LOCUS       NM_001013845            1333 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens endothelium and lymphocyte associated ASCH domain 2
            (EOLA2), mRNA.
ACCESSION   NM_001013845 XM_003846773 XM_003846774 XM_003846775 XM_003846776
            XM_003846777 XM_003846778 XM_003846779 XM_003846780 XM_003846781
            XM_003846782 XM_003846783
VERSION     NM_001013845.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1333)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1333)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   3  (bases 1 to 1333)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   4  (bases 1 to 1333)
  AUTHORS   Timms,K.M., Bondeson,M.L., Ansari-Lari,M.A., Lagerstedt,K.,
            Muzny,D.M., Dugan-Rocha,S.P., Nelson,D.L., Pettersson,U. and
            Gibbs,R.A.
  TITLE     Molecular and phenotypic variation in patients with severe Hunter
            syndrome
  JOURNAL   Hum Mol Genet 6 (3), 479-486 (1997)
   PUBMED   9147653
REFERENCE   5  (bases 1 to 1333)
  AUTHORS   Timms,K.M., Lu,F., Shen,Y., Pierson,C.A., Muzny,D.M., Gu,Y.,
            Nelson,D.L. and Gibbs,R.A.
  TITLE     130 kb of DNA sequence reveals two new genes and a regional
            duplication distal to the human iduronate-2-sulfate sulfatase locus
  JOURNAL   Genome Res 5 (1), 71-78 (1995)
   PUBMED   8717057
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM847839.1, U66042.1 and BC009523.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001013845.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U66042.1, SRR1660803.273610.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370406.8/ ENSP00000359434.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BM847839.1         8-13
            7-1331              U66042.1           1-1325
            1332-1333           BC009523.1         945-946
FEATURES             Location/Qualifiers
     source          1..1333
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..1333
                     /gene="EOLA2"
                     /gene_synonym="CXorf40B"
                     /note="endothelium and lymphocyte associated ASCH domain
                     2"
                     /db_xref="GeneID:541578"
                     /db_xref="HGNC:HGNC:17402"
     exon            1..299
                     /gene="EOLA2"
                     /gene_synonym="CXorf40B"
                     /inference="alignment:Splign:2.1.0"
     exon            300..347
                     /gene="EOLA2"
                     /gene_synonym="CXorf40B"
                     /inference="alignment:Splign:2.1.0"
     exon            348..480
                     /gene="EOLA2"
                     /gene_synonym="CXorf40B"
                     /inference="alignment:Splign:2.1.0"
     exon            481..762
                     /gene="EOLA2"
                     /gene_synonym="CXorf40B"
                     /inference="alignment:Splign:2.1.0"
     CDS             510..986
                     /gene="EOLA2"
                     /gene_synonym="CXorf40B"
                     /note="protein CXorf40B"
                     /codon_start=1
                     /product="protein EOLA2"
                     /protein_id="NP_001013867.1"
                     /db_xref="CCDS:CCDS35426.1"
                     /db_xref="GeneID:541578"
                     /db_xref="HGNC:HGNC:17402"
                     /translation="MKFGCLSFRQPYAGFVLNGIKTVETRWRPLLSSQRNCTIAVHIA
                     HRDWEGDACRELLVERLGMTPAQIQALLRKGEKFGRGVIAGLVDIGETLQCPEDLTPD
                     EVVELENQAALTNLKQKYLTVISNPRWLLEPIPRKGGKDVFQVDIPEHLIPLGHEV"
     exon            763..1333
                     /gene="EOLA2"
                     /gene_synonym="CXorf40B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1314..1319
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EOLA2"
                     /gene_synonym="CXorf40B"
                     /note="hexamer: AATAAA"
     polyA_site      1333
                     /gene="EOLA2"
                     /gene_synonym="CXorf40B"
                     /note="major polyA site"
ORIGIN      
        1 gcacacgtac gttcctcatg aaagggacga cgggagctgc atgaaagccg aagttatgga
       61 ccgctagcat ctgtcactgg ccaccggttt ccgggagtaa gcggcagcta ccttacagcc
      121 ctgacacgag ccgggtgctc tctcttctca ccgcggccca cgtctcctcg ctggctccgg
      181 tggcctcgct gggtcgcgag gaggcggagg actgtactct gaggccaaaa gccagagtcg
      241 gccctgaacg cccacgactc tcagggtcca gaggccgtga gaccggccgc ggctgaaagg
      301 taaagaaacc aagtggaaga gtgtttcctc ctctggccgt aaagcagctg tccccgccct
      361 actccggacc gccccaaaga ctccatggga tggacctgag tcagccgaat cctagcccct
      421 tcccttgggc ctgctgtggt gctcgacatc agtgacagac ggaagcagca gaccatcaag
      481 gctacgggag gcccggggcg cttgcgaaga tgaagtttgg ctgcctctcc ttccggcagc
      541 cttatgctgg ctttgtctta aatggaatca agactgtgga gacgcgctgg cgtcctctgc
      601 tgagcagcca gcggaactgt accatcgccg tccacattgc tcacagggac tgggaaggcg
      661 atgcctgtcg ggagctgctg gtggagagac tcgggatgac tcctgctcag attcaggcct
      721 tgctcaggaa aggggaaaag tttggtcgag gagtgatagc gggactcgtt gacattgggg
      781 aaactttgca atgccccgaa gacttaactc ccgatgaggt tgtggaacta gaaaatcaag
      841 ctgcactgac caacctgaag cagaagtacc tgactgtgat ttcaaacccc aggtggttac
      901 tggagcccat acctaggaaa ggaggcaagg atgtattcca ggtagacatc ccagagcacc
      961 tgatcccttt ggggcatgaa gtgtgacaag tgtgggctcc tgaaaggaat gttccagaga
     1021 aaccagctaa atcatggcac cttcaatttg ccatcgtgac gcagacctgt ataaattagg
     1081 ttaaagatga atttccactg ctttggagag tcccacccac taagcactgt gcatgtaaac
     1141 aggttccttt gctcagatga aggaagtagg gggtggggct ttccttgtgt gatgcctcct
     1201 taggcacaca ggcaatgtct caagtacttt gaccttaggg tagaaggcaa agctgccagt
     1261 aaatgtctca gcattgctgc taattttggt cctgctagtt tctggattgt acaaataaat
     1321 gtgttgtaga tga
//
