LOCUS       NM_001429               8779 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens E1A binding protein p300 (EP300), transcript variant
            1, mRNA.
ACCESSION   NM_001429
VERSION     NM_001429.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8779)
  AUTHORS   Zhu,X., Li,Y., Shao,Z., Lu,X. and Chen,Y.
  TITLE     NAP1L1 Promotes Endometrial Cancer Progression via EP300-Mediated
            DDX5 Promoter Acetylation
  JOURNAL   Mol Cancer Res 22 (11), 1011-1021 (2024)
   PUBMED   38953887
  REMARK    GeneRIF: NAP1L1 Promotes Endometrial Cancer Progression via
            EP300-Mediated DDX5 Promoter Acetylation.
REFERENCE   2  (bases 1 to 8779)
  AUTHORS   Sardar,S., McNair,C.M., Ravindranath,L., Chand,S.N., Yuan,W.,
            Bogdan,D., Welti,J., Sharp,A., Ryan,N.K., Knudsen,L.A.,
            Schiewer,M.J., DeArment,E.G., Janas,T., Su,X.A., Butler,L.M., de
            Bono,J.S., Frese,K., Brooks,N., Pegg,N., Knudsen,K.E. and
            Shafi,A.A.
  TITLE     AR coactivators, CBP/p300, are critical mediators of DNA repair in
            prostate cancer
  JOURNAL   Oncogene 43 (43), 3197-3213 (2024)
   PUBMED   39266679
  REMARK    GeneRIF: AR coactivators, CBP/p300, are critical mediators of DNA
            repair in prostate cancer.
REFERENCE   3  (bases 1 to 8779)
  AUTHORS   Yu,W., Han,S., Hu,S., Ru,L., Hua,C., Xue,G., Zhang,G., Lv,K.,
            Ge,H., Wang,M., Zheng,L., Zhou,J., Hou,S., Teng,Y., Deng,W. and
            Guo,W.
  TITLE     KIF15 promotes human glioblastoma progression under the synergistic
            transactivation of REST and P300
  JOURNAL   Int J Biol Sci 20 (13), 5127-5144 (2024)
   PUBMED   39430242
  REMARK    GeneRIF: KIF15 promotes human glioblastoma progression under the
            synergistic transactivation of REST and P300.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8779)
  AUTHORS   Yuan,X., Hao,X., Chan,H.L., Zhao,N., Pedroza,D.A., Liu,F., Le,K.,
            Smith,A.J., Calderon,S.J., Lieu,N., Soth,M.J., Jones,P., Zhang,X.H.
            and Rosen,J.M.
  TITLE     CREB-binding protein/P300 bromodomain inhibition reduces neutrophil
            accumulation and activates antitumor immunity in triple-negative
            breast cancer
  JOURNAL   JCI Insight 9 (20), e182621 (2024)
   PUBMED   39287984
  REMARK    GeneRIF: CREB-binding protein/P300 bromodomain inhibition reduces
            neutrophil accumulation and activates antitumor immunity in
            triple-negative breast cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8779)
  AUTHORS   Wang,Y., Zhang,Y. and Qi,X.
  TITLE     EP300 promotes tumor stemness via epigenetic activation of CRISP3
            leading to lobaplatin resistance in triple-negative breast cancer
  JOURNAL   Hum Cell 37 (5), 1475-1488 (2024)
   PUBMED   38879857
  REMARK    GeneRIF: EP300 promotes tumor stemness via epigenetic activation of
            CRISP3 leading to lobaplatin resistance in triple-negative breast
            cancer.
REFERENCE   6  (bases 1 to 8779)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   7  (bases 1 to 8779)
  AUTHORS   Lundblad,J.R., Kwok,R.P., Laurance,M.E., Harter,M.L. and
            Goodman,R.H.
  TITLE     Adenoviral E1A-associated protein p300 as a functional homologue of
            the transcriptional co-activator CBP
  JOURNAL   Nature 374 (6517), 85-88 (1995)
   PUBMED   7870179
REFERENCE   8  (bases 1 to 8779)
  AUTHORS   Eckner,R., Ewen,M.E., Newsome,D., Gerdes,M., DeCaprio,J.A.,
            Lawrence,J.B. and Livingston,D.M.
  TITLE     Molecular cloning and functional analysis of the adenovirus
            E1A-associated 300-kD protein (p300) reveals a protein with
            properties of a transcriptional adaptor
  JOURNAL   Genes Dev 8 (8), 869-884 (1994)
   PUBMED   7523245
REFERENCE   9  (bases 1 to 8779)
  AUTHORS   Stevens,C.A.
  TITLE     Rubinstein-Taybi Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301699
REFERENCE   10 (bases 1 to 8779)
  AUTHORS   Dyson,N., Guida,P., Munger,K. and Harlow,E.
  TITLE     Homologous sequences in adenovirus E1A and human papillomavirus E7
            proteins mediate interaction with the same set of cellular proteins
  JOURNAL   J Virol 66 (12), 6893-6902 (1992)
   PUBMED   1331501
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL080243.21, CN278277.1,
            BC053889.1, DB047746.1, CN278282.1, U01877.1, AL035658.7 and
            N57495.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001429.3.
            
            Summary: This gene encodes the adenovirus E1A-associated cellular
            p300 transcriptional co-activator protein. It functions as histone
            acetyltransferase that regulates transcription via chromatin
            remodeling and is important in the processes of cell proliferation
            and differentiation. It mediates cAMP-gene regulation by binding
            specifically to phosphorylated CREB protein. This gene has also
            been identified as a co-activator of HIF1A (hypoxia-inducible
            factor 1 alpha), and thus plays a role in the stimulation of
            hypoxia-induced genes such as VEGF. Defects in this gene are a
            cause of Rubinstein-Taybi syndrome and may also play a role in
            epithelial cancer. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U01877.1, SRR11853559.22209.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263253.9/ ENSP00000263253.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AL080243.21        116974-116991
            19-50               CN278277.1         1-32
            51-3595             BC053889.1         1-3545
            3596-3802           DB047746.1         48-254
            3803-5062           BC053889.1         3753-5012
            5063-5119           CN278282.1         349-405
            5120-6182           U01877.1           5906-6968
            6183-8446           AL035658.7         12724-14987
            8447-8779           N57495.1           1-333               c
FEATURES             Location/Qualifiers
     source          1..8779
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..8779
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /note="E1A binding protein p300"
                     /db_xref="GeneID:2033"
                     /db_xref="HGNC:HGNC:3373"
                     /db_xref="MIM:602700"
     exon            1..507
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             414..7658
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /EC_number="2.3.1.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     E1A-binding protein, 300kD; histone acetyltransferase
                     p300; E1A-associated protein p300; p300 HAT; histone
                     butyryltransferase p300; histone crotonyltransferase p300;
                     protein propionyltransferase p300; protein
                     2-hydroxyisobutyryltransferase p300; protein
                     lactyltransferas p300"
                     /codon_start=1
                     /product="histone acetyltransferase p300 isoform 1"
                     /protein_id="NP_001420.2"
                     /db_xref="CCDS:CCDS14010.1"
                     /db_xref="GeneID:2033"
                     /db_xref="HGNC:HGNC:3373"
                     /db_xref="MIM:602700"
                     /translation="MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLP
                     DELINSTELGLTNGGDINQLQTSLGMVQDAASKHKQLSELLRSGSSPNLNMGVGGPGQ
                     VMASQAQQSSPGLGLINSMVKSPMTQAGLTSPNMGMGTSGPNQGPTQSTGMMNSPVNQ
                     PAMGMNTGMNAGMNPGMLAAGNGQGIMPNQVMNGSIGAGRGRQNMQYPNPGMGSAGNL
                     LTEPLQQGSPQMGGQTGLRGPQPLKMGMMNNPNPYGSPYTQNPGQQIGASGLGLQIQT
                     KTVLSNNLSPFAMDKKAVPGGGMPNMGQQPAPQVQQPGLVTPVAQGMGSGAHTADPEK
                     RKLIQQQLVLLLHAHKCQRREQANGEVRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAH
                     CASSRQIISHWKNCTRHDCPVCLPLKNAGDKRNQQPILTGAPVGLGNPSSLGVGQQSA
                     PNLSTVSQIDPSSIERAYAALGLPYQVNQMPTQPQVQAKNQQNQQPGQSPQGMRPMSN
                     MSASPMGVNGGVGVQTPSLLSDSMLHSAINSQNPMMSENASVPSLGPMPTAAQPSTTG
                     IRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESAN
                     NRAEYYHLLAEKIYKIQKELEEKRRTRLQKQNMLPNAAGMVPVSMNPGPNMGQPQPGM
                     TSNGPLPDPSMIRGSVPNQMMPRITPQSGLNQFGQMSMAQPPIVPRQTPPLQHHGQLA
                     QPGALNPPMGYGPRMQQPSNQGQFLPQTQFPSQGMNVTNIPLAPSSGQAPVSQAQMSS
                     SSCPVNSPIMPPGSQGSHIHCPQLPQPALHQNSPSPVPSRTPTPHHTPPSIGAQQPPA
                     TTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPSLPAAPSADQPQQQP
                     RSQQSTAASVPTPTAPLLPPQPATPLSQPAVSIEGQVSNPPSTSSTEVNSQAIAEKQP
                     SQEVKMEAKMEVDQPEPADTQPEDISESKVEDCKMESTETEERSTELKTEIKEEEDQP
                     STSATQSSPAPGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPD
                     YFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLS
                     EVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYHFCEKC
                     FNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTECGRKMHQICVLHH
                     EIIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQNHPESGE
                     VTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHV
                     QEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIW
                     ACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKDIFKQATEDR
                     LTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENTSNESTDVTKGDSKNAKKKN
                     NKKTSKNKSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRLIAGPAANSLP
                     PIVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQDRFVY
                     TCNECKHHVETRWHCTVCEDYDLCITCYNTKNHDHKMEKLGLGLDDESNNQQAAATQS
                     PGDSRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQ
                     LIALCCYHAKHCQENKCPVPFCLNIKQKLRQQQLQHRLQQAQMLRRRMASMQRTGVVG
                     QQQGLPSPTPATPTTPTGQQPTTPQTPQPTSQPQPTPPNSMPPYLPRTQAAGPVSQGK
                     AAGQVTPPTPPQTAQPPLPGPPPAAVEMAMQIQRAAETQRQMAHVQIFQRPIQHQMPP
                     MTPMAPMGMNPPPMTRGPSGHLEPGMGPTGMQQQPPWSQGGLPQPQQLQSGMPRPAMM
                     SVAQHGQPLNMAPQPGLGQVGISPLKPGTVSQQALQNLLRTLRSPSSPLQQQQVLSIL
                     HANPQLLAAFIKQRAAKYANSNPQPIPGQPGMPQGQPGLQPPTMPGQQGVHSNPAMQN
                     MNPMQAGVQRAGLPQQQPQQQLQPPMGGMSPQAQQMNMNHNTMPSQFRDILRRQQMMQ
                     QQQQQGAGPGIGPGMANHNQFQQPQGVGYPPQQQQRMQHHMQQMQQGNMGQIGQLPQA
                     LGAEAGASLQAYQQRLLQQQMGSPVQPNPMSPQQHMLPNQAQSPHLQGQQIPNSLSNQ
                     VRSPQPVPSPRPQSQPPHSSPSPRMQPQPSPHHVSPQTSSPHPGLVAAQANPMEQGHF
                     ASPDQNSMLSQLASNPGMANLHGASATDLGLSTDNSDLNSNLSQSTLDIH"
     exon            508..1142
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1319
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1581
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1695
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1941
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2035
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2173
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2291
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2466
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2544
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2654
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2792
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2793..3230
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..3410
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3411..3555
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3556..3674
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3675..3914
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3915..4003
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            4004..4084
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            4085..4141
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            4142..4219
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            4220..4287
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            4288..4438
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            4439..4585
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            4586..4699
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            4700..4865
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            4866..5030
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            5031..5192
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            5193..5474
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            5475..8779
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      8230
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
     regulatory      8758..8763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /note="hexamer: AATAAA"
     polyA_site      8779
                     /gene="EP300"
                     /gene_synonym="KAT3B; MKHK2; p300; RSTS2"
                     /note="major polyA site"
ORIGIN      
        1 gagaaggagg aggacagcgc cgaggaggaa gaggttgatg gcggcggcgg agctccgaga
       61 gacctcggct gggcaggggc cggccgtggc gggccgggga ctgcgcctct agagccgcga
      121 gttctcggga attcgccgca gcggacgcgc tcggcgaatt tgtgctcttg tgccctcctc
      181 cgggcttggg cccaggcccg gcccctcgca cttgccctta ccttttctat cgagtccgca
      241 tccctctcca gccactgcga cccggcgaag agaaaaagga acttccccca ccccctcggg
      301 tgccgtcgga gccccccagc ccacccctgg gtgcggcgcg gggaccccgg gccgaagaag
      361 agatttcctg aggattctgg ttttcctcgc ttgtatctcc gaaagaatta aaaatggccg
      421 agaatgtggt ggaaccgggg ccgccttcag ccaagcggcc taaactctca tctccggccc
      481 tctcggcgtc cgccagcgat ggcacagatt ttggctctct atttgacttg gagcacgact
      541 taccagatga attaatcaac tctacagaat tgggactaac caatggtggt gatattaatc
      601 agcttcagac aagtcttggc atggtacaag atgcagcttc taaacataaa cagctgtcag
      661 aattgctgcg atctggtagt tcccctaacc tcaatatggg agttggtggc ccaggtcaag
      721 tcatggccag ccaggcccaa cagagcagtc ctggattagg tttgataaat agcatggtca
      781 aaagcccaat gacacaggca ggcttgactt ctcccaacat ggggatgggc actagtggac
      841 caaatcaggg tcctacgcag tcaacaggta tgatgaacag tccagtaaat cagcctgcca
      901 tgggaatgaa cacagggatg aatgcgggca tgaatcctgg aatgttggct gcaggcaatg
      961 gacaagggat aatgcctaat caagtcatga acggttcaat tggagcaggc cgagggcgac
     1021 agaatatgca gtacccaaac ccaggcatgg gaagtgctgg caacttactg actgagcctc
     1081 ttcagcaggg ctctccccag atgggaggac aaacaggatt gagaggcccc cagcctctta
     1141 agatgggaat gatgaacaac cccaatcctt atggttcacc atatactcag aatcctggac
     1201 agcagattgg agccagtggc cttggtctcc agattcagac aaaaactgta ctatcaaata
     1261 acttatctcc atttgctatg gacaaaaagg cagttcctgg tggaggaatg cccaacatgg
     1321 gtcaacagcc agccccgcag gtccagcagc caggcctggt gactccagtt gcccaaggga
     1381 tgggttctgg agcacataca gctgatccag agaagcgcaa gctcatccag cagcagcttg
     1441 ttctcctttt gcatgctcac aagtgccagc gccgggaaca ggccaatggg gaagtgaggc
     1501 agtgcaacct tccccactgt cgcacaatga agaatgtcct aaaccacatg acacactgcc
     1561 agtcaggcaa gtcttgccaa gtggcacact gtgcatcttc tcgacaaatc atttcacact
     1621 ggaagaattg tacaagacat gattgtcctg tgtgtctccc cctcaaaaat gctggtgata
     1681 agagaaatca acagccaatt ttgactggag cacccgttgg acttggaaat cctagctctc
     1741 taggggtggg tcaacagtct gcccccaacc taagcactgt tagtcagatt gatcccagct
     1801 ccatagaaag agcctatgca gctcttggac taccctatca agtaaatcag atgccgacac
     1861 aaccccaggt gcaagcaaag aaccagcaga atcagcagcc tgggcagtct ccccaaggca
     1921 tgcggcccat gagcaacatg agtgctagtc ctatgggagt aaatggaggt gtaggagttc
     1981 aaacgccgag tcttctttct gactcaatgt tgcattcagc cataaattct caaaacccaa
     2041 tgatgagtga aaatgccagt gtgccctccc tgggtcctat gccaacagca gctcaaccat
     2101 ccactactgg aattcggaaa cagtggcacg aagatattac tcaggatctt cgaaatcatc
     2161 ttgttcacaa actcgtccaa gccatatttc ctacgccgga tcctgctgct ttaaaagaca
     2221 gacggatgga aaacctagtt gcatatgctc ggaaagttga aggggacatg tatgaatctg
     2281 caaacaatcg agcggaatac taccaccttc tagctgagaa aatctataag atccagaaag
     2341 aactagaaga aaaacgaagg accagactac agaagcagaa catgctacca aatgctgcag
     2401 gcatggttcc agtttccatg aatccagggc ctaacatggg acagccgcaa ccaggaatga
     2461 cttctaatgg ccctctacct gacccaagta tgatccgtgg cagtgtgcca aaccagatga
     2521 tgcctcgaat aactccacaa tctggtttga atcaatttgg ccagatgagc atggcccagc
     2581 cccctattgt accccggcaa acccctcctc ttcagcacca tggacagttg gctcaacctg
     2641 gagctctcaa cccgcctatg ggctatgggc ctcgtatgca acagccttcc aaccagggcc
     2701 agttccttcc tcagactcag ttcccatcac agggaatgaa tgtaacaaat atccctttgg
     2761 ctccgtccag cggtcaagct ccagtgtctc aagcacaaat gtctagttct tcctgcccgg
     2821 tgaactctcc tataatgcct ccagggtctc aggggagcca cattcactgt ccccagcttc
     2881 ctcaaccagc tcttcatcag aattcaccct cgcctgtacc tagtcgtacc cccacccctc
     2941 accatactcc cccaagcata ggggctcagc agccaccagc aacaacaatt ccagcccctg
     3001 ttcctacacc tcctgccatg ccacctgggc cacagtccca ggctctacat ccccctccaa
     3061 ggcagacacc tacaccacca acaacacaac ttccccaaca agtgcagcct tcacttcctg
     3121 ctgcaccttc tgctgaccag ccccagcagc agcctcgctc acagcagagc acagcagcgt
     3181 ctgttcctac cccaacagca ccgctgcttc ctccgcagcc tgcaactcca ctttcccagc
     3241 cagctgtaag cattgaagga caggtatcaa atcctccatc tactagtagc acagaagtga
     3301 attctcaggc cattgctgag aagcagcctt cccaggaagt gaagatggag gccaaaatgg
     3361 aagtggatca accagaacca gcagatactc agccggagga tatttcagag tctaaagtgg
     3421 aagactgtaa aatggaatct accgaaacag aagagagaag cactgagtta aaaactgaaa
     3481 taaaagagga ggaagaccag ccaagtactt cagctaccca gtcatctccg gctccaggac
     3541 agtcaaagaa aaagattttc aaaccagaag aactacgaca ggcactgatg ccaactttgg
     3601 aggcacttta ccgtcaggat ccagaatccc ttccctttcg tcaacctgtg gaccctcagc
     3661 ttttaggaat ccctgattac tttgatattg tgaagagccc catggatctt tctaccatta
     3721 agaggaagtt agacactgga cagtatcagg agccctggca gtatgtcgat gatatttggc
     3781 ttatgttcaa taatgcctgg ttatataacc ggaaaacatc acgggtatac aaatactgct
     3841 ccaagctctc tgaggtcttt gaacaagaaa ttgacccagt gatgcaaagc cttggatact
     3901 gttgtggcag aaagttggag ttctctccac agacactgtg ttgctacggc aaacagttgt
     3961 gcacaatacc tcgtgatgcc acttattaca gttaccagaa caggtatcat ttctgtgaga
     4021 agtgtttcaa tgagatccaa ggggagagcg tttctttggg ggatgaccct tcccagcctc
     4081 aaactacaat aaataaagaa caattttcca agagaaaaaa tgacacactg gatcctgaac
     4141 tgtttgttga atgtacagag tgcggaagaa agatgcatca gatctgtgtc cttcaccatg
     4201 agatcatctg gcctgctgga ttcgtctgtg atggctgttt aaagaaaagt gcacgaacta
     4261 ggaaagaaaa taagttttct gctaaaaggt tgccatctac cagacttggc acctttctag
     4321 agaatcgtgt gaatgacttt ctgaggcgac agaatcaccc tgagtcagga gaggtcactg
     4381 ttagagtagt tcatgcttct gacaaaaccg tggaagtaaa accaggcatg aaagcaaggt
     4441 ttgtggacag tggagagatg gcagaatcct ttccataccg aaccaaagcc ctctttgcct
     4501 ttgaagaaat tgatggtgtt gacctgtgct tctttggcat gcatgttcaa gagtatggct
     4561 ctgactgccc tccacccaac cagaggagag tatacatatc ttacctcgat agtgttcatt
     4621 tcttccgtcc taaatgcttg aggactgcag tctatcatga aatcctaatt ggatatttag
     4681 aatatgtcaa gaaattaggt tacacaacag ggcatatttg ggcatgtcca ccaagtgagg
     4741 gagatgatta tatcttccat tgccatcctc ctgaccagaa gatacccaag cccaagcgac
     4801 tgcaggaatg gtacaaaaaa atgcttgaca aggctgtatc agagcgtatt gtccatgact
     4861 acaaggatat ttttaaacaa gctactgaag atagattaac aagtgcaaag gaattgcctt
     4921 atttcgaggg tgatttctgg cccaatgttc tggaagaaag cattaaggaa ctggaacagg
     4981 aggaagaaga gagaaaacga gaggaaaaca ccagcaatga aagcacagat gtgaccaagg
     5041 gagacagcaa aaatgctaaa aagaagaata ataagaaaac cagcaaaaat aagagcagcc
     5101 tgagtagggg caacaagaag aaacccggga tgcccaatgt atctaacgac ctctcacaga
     5161 aactatatgc caccatggag aagcataaag aggtcttctt tgtgatccgc ctcattgctg
     5221 gccctgctgc caactccctg cctcccattg ttgatcctga tcctctcatc ccctgcgatc
     5281 tgatggatgg tcgggatgcg tttctcacgc tggcaaggga caagcacctg gagttctctt
     5341 cactccgaag agcccagtgg tccaccatgt gcatgctggt ggagctgcac acgcagagcc
     5401 aggaccgctt tgtctacacc tgcaatgaat gcaagcacca tgtggagaca cgctggcact
     5461 gtactgtctg tgaggattat gacttgtgta tcacctgcta taacactaaa aaccatgacc
     5521 acaaaatgga gaaactaggc cttggcttag atgatgagag caacaaccag caggctgcag
     5581 ccacccagag cccaggcgat tctcgccgcc tgagtatcca gcgctgcatc cagtctctgg
     5641 tccatgcttg ccagtgtcgg aatgccaatt gctcactgcc atcctgccag aagatgaagc
     5701 gggttgtgca gcataccaag ggttgcaaac ggaaaaccaa tggcgggtgc cccatctgca
     5761 agcagctcat tgccctctgc tgctaccatg ccaagcactg ccaggagaac aaatgcccgg
     5821 tgccgttctg cctaaacatc aagcagaagc tccggcagca acagctgcag caccgactac
     5881 agcaggccca aatgcttcgc aggaggatgg ccagcatgca gcggactggt gtggttgggc
     5941 agcaacaggg cctcccttcc cccactcctg ccactccaac gacaccaact ggccaacagc
     6001 caaccacccc gcagacgccc cagcccactt ctcagcctca gcctacccct cccaatagca
     6061 tgccacccta cttgcccagg actcaagctg ctggccctgt gtcccagggt aaggcagcag
     6121 gccaggtgac ccctccaacc cctcctcaga ctgctcagcc accccttcca gggcccccac
     6181 ctgcagcagt ggaaatggca atgcagattc agagagcagc ggagacgcag cgccagatgg
     6241 cccacgtgca aatttttcaa aggccaatcc aacaccagat gcccccgatg actcccatgg
     6301 cccccatggg tatgaaccca cctcccatga ccagaggtcc cagtgggcat ttggagccag
     6361 ggatgggacc gacagggatg cagcaacagc caccctggag ccaaggagga ttgcctcagc
     6421 cccagcaact acagtctggg atgccaaggc cagccatgat gtcagtggcc cagcatggtc
     6481 aacctttgaa catggctcca caaccaggat tgggccaggt aggtatcagc ccactcaaac
     6541 caggcactgt gtctcaacaa gccttacaaa accttttgcg gactctcagg tctcccagct
     6601 ctcccctgca gcagcaacag gtgcttagta tccttcacgc caacccccag ctgttggctg
     6661 cattcatcaa gcagcgggct gccaagtatg ccaactctaa tccacaaccc atccctgggc
     6721 agcctggcat gccccagggg cagccagggc tacagccacc taccatgcca ggtcagcagg
     6781 gggtccactc caatccagcc atgcagaaca tgaatccaat gcaggcgggc gttcagaggg
     6841 ctggcctgcc ccagcagcaa ccacagcagc aactccagcc acccatggga gggatgagcc
     6901 cccaggctca gcagatgaac atgaaccaca acaccatgcc ttcacaattc cgagacatct
     6961 tgagacgaca gcaaatgatg caacagcagc agcaacaggg agcagggcca ggaataggcc
     7021 ctggaatggc caaccataac cagttccagc aaccccaagg agttggctac ccaccacagc
     7081 agcagcagcg gatgcagcat cacatgcaac agatgcaaca aggaaatatg ggacagatag
     7141 gccagcttcc ccaggccttg ggagcagagg caggtgccag tctacaggcc tatcagcagc
     7201 gactccttca gcaacagatg gggtcccctg ttcagcccaa ccccatgagc ccccagcagc
     7261 atatgctccc aaatcaggcc cagtccccac acctacaagg ccagcagatc cctaattctc
     7321 tctccaatca agtgcgctct ccccagcctg tcccttctcc acggccacag tcccagcccc
     7381 cccactccag tccttcccca aggatgcagc ctcagccttc tccacaccac gtttccccac
     7441 agacaagttc cccacatcct ggactggtag ctgcccaggc caaccccatg gaacaagggc
     7501 attttgccag cccggaccag aattcaatgc tttctcagct tgctagcaat ccaggcatgg
     7561 caaacctcca tggtgcaagc gccacggacc tgggactcag caccgataac tcagacttga
     7621 attcaaacct ctcacagagt acactagaca tacactagag acaccttgta gtattttggg
     7681 agcaaaaaaa ttattttctc ttaacaagac tttttgtact gaaaacaatt tttttgaatc
     7741 tttcgtagcc taaaagacaa ttttccttgg aacacataag aactgtgcag tagccgtttg
     7801 tggtttaaag caaacatgca agatgaacct gagggatgat agaatacaaa gaatatattt
     7861 ttgttatggc tggttaccac cagcctttct tcccctttgt gtgtgtggtt caagtgtgca
     7921 ctgggaggag gctgaggcct gtgaagccaa acaatatgct cctgccttgc acctccaata
     7981 ggttttatta ttttttttaa attaatgaac atatgtaata ttaatagtta ttatttactg
     8041 gtgcagatgg ttgacatttt tccctatttt cctcacttta tggaagagtt aaaacatttc
     8101 taaaccagag gacaaaaggg gttaatgtta ctttaaaatt acattctata tatatataaa
     8161 tatatataaa tatatattaa aataccagtt ttttttctct gggtgcaaag atgttcattc
     8221 ttttaaaaaa tgtttaaaaa aaaaaaaaaa ctgcctttct tcccctcaag tcaacttttg
     8281 tgctccagaa aattttctat tctgtaagtc tgagcgtaaa acttcaagta ttaaaataat
     8341 ttgtacatgt agagagaaaa atgacttttt caaaaatata caggggcagc tgccaaattg
     8401 atgtattata tattgtggtt tctgtttctt gaaagaattt ttttcgttat ttttacatct
     8461 aacaaagtaa aaaaattaaa aagagggtaa gaaacgattc cggtgggatg attttaacat
     8521 gcaaaatgtc cctgggggtt tcttctttgc ttgctttctt cctccttacc ctacccccca
     8581 ctcacacaca cacacacaca cacacacaca cacacacaca cacactttct ataaaacttg
     8641 aaaatagcaa aaaccctcaa ctgttgtaaa tcatgcaatt aaagttgatt acttataaat
     8701 atgaactttg gatcactgta tagactgtta aatttgattt cttattacct attgttaaat
     8761 aaactgtgtg agacagaca
//
