LOCUS       NM_012156               6276 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens erythrocyte membrane protein band 4.1 like 1
            (EPB41L1), transcript variant 1, mRNA.
ACCESSION   NM_012156
VERSION     NM_012156.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6276)
  AUTHORS   Wang,Y., Zhang,H., Kang,Q., Liu,J., Weng,H., Li,W., Mohandas,N.,
            An,X. and Chen,L.
  TITLE     Protein 4.1N is required for the formation of the lateral membrane
            domain in human bronchial epithelial cells
  JOURNAL   Biochim Biophys Acta Biomembr 1860 (5), 1143-1151 (2018)
   PUBMED   29428502
  REMARK    GeneRIF: 4.1N, betaII spectrin and ankyrin G are structural
            components of the lateral membrane skeleton and this skeleton plays
            an essential role in the assembly of a fully functional lateral
            membrane.
REFERENCE   2  (bases 1 to 6276)
  AUTHORS   Yang,Q., Zhu,M., Wang,Z., Li,H., Zhou,W., Xiao,X., Zhang,B., Hu,W.
            and Liu,J.
  TITLE     4.1N is involved in a flotillin-1/beta-catenin/Wnt pathway and
            suppresses cell proliferation and migration in non-small cell lung
            cancer cell lines
  JOURNAL   Tumour Biol 37 (9), 12713-12723 (2016)
   PUBMED   27448302
  REMARK    GeneRIF: Data show that overexpression of 4.1N protein decreased
            expression of flotillin-1, decreased activation of beta-catenin/Wnt
            pathway in non-small-cell lung cancer (NSCLC) cells.
REFERENCE   3  (bases 1 to 6276)
  AUTHORS   Wang,Z., Ma,B., Li,H., Xiao,X., Zhou,W., Liu,F., Zhang,B., Zhu,M.,
            Yang,Q., Zeng,Y., Sun,Y., Sun,S., Wang,Y., Zhang,Y., Weng,H.,
            Chen,L., Ye,M., An,X. and Liu,J.
  TITLE     Protein 4.1N acts as a potential tumor suppressor linking PP1 to
            JNK-c-Jun pathway regulation in NSCLC
  JOURNAL   Oncotarget 7 (1), 509-523 (2016)
   PUBMED   26575790
  REMARK    GeneRIF: Data suggest that repression of JNK-c-Jun signaling
            through pancreatic polypeptide receptor 1 (PP1) is one of the key
            anti-tumor mechanisms of neuronal membrane cytoskeletal protein 4.1
            (4.1N).
            Erratum:[Oncotarget. 2019 Oct 22;10(58):6285. doi:
            10.18632/oncotarget.27282.. PMID: 31692885]
REFERENCE   4  (bases 1 to 6276)
  AUTHORS   Zhang,L., Hu,A., Li,M., Zhang,H., Ren,C., An,X. and Liu,C.
  TITLE     4.1N suppresses hypoxia-induced epithelial-mesenchymal transition
            in epithelial ovarian cancer cells
  JOURNAL   Mol Med Rep 13 (1), 837-844 (2016)
   PUBMED   26648170
  REMARK    GeneRIF: the data of the current study identified 4.1N as an
            inhibitor of hypoxiainduced tumor progression in epithelial ovarian
            cancer cells.
REFERENCE   5  (bases 1 to 6276)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6276)
  AUTHORS   Shen,L., Liang,F., Walensky,L.D. and Huganir,R.L.
  TITLE     Regulation of AMPA receptor GluR1 subunit surface expression by a
            4. 1N-linked actin cytoskeletal association
  JOURNAL   J Neurosci 20 (21), 7932-7940 (2000)
   PUBMED   11050113
REFERENCE   7  (bases 1 to 6276)
  AUTHORS   Ye,K., Compton,D.A., Lai,M.M., Walensky,L.D. and Snyder,S.H.
  TITLE     Protein 4.1N binding to nuclear mitotic apparatus protein in PC12
            cells mediates the antiproliferative actions of nerve growth factor
  JOURNAL   J Neurosci 19 (24), 10747-10756 (1999)
   PUBMED   10594058
REFERENCE   8  (bases 1 to 6276)
  AUTHORS   Walensky,L.D., Blackshaw,S., Liao,D., Watkins,C.C., Weier,H.U.,
            Parra,M., Huganir,R.L., Conboy,J.G., Mohandas,N. and Snyder,S.H.
  TITLE     A novel neuron-enriched homolog of the erythrocyte membrane
            cytoskeletal protein 4.1
  JOURNAL   J Neurosci 19 (15), 6457-6467 (1999)
   PUBMED   10414974
REFERENCE   9  (bases 1 to 6276)
  AUTHORS   Peters,L.L., Weier,H.U., Walensky,L.D., Snyder,S.H., Parra,M.,
            Mohandas,N. and Conboy,J.G.
  TITLE     Four paralogous protein 4.1 genes map to distinct chromosomes in
            mouse and human
  JOURNAL   Genomics 54 (2), 348-350 (1998)
   PUBMED   9828140
REFERENCE   10 (bases 1 to 6276)
  AUTHORS   Kim,A.C., Van Huffel,C., Lutchman,M. and Chishti,A.H.
  TITLE     Radiation hybrid mapping of EPB41L1, a novel protein 4.1 homologue,
            to human chromosome 20q11.2-q12
  JOURNAL   Genomics 49 (1), 165-166 (1998)
   PUBMED   9570967
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB503878.1, AB002336.1 and
            AL121895.26.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 23, 2003 this sequence version replaced NM_012156.1.
            
            Summary: Erythrocyte membrane protein band 4.1 (EPB41) is a
            multifunctional protein that mediates interactions between the
            erythrocyte cytoskeleton and the overlying plasma membrane. The
            encoded protein binds and stabilizes D2 and D3 dopamine receptors
            at the neuronal plasma membrane. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB002336.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338074.7/ ENSP00000337168.2
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                DB503878.1         1-10
            11-3788             AB002336.1         1-3778
            3789-6276           AL121895.26        88166-90653
FEATURES             Location/Qualifiers
     source          1..6276
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.23"
     gene            1..6276
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /note="erythrocyte membrane protein band 4.1 like 1"
                     /db_xref="GeneID:2036"
                     /db_xref="HGNC:HGNC:3378"
                     /db_xref="MIM:602879"
     exon            1..157
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /inference="alignment:Splign:2.1.0"
     exon            158..348
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..2817
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /note="isoform a is encoded by transcript variant 1;
                     neuron-type nonerythroid protein 4.1; neuronal protein
                     4.1; band 4.1-like protein 1"
                     /codon_start=1
                     /product="band 4.1-like protein 1 isoform a"
                     /protein_id="NP_036288.2"
                     /db_xref="CCDS:CCDS13271.1"
                     /db_xref="GeneID:2036"
                     /db_xref="HGNC:HGNC:3378"
                     /db_xref="MIM:602879"
                     /translation="MTTETGPDSEVKKAQEEAPQQPEAAAAVTTPVTPAGHGHPEANS
                     NEKHPSQQDTRPAEQSLDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVT
                     LLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKK
                     QIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSY
                     AVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLEN
                     AKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNF
                     YIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSK
                     FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGP
                     DGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQ
                     ASINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKANERAGLREGSEE
                     KVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIERKCSSITVSSTSSLEAEVDFTV
                     IGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRG
                     ACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDNTQQVDGSASVGREF
                     IATTPSITTETISTTMENSLKSGKGAAAMIPGPQTVATEIRSLSPIIGKDVLTSTYGA
                     TAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQALALAIKEAKLQHPDM
                     LVTKAVVYRETDPSPEERDKKPQES"
     exon            349..513
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /inference="alignment:Splign:2.1.0"
     exon            514..618
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /inference="alignment:Splign:2.1.0"
     exon            619..661
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /inference="alignment:Splign:2.1.0"
     exon            662..737
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /inference="alignment:Splign:2.1.0"
     exon            738..956
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1044
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1197
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1295
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1471
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1620
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1656
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1839
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..2250
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2355
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2439
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2526
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..2610
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2691
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2808
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..6276
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6250..6255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /note="hexamer: AATAAA"
     polyA_site      6276
                     /gene="EPB41L1"
                     /gene_synonym="4.1N; MRD11"
                     /note="major polyA site"
ORIGIN      
        1 agtcggcatc catcagcggg cgggggtgtc gccgaacagg ctgctccgca gagcccgccg
       61 cgaccccgcg ccgccccgcc ccgcggcctg cctgccagag gagccgaggg ggccgcccct
      121 cgcccaacct gcccgacatg gggaaccccg ggcccaggcg tgctggtcac catgacaaca
      181 gagacaggcc ccgactctga ggtgaagaaa gctcaggagg aggccccgca gcagcccgag
      241 gctgctgccg ctgtgaccac ccctgtgacc cctgcaggcc acggccaccc agaggccaac
      301 tccaatgaga agcatccatc ccagcaggac acgcggcctg ctgaacagag cctagacatg
      361 gaggagaagg actacagtga ggccgatggc ctttcggaga ggaccacgcc cagcaaggcc
      421 cagaaatcgc cccagaagat tgccaagaaa tacaagagtg ccatctgccg ggtcactctg
      481 cttgatgcct cggagtatga gtgtgaggtg gagaaacatg gccggggcca ggtgctgttt
      541 gacctggtct gtgaacacct caacctccta gagaaggact acttcggcct gaccttctgt
      601 gatgctgaca gccagaagaa ctggctggac ccctccaagg agatcaagaa gcagatccgg
      661 agtagcccct ggaattttgc cttcacagtc aagttctacc cgcctgatcc tgcccagctg
      721 acagaagaca tcacaagata ctacctgtgc ctgcagctgc gggcagacat catcacgggc
      781 cggctgccat gctcctttgt cacgcatgcc ctactgggct cctacgctgt gcaggctgag
      841 ctgggtgact atgatgctga ggagcatgtg ggcaactatg tcagcgagct ccgcttcgcc
      901 cctaaccaga cccgggagct ggaggagagg atcatggagc tgcataagac atataggggg
      961 atgaccccgg gagaagcaga aatccacttc ttagagaatg ccaagaagct ttccatgtac
     1021 ggagtagacc tgcaccatgc caaggactct gagggcatcg acatcatgtt aggcgtttgt
     1081 gccaatggcc tgctcatcta ccgggaccgg ctgagaatca accgctttgc ctggcccaag
     1141 atcctcaaga tctcctacaa gaggagtaac ttctatatca agatccggcc tggggagtat
     1201 gagcaatttg agagcacaat tggctttaag ctcccaaacc accggtcagc caagagactg
     1261 tggaaggtct gcatcgagca tcatacattc ttccggctgg tgtcccctga gcccccaccc
     1321 aagggcttcc tggtgatggg ctccaagttc cggtacagtg ggaggaccca ggcacagact
     1381 cgccaggcca gcgccctcat tgaccggcct gcacccttct ttgagcgttc ttccagcaaa
     1441 cggtacacca tgtcccgcag ccttgatgga gcagagttct cccgcccagc ctcggtcagc
     1501 gagaaccatg atgcagggcc tgacggtgac aagcgggatg aggatggcga gtctgggggg
     1561 caacggtcag aggctgagga gggagaggtc aggactccaa ccaagatcaa ggagctaaag
     1621 ccggagcagg aaaccacgcc gagacacaag caggagttct tagacaagcc agaagatgtc
     1681 ttgctgaagc accaggccag catcaatgag ctcaaaagga ccctgaagga gcccaacagc
     1741 aaactcatcc accgggatcg agactgggaa cgggagcgca ggctgccctc ctcccccgcc
     1801 tccccctccc ccaagggcac ccctgagaaa gccaatgaga gagcagggct gagggagggc
     1861 tccgaggaga aagtcaaacc accacgtccc cgggccccag agagtgacac aggcgatgag
     1921 gaccaggacc aggagaggga cacggtgttc ctgaaggaca accacctggc cattgagcgc
     1981 aagtgctcca gcatcacggt cagctctacg tctagcctgg aggctgaggt ggacttcacg
     2041 gtcattggtg actaccatgg cagcgccttc gaagacttct cccgcagcct gcctgagctc
     2101 gaccgggaca aaagcgactc ggacactgag ggcctgctgt tctcccggga tctcaacaag
     2161 ggggccccca gccaggatga tgagtctggg ggcattgagg acagcccgga tcgaggggcc
     2221 tgctccaccc cggatatgcc ccagtttgag cccgtgaaaa cagaaaccat gactgtcagc
     2281 agtctggcca ttagaaagaa gattgagccg gaggccgtac tgcagaccag agtctccgct
     2341 atggataaca cccagcaggt tgatgggagt gcctcagtgg ggagggagtt catagcaacc
     2401 actccctcca tcaccacgga gaccatatcg accaccatgg agaacagtct caagtccggg
     2461 aagggggcag ctgccatgat cccaggccca cagacggtgg ccacggaaat ccgttctctt
     2521 tctccgatca tcgggaaaga tgtcctcacc agcacctacg gcgccactgc ggaaaccctc
     2581 tcaacctcca ccaccaccca tgtcaccaaa actgtgaaag gagggttttc tgagacaagg
     2641 atcgagaagc gaatcatcat tactggggat gaagatgtcg atcaagacca ggccctggct
     2701 ttggccatca aggaggccaa actgcagcat cctgatatgc tggtaaccaa agctgtcgta
     2761 tacagagaaa cagacccatc cccagaggag agggacaaga agccacagga atcctgacct
     2821 ctgtgaagag atcctggcat ttctggtcca acccaagcca gagaaccatt aagaaggggc
     2881 cttcattctg gattctccga cgcaacactg acgtcccagc tgcgacgtac tgtcactgat
     2941 gagagactgg gaagggaaaa gcatatatat atagatatat agagatatag atatatatac
     3001 aggaaacacc gcatccttgc actgctgctg gggctggcag agcagttggc tgacagcaac
     3061 aaccgacatc tgaacaccta catttccttt gcagacaaat tgaagaactg gtgggatttt
     3121 tttcaagaaa aaaaattata taataactat aatcccttgc tcaccccttt cccccgccaa
     3181 ataagaaacg caagccagac cacgatgatt gtagaagtcc ctcccgccct ggttctgcac
     3241 gttacagtta gcagacgagc aattccattt gttcttctcc agcatctcta aggcccactt
     3301 gaatgcaaag gaaaacactt gcacagcaaa gcaagagaag tcacagcagc aagacacgca
     3361 cagtcaacca ttttccgaga aaaaaagaaa attccccact tggaaagaaa gaggaggaac
     3421 actggattct tactttctgg atcttgacac tgggctgcaa aacctacctt cctctctccc
     3481 gcctcccctc accctcaact ctcaatgtct tgctgtcatt ttctgtctcg gctccctcct
     3541 cccccttccc ccttccccca ccccacaccc ttcaccctct gtgtcctggt ccttctgagg
     3601 gccactgcag atgactctcc tttgaaatga gaaaaagaaa agaaagcaag aacagaaaac
     3661 gaagccacag gaagggaagt agacattgta tgcttatggt ttctcattat gaaggtgcag
     3721 cttgtaggag gtttgtacgg atgtgctttg aagttatgta tattacatat aacaggaaaa
     3781 aatattaaaa taaacagtgc tggtaagtat gaagctgaca ttctaaaatt ataattatct
     3841 gactgtgatt gatgtatcct gaggttccta gatctcactg aactggccca gctaaggaga
     3901 cctggactct gggtgtgggt tggctcacag taggggctga cgggttcagt gtagtaatac
     3961 tgtgtgtggt gtttgtaatt ggttgattgg tggggagggg tggggggccc taatggagag
     4021 gtgtgggttt ggcaagaaag aagcaacaca gatgtcgtcc ccaaaatgcc agttcaagac
     4081 accttctccc tgcccccctg gtagtaacag tcagggcctg gtctgtgctc aggtactggg
     4141 tcccagtctg ggactctgct gctgaagttg ccacagtaga ggtccctggc ttagtcctta
     4201 tctccctacg gggcttgcct tggttttcag tcttctctct ctttctctct tttttttttt
     4261 tttgccacat tctgcccttc cctgacccca ttgtaataac caactccata tccaaaggga
     4321 ggtggtgctc tcagccattg tagaagatgg tggctttaac ctgactgtct aaaaattccc
     4381 agctaagcct tttcctctac tctcttcctt gttctgaatc atttcttctt ctcaggccaa
     4441 agtagccatg gtaaggaggc ttcatggggc agaccctgaa agatcaaaac tgcatttgca
     4501 aagccctccc ctgtcccagg acaaagctga gactgacggg tgatgttgct cataggctcc
     4561 agctctgcat aagaccttgg cttggagacc tccctctcag tcaacagctg aactctgagc
     4621 ttgtgcccag aaattacccc aagaccacag gaacccttca agaagctccc atcacaagct
     4681 tggcattgct ctctgccaca cgtgggcttc ctcaggcttg tctgccacaa gctacttctc
     4741 tgagctcaga aagtgcccct tgatgaggga aaatgtccca ctgcactgcg aatttctcag
     4801 ttccatttta cctcccagtc ctccttctaa accagttaat aaattcattc cacaagtatt
     4861 tactgattac ctgcttgtgc cagggactat tctcaggctg aagaaggtgg gaggggaggg
     4921 cggaacctga ggagccacct gagccagctt tatatttcaa ccatggctgg cccatctgag
     4981 agcatctccc cactctcgcc aacctatcgg ggcatagccc agggatgccc ccaggcggcc
     5041 caggttagat gcgtcccttt ggcttgtcag tgatgacata caccttagct gcttagctgg
     5101 tgctggcctg aggcagggca ggaaatcaga atagcatttg cttctctggg caaatgggaa
     5161 gttcagcggg gcagcagaat cagtggcatt ccccctggtg caggccggtg ggtccactcc
     5221 aactccccct gagtgtagca gcacactttc catacaccag gttctttcta caatcctggt
     5281 ggaaaagcca cagaaccttc ttcctgccct tcttgagagt tccccctctt tctgggtcaa
     5341 gagctggagt ggtggctcca tcctctctgg gccacttcgg tctaggaact catctttgca
     5401 ggaaccagga gtcctgagca cactgaacac acctcagagg gaggatcctt gttgtggatt
     5461 ttgcacctgg ctttggggca ggggtgaagt gaccaggctt agcttgtgga gtttatgggc
     5521 caccagggtt tggggaaatc accatcccgc ggatgctgtg acctcccttc tacggagatg
     5581 caggcagtgc cacgagggag gaggggacct gcaaagctag aatctagggc actgtttcct
     5641 ccccatcctt ctctttgtag agaatagaga cgtttgtctt gtctgtcttc aacctacttt
     5701 tccttttctc ttttttgttt ctcatcctct ctgtgccacc tctccaccca ggaggccatg
     5761 tagcatagtg gaaaaagtcc ctgagggcgg ttaggagttc tgggtgacca tcctggctca
     5821 gctcctaact caccatgtga catcaggcta tccccattcc ccctcttggg cctcagtttc
     5881 ccgacttgca aaataagcag aaagaaccag atgctctcca gggtcttttt ctactttgct
     5941 atctcatggg tcttcatttt ctcttatttt gttttctctg gatcttttcc atctgagggt
     6001 acaggaagta ccaggacctg tttcagtttt tgaatcctgc aagcacattc caagactggc
     6061 ctgaaactgc atgagcaaca tcactcgaaa taattttttt tttcaaaagc accttaacaa
     6121 ccaattgcga tgctgtcctg ttccttttta ctcacaccct tctctccttt ctcgtcccca
     6181 tgctccccca cctcagtgct ccgtgctgta tgcgtgtgct ctctgttctt gtatactcaa
     6241 tataagtgaa ataaatgtgt ttgatgctga accata
//
