctgtttgttt tacaactcag gcatgacatt ctttctggaa aattgaaatg
     1201 cccttatgaa acagctgtgg aattagctgc tctctgtcta caagcggagc ttggggagtg
     1261 cgagcttcca gaacacacac cagagcttgt gtctgagttt cggttcattc caaatcagac
     1321 agaagcaatg gaatttgata tcttccagag atggaaagag tgcaggggaa agagccctgc
     1381 ccaggcggaa ctctcctatc tgaataaagc gaagtggctg gaaatgtatg gggtagacat
     1441 gcacgttgtc aggggaagag atggctgtga atattctctt ggactgaccc cgacaggcat
     1501 attaatcttt gaaggagcta acaaaatagg cttattcttt tggcctaaaa ttaccaaaat
     1561 ggattttaaa aagagcaaat tgacactcgt ggtggtcgag gatgatgatc agggacgtga
     1621 gcaagagcac acgtttgtgt tccggttaga cagtgccagg acctgcaaac acctttggaa
     1681 gtgtgcagtt gagcaccacg cattcttccg actgcggacg ccaggaaaca gcaaatccaa
     1741 tagatccgac tttatcaggc tgggctctcg cttcagattc agtgggcgga cagaatatca
     1801 agctacacat ggctccaggt tacgaagaac cagcaccttt gagaggaagc ctagtaaacg
     1861 ttatccatcc cggagacatt caacgttcaa agcaagcaac ccagtgatag cagcccagct
     1921 ctgctctaaa acaaatccag aagtccataa ttaccagcct caatatcatc ctaatatcca
     1981 tcccagccag ccccggtggc atcctcactc tccaaatgtc agctacccgc tcccttcccc
     2041 agtgcttagc agctcggacc ggttgccttt tggcattgag gagaatgggg gcacaccgtt
     2101 cctcaccgca gcttcaggaa ggcatcacca ccagcaccag catcagcatc agcaccagca
     2161 ccactcaaac tacagcctct cactgaccct ggagaacaaa gaggggcctc tgaggtcccc
     2221 aaactccagc agcaagtccc ttacaaaact gagtccagga acacctgcct tgttcagtga
     2281 agccgctgcc catctaaaga agctggaact ggaaactgtg aaggctgctg gaccctggcc
     2341 tcctctgcac atcaacataa acaaggctga agaaaagaaa gtctcggaga aaactcttca
     2401 gactccactt ttgccttccc ctgttgcgga tcatgtgaag tgtaacattc tgaaagccca
     2461 gttggaaaat gcttcccgag tgaacatcca gggtggaaag gaggaatcac cgtttgtaaa
     2521 tatcaataag aaatccagtc ttcaggacgc tagtgtaaga agtcctattc ctattcgtgt
     2581 ggaaactgcc cagccagctg tggaaaagcc ggaaatcaag cctccccgag tgaggaagtt
     2641 aacaagacag tatagttttg atgaagacga cctccctcca gacctggccg aggcagtggg
     2701 agtgaccaca tctacaacca caaacaccac aacggccgcc acacaagtct ccgtgccgct
     2761 gccgtccccc aaggtccaga atgtcagctc gcctcacaag tcagaaggca aaggcctgct
     2821 gtcccctggg gccaagagcc cctctgaccg aggaggtgcc tttaccctgg agccgggtga
     2881 tcttctgatg gatttcacag aagccactcc tctggcagag cccgccagca acccccactg
     2941 tgcccactct cgctgttctc ctccactctc tctccccatg aaggaagaga ccactggagt
     3001 ttgcatgtac cctccaatca aaacgaggct gataaaaaca ttcccggttg atacaatgaa
     3061 cccgtttcct gatactttca ccacagggcc acagtttact gcagacttca gagacagtaa
     3121 attacagtgc tgtcctggcc cgacttcccc gctgatccca gcagcgaccc tgaggccttt
     3181 gacagagacc gtctccacag tgcagaccat ttacaccacc cggaaacctg tttctctggc
     3241 agccagtgca gagacactcc ggcaggaact ggagagagag aagatgatga aaagactgtt
     3301 gatgaccgaa ctgtgaaatt ctccccttgt cacctggaag atggcatggt gccttctgtc
     3361 cgtcttcttt cttcgggctt tgtgtgctca ctctagcaca gcatacaagt gtgtgctctg
     3421 ttcgcccagg tctccatggt tagttgaagc caatttctgg cttgactttt atgggaaaag
     3481 ttattttatg tctcctaagc attagagttt ttctattact ctatgtagtt gagacaggat
     3541 ttgataagtc taggaaaaga aagatgggaa aacgggattc cttttcagaa gtacctgtgt
     3601 gtatctgtta ataaccacag gggttaatat gatgtaggat cttttactat caatttcaac
     3661 catttgattt tgtatgattg aaacttgcac cgagctttga ctgtttgtta aagagtcatt
     3721 tttaatgaaa gaataattct ttattgctgg tttttcattt acactgataa atacacagat
     3781 cttataaagt ctttaacatt catttgtatt cagatgtgag tagaagaact aaaaaaagaa
     3841 agttacatat cactatgact gaaggtactt cagcttaatc tgaaatataa tttaacttgt
     3901 gaactccttg gatatgatat tatttggaat aaacagaatt tatcattgaa cccaaagtag
     3961 gaaatgatag cttacattgt ctaaaaatcc ttacaaggtt aagatgattc aatatcaaga
     4021 agattcagaa aattatttct aaagttgatc gattcatgtc gtattgatag aatcttgacc
     4081 agaagaaatt ttgctctttt tatatagttt caagaaatgt gtttttaaat ttttattaat
     4141 gcacttgaac aactttgcag gaataaagca accccctaac cacaaaatat ccctctaaat
     4201 tagttcccta gctttctcaa tgaatacaca catattttta catagctatg atcgttgtgt
     4261 acattctcct ttgttttact tctcggccta acacttgtct cctcttgtca acacagattc
     4321 tactctcacc aatttaaatg tctttatatc catgtaacat gggtaacctc acttcacccc
     4381 attattagat atttgagtta tatctaattt ttcactctta taaatagtgc tgctatgaat
     4441 gtctgtaaaa aaaaaaaact gctccttctt ttggattatt cccttaggaa tatctccaaa
     4501 gagggattac aaggtcaaag agcatgaagt attttatagc tcttgtttta tattgccaga
     4561 ttgctttcta gaaagatcca atctttgggt tggaaggacc ttaaaggtca tctagtttag
     4621 cctccccacc ccctctgaat gcttgaatcc cctcgacaat ttatgatgcc accagcaatg
     4681 tataagcatt tctgtttacc aatagctctg ccagtattgg gttttgccat ttttatttat
     4741 ttttgctagt ttaataggta tgtatagttg ttcttgaaga gttgttttat ttcattaatt
     4801 gctagcaagg ctgagcactt ttccatgtga tgatttacta gttgtatttc cttgtgtgta
     4861 aaatgttcat tcatttctta tgaccacttg ttaagaggaa ctgatctcat atatttgtat
     4921 cagaactgta tttttatgtt atattgtata gtttgctctc ctgcccctct ccttaaaact
     4981 gaatggtgcc aataatttga tactaatgac tacaaaaaaa ggtaatgcct catttactag
     5041 tattgttgta aaatgaggaa tgtatgtgaa tattcagata accgaggatt aaccctttaa
     5101 gtgctgaatc tttaaaattt taatatattt ttttttgagg gaaatctttc taaaatgtat
     5161 tacgcacttc cctgccttag taaacagagt atactggaga gtatttaacc ttttcttgat
     5221 gagtcatggt catgattata aacatcagcc ccttttatac cttggtacgg tgcagtgata
     5281 tcattaagag ctatcaatat gtgtagggct tggcttggcc ttttatagga tattatgctg
     5341 ttctcactga tggtttttta ctgctctctg ctctgtcagt ggagctatcc ggggcaattg
     5401 tagcgtttgg gtccttttac ccctatgtcc cccggctata cttttaaaac agctttagct
     5461 gttctttatc ttgtgcacat gatacaaaat atgttcccgt acaatatggg gctgtcactt
     5521 cttgccaacc cagcaccctc ttcctcttct aacctgcttt ctgaggcttc tgctcttcac
     5581 ctcctgctcg ctgatggaaa cctccagggc aaagctgaag gtttcttggg gaagccagga
     5641 aagccagtat ttcctatgtg tcagatctgc ttggcttcca agaagggatg catgggcttt
     5701 ttggccagtg tttccaggag gctctgggct tcctgcttct tccccgcttc ccccagagtt
     5761 cacagatgtt gaagtttctg aaggttgacg tcactggaag tctgaccaca aacaagttgg
     5821 ctgttactgt atttgaaacc cagtaccttt ggcagctcac ctctaaccag taaaataaga
     5881 ggattccatg gtttca
//
