LOCUS       NM_020189               2901 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ENY2 transcription and export complex 2 subunit
            (ENY2), transcript variant 1, mRNA.
ACCESSION   NM_020189
VERSION     NM_020189.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2901)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 2901)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2901)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2901)
  AUTHORS   Li,W., Atanassov,B.S., Lan,X., Mohan,R.D., Swanson,S.K.,
            Farria,A.T., Florens,L., Washburn,M.P., Workman,J.L. and
            Dent,S.Y.R.
  TITLE     Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA
            Deubiquitinase Module
  JOURNAL   Mol Cell Biol 36 (22), 2855-2866 (2016)
   PUBMED   27601583
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2901)
  AUTHORS   Atanassov,B.S., Mohan,R.D., Lan,X., Kuang,X., Lu,Y., Lin,K.,
            McIvor,E., Li,W., Zhang,Y., Florens,L., Byrum,S.D.,
            Mackintosh,S.G., Calhoun-Davis,T., Koutelou,E., Wang,L., Tang,D.G.,
            Tackett,A.J., Washburn,M.P., Workman,J.L. and Dent,S.Y.
  TITLE     ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B
            Deubiquitinases Important for Cellular Proliferation and Tumor
            Growth
  JOURNAL   Mol Cell 62 (4), 558-571 (2016)
   PUBMED   27132940
  REMARK    GeneRIF: ATXN7L3 and ENY2 orchestrate activities of multiple
            deubiquitinating enzymes, including USP27x and USP51, and that
            imbalances in these activities likely potentiate human diseases
            including cancer.
REFERENCE   6  (bases 1 to 2901)
  AUTHORS   Martinez,E., Palhan,V.B., Tjernberg,A., Lymar,E.S., Gamper,A.M.,
            Kundu,T.K., Chait,B.T. and Roeder,R.G.
  TITLE     Human STAGA complex is a chromatin-acetylating transcription
            coactivator that interacts with pre-mRNA splicing and DNA
            damage-binding factors in vivo
  JOURNAL   Mol Cell Biol 21 (20), 6782-6795 (2001)
   PUBMED   11564863
REFERENCE   7  (bases 1 to 2901)
  AUTHORS   Georgieva,S., Nabirochkina,E., Dilworth,F.J., Eickhoff,H.,
            Becker,P., Tora,L., Georgiev,P. and Soldatov,A.
  TITLE     The novel transcription factor e(y)2 interacts with TAF(II)40 and
            potentiates transcription activation on chromatin templates
  JOURNAL   Mol Cell Biol 21 (15), 5223-5231 (2001)
   PUBMED   11438676
REFERENCE   8  (bases 1 to 2901)
  AUTHORS   Brand,M., Moggs,J.G., Oulad-Abdelghani,M., Lejeune,F.,
            Dilworth,F.J., Stevenin,J., Almouzni,G. and Tora,L.
  TITLE     UV-damaged DNA-binding protein in the TFTC complex links DNA damage
            recognition to nucleosome acetylation
  JOURNAL   EMBO J 20 (12), 3187-3196 (2001)
   PUBMED   11406595
REFERENCE   9  (bases 1 to 2901)
  AUTHORS   Brand,M., Yamamoto,K., Staub,A. and Tora,L.
  TITLE     Identification of TATA-binding protein-free TAFII-containing
            complex subunits suggests a role in nucleosome acetylation and
            signal transduction
  JOURNAL   J Biol Chem 274 (26), 18285-18289 (1999)
   PUBMED   10373431
REFERENCE   10 (bases 1 to 2901)
  AUTHORS   Wieczorek,E., Brand,M., Jacq,X. and Tora,L.
  TITLE     Function of TAF(II)-containing complex without TBP in transcription
            by RNA polymerase II
  JOURNAL   Nature 393 (6681), 187-191 (1998)
   PUBMED   9603525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF173296.1, AK095651.1 and BU737295.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020189.5.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA292445.1, SRR1660805.187602.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000521688.6/ ENSP00000429986.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-637               AF173296.1         95-731
            638-2900            AK095651.1         706-2968
            2901-2901           BU737295.1         24-24               c
FEATURES             Location/Qualifiers
     source          1..2901
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q23.1"
     gene            1..2901
                     /gene="ENY2"
                     /gene_synonym="DC6; e(y)2; Sus1"
                     /note="ENY2 transcription and export complex 2 subunit"
                     /db_xref="GeneID:56943"
                     /db_xref="HGNC:HGNC:24449"
                     /db_xref="MIM:619015"
     exon            1..128
                     /gene="ENY2"
                     /gene_synonym="DC6; e(y)2; Sus1"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..428
                     /gene="ENY2"
                     /gene_synonym="DC6; e(y)2; Sus1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     enhancer of yellow 2 transcription factor homolog;
                     transcription and mRNA export factor ENY2; enhancer of
                     yellow 2 homolog"
                     /codon_start=1
                     /product="transcription and mRNA export factor ENY2
                     isoform 1"
                     /protein_id="NP_064574.1"
                     /db_xref="CCDS:CCDS43762.1"
                     /db_xref="GeneID:56943"
                     /db_xref="HGNC:HGNC:24449"
                     /db_xref="MIM:619015"
                     /translation="MVVSKMNKDAQMRAAINQKLIETGERERLKELLRAKLIECGWKD
                     QLKAHCKEVIKEKGLEHVTVDDLVAEITPKGRALVPDSVKKELLQRIRTFLAQHASL"
     exon            129..205
                     /gene="ENY2"
                     /gene_synonym="DC6; e(y)2; Sus1"
                     /inference="alignment:Splign:2.1.0"
     exon            206..276
                     /gene="ENY2"
                     /gene_synonym="DC6; e(y)2; Sus1"
                     /inference="alignment:Splign:2.1.0"
     exon            277..351
                     /gene="ENY2"
                     /gene_synonym="DC6; e(y)2; Sus1"
                     /inference="alignment:Splign:2.1.0"
     exon            352..2901
                     /gene="ENY2"
                     /gene_synonym="DC6; e(y)2; Sus1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      592..597
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENY2"
                     /gene_synonym="DC6; e(y)2; Sus1"
                     /note="hexamer: AATAAA"
     polyA_site      618
                     /gene="ENY2"
                     /gene_synonym="DC6; e(y)2; Sus1"
                     /note="major polyA site"
     regulatory      1376..1381
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENY2"
                     /gene_synonym="DC6; e(y)2; Sus1"
                     /note="hexamer: AATACA"
     polyA_site      1398
                     /gene="ENY2"
                     /gene_synonym="DC6; e(y)2; Sus1"
     regulatory      2881..2886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENY2"
                     /gene_synonym="DC6; e(y)2; Sus1"
                     /note="hexamer: AATAAA"
     polyA_site      2901
                     /gene="ENY2"
                     /gene_synonym="DC6; e(y)2; Sus1"
ORIGIN      
        1 gtgtgcttag gtgcccgagc tactgagggt ctaagtccgg gcagccgaag agtgtggtag
       61 gtaacggtcc tcagcgcaag ggtcatttcg tcgctgggaa gggacggccc tcgcccgcgg
      121 tgatggtggt tagcaagatg aacaaagatg cgcagatgag agcagcgatt aaccaaaagt
      181 tgatagaaac tggagaaaga gaacgcctca aagagttgct gagagctaaa ttaattgaat
      241 gtggctggaa ggatcagttg aaggcacact gtaaagaggt aattaaagaa aaaggactag
      301 aacacgttac tgttgatgac ttggtggctg aaatcactcc aaaaggcaga gccctggtac
      361 ctgacagtgt aaagaaggag ctcctacaaa gaataagaac attccttgct cagcatgcca
      421 gcctttaaga ttgaattaga ttgtgttgtt gtggttttat ttctgaaagt aaaacttgcc
      481 ataaattaga aaacaatttc ccaaaataaa atcctttttt gtatgatggt atacagtttt
      541 cagtaatgat gtatacattg tattgatttt tttccctaaa tgtgttattt taataaatat
      601 ctcatgaatg agtttgaagt ttgcttggat tttgaaatga atgggacttt gtctttatta
      661 ctaattcacc aaatttgttg agcgcaaaag caattaatgt agtttaagta tttagtatgt
      721 acagttctct gtgttaacag ctgagaagta agcaaccttt tctgactgca tatggtgtat
      781 tcctcttttg agtccccata atattttata aattgtaatg ccccatcttg tactacagtt
      841 gtcttattcg tattgtttat aaactttgag ggttaggact gggtcttact catctttatg
      901 tgccttcctt atgcttcaaa gaatttacca tctaatggaa gagaacattt gcaagttggc
      961 tccataccaa gctccttcca catactctac tcatctgaac tttgaatgca gaatctttaa
     1021 attgcaaccc cacatactaa ggtcaagaaa gaacttaatg ggaattaatc tccacccatt
     1081 agctttaccc tgacatcagg attgccaaat ccaatggact cttgtctatt cttacgtgac
     1141 ttctgctgga aaatgcgaat gttgaccatc ctgccacttg gaactctctt cccactcctc
     1201 acattgcttt tgctaccact ggaagttcct tctgtttctt gtggagtacc ttttgctgtc
     1261 tgggacttgt agataatggt gtttcctagg gctccctcca gggccctctg cctcactaac
     1321 tggatatact tttcctgagc aaatcccagg aaacttgcgt cagaccgtga cttcaaatac
     1381 aggttgataa atgctaaact gtctccaaac cagacttcat cctagcctcc acacccagac
     1441 acccaactgc tatggatcaa ctttttagaa tatcctcact tcaaactgac cttacctaaa
     1501 ataatgactt tttcccccaa taattgcccc tgctatattc cttatttctg aatggtacct
     1561 cctagctata tagattatct gaggagctta ctgaaatgct gattctgaag ataaggggca
     1621 tggctttaag attctgtatt tctggcgagt acccaactgg tgctcatgct gctgattgag
     1681 aaccacttct gaatatagca aggctgtaaa ttatccacta cgtgccctcg taattgtctt
     1741 agttcaagcc cagattattg tagtagactt agtatttctt tgccttagtt gatctgtgac
     1801 ccctccaata tctattccac actgttgcct aagtggcctt agtaaaattc aagtctggtt
     1861 attttattcc cctgcttgga atttctcaat gtagaatgaa actcattcag cattaacaca
     1921 taggcccttc ttgatctgac atcgtgtttc tctagttaga ctaaagaatc cccactatga
     1981 agttgtttca tccgtaagta cctttgaacc cagaagcccc ctttctcata tgtttctcat
     2041 tcctgtttgc ccttcagagt tcagctttag ttgctaaaac attcagacat ccctctgact
     2101 tagatccccc actactgttt ttctgtgaga agcagctatg cataattcct cttcaacaca
     2161 gtagttcttg aaattttgca ggcctctcct ggaaaggagg aaatgacttc tctgactttg
     2221 tatgatgctt atttgtggat gaatgggcaa gggaaaaaat gaaggaacaa gtgaatgaac
     2281 agtatgggag tatgagaaaa ggtataaatt gggtatagtt gagaaaagga ttcaaattga
     2341 tctttggttc gagagacaat ttcatctttc tgatgaattt aaagtgtagt ctttgaacca
     2401 gctgggctta attatgtaaa gttttgagcc tgagataagc acacaatcac aaaacctacc
     2461 caaacaagtt ttttgtttca cttcatctct tataaaacaa tgttctaaag taagtgatag
     2521 ggatgctcat cattctgcta cctattatca caatgaaaac aatcataaat agtacacagg
     2581 aaaggtgaga aatagcggat agttcttatt tcatagtact gtatatggaa ataaaccaaa
     2641 tttgctcata gagatactat tttattacct caaaaatata taaaaatgaa aacgttatga
     2701 aaatatttta aaatgggatt taaaaataat tgagaacatc acagcaattt agaatactaa
     2761 agagcatagc tttaaaatga tagtgctgag aactccccac ctctacccca ccacctgtag
     2821 gcttctttga caacttacaa atgttctcta gtttgtatct agaatcactt atatctttca
     2881 aataaaccaa ctttgtgaac a
//
