LOCUS       NM_012307               4459 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens erythrocyte membrane protein band 4.1 like 3
            (EPB41L3), transcript variant 1, mRNA.
ACCESSION   NM_012307
VERSION     NM_012307.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4459)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 4459)
  AUTHORS   Dickey,B.L., Nedjai,B., Preece,M.D., Schell,M.J., Boulware,D.,
            Whiting,J., Sirak,B., Abrahamsen,M., Isaacs-Soriano,K.A.,
            Kennedy,K., Chung,C.H. and Giuliano,A.R.
  TITLE     Methylation of HPV16 and EPB41L3 in oral gargles and the detection
            of early and late oropharyngeal cancer
  JOURNAL   Cancer Med 11 (20), 3735-3742 (2022)
   PUBMED   35619332
  REMARK    GeneRIF: Methylation of HPV16 and EPB41L3 in oral gargles and the
            detection of early and late oropharyngeal cancer.
REFERENCE   3  (bases 1 to 4459)
  AUTHORS   Tuerxun,G., Abulimiti,T., Abudurexiti,G., Abuduxikuer,G., Zhang,Y.
            and Abulizi,G.
  TITLE     Over-expression of EPB41L3 promotes apoptosis of human cervical
            carcinoma cells through PI3K/AKT signaling
  JOURNAL   Acta Biochim Pol 69 (2), 283-289 (2022)
   PUBMED   35569139
  REMARK    GeneRIF: Over-expression of EPB41L3 promotes apoptosis of human
            cervical carcinoma cells through PI3K/AKT signaling.
REFERENCE   4  (bases 1 to 4459)
  AUTHORS   Zhang,S., Guo,M., Guo,T., Yang,M., Cheng,J., Cui,C., Kang,J.,
            Wang,J., Nian,Y., Ma,W., Weng,H. and Weng,H.
  TITLE     DAL-1/4.1B promotes the uptake of exosomes in lung cancer cells via
            Heparan Sulfate Proteoglycan 2 (HSPG2)
  JOURNAL   Mol Cell Biochem 477 (1), 241-254 (2022)
   PUBMED   34657240
  REMARK    GeneRIF: DAL-1/4.1B promotes the uptake of exosomes in lung cancer
            cells via Heparan Sulfate Proteoglycan 2 (HSPG2).
REFERENCE   5  (bases 1 to 4459)
  AUTHORS   Wang,H., Jiang,Y., Yu,L., Xu,L., Guan,R., Cai,M., Dong,K.,
            Liang,X., Bai,J. and Yu,J.
  TITLE     The rs9953490 polymorphism of DAL-1 gene is associated with gastric
            cancer risk in the Han population in Northeast China
  JOURNAL   BMC Gastroenterol 21 (1), 354 (2021)
   PUBMED   34579655
  REMARK    GeneRIF: The rs9953490 polymorphism of DAL-1 gene is associated
            with gastric cancer risk in the Han population in Northeast China.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4459)
  AUTHORS   Tan,J.S., Mohandas,N. and Conboy,J.G.
  TITLE     Evolutionarily conserved coupling of transcription and alternative
            splicing in the EPB41 (protein 4.1R) and EPB41L3 (protein 4.1B)
            genes
  JOURNAL   Genomics 86 (6), 701-707 (2005)
   PUBMED   16242908
REFERENCE   7  (bases 1 to 4459)
  AUTHORS   Tran,Y.K., Bogler,O., Gorse,K.M., Wieland,I., Green,M.R. and
            Newsham,I.F.
  TITLE     A novel member of the NF2/ERM/4.1 superfamily with growth
            suppressing properties in lung cancer
  JOURNAL   Cancer Res 59 (1), 35-43 (1999)
   PUBMED   9892180
REFERENCE   8  (bases 1 to 4459)
  AUTHORS   Peters,L.L., Weier,H.U., Walensky,L.D., Snyder,S.H., Parra,M.,
            Mohandas,N. and Conboy,J.G.
  TITLE     Four paralogous protein 4.1 genes map to distinct chromosomes in
            mouse and human
  JOURNAL   Genomics 54 (2), 348-350 (1998)
   PUBMED   9828140
REFERENCE   9  (bases 1 to 4459)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   10 (bases 1 to 4459)
  AUTHORS   Adams,M.D., Soares,M.B., Kerlavage,A.R., Fields,C. and Venter,J.C.
  TITLE     Rapid cDNA sequencing (expressed sequence tags) from a
            directionally cloned human infant brain cDNA library
  JOURNAL   Nat Genet 4 (4), 373-380 (1993)
   PUBMED   8401585
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP005059.2 and AP005671.2.
            
            On Jun 26, 2020 this sequence version replaced NM_012307.4.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB023204.1, SRR1660807.204944.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341928.7/ ENSP00000343158.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AP005059.2         145854-145938       c
            86-279              AP005059.2         90942-91135         c
            280-477             AP005059.2         80182-80379         c
            478-582             AP005059.2         47081-47185         c
            583-625             AP005059.2         45779-45821         c
            626-701             AP005059.2         39976-40051         c
            702-920             AP005059.2         35844-36062         c
            921-1008            AP005059.2         35410-35497         c
            1009-1161           AP005059.2         30254-30406         c
            1162-1259           AP005059.2         26203-26300         c
            1260-1435           AP005059.2         25319-25494         c
            1436-1602           AP005059.2         21652-21818         c
            1603-2163           AP005059.2         17759-18319         c
            2164-2217           AP005059.2         12507-12560         c
            2218-2253           AP005059.2         9642-9677           c
            2254-2445           AP005059.2         8718-8909           c
            2446-2568           AP005671.2         83782-83904         c
            2569-2937           AP005671.2         82819-83187         c
            2938-3069           AP005671.2         81962-82093         c
            3070-3168           AP005671.2         81370-81468         c
            3169-3249           AP005671.2         80828-80908         c
            3250-3366           AP005671.2         80438-80554         c
            3367-4459           AP005671.2         78147-79239         c
FEATURES             Location/Qualifiers
     source          1..4459
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.31"
     gene            1..4459
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /note="erythrocyte membrane protein band 4.1 like 3"
                     /db_xref="GeneID:23136"
                     /db_xref="HGNC:HGNC:3380"
                     /db_xref="MIM:605331"
     exon            1..85
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            86..279
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..3360
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /note="isoform 1 is encoded by transcript variant 1; band
                     4.1-like protein 3; differentially expressed in
                     adenocarcinoma of the lung protein 1"
                     /codon_start=1
                     /product="band 4.1-like protein 3 isoform 1"
                     /protein_id="NP_036439.2"
                     /db_xref="CCDS:CCDS11838.1"
                     /db_xref="GeneID:23136"
                     /db_xref="HGNC:HGNC:3380"
                     /db_xref="MIM:605331"
                     /translation="MTTESGSDSESKPDQEAEPQEAAGAQGRAGAPVPEPPKEEQQQA
                     LEQFAAAAAHSTPVRREVTDKEQEFAARAAKQLEYQQLEDDKLSQKSSSSKLSRSPLK
                     IVKKPKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAEN
                     QKNWLDPAKEIKKQVRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRL
                     PCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRG
                     MTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAW
                     PKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLP
                     EAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGEVGT
                     GQYATTKGISQTNLITTVTPEKKAEEERDEEEDKRRKGEEVTPISAIRHEGKSPGLGT
                     DSCPLSPPSTHCAPTSPTELRRRCKENDCKLPGYEPSRAEHLPGEPALDSDGPGRPYL
                     GDQDVAFSYRQQTGKGTTLFSFSLQLPESFPSLLDDDGYLSFPNLSETNLLPQSLQHY
                     LPIRSPSLVPCFLFIFFFLLSASFSVPYALTLSFPLALCLCYLEPKAASLSASLDNDP
                     SDSSEEETDSERTDTAADGETTATESDQEEDAELKAQELEKTQDDLMKHQTNISELKR
                     TFLETSTDTAVTNEWEKRLSTSPVRLAARQEDAPMIEPLVPEETKQSSGEKLMDGSEI
                     FSLLESARKPTEFIGGVTSTSQSWVQKMETKTESSGIETEPTVHHLPLSTEKVVQETV
                     LVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEGAKEEGGEEVAKAVL
                     EQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGSVSPGGVKLEIST
                     KEVPVVHTETKTITYESSQVDPGTDLEPGVLMSAQTITSETTSTTTTTHITKTVKGGI
                     SETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEITPEDGED"
     exon            280..477
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            478..582
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            583..625
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            626..701
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            702..920
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1008
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1161
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1259
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1435
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1602
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..2163
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2217
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2253
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2445
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2568
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2937
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2938..3069
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3070..3168
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..3249
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..3366
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3367..4459
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4435..4440
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /note="hexamer: AATAAA"
     polyA_site      4459
                     /gene="EPB41L3"
                     /gene_synonym="4.1B; DAL-1; DAL1"
                     /note="major polyA site"
ORIGIN      
        1 gagtctcctg cgcaccgccg ccgaggacgc gcgcccgagc ctagtcccca cgccgcggcg
       61 cgcccgggct ccctgctgat cccagaacaa tcaaccatga cgaccgaatc tggatcagac
      121 tcggaatcca agccggacca ggaggccgag ccccaggagg cggcgggggc gcaggggcgc
      181 gcgggggcgc ccgtgccgga gccgcccaag gaggagcagc agcaggccct ggagcagttc
      241 gccgccgctg cagcgcacag caccccggtg cggagggagg tcactgacaa ggaacaggag
      301 tttgctgcca gggctgcaaa acagctcgaa tatcagcaat tagaagacga taaactttct
      361 cagaaatcat ctagcagtaa actctctcgg tctccattaa agattgtcaa aaagcctaaa
      421 agcatgcagt gcaaagtgat acttctcgat ggatcagaat atacctgtga tgtagagaaa
      481 cgctccagag gacaagtgct gtttgataaa gtgtgtgaac acttgaactt gctagagaaa
      541 gactactttg ggcttacgta tcgagatgct gaaaaccaga agaattggtt ggaccctgct
      601 aaggaaataa aaaaacaggt tcgaagtggt gcttggcact tttcatttaa tgtgaaattt
      661 tatccaccag accctgccca actatctgaa gatatcacca ggtactacct ctgcttgcag
      721 ttgcgagatg acatcgtgtc cggaaggctg ccctgctcct ttgttaccct ggccttgctg
      781 ggctcctaca ctgtccagtc agagctcgga gactatgacc cagatgaatg tgggagcgat
      841 tacattagtg agttccgctt tgcaccaaac cacactaaag aactggaaga caaagtgatc
      901 gagctgcaca agagccacag aggaatgacg ccagcagaag cagagatgca tttcttggaa
      961 aatgccaaaa aattatcaat gtatggggta gatttacatc atgctaagga ctcagaaggg
     1021 gtagaaatta tgttaggagt ttgtgcaagt ggtctgttga tatatcgcga ccggctgcga
     1081 ataaacagat ttgcctggcc caaggttcta aagatttcat acaaacggaa caacttttac
     1141 attaagatcc ggccgggaga gtttgaacaa tttgaaagca ccattgggtt taagctgcca
     1201 aaccatcgag ctgccaagcg tttatggaaa gtatgtgttg agcatcatac atttttcaga
     1261 ctactgttac cagaagcacc tcccaagaaa ttcctaacct tgggttccaa gtttcgttat
     1321 agtggcagga cacaagcgca aacgagaaga gccagtgcgt tgatagatcg cccagcacct
     1381 tactttgaac gctcatccag caaacgttat accatgtctc gcagcttgga tggagaggtt
     1441 ggtactggcc agtacgccac aacaaaaggc atctctcaga ccaacttgat caccactgtg
     1501 actccggaga agaaggctga ggaggagcgg gacgaggaag aggacaaacg gaggaagggg
     1561 gaagaagtca cgcccatctc ggccatccgg cacgagggaa agtcacctgg gcttggcact
     1621 gactcatgtc ccttgtcacc cccatccacc cattgtgccc ccacatctcc cacagagctc
     1681 cgtaggaggt gtaaggagaa tgactgcaaa ctgccaggtt atgagccgtc cagagctgag
     1741 cacctgcctg gagagcccgc cttggactct gatggcccag ggaggcctta cctaggggat
     1801 caagatgtgg cttttagcta cagacagcaa actggcaagg ggaccaccct gttctccttc
     1861 tccttgcagc tccctgagtc attcccctcc ctcctagatg atgatggata cctctctttc
     1921 cccaaccttt ctgaaaccaa cctcctgccc cagagcttgc agcattacct cccgatccgc
     1981 tcaccgtccc ttgtgccctg tttcctcttc atctttttct ttctgctgtc tgcctccttc
     2041 tcagtgccat acgctctcac tctctccttc cctctggctc tgtgcctctg ctacctggag
     2101 cccaaggcgg cctccttgag cgcctcccta gacaatgacc cgagtgacag ttcagaggaa
     2161 gagactgaca gtgagcgcac ggacaccgca gccgacgggg agaccactgc cactgagtcg
     2221 gaccaggagg aagatgcaga gctcaaggca caggagctag aaaaaactca agatgacctg
     2281 atgaaacatc aaaccaacat tagcgagctg aaaagaacct tcttagaaac ctcaacagac
     2341 actgccgtaa cgaatgaatg ggagaagagg ctttccacct cccccgtgcg actggccgcc
     2401 aggcaggagg atgcccccat gatcgaacca cttgtccctg aagagactaa gcagtcttct
     2461 ggggaaaagc tcatggatgg ctctgaaatc ttcagtttat tagagtctgc gcgaaaacca
     2521 acagaattca taggaggggt tacttctact tctcaaagct gggttcagaa aatggaaacc
     2581 aagacggagt ccagtggaat agagacggaa cccaccgtgc accacctgcc gcttagcact
     2641 gagaaggtgg tgcaggagac cgtgttggtg gaggagcggc gtgtggtgca cgcgagtggg
     2701 gatgcttctt actcggcggg agacagcggg gatgctgcag cacagcccgc attcacaggc
     2761 attaaaggga aagagggctc tgccttgacg gagggggcta aagaggaagg aggggaggag
     2821 gtcgctaaag ctgtcctgga acaggaagag acagccgctg cttcccgtga gcgacaagag
     2881 gagcagagtg cagccatcca catttcagaa actttggaac aaaaacctca ttttgagtcc
     2941 tcaacggtga agacggaaac catcagtttt ggcagtgttt caccgggagg agtaaagcta
     3001 gaaatttcca cgaaggaagt gccagtagtt cacaccgaaa ccaaaaccat cacatatgaa
     3061 tcatcacagg tcgatccagg cacagatctg gagccaggcg tgctgatgag tgcacagacg
     3121 atcacatctg aaaccaccag taccaccacc actacgcaca tcaccaaaac tgtgaaaggg
     3181 ggcatttcag agacaagaat tgagaagcga atagtcatca cgggggatgc agacattgac
     3241 catgaccagg cgctggctca ggcaattaaa gaggccaaag agcagcaccc tgacatgtca
     3301 gtgaccaaag tagtggtcca taaagagaca gagatcacac cagaagatgg agaggattga
     3361 ccagaggaat aacttagctt gcacatgaat gcagtcatgc aaaccgttag gaaaaccaga
     3421 gcctatatgg agttccctct tctaacccaa ctgacttgta tctgtccgtg gaaaatttca
     3481 gtccagaaga attgaccttg accattaata aagacactgg cagagagatc ttcccataat
     3541 aaagcaatct gattcagcat cactaaaccg ataatgcatg aagcaacgat aaaattacaa
     3601 aagagcagca tttttaattt tcacaaaatg tctcagtttt cagctatacc tgcacgttca
     3661 taaccaacaa tataaaccgt ggtctcatgt aacacataaa caattcatgc ctttcatagt
     3721 ttattattat taaagtctaa acaaaattgc aatttcttag gtaaccttat atttacaata
     3781 aatgaagatt accctcaaat gctagaagct gtctaggtcc gtccggtgtg tcagattttc
     3841 ctcagattag atgtgccaat aaccaagttt attcagtaaa caacttgtac ttgtttcatc
     3901 tggttttatt actctcaccc ataaacagta atgactctct gaccctctgg aaatatgtaa
     3961 tgcttccaat cttgctttgt gtatctcatt taatttgtta taaggtagta ctgattttag
     4021 catattaatg cgatttcttc cttgttgttt gctttggtct gtgttcaatc cagagagctt
     4081 aaattgtcat tattttggga agaaaacctg tatttttgtt agtttacaat attatgaaat
     4141 ttcacttcag gagaaactgc tgggcttcct gtggctttgt tttcttagtt actttttccg
     4201 tgccgtgtat tttttaattg atttttcttc ttttacttga aaagaaagtg ttttattttc
     4261 aaatctggtc catatttaca ttctagttca gagccaagcc ttaaactgta cagaatttcc
     4321 actgtaatta aaactattta gtgttagtta taaatagcct tcaaaaagag agattctcca
     4381 ttacacgatc acctgcatca cagcccatgg tgaatgtatg tttctgcata gcgaaataaa
     4441 aatggcaaat gcactgaaa
//
