LOCUS       NM_001278182            3264 bp    mRNA    linear   PRI 27-JUL-2024
DEFINITION  Homo sapiens eomesodermin (EOMES), transcript variant 1, mRNA.
ACCESSION   NM_001278182
VERSION     NM_001278182.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3264)
  AUTHORS   Joulia,E., Michieletto,M.F., Agesta,A., Peillex,C., Girault,V., Le
            Dorze,A.L., Peroceschi,R., Bucciarelli,F., Szelechowski,M.,
            Chaubet,A., Hakim,N., Marrocco,R., Lhuillier,E., Lebeurrier,M.,
            Arguello,R.J., Saoudi,A., El Costa,H., Adoue,V., Walzer,T.,
            Sarry,J.E. and Dejean,A.S.
  TITLE     Eomes-dependent mitochondrial regulation promotes survival of
            pathogenic CD4+ T cells during inflammation
  JOURNAL   J Exp Med 221 (2) (2024)
   PUBMED   38189779
  REMARK    GeneRIF: Eomes-dependent mitochondrial regulation promotes survival
            of pathogenic CD4+ T cells during inflammation.
REFERENCE   2  (bases 1 to 3264)
  AUTHORS   Wong,P., Foltz,J.A., Chang,L., Neal,C.C., Yao,T., Cubitt,C.C.,
            Tran,J., Kersting-Schadek,S., Palakurty,S., Jaeger,N.,
            Russler-Germain,D.A., Marin,N.D., Gang,M., Wagner,J.A., Zhou,A.Y.,
            Jacobs,M.T., Foster,M., Schappe,T., Marsala,L., McClain,E.,
            Pence,P., Becker-Hapak,M., Fisk,B., Petti,A.A., Griffith,O.L.,
            Griffith,M., Berrien-Elliott,M.M. and Fehniger,T.A.
  TITLE     T-BET and EOMES sustain mature human NK cell identity and antitumor
            function
  JOURNAL   J Clin Invest 133 (13), e162530 (2023)
   PUBMED   37279078
  REMARK    GeneRIF: T-BET and EOMES sustain mature human NK cell identity and
            antitumor function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3264)
  AUTHORS   Wildner,N.H., Walker,A., Brauneck,F., Ditt,V., Peine,S., Huber,S.,
            Haag,F., Beisel,C., Timm,J. and Schulze Zur Wiesch,J.
  TITLE     Transcriptional Pattern Analysis of Virus-Specific CD8+ T Cells in
            Hepatitis C Infection: Increased Expression of TOX and Eomesodermin
            During and After Persistent Antigen Recognition
  JOURNAL   Front Immunol 13, 886646 (2022)
   PUBMED   35734162
  REMARK    GeneRIF: Transcriptional Pattern Analysis of Virus-Specific CD8+ T
            Cells in Hepatitis C Infection: Increased Expression of TOX and
            Eomesodermin During and After Persistent Antigen Recognition.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3264)
  AUTHORS   Yu,L., Guan,Y., Li,L., Lu,N. and Zhang,C.
  TITLE     The transcription factor Eomes promotes expression of inhibitory
            receptors on hepatic CD8+ T cells during HBV persistence
  JOURNAL   FEBS J 289 (11), 3241-3261 (2022)
   PUBMED   34986510
  REMARK    GeneRIF: The transcription factor Eomes promotes expression of
            inhibitory receptors on hepatic CD8(+) T cells during HBV
            persistence.
REFERENCE   5  (bases 1 to 3264)
  AUTHORS   Kiekens,L., Van Loocke,W., Taveirne,S., Wahlen,S., Persyn,E., Van
            Ammel,E., De Vos,Z., Matthys,P., Van Nieuwerburgh,F., Taghon,T.,
            Van Vlierberghe,P., Vandekerckhove,B. and Leclercq,G.
  TITLE     T-BET and EOMES Accelerate and Enhance Functional Differentiation
            of Human Natural Killer Cells
  JOURNAL   Front Immunol 12, 732511 (2021)
   PUBMED   34630413
  REMARK    GeneRIF: T-BET and EOMES Accelerate and Enhance Functional
            Differentiation of Human Natural Killer Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3264)
  AUTHORS   Atreya,I., Schimanski,C.C., Becker,C., Wirtz,S., Dornhoff,H.,
            Schnurer,E., Berger,M.R., Galle,P.R., Herr,W. and Neurath,M.F.
  TITLE     The T-box transcription factor eomesodermin controls CD8 T cell
            activity and lymph node metastasis in human colorectal cancer
  JOURNAL   Gut 56 (11), 1572-1578 (2007)
   PUBMED   17566017
REFERENCE   7  (bases 1 to 3264)
  AUTHORS   Baala,L., Briault,S., Etchevers,H.C., Laumonnier,F., Natiq,A.,
            Amiel,J., Boddaert,N., Picard,C., Sbiti,A., Asermouh,A.,
            Attie-Bitach,T., Encha-Razavi,F., Munnich,A., Sefiani,A. and
            Lyonnet,S.
  TITLE     Homozygous silencing of T-box transcription factor EOMES leads to
            microcephaly with polymicrogyria and corpus callosum agenesis
  JOURNAL   Nat Genet 39 (4), 454-456 (2007)
   PUBMED   17353897
  REMARK    GeneRIF: Breakpoint on chromosome 3 silences the eomesodermin
            transcript (EOMES) leading to malformative microcephaly syndromes.
REFERENCE   8  (bases 1 to 3264)
  AUTHORS   Intlekofer,A.M., Takemoto,N., Wherry,E.J., Longworth,S.A.,
            Northrup,J.T., Palanivel,V.R., Mullen,A.C., Gasink,C.R.,
            Kaech,S.M., Miller,J.D., Gapin,L., Ryan,K., Russ,A.P., Lindsten,T.,
            Orange,J.S., Goldrath,A.W., Ahmed,R. and Reiner,S.L.
  TITLE     Effector and memory CD8+ T cell fate coupled by T-bet and
            eomesodermin
  JOURNAL   Nat Immunol 6 (12), 1236-1244 (2005)
   PUBMED   16273099
  REMARK    GeneRIF: A key transcription factor that links the long-term
            renewal of memory CD8+ T cells to their characteristic effector
            potency.
            Erratum:[Nat Immunol. 2006 Jan;7(1):113]
REFERENCE   9  (bases 1 to 3264)
  AUTHORS   Kimura,N., Nakashima,K., Ueno,M., Kiyama,H. and Taga,T.
  TITLE     A novel mammalian T-box-containing gene, Tbr2, expressed in mouse
            developing brain
  JOURNAL   Brain Res Dev Brain Res 115 (2), 183-193 (1999)
   PUBMED   10407135
  REMARK    GeneRIF: Describes cloning of the human TBR2 gene and compares the
            human and mouse protein sequences.
REFERENCE   10 (bases 1 to 3264)
  AUTHORS   Yi,C.H., Terrett,J.A., Li,Q.Y., Ellington,K., Packham,E.A.,
            Armstrong-Buisseret,L., McClure,P., Slingsby,T. and Brook,J.D.
  TITLE     Identification, mapping, and phylogenomic analysis of four new
            human members of the T-box gene family: EOMES, TBX6, TBX18, and
            TBX19
  JOURNAL   Genomics 55 (1), 10-20 (1999)
   PUBMED   9888994
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK297461.1, BC037568.1,
            AB031038.1, BC025363.1, BM720063.1 and BX096900.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001278182.1.
            
            Summary: This gene belongs to the TBR1 (T-box brain protein 1)
            sub-family of T-box genes that share the common DNA-binding T-box
            domain. The encoded protein is a transcription factor which is
            crucial for embryonic development of mesoderm and the central
            nervous system in vertebrates. The protein may also be necessary
            for the differentiation of effector CD8+ T cells which are involved
            in defense against viral infections. A similar gene disrupted in
            mice is shown to be essential during trophoblast development and
            gastrulation. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.208861.1, BC037568.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000449599.4/ ENSP00000388620.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AK297461.1         391-401
            12-387              BC037568.1         1-376
            388-388             AB031038.1         359-359
            389-2432            BC037568.1         384-2427
            2433-2840           BC025363.1         1461-1868
            2841-2862           BM720063.1         15-36
            2863-3264           BX096900.1         1-402
FEATURES             Location/Qualifiers
     source          1..3264
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.1"
     gene            1..3264
                     /gene="EOMES"
                     /gene_synonym="TBR2"
                     /note="eomesodermin"
                     /db_xref="GeneID:8320"
                     /db_xref="HGNC:HGNC:3372"
                     /db_xref="MIM:604615"
     exon            1..910
                     /gene="EOMES"
                     /gene_synonym="TBR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..2147
                     /gene="EOMES"
                     /gene_synonym="TBR2"
                     /note="isoform 1 is encoded by transcript variant 1; T-box
                     brain protein 2; eomesodermin homolog"
                     /codon_start=1
                     /product="eomesodermin homolog isoform 1"
                     /protein_id="NP_001265111.1"
                     /db_xref="CCDS:CCDS63585.1"
                     /db_xref="GeneID:8320"
                     /db_xref="HGNC:HGNC:3372"
                     /db_xref="MIM:604615"
                     /translation="MQLGEQLLVSSVNLPGAHFYPLESARGGSGGSAGHLPSAAPSPQ
                     KLDLDKASKKFSGSLSCEAVSGEPAAASAGAPAAMLSDTDAGDAFASAAAVAKPGPPD
                     GRKGSPCGEEELPSAAAAAAAAAAAAAATARYSMDSLSSERYYLQSPGPQGSELAAPC
                     SLFPYQAAAGAPHGPVYPAPNGARYPYGSMLPPGGFPAAVCPPGRAQFGPGAGAGSGA
                     GGSSGGGGGPGTYQYSQGAPLYGPYPGAAAAGSCGGLGGLGVPGSGFRAHVYLCNRPL
                     WLKFHRHQTEMIITKQGRRMFPFLSFNINGLNPTAHYNVFVEVVLADPNHWRFQGGKW
                     VTCGKADNNMQGNKMYVHPESPNTGSHWMRQEISFGKLKLTNNKGANNNNTQMIVLQS
                     LHKYQPRLHIVEVTEDGVEDLNEPSKTQTFTFSETQFIAVTAYQNTDITQLKIDHNPF
                     AKGFRDNYDSMYTASENDRLTPSPTDSPRSHQIVPGGRYGVQSFFPEPFVNTLPQARY
                     YNGERTVPQTNGLLSPQQSEEVANPPQRWLVTPVQQPGTNKLDISSYESEYTSSTLLP
                     YGIKSLPLQTSHALGYYPDPTFPAMAGWGGRGSYQRKMAAGLPWTSRTSPTVFSEDQL
                     SKEKVKEEIGSSWIETPPSIKSLDSNDSGVYTSACKRRRLSPSNSSNENSPSIKCEDI
                     NAEEYSKDTSKGMGGYYAFYTTP"
     exon            911..1065
                     /gene="EOMES"
                     /gene_synonym="TBR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1187
                     /gene="EOMES"
                     /gene_synonym="TBR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1346
                     /gene="EOMES"
                     /gene_synonym="TBR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1408
                     /gene="EOMES"
                     /gene_synonym="TBR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..3264
                     /gene="EOMES"
                     /gene_synonym="TBR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3241..3246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EOMES"
                     /gene_synonym="TBR2"
                     /note="hexamer: AATAAA"
     polyA_site      3264
                     /gene="EOMES"
                     /gene_synonym="TBR2"
                     /note="major polyA site"
ORIGIN      
        1 agccagctgc cgtctgcgct ttgcaaagca tgcagttagg ggagcagctc ttggtgagct
       61 cagtgaacct gcctggcgcg cacttctacc cgctggagag tgcgcgaggc ggcagcggcg
      121 ggagcgctgg ccacctcccc agcgcggccc cctctcctca gaagttggac ttagacaaag
      181 cgtccaagaa gttttccggc agtctctcct gcgaggcggt gagcggggag cccgcagccg
      241 ccagcgcagg ggcccccgcg gccatgctta gtgacaccga cgccggggac gcatttgcca
      301 gcgctgcggc agtggccaag ccggggcccc cggacggccg caagggctcc ccctgcgggg
      361 aggaggagct gccctccgcc gctgcagccg ccgccgccgc cgccgccgcg gctgcggcca
      421 ctgcgcgcta ctccatggac agcctgagct ccgagcggta ctacctccag tcccccggtc
      481 ctcaggggtc ggagctggct gcgccctgct cactcttccc gtaccaggcg gcggctgggg
      541 cgccccacgg acctgtgtac ccggctccta acggggcgcg ctacccctac ggctccatgc
      601 tgccccccgg cggcttcccc gcggctgtgt gcccacccgg gagggcgcag ttcggcccag
      661 gagccggtgc gggcagtggc gcgggcggta gcagcggcgg gggcggcggc ccgggcacct
      721 atcagtacag ccagggggct ccgctctacg ggccgtaccc tggagccgca gcggcgggat
      781 cttgcggagg actggggggc ctgggggttc caggttctgg cttccgtgcc cacgtctacc
      841 tgtgcaaccg gcctctgtgg ctcaaattcc accgccacca aactgagatg atcattacga
      901 aacagggcag gcgcatgttt cctttcttga gcttcaacat aaacggactc aatcccactg
      961 cccactacaa tgtgttcgta gaggtggtgc tggcggaccc caaccactgg cgcttccagg
     1021 ggggcaaatg ggtgacctgt ggcaaagccg acaataacat gcagggcaac aaaatgtatg
     1081 ttcacccaga gtctcctaat actggttccc actggatgag acaggagatt tcattcggga
     1141 aattaaaact caccaataac aaaggcgcaa ataacaacaa cacccagatg atagtcttac
     1201 aatccttaca caaataccaa ccccgactgc atattgttga agttacagag gatggcgtgg
     1261 aggacttgaa tgagccctca aagacccaga cttttacctt ctcagaaacg caattcattg
     1321 cagtgactgc ctaccaaaac accgatatta ctcaactaaa gattgatcat aacccctttg
     1381 caaaaggctt cagagacaac tatgattcca tgtacaccgc ttcagaaaat gacaggttaa
     1441 ctccatctcc cacggattct cctagatccc atcagattgt ccctggaggt cggtacggcg
     1501 ttcaatcctt cttcccggag ccctttgtca acactttacc tcaagcccgc tattataatg
     1561 gcgagagaac cgtgccacag accaacggcc tcctttcacc ccaacagagc gaagaggtgg
     1621 ccaaccctcc ccagcggtgg cttgtcacgc ctgtccagca acctgggacc aacaaactag
     1681 acatcagttc ctatgaatct gaatatactt ctagcacatt gctcccatat ggcattaaat
     1741 ccttgcccct tcagacatcc catgccctgg ggtattaccc agacccaacc tttcctgcaa
     1801 tggcagggtg gggaggtcga ggttcttacc agaggaagat ggcagctgga ctaccatgga
     1861 cctccagaac aagccccact gtgttctctg aagatcagct ctccaaggag aaagtgaaag
     1921 aggaaattgg ctcttcttgg atagagacac ccccttccat caaatctcta gattccaatg
     1981 attcaggagt atacaccagt gcttgtaagc gaaggcggct gtctcctagc aactccagta
     2041 atgaaaattc accctccata aagtgtgagg acattaatgc tgaagagtat agtaaagaca
     2101 cctcaaaagg catgggaggg tattatgctt tttacacaac tccctaaaga gttattttaa
     2161 cctcaaaaat tagctaactt tttgcagatg gacttggtgg tgttttttgt tgtcttcttt
     2221 gcctaggttg ccaaaaagat gtttgccttc caccttgatg catcctgttt tgtgcaattc
     2281 tctaaaagaa ggtgccaaag ctttttgatt gctgcaggta actgaaacaa acctagcatt
     2341 tttaaaaaat aagattaatg gaagacttta aggtatttta aaattcgaag ggtatccaag
     2401 gttctgtatt tatttattgg ggagacacta acccttcaaa gaagcaggct gtgaacattg
     2461 ggtgcccagt gctatcagat gagttaaaac ctttgattct catttctatt tgtaaattct
     2521 taagcaaata gaagccgagt gttaaggtgt tttgcttctg aaagagggct gtgccttccg
     2581 tttcagaagg agacattttg ctgttacatt ctgccagggg caaaagatac taggcccagg
     2641 agtcaagaaa agcttttgtg aaagtgatag tttcacctga ctttgattcc ttaacccccg
     2701 gcttttggaa caagccatgt ttgccctagt ccaggattgc ctcacttgag acttgctagg
     2761 cctctgctgt gtgctggggt ggccagtggg actcaggaga gagcaagcta aggagtcacc
     2821 aaaaaaaaaa aaaaaaaaaa gggagaattt aaaagtgtac agttgtgtgt ttagatacac
     2881 tatagaataa tgtggtatat attgtacaaa tagtctacat aggtgtctgg gataatgtaa
     2941 aactggtgct ttggctttgt aaagaatttg caaatcactt aacagctgca ggggcaaggg
     3001 gagagtttca tcatccccat gatatttggg aatattctgt ttacttctta gatagttaag
     3061 aatgtattca gctactatgt actaacttga accgtgttta aggaaaactc ctatttcatc
     3121 ctcttcttgc gccatcccct ctccctaact tggtaatgtg aagaaactaa aacctgatac
     3181 cacagctcct ataggcattt tagagatctt ggatttttat gtacagtctt agtcattttt
     3241 aataaatgtg gttcagtaag ggaa
//
