LOCUS       NM_001376013            6031 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens erythrocyte membrane protein band 4.1 (EPB41),
            transcript variant 7, mRNA.
ACCESSION   NM_001376013 XM_005245761
VERSION     NM_001376013.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6031)
  AUTHORS   Cao,M., Huang,Z., Zhou,H., Lin,J. and Zhang,D.
  TITLE     Clinical and molecular genetic analysis of a Chinese family with
            hereditary elliptocytosis caused by a novel mutation in the EPB41
            gene
  JOURNAL   J Clin Lab Anal 35 (6), e23781 (2021)
   PUBMED   33942936
  REMARK    GeneRIF: Clinical and molecular genetic analysis of a Chinese
            family with hereditary elliptocytosis caused by a novel mutation in
            the EPB41 gene.
REFERENCE   2  (bases 1 to 6031)
  AUTHORS   Yuan,J., Xing,H., Li,Y., Song,Y., Zhang,N., Xie,M., Liu,J., Xu,Y.,
            Shen,Y., Wang,B., Zhang,L. and Yang,M.
  TITLE     EPB41 suppresses the Wnt/beta-catenin signaling in non-small cell
            lung cancer by sponging ALDOC
  JOURNAL   Cancer Lett 499, 255-264 (2021)
   PUBMED   33242559
  REMARK    GeneRIF: EPB41 suppresses the Wnt/beta-catenin signaling in
            non-small cell lung cancer by sponging ALDOC.
REFERENCE   3  (bases 1 to 6031)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 6031)
  AUTHORS   Huang,S.C., Liang,J.Y., Vu,L.V., Yu,F.H., Ou,A.C., Ou,J.P.,
            Zhang,H.S., Burnett,K.M. and Benz,E.J. Jr.
  TITLE     Epithelial-specific isoforms of protein 4.1R promote adherens
            junction assembly in maturing epithelia
  JOURNAL   J Biol Chem 295 (1), 191-211 (2020)
   PUBMED   31776189
  REMARK    GeneRIF: Epithelial-specific isoforms of protein 4.1R promote
            adherens junction assembly in maturing epithelia.
REFERENCE   5  (bases 1 to 6031)
  AUTHORS   Chen,J., Zhou,W.J., Li,Y.X., Chen,Y.N., Chen,H.G. and Ding,X.P.
  TITLE     [Identification of a Novel Mutation of EPB41 Gene in a Family
            Affected with Hereditary Elliptocytosis]
  JOURNAL   Sichuan Da Xue Xue Bao Yi Xue Ban 51 (1), 97-101 (2020)
   PUBMED   31950797
  REMARK    GeneRIF: The c.1215G>A mutation of the EPB41 gene probably accounts
            for the Elliptocytosis in this family
REFERENCE   6  (bases 1 to 6031)
  AUTHORS   Dalla Venezia,N., Gilsanz,F., Alloisio,N., Ducluzeau,M.T.,
            Benz,E.J. Jr. and Delaunay,J.
  TITLE     Homozygous 4.1(-) hereditary elliptocytosis associated with a point
            mutation in the downstream initiation codon of protein 4.1 gene
  JOURNAL   J Clin Invest 90 (5), 1713-1717 (1992)
   PUBMED   1430200
REFERENCE   7  (bases 1 to 6031)
  AUTHORS   Jons,T. and Drenckhahn,D.
  TITLE     Identification of the binding interface involved in linkage of
            cytoskeletal protein 4.1 to the erythrocyte anion exchanger
  JOURNAL   EMBO J 11 (8), 2863-2867 (1992)
   PUBMED   1639060
REFERENCE   8  (bases 1 to 6031)
  AUTHORS   Subrahmanyam,G., Bertics,P.J. and Anderson,R.A.
  TITLE     Phosphorylation of protein 4.1 on tyrosine-418 modulates its
            function in vitro
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5222-5226 (1991)
   PUBMED   1647028
REFERENCE   9  (bases 1 to 6031)
  AUTHORS   Conboy,J.G., Chan,J.Y., Chasis,J.A., Kan,Y.W. and Mohandas,N.
  TITLE     Tissue- and development-specific alternative RNA splicing regulates
            expression of multiple isoforms of erythroid membrane protein 4.1
  JOURNAL   J Biol Chem 266 (13), 8273-8280 (1991)
   PUBMED   2022644
REFERENCE   10 (bases 1 to 6031)
  AUTHORS   Horne,W.C., Prinz,W.C. and Tang,E.K.
  TITLE     Identification of two cAMP-dependent phosphorylation sites on
            erythrocyte protein 4.1
  JOURNAL   Biochim Biophys Acta 1055 (1), 87-92 (1990)
   PUBMED   2171679
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL009181.1, AL138785.8 and
            AL357500.17.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 7, 2019 this sequence version replaced XM_005245761.1.
            
            Summary: The protein encoded by this gene, together with spectrin
            and actin, constitute the red cell membrane cytoskeletal network.
            This complex plays a critical role in erythrocyte shape and
            deformability. Mutations in this gene are associated with type 1
            elliptocytosis (EL1). Alternatively spliced transcript variants
            encoding different isoforms have been described for this
            gene.[provided by RefSeq, Oct 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1383076.1,
                                           SRR14038196.744171.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343067.9/ ENSP00000345259.4
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               AL009181.1         43824-44023         c
            201-675             AL138785.8         30840-31314
            676-888             AL138785.8         36739-36951
            889-993             AL138785.8         40624-40728
            994-1036            AL138785.8         55274-55316
            1037-1112           AL138785.8         59101-59176
            1113-1331           AL138785.8         61633-61851
            1332-1419           AL138785.8         73809-73896
            1420-1572           AL138785.8         76502-76654
            1573-1670           AL138785.8         79235-79332
            1671-1843           AL138785.8         82663-82835
            1844-2052           AL138785.8         96513-96721
            2053-2109           AL138785.8         101998-102054
            2110-2151           AL138785.8         102220-102261
            2152-2214           AL138785.8         103831-103893
            2215-2391           AL138785.8         108391-108567
            2392-2520           AL357500.17        33607-33735
            2521-2622           AL357500.17        45136-45237
            2623-2703           AL357500.17        48168-48248
            2704-2808           AL357500.17        51499-51603
            2809-6031           AL357500.17        52619-55841
FEATURES             Location/Qualifiers
     source          1..6031
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.3"
     gene            1..6031
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /note="erythrocyte membrane protein band 4.1"
                     /db_xref="GeneID:2035"
                     /db_xref="HGNC:HGNC:3377"
                     /db_xref="MIM:130500"
     exon            1..200
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            201..675
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..2802
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /note="isoform 1 is encoded by transcript variant 7;
                     protein 4.1; erythrocyte surface protein band 4.1; P4.1;
                     EPB4.1; elliptocytosis 1, RH-linked"
                     /codon_start=1
                     /product="protein 4.1 isoform 1"
                     /protein_id="NP_001362942.1"
                     /db_xref="CCDS:CCDS53288.1"
                     /db_xref="GeneID:2035"
                     /db_xref="HGNC:HGNC:3377"
                     /db_xref="MIM:130500"
                     /translation="MTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAE
                     GDNWCEQKLKASNGDTPTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQVSEEEGKEV
                     ESDKEKGEGGQKEIEFGTSLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQE
                     ELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLD
                     DTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQVR
                     GVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQ
                     SELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKK
                     LSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIK
                     IRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFR
                     YSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQ
                     GQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKTHIEVT
                     VPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHH
                     ASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTIS
                     DNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSST
                     TTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVH
                     QETEIADE"
     exon            676..888
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            889..993
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1036
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1112
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1331
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1419
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1572
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1670
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1843
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..2052
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2109
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2151
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2214
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2391
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2520
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..2622
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2703
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2808
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..6031
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6011..6016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /note="hexamer: AATAAA"
     polyA_site      6031
                     /gene="EPB41"
                     /gene_synonym="4.1R; EL1; HE"
                     /note="major polyA site"
ORIGIN      
        1 agagggaagg cgggagggcg cgcgccaggg tcgctcgctc gctccctccc tccgctggtg
       61 cgtttagtca gtcagccagc agcagccggc gggcccgcga gccgcagagg gcccgagcct
      121 cggacgccgg cgcctcctcc tgccattgtt cgtcgggctg cagcagtggc gggcgcagga
      181 gcccggcccc ggagccaccg caacatcatg acaacagaga agagtttagt gactgaggcc
      241 gaaaattcac agcaccaaca gaaggaagag ggtgaggaag ccataaactc aggccaacaa
      301 gaacctcagc aggaggaatc ttgtcaaaca gcagctgaag gagataattg gtgtgaacag
      361 aagctgaaag cttctaatgg agacactcct acacatgaag acttgaccaa gaacaaggag
      421 cggacatcag aaagcagagg actttcacga ctattctcct cgtttctcaa aaggcccaaa
      481 tctcaggtgt ccgaggaaga aggcaaagaa gtagagtcag ataaagaaaa aggtgaagga
      541 ggtcagaaag agatagaatt tggaaccagt cttgatgaag agatcatttt aaaggcccca
      601 attgcagctc ctgaaccgga actcaaaaca gacccatctt tggatcttca ttcattaagc
      661 agtgcagaaa cacagcctgc tcaggaagaa ctcagagaag atccagattt tgaaattaag
      721 gaaggagaag gacttgaaga gtgctccaaa atagaagtaa aagaagaaag ccctcaatca
      781 aaagcagaaa cagaattaaa agcttcccaa aaaccaatca gaaaacacag gaacatgcac
      841 tgcaaggttt ctttgttgga tgacacagtt tatgaatgtg ttgtggagaa acatgctaag
      901 ggacaagatt tgcttaaacg agtatgtgag catctcaatc ttttggaaga agactatttt
      961 ggtctagcca tttgggataa cgcaacctct aagacatggc tggattccgc caaagaaata
     1021 aaaaagcagg ttcgtggtgt cccttggaat tttacattta atgtaaagtt ttatccacct
     1081 gacccagcac agttaacaga agacataaca agatattatt tatgtcttca gcttcggcag
     1141 gacatagttg caggacgtct gccctgttcc tttgcaacct tagcattatt aggttcttac
     1201 accatccagt ctgaactggg agactacgac ccagaactcc atggcgtgga ttatgttagt
     1261 gattttaaac tggccccgaa tcagaccaag gaacttgaag agaaggtcat ggaactgcat
     1321 aagtcataca ggtccatgac tccagctcag gctgacttgg agtttcttga gaatgccaaa
     1381 aagttgtcta tgtatggagt tgatcttcat aaagcaaagg acttggaagg agtagatatc
     1441 atcctaggtg tctgctctag tggccttctg gtttacaaag ataagctgag aattaaccgc
     1501 ttcccttggc ccaaagtgct gaagatttct tataaacgta gtagcttttt catcaagatt
     1561 cggcctggag agcaagagca gtatgaaagt accatcggat tcaaacttcc cagttaccga
     1621 gcagctaaga aattatggaa agtctgtgta gaacatcaca cgtttttcag attgacatct
     1681 acagacacca ttcccaaaag caaatttctt gcgctaggat ccaaatttcg atacagtggc
     1741 cggactcaag ctcagaccag gcaagctagt gctctaattg acaggcctgc cccacacttc
     1801 gagcgtacag caagtaaacg ggcgtcccgg agcctcgatg gagcagcagc tgtcgattcg
     1861 gcagaccgaa gtcctcggcc cacttctgca cctgccatta ctcagggtca ggttgcagaa
     1921 ggtggcgtcc tagatgcctc tgctaaaaaa acagtggtcc ctaaagcaca gaaggaaaca
     1981 gtgaaggctg aagtgaaaaa ggaagacgag ccacctgagc aagctgagcc agagcccaca
     2041 gaagcatgga aggtggaaaa aacccacatc gaggtgacag tacccacctc aaatggtgac
     2101 caaacacaga agcttgcaga aaaaactgaa gatctgataa gaatgaggaa gaaaaagaga
     2161 gaaagactag atggtgaaaa catttatatc agacatagca atttaatgtt ggaggattta
     2221 gacaagagtc aagaggagat caaaaaacat catgccagca tcagtgagct gaaaaagaac
     2281 ttcatggagt ctgtaccaga accacggcct agtgaatggg ataaacgctt atccactcac
     2341 tcacccttcc gaactcttaa catcaatggg caaatcccca caggagaagg acctcccctg
     2401 gtgaagacac aaactgtcac catctcagat aatgccaatg ctgtgaaaag tgaaatccca
     2461 accaaagacg tccctattgt ccacactgag accaagacca tcacttatga ggctgcccag
     2521 actgacgaca acagtggaga cttggaccca ggagtcttgc tgacagctca aactatcaca
     2581 tctgagaccc caagcagcac caccacaact caaattacca agactgtaaa aggtgggatt
     2641 tcagagacac gtattgaaaa gagaattgtg atcacaggag atgctgatat tgaccatgat
     2701 caggtccttg tacaagccat caaggaggca aaggagcagc acccagacat gtcagtgacc
     2761 aaggtggtcg tccaccagga gaccgagatt gctgatgagt gagctcagga actaacctac
     2821 cccaactctg cccttctccc atccaagaga aaccagcaaa atgataaaga agctaacctg
     2881 ccatagtcag acttcagact ttcaagatta ttctaaatca ccagaaaatt aatttcagtt
     2941 tctattggga gtttatacca agagattctt ctagatctca ttgatccttt tgaagagctt
     3001 tttctatatt aggatatcag aattgttcaa cttttcactc tatagactgt tttaagagtt
     3061 ttggggtttt tttaattggg tggtttgtaa ccccttcagc ctagcctctc tgcccattta
     3121 tttccaaccc caacagacac tgacagggtc catggaattc ttcgggaaat cctccaagga
     3181 ctcttgtcag ctgtgttgga agccaaagcc agcttagtgg gacttccgcg tctctcccta
     3241 gtcttatccc ctttggatga tggcagaaac ttcatgaacc agccctttct cagagccagt
     3301 gatgtgagtg tatcagaatg ccagggaggg caccagccct gatccacaga cctcggaaag
     3361 atgcccctgt tcctttgttg cgggtggttt tggtaaggca gagccctctg ctgagaatgt
     3421 agtattgttt ttcccctctc cctcctgctt tctttttgga gcttctttgg gtcaaagaca
     3481 tggaagttgc ttcagatatc tgatactgtg aatgtttgaa catatccgtg gccttcacct
     3541 ctccagctac ccttttacct catcagaagc agtggctcag ctaagtgctc cccctagctc
     3601 ccatctcagg agaccaaatc tcacagaaaa ataggcactt tgggccaaaa gctctaatgg
     3661 aacattttta gtggtgattt ggggaaggaa agttaatgag gtttttaaaa taaggttttc
     3721 tagttttgag agtgtgcact tcacacaggg gaatggggtt acttctgtct gatcctgggc
     3781 ctttctttca tcccaaatga caaggaatgt ggctcagaga agggtttttc ttttttgacc
     3841 tttcttctct caacaggaac ctgcctgagg acacccttct agagcaagga attgactttt
     3901 aggagccgtt ctccccacaa gacaccacat gacaaggggt ataagcccca gccctgctca
     3961 ttcccactca ccagctgagg tctgtcaggt tttgaaggct tgattttgtg gtgggtttgg
     4021 ggcttagttt tccttttttt cattttgatt tttgaaagtg aagatgatgc cctaattcct
     4081 ggtaaggatt tggggcatag ttttttgttt ttttgagacg gagtttcgct cttgttgccc
     4141 aagctggagt gcagtggcgc gatctcggct cactgcaacc tccgcctcct gggttcaagc
     4201 agttctcttg cctcagcctc ccaagtagct gggatgacag gcgcacacca ccacgcccag
     4261 caaatttttt gtatttttag tagaaacggg atttcacctt gttaggctgg tctcgaactc
     4321 ctgacctcag gtgatccacc caccttggcc tcccaaagtg ctgggattac aggtgtgagc
     4381 caccacgccc ggccgatttg gggcattttt atttaacaga acttctctaa ccttccaact
     4441 gcttcccaca aacacattgg cctcaaggct ccttagaatc ccagttccag cttcctaaaa
     4501 tagacagtgg gtatcgggca gcagtcactg gggctcaagg gcagtgagca agagaaatgt
     4561 ctaaagctgc ttctcccaac accgtccaaa gtctccactg cctgagtttt gtttcggctg
     4621 gtttgaactc atttcgggtg tgtgcatttt tcttttggta cccatgtgag acatgaacaa
     4681 caggagggag ggaaagagcc caggtgggac gtgggacagg cttaggggaa agagcttgtc
     4741 ctatctcagg aacaaaatta taggctgtgg gcagagggtc tgaaaggtgg gctttggggt
     4801 agtgcccaag cctggtcgtg ttgccaggag tggtgacaag aaatgcagct tacatcaaac
     4861 gaacatgtag tgcatgccca ctgcctgatg gccagatggc ctgtaggaag agctaccagg
     4921 gcttccagac ctgtggaacg aagaggatgg ggaaaaggca gagggcactg agtgtccctt
     4981 taaaaactaa cccactgaat attccgtgtg atctagaaca gtgtggcagc tttcacagca
     5041 caggaccgtt catcgggggc ctaaacgttt ccctcagctc tgtcaccaac tcacttctct
     5101 cggcttcgtt gtctgtaaat tggatgaaaa gagctctaat gcctttcagg ctcttagaag
     5161 ccatagattt ggacaagccc agcaagatgg gtgtccttcc aggcctcttc ccctttcctc
     5221 catctctggc aacagttctt ggggtttggc aattgtttgg attttttttc tttctgcagt
     5281 tgtgtgtatg tgtgtttgtg tgaagaaaaa cagactctgt ccaggtagaa atggtgagga
     5341 gggggaagag aattacattt ccagggtcag aaacttggca acagttttcc tagagtgact
     5401 cagacacacc acagtaacaa ctctcgctgc aattttattt taatttgaga aataaagatt
     5461 tcctccaagc cacatgagga ctctggcacc cacccacaaa gcaagacctg tatttataag
     5521 ccgagggctc agggagccta actgcgggac ccgtcagggc cccgtgaccc atccccgtcc
     5581 ccaccccccc ctccaccgct gggcccatca gtgtgtgttg gggggatgct tggcagctgg
     5641 gggtgaggag acaacaaacc tcgggaactg gagccagagc tgcggcctga ctgacgcctt
     5701 ttgatgctca cgggaaattt ctgcccagga tctcagcccc aggctggttg tttctacaaa
     5761 tctctctcaa atgtattatt ttggtgacaa aaatgaagga gctttgtaaa ttttttttaa
     5821 aattatgaat catatcaagt agttgtttac atttcttgaa aaaataggaa ctcgggcagc
     5881 agaatcagat tggcagaatc tttagactac acaggcaata atcaagtctg ctgttttggc
     5941 ctttcgtagt agaagtggtt gtagtgttta gatatctgtt tggtcttgct tcttgtattg
     6001 catttttttc aataaacaac aacaaaaaga a
//
