LOCUS       NM_001171907            2407 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens endothelium and lymphocyte associated ASCH domain 1
            (EOLA1), transcript variant 2, mRNA.
ACCESSION   NM_001171907 XM_005276108
VERSION     NM_001171907.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2407)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2407)
  AUTHORS   Kim,M., Park,S.H., Park,J.S., Kim,H.J. and Han,B.W.
  TITLE     Crystal Structure of Human EOLA1 Implies Its Possibility of RNA
            Binding
  JOURNAL   Molecules 24 (19), 3529 (2019)
   PUBMED   31569543
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2407)
  AUTHORS   Wu,M., Leng,W., Pan,H., Lei,X., Chen,L., Ouyang,X. and Liang,Z.
  TITLE     The Reduced Expression of EOLA1 May Be Related to Refractory
            Diabetic Foot Ulcer
  JOURNAL   Mediators Inflamm 2019, 6705424 (2019)
   PUBMED   31007603
  REMARK    GeneRIF: The results of immunofluorescence and immunohistochemistry
            showed that EOLA1 was expressed in the epithelial tissues of
            Diabetic Foot Ulcer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2407)
  AUTHORS   Liu,Y., Liu,H., Chen,W., Yang,T. and Zhang,W.
  TITLE     EOLA1 protects lipopolysaccharide induced IL-6 production and
            apoptosis by regulation of MT2A in human umbilical vein endothelial
            cells
  JOURNAL   Mol Cell Biochem 395 (1-2), 45-51 (2014)
   PUBMED   24916366
  REMARK    GeneRIF: Data shows that EOLA1 in HUVEC dramatically decreased
            inflammation factor IL-6 production and apoptosis induced by LPS
            treatment.
REFERENCE   5  (bases 1 to 2407)
  AUTHORS   Liang,Z. and Yang,Z.
  TITLE     Identification and characterization of a novel gene EOLA1
            stimulating ECV304 cell proliferation
  JOURNAL   Biochem Biophys Res Commun 325 (3), 798-802 (2004)
   PUBMED   15541360
  REMARK    GeneRIF: EOLA1 and MT2A may have an important role of cell
            protection in inflammation reaction.
REFERENCE   6  (bases 1 to 2407)
  AUTHORS   Hinz,T., Allam,A., Wesch,D., Schindler,D. and Kabelitz,D.
  TITLE     Cell-surface expression of transrearranged Vgamma-cbeta T-cell
            receptor chains in healthy donors and in ataxia telangiectasia
            patients
  JOURNAL   Br J Haematol 109 (1), 201-210 (2000)
   PUBMED   10848801
REFERENCE   7  (bases 1 to 2407)
  AUTHORS   Timms,K.M., Bondeson,M.L., Ansari-Lari,M.A., Lagerstedt,K.,
            Muzny,D.M., Dugan-Rocha,S.P., Nelson,D.L., Pettersson,U. and
            Gibbs,R.A.
  TITLE     Molecular and phenotypic variation in patients with severe Hunter
            syndrome
  JOURNAL   Hum Mol Genet 6 (3), 479-486 (1997)
   PUBMED   9147653
REFERENCE   8  (bases 1 to 2407)
  AUTHORS   Timms,K.M., Lu,F., Shen,Y., Pierson,C.A., Muzny,D.M., Gu,Y.,
            Nelson,D.L. and Gibbs,R.A.
  TITLE     130 kb of DNA sequence reveals two new genes and a regional
            duplication distal to the human iduronate-2-sulfate sulfatase locus
  JOURNAL   Genome Res 5 (1), 71-78 (1995)
   PUBMED   8717057
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB156531.1, BC104930.1, L43576.1, AW952651.1, BF115859.1,
            DC426016.1 and AI088770.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001171907.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.165520.1,
                                           SRR1803616.152411.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393985.8/ ENSP00000421745.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               CB156531.1         39-151
            114-1230            BC104930.1         1-1117
            1231-1755           L43576.1           446-970
            1756-1843           AW952651.1         1-88                c
            1844-2048           BF115859.1         77-281
            2049-2406           DC426016.1         1-358               c
            2407-2407           AI088770.1         37-37               c
FEATURES             Location/Qualifiers
     source          1..2407
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..2407
                     /gene="EOLA1"
                     /gene_synonym="CXorf40; CXorf40A"
                     /note="endothelium and lymphocyte associated ASCH domain
                     1"
                     /db_xref="GeneID:91966"
                     /db_xref="HGNC:HGNC:28089"
                     /db_xref="MIM:300954"
     exon            1..332
                     /gene="EOLA1"
                     /gene_synonym="CXorf40; CXorf40A"
                     /inference="alignment:Splign:2.1.0"
     exon            333..399
                     /gene="EOLA1"
                     /gene_synonym="CXorf40; CXorf40A"
                     /inference="alignment:Splign:2.1.0"
     exon            400..532
                     /gene="EOLA1"
                     /gene_synonym="CXorf40; CXorf40A"
                     /inference="alignment:Splign:2.1.0"
     exon            533..814
                     /gene="EOLA1"
                     /gene_synonym="CXorf40; CXorf40A"
                     /inference="alignment:Splign:2.1.0"
     CDS             562..1038
                     /gene="EOLA1"
                     /gene_synonym="CXorf40; CXorf40A"
                     /note="isoform a is encoded by transcript variant 2;
                     endothelial-overexpressed lipopolysaccharide-associated
                     factor 1; protein CXorf40A; protein EOLA1"
                     /codon_start=1
                     /product="protein EOLA1 isoform a"
                     /protein_id="NP_001165378.1"
                     /db_xref="CCDS:CCDS14687.1"
                     /db_xref="GeneID:91966"
                     /db_xref="HGNC:HGNC:28089"
                     /db_xref="MIM:300954"
                     /translation="MKFGCLSFRQPYAGFVLNGIKTVETRWRPLLSSQRNCTIAVHIA
                     HRDWEGDAWRELLVERLGMTPAQIQALLRKGEKFGRGVIAGLVDIGETLQCPEDLTPD
                     EVVELENQAVLTNLKQKYLTVISNPRWLLEPIPRKGGKDVFQVDIPEHLIPLGHEV"
     exon            815..2407
                     /gene="EOLA1"
                     /gene_synonym="CXorf40; CXorf40A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1366..1371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EOLA1"
                     /gene_synonym="CXorf40; CXorf40A"
                     /note="hexamer: AATAAA"
     polyA_site      1385
                     /gene="EOLA1"
                     /gene_synonym="CXorf40; CXorf40A"
                     /note="major polyA site"
     regulatory      2361..2366
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EOLA1"
                     /gene_synonym="CXorf40; CXorf40A"
                     /note="hexamer: ATTAAA"
     polyA_site      2407
                     /gene="EOLA1"
                     /gene_synonym="CXorf40; CXorf40A"
                     /note="major polyA site"
ORIGIN      
        1 ggaagagtta tagaccgcta acacctgtca ctggccactg gtttcccgga gttagcggca
       61 acgaccttgc agcctggaca ctagccaggc gctccctctt ctcacagcgg cccacgtctc
      121 cttgcttggg agcccatcgt cctggctccg gtggcctcgc tgggtctcgg ggaagcagag
      181 gactgttcat tcctgtggcg aaaagccgga gtcggcccta gacacccacg actcgcaggg
      241 tccatggttc cggaggccgt gagacctgcc ggggctgaca ggtgccaggg cccatgctgc
      301 gggagcctgt gtgctcagcc ttcttgcgga cggtaaagaa gctaagtgga agagtgtttc
      361 ctcctctggc cgtaaagcag gtactctctg cagcaccagc tgtccccgcc ctactccgga
      421 ccgccccaaa gactccatgg gatggacctg agtcagccga atcccagccc cttcccttgg
      481 gcctgctgtg gtgctggaca tcagtgacag acggaagcag gagaccatca aggctacggg
      541 aggcccgggg cgcttgcgaa gatgaagttt ggctgcctct ccttccggca gccttatgct
      601 ggctttgtct taaatggaat caagactgtg gagacgcgct ggcgtcccct gctgagcagc
      661 cagcggaact gtaccatcgc cgtccacatt gctcacaggg actgggaagg cgatgcctgg
      721 cgggagctgc tggtggagag actcgggatg actcctgctc agattcaggc cttgctcagg
      781 aaaggggaaa agtttggtcg aggagtgata gcgggactcg ttgacattgg ggaaactttg
      841 caatgccccg aagacttaac tcccgatgag gttgtggaac tagaaaatca agctgtactg
      901 accaacctga agcagaagta cctgactgtg atttcaaacc ccaggtggtt actggagccc
      961 atacctagga aaggaggcaa ggatgtattc caggtagaca tcccagagca cctgatccct
     1021 ttggggcatg aagtgtgaca agtgtgggct cctgaaagga atgttccaga gaaaccagct
     1081 aaatcatgac accttcaatt tgccatcatg acgcagacct gtatacatta ggttaaatct
     1141 gaatttccac tgctttggag agtcccaccc actaagcact gtgcatgtaa acaggttcct
     1201 ttgctcagat gaaggaagta gggggtgggg ctttccttgt gtgatgcctc cttaggcaca
     1261 caggcaatgt ctcaagtact ttgaccttag ggtagaaggc aaagctgcca gtaaatgtct
     1321 cagcattgct gctaattttg gtcctgctag tttctggatt gtacaaataa atgtgttgta
     1381 gatgactggt tagtgtttga ggctttgttc tatgttttcc cctgatttgt tctggtcaaa
     1441 actcatcaaa tgtgtaacta gcatccaggc gacaatacag aaagtctggg acctggcact
     1501 gaatgtttgc ctggtagtga ctagccgtta atcaaccgac tcatccagga tgaagaggac
     1561 gtcagactta gagcagctgt ctgtcctttc aggttactct cactcttctg aaagtgtctg
     1621 tcagtttctg aagcatgtgt gttacctgca tcacacagct acttcctatc ctagcaatac
     1681 atccaaaata cagctctagt agagtgaggt taacttggaa atgtgatcag tagtgttgtt
     1741 ttattttgta gtaatttttt tttttttttg gtgatttagc aaagtttcta gttgttatcc
     1801 atgaggatga tgggcatttc cccccaggta ttgactgcag tggcccttct cttctgagcc
     1861 aggatgttat ggtggttgta catcccatgg cagatggggt ggcctgactt tcaagtgggc
     1921 ctctttggag gcccctggat gctaggctag ggatgctgag ctgctgacca gacacttcct
     1981 ggcaacattg ggagggaccc atgaggaaac aatctcctgt ttgaagatac aggaagatat
     2041 tgccggaatc aggcgtctat tctttctcct gaccagcagg ccaatctcag gggaccaggt
     2101 cttcctgggc ttggcctcga cacttcctag caacatcctt tgctgagtgt gtgaaaatgc
     2161 tgcttctcca aataaacaag gacaatgggg accaaagcct gtcttggaca ggatttccag
     2221 cctcccctgg tttctgccaa tgagatgtat ataatataca aggttaaaaa aaacacagac
     2281 aacagttctc atttaaattg tttattattt atttccatgg aattttgttt ttctttatta
     2341 agaccaaaaa tgtgtttctc attaaaaaat ggcaactttt atgggccatt agtggcctgt
     2401 gacttca
//
