LOCUS       NM_203342               5980 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens erythrocyte membrane protein band 4.1 (EPB41),
            transcript variant 4, mRNA.
ACCESSION   NM_203342
VERSION     NM_203342.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5980)
  AUTHORS   Cao,M., Huang,Z., Zhou,H., Lin,J. and Zhang,D.
  TITLE     Clinical and molecular genetic analysis of a Chinese family with
            hereditary elliptocytosis caused by a novel mutation in the EPB41
            gene
  JOURNAL   J Clin Lab Anal 35 (6), e23781 (2021)
   PUBMED   33942936
  REMARK    GeneRIF: Clinical and molecular genetic analysis of a Chinese
            family with hereditary elliptocytosis caused by a novel mutation in
            the EPB41 gene.
REFERENCE   2  (bases 1 to 5980)
  AUTHORS   Yuan,J., Xing,H., Li,Y., Song,Y., Zhang,N., Xie,M., Liu,J., Xu,Y.,
            Shen,Y., Wang,B., Zhang,L. and Yang,M.
  TITLE     EPB41 suppresses the Wnt/beta-catenin signaling in non-small cell
            lung cancer by sponging ALDOC
  JOURNAL   Cancer Lett 499, 255-264 (2021)
   PUBMED   33242559
  REMARK    GeneRIF: EPB41 suppresses the Wnt/beta-catenin signaling in
            non-small cell lung cancer by sponging ALDOC.
REFERENCE   3  (bases 1 to 5980)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 5980)
  AUTHORS   Huang,S.C., Liang,J.Y., Vu,L.V., Yu,F.H., Ou,A.C., Ou,J.P.,
            Zhang,H.S., Burnett,K.M. and Benz,E.J. Jr.
  TITLE     Epithelial-specific isoforms of protein 4.1R promote adherens
            junction assembly in maturing epithelia
  JOURNAL   J Biol Chem 295 (1), 191-211 (2020)
   PUBMED   31776189
  REMARK    GeneRIF: Epithelial-specific isoforms of protein 4.1R promote
            adherens junction assembly in maturing epithelia.
REFERENCE   5  (bases 1 to 5980)
  AUTHORS   Chen,J., Zhou,W.J., Li,Y.X., Chen,Y.N., Chen,H.G. and Ding,X.P.
  TITLE     [Identification of a Novel Mutation of EPB41 Gene in a Family
            Affected with Hereditary Elliptocytosis]
  JOURNAL   Sichuan Da Xue Xue Bao Yi Xue Ban 51 (1), 97-101 (2020)
   PUBMED   31950797
  REMARK    GeneRIF: The c.1215G>A mutation of the EPB41 gene probably accounts
            for the Elliptocytosis in this family
REFERENCE   6  (bases 1 to 5980)
  AUTHORS   Dalla Venezia,N., Gilsanz,F., Alloisio,N., Ducluzeau,M.T.,
            Benz,E.J. Jr. and Delaunay,J.
  TITLE     Homozygous 4.1(-) hereditary elliptocytosis associated with a point
            mutation in the downstream initiation codon of protein 4.1 gene
  JOURNAL   J Clin Invest 90 (5), 1713-1717 (1992)
   PUBMED   1430200
REFERENCE   7  (bases 1 to 5980)
  AUTHORS   Jons,T. and Drenckhahn,D.
  TITLE     Identification of the binding interface involved in linkage of
            cytoskeletal protein 4.1 to the erythrocyte anion exchanger
  JOURNAL   EMBO J 11 (8), 2863-2867 (1992)
   PUBMED   1639060
REFERENCE   8  (bases 1 to 5980)
  AUTHORS   Subrahmanyam,G., Bertics,P.J. and Anderson,R.A.
  TITLE     Phosphorylation of protein 4.1 on tyrosine-418 modulates its
            function in vitro
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5222-5226 (1991)
   PUBMED   1647028
REFERENCE   9  (bases 1 to 5980)
  AUTHORS   Conboy,J.G., Chan,J.Y., Chasis,J.A., Kan,Y.W. and Mohandas,N.
  TITLE     Tissue- and development-specific alternative RNA splicing regulates
            expression of multiple isoforms of erythroid membrane protein 4.1
  JOURNAL   J Biol Chem 266 (13), 8273-8280 (1991)
   PUBMED   2022644
REFERENCE   10 (bases 1 to 5980)
  AUTHORS   Horne,W.C., Prinz,W.C. and Tang,E.K.
  TITLE     Identification of two cAMP-dependent phosphorylation sites on
            erythrocyte protein 4.1
  JOURNAL   Biochim Biophys Acta 1055 (1), 87-92 (1990)
   PUBMED   2171679
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB209649.1, J03796.1,
            AL138785.8, BC039079.1 and AI076831.1.
            
            On Aug 13, 2020 this sequence version replaced NM_203342.2.
            
            Summary: The protein encoded by this gene, together with spectrin
            and actin, constitute the red cell membrane cytoskeletal network.
            This complex plays a critical role in erythrocyte shape and
            deformability. Mutations in this gene are associated with type 1
            elliptocytosis (EL1). Alternatively spliced transcript variants
            encoding different isoforms have been described for this
            gene.[provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (4) contains an additional exon at
            the 5' end, and is missing an internal, in-frame coding exon
            compared to variant 1. This results in translation start from a
            downstream AUG and a shorter isoform (4) compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M61733.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149004 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AB209649.1         10-120
            112-586             J03796.1           40-514
            587-666             AL138785.8         32765-32844
            667-2340            BC039079.1         666-2339
            2341-5978           AB209649.1         2133-5770
            5979-5980           AI076831.1         11-12               c
FEATURES             Location/Qualifiers
     source          1..5980
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.3"
     gene            1..5980
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /note="erythrocyte membrane protein band 4.1"
                     /db_xref="GeneID:2035"
                     /db_xref="HGNC:HGNC:3377"
                     /db_xref="MIM:130500"
     exon            1..111
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            112..586
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            587..666
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            667..879
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     CDS             826..2751
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /note="isoform 4 is encoded by transcript variant 4;
                     protein 4.1; erythrocyte surface protein band 4.1; P4.1;
                     EPB4.1; elliptocytosis 1, RH-linked"
                     /codon_start=1
                     /product="protein 4.1 isoform 4"
                     /protein_id="NP_976217.1"
                     /db_xref="GeneID:2035"
                     /db_xref="HGNC:HGNC:3377"
                     /db_xref="MIM:130500"
                     /translation="MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGL
                     AIWDNATSKTWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQ
                     DIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVME
                     LHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKL
                     RINRFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHT
                     FFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSL
                     DGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
                     PPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDK
                     SQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPL
                     VKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQT
                     ITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPD
                     MSVTKVVVHQETEIADE"
     exon            880..984
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1027
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1103
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1322
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1410
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1563
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1661
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1834
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..2043
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2100
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2163
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2340
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2469
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2571
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            2572..2652
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2757
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            2758..5980
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5960..5965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /note="hexamer: AATAAA"
     polyA_site      5980
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /note="major polyA site"
ORIGIN      
        1 gtcagtgcag gtggaggccc cggcggggca aagtggcagg aacctcttaa agggcgagag
       61 cggcgcggag ccagaacgcg gtcggcccgg tccccgccgc acccagccca gcaacatcat
      121 gacaacagag aagagtttag tgactgaggc cgaaaattca cagcaccaac agaaggaaga
      181 gggtgaggaa gccataaact caggccaaca agaacctcag caggaggaat cttgtcaaac
      241 agcagctgaa ggagataatt ggtgtgaaca gaagctgaaa gcttctaatg gagacactcc
      301 tacacatgaa gacttgacca agaacaagga gcggacatca gaaagcagag gactttcacg
      361 actattctcc tcgtttctca aaaggcccaa atctcaggtg tccgaggaag aaggcaaaga
      421 agtagagtca gataaagaaa aaggtgaagg aggtcagaaa gagatagaat ttggaaccag
      481 tcttgatgaa gagatcattt taaaggcccc aattgcagct cctgaaccgg aactcaaaac
      541 agacccatct ttggatcttc attcattaag cagtgcagaa acacagcctc accattacaa
      601 ttaagaatta ttttcagagt cttcttattt ctgaagcatg tgaatattat ctgcatcgtt
      661 aaaagtcctg ctcaggaaga actcagagaa gatccagatt ttgaaattaa ggaaggagaa
      721 ggacttgaag agtgctccaa aatagaagta aaagaagaaa gccctcaatc aaaagcagaa
      781 acagaattaa aagcttccca aaaaccaatc agaaaacaca ggaacatgca ctgcaaggtt
      841 tctttgttgg atgacacagt ttatgaatgt gttgtggaga aacatgctaa gggacaagat
      901 ttgcttaaac gagtatgtga gcatctcaat cttttggaag aagactattt tggtctagcc
      961 atttgggata acgcaacctc taagacatgg ctggattccg ccaaagaaat aaaaaagcag
     1021 gttcgtggtg tcccttggaa ttttacattt aatgtaaagt tttatccacc tgacccagca
     1081 cagttaacag aagacataac aagatattat ttatgtcttc agcttcggca ggacatagtt
     1141 gcaggacgtc tgccctgttc ctttgcaacc ttagcattat taggttctta caccatccag
     1201 tctgaactgg gagactacga cccagaactc catggcgtgg attatgttag tgattttaaa
     1261 ctggccccga atcagaccaa ggaacttgaa gagaaggtca tggaactgca taagtcatac
     1321 aggtccatga ctccagctca ggctgacttg gagtttcttg agaatgccaa aaagttgtct
     1381 atgtatggag ttgatcttca taaagcaaag gacttggaag gagtagatat catcctaggt
     1441 gtctgctcta gtggccttct ggtttacaaa gataagctga gaattaaccg cttcccttgg
     1501 cccaaagtgc tgaagatttc ttataaacgt agtagctttt tcatcaagat tcggcctgga
     1561 gagcaagagc agtatgaaag taccatcgga ttcaaacttc ccagttaccg agcagctaag
     1621 aaattatgga aagtctgtgt agaacatcac acgtttttca gattgacatc tacagacacc
     1681 attcccaaaa gcaaatttct tgcgctagga tccaaatttc gatacagtgg ccggactcaa
     1741 gctcagacca ggcaagctag tgctctaatt gacaggcctg ccccacactt cgagcgtaca
     1801 gcaagtaaac gggcgtcccg gagcctcgat ggagcagcag ctgtcgattc ggcagaccga
     1861 agtcctcggc ccacttctgc acctgccatt actcagggtc aggttgcaga aggtggcgtc
     1921 ctagatgcct ctgctaaaaa aacagtggtc cctaaagcac agaaggaaac agtgaaggct
     1981 gaagtgaaaa aggaagacga gccacctgag caagctgagc cagagcccac agaagcatgg
     2041 aaggtggaaa aaacccacat cgaggtgaca gtacccacct caaatggtga ccaaacacag
     2101 aaaaagagag aaagactaga tggtgaaaac atttatatca gacatagcaa tttaatgttg
     2161 gaggatttag acaagagtca agaggagatc aaaaaacatc atgccagcat cagtgagctg
     2221 aaaaagaact tcatggagtc tgtaccagaa ccacggccta gtgaatggga taaacgctta
     2281 tccactcact cacccttccg aactcttaac atcaatgggc aaatccccac aggagaagga
     2341 cctcccctgg tgaagacaca aactgtcacc atctcagata atgccaatgc tgtgaaaagt
     2401 gaaatcccaa ccaaagacgt ccctattgtc cacactgaga ccaagaccat cacttatgag
     2461 gctgcccaga ctgacgacaa cagtggagac ttggacccag gagtcttgct gacagctcaa
     2521 actatcacat ctgagacccc aagcagcacc accacaactc aaattaccaa gactgtaaaa
     2581 ggtgggattt cagagacacg tattgaaaag agaattgtga tcacaggaga tgctgatatt
     2641 gaccatgatc aggtccttgt acaagccatc aaggaggcaa aggagcagca cccagacatg
     2701 tcagtgacca aggtggtcgt ccaccaggag accgagattg ctgatgagtg agctcaggaa
     2761 ctaacctacc ccaactctgc ccttctccca tccaagagaa accagcaaaa tgataaagaa
     2821 gctaacctgc catagtcaga cttcagactt tcaagattat tctaaatcac cagaaaatta
     2881 atttcagttt ctattgggag tttataccaa gagattcttc tagatctcat tgatcctttt
     2941 gaagagcttt ttctatatta ggatatcaga attgttcaac ttttcactct atagactgtt
     3001 ttaagagttt tggggttttt ttaattgggt ggtttgtaac cccttcagcc tagcctctct
     3061 gcccatttat ttccaacccc aacagacact gacagggtcc atggaattct tcgggaaatc
     3121 ctccaaggac tcttgtcagc tgtgttggaa gccaaagcca gcttagtggg acttccgcgt
     3181 ctctccctag tcttatcccc tttggatgat ggcagaaact tcatgaacca gccctttctc
     3241 agagccagtg atgtgagtgt atcagaatgc cagggagggc accagccctg atccacagac
     3301 ctcggaaaga tgcccctgtt cctttgttgc gggtggtttt ggtaaggcag agccctctgc
     3361 tgagaatgta gtattgtttt tcccctctcc ctcctgcttt ctttttggag cttctttggg
     3421 tcaaagacat ggaagttgct tcagatatct gatactgtga atgtttgaac atatccgtgg
     3481 ccttcacctc tccagctacc cttttacctc atcagaagca gtggctcagc taagtgctcc
     3541 ccctagctcc catctcagga gaccaaatct cacagaaaaa taggcacttt gggccaaaag
     3601 ctctaatgga acatttttag tggtgatttg gggaaggaaa gttaatgagg tttttaaaat
     3661 aaggttttct agttttgaga gtgtgcactt cacacagggg aatggggtta cttctgtctg
     3721 atcctgggcc tttctttcat cccaaatgac aaggaatgtg gctcagagaa gggtttttct
     3781 tttttgacct ttcttctctc aacaggaacc tgcctgagga cacccttcta gagcaaggaa
     3841 ttgactttta ggagccgttc tccccacaag acaccacatg acaaggggta taagccccag
     3901 ccctgctcat tcccactcac cagctgaggt ctgtcaggtt ttgaaggctt gattttgtgg
     3961 tgggtttggg gcttagtttt cctttttttc attttgattt ttgaaagtga agatgatgcc
     4021 ctaattcctg gtaaggattt ggggcatagt tttttgtttt tttgagacgg agtttcgctc
     4081 ttgttgccca agctggagtg cagtggcgcg atctcggctc actgcaacct ccgcctcctg
     4141 ggttcaagca gttctcttgc ctcagcctcc caagtagctg ggatgacagg cgcacaccac
     4201 cacgcccagc aaattttttg tatttttagt agaaacggga tttcaccttg ttaggctggt
     4261 ctcgaactcc tgacctcagg tgatccaccc accttggcct cccaaagtgc tgggattaca
     4321 ggtgtgagcc accacgcccg gccgatttgg ggcattttta tttaacagaa cttctctaac
     4381 cttccaactg cttcccacaa acacattggc ctcaaggctc cttagaatcc cagttccagc
     4441 ttcctaaaat agacagtggg tatcgggcag cagtcactgg ggctcaaggg cagtgagcaa
     4501 gagaaatgtc taaagctgct tctcccaaca ccgtccaaag tctccactgc ctgagttttg
     4561 tttcggctgg tttgaactca tttcgggtgt gtgcattttt cttttggtac ccatgtgaga
     4621 catgaacaac aggagggagg gaaagagccc aggtgggacg tgggacaggc ttaggggaaa
     4681 gagcttgtcc tatctcagga acaaaattat aggctgtggg cagagggtct gaaaggtggg
     4741 ctttggggta gtgcccaagc ctggtcgtgt tgccaggagt ggtgacaaga aatgcagctt
     4801 acatcaaacg aacatgtagt gcatgcccac tgcctgatgg ccagatggcc tgtaggaaga
     4861 gctaccaggg cttccagacc tgtggaacga agaggatggg gaaaaggcag agggcactga
     4921 gtgtcccttt aaaaactaac ccactgaata ttccgtgtga tctagaacag tgtggcagct
     4981 ttcacagcac aggaccgttc atcgggggcc taaacgtttc cctcagctct gtcaccaact
     5041 cacttctctc ggcttcgttg tctgtaaatt ggatgaaaag agctctaatg cctttcaggc
     5101 tcttagaagc catagatttg gacaagccca gcaagatggg tgtccttcca ggcctcttcc
     5161 cctttcctcc atctctggca acagttcttg gggtttggca attgtttgga ttttttttct
     5221 ttctgcagtt gtgtgtatgt gtgtttgtgt gaagaaaaac agactctgtc caggtagaaa
     5281 tggtgaggag ggggaagaga attacatttc cagggtcaga aacttggcaa cagttttcct
     5341 agagtgactc agacacacca cagtaacaac tctcgctgca attttatttt aatttgagaa
     5401 ataaagattt cctccaagcc acatgaggac tctggcaccc acccacaaag caagacctgt
     5461 atttataagc cgagggctca gggagcctaa ctgcgggacc cgtcagggcc ccgtgaccca
     5521 tccccgtccc cacccccccc tccaccgctg ggcccatcag tgtgtgttgg ggggatgctt
     5581 ggcagctggg ggtgaggaga caacaaacct cgggaactgg agccagagct gcggcctgac
     5641 tgacgccttt tgatgctcac gggaaatttc tgcccaggat ctcagcccca ggctggttgt
     5701 ttctacaaat ctctctcaaa tgtattattt tggtgacaaa aatgaaggag ctttgtaaat
     5761 tttttttaaa attatgaatc atatcaagta gttgtttaca tttcttgaaa aaataggaac
     5821 tcgggcagca gaatcagatt ggcagaatct ttagactaca caggcaataa tcaagtctgc
     5881 tgttttggcc tttcgtagta gaagtggttg tagtgtttag atatctgttt ggtcttgctt
     5941 cttgtattgc atttttttca ataaacaaca acaaaaagaa
//
